{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:04:24Z","timestamp":1757700264966,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic kidney disease is a prognostic factor for cardiovascular disease. Worsening renal function (WRF), specifically, is an important predictor of mortality in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention (PCI). We evaluate the prognostic impact of mid-term WRF after PCI on future cardiovascular events. We examined the renal function data of 1086 patients in the first year after PCI using the SHINANO 5-year registry. Patients were divided into two groups, mid-term WRF and non-mid-term WRF, and primary outcomes were major adverse cardiovascular events (MACE) and death. Mid-term WRF was defined as an increase in creatinine (\u2265\u20090.3\u00a0mg\/dL) in the first year after PCI. Mid-term WRF was found in 101 patients (9.3%), and compared to non-mid-term WRF, it significantly increased the incidence of MACE (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and all-cause death (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), myocardial infarction (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Furthermore, mid-term WRF patients had higher incidence of future heart failure (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and new-onset atrial fibrillation (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Patients with both mid-term WRF and chronic kidney disease had increased MACE compared to patients with either condition alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similarly, patients with mid-term WRF and acute kidney injury had increased MACE compared to patients with either condition alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate Cox regression analysis revealed mid-term WRF as a strong predictor of MACE (hazard ratio: 2.50, 95% confidence interval 1.57\u20133.98, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mid-term WRF after PCI negatively affects MACE, as well as future admission due to heart failure and new-onset atrial fibrillation, chronic kidney disease, and acute kidney injury.<\/jats:p>","DOI":"10.1007\/s00380-021-01837-8","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T15:03:34Z","timestamp":1617807814000},"page":"1496-1505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic ability of mid-term worsening renal function after percutaneous coronary intervention: findings from the SHINANO registry"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-1915","authenticated-orcid":false,"given":"Yoshiteru","family":"Okina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Senda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minami","family":"Taki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Okuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyuhachi","family":"Otagiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Shoin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Ebisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Karube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Saigusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Machida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetomo","family":"Nomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Yui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Mochidome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uichi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"1837_CR1","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1056\/NEJMoa041031","volume":"351","author":"AS Go","year":"2004","unstructured":"Go AS, Chertow MG, Fan D, McCulloch CE, Hsu C (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351:1296\u20131305","journal-title":"N Engl J Med"},{"key":"1837_CR2","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s10157-018-1622-y","volume":"23","author":"T Aoki","year":"2019","unstructured":"Aoki T, Ishii H, Tanaka A, Suzuki S, Ichimiya S, Kanashiro M, Murohara T (2019) Influence of chronic kidney disease and worsening renal function on clinical outcome in patients undergoing primary percutaneous coronary intervention. Clin Exp Nephrol 23:182\u2013188","journal-title":"Clin Exp Nephrol"},{"key":"1837_CR3","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.ijcard.2012.01.097","volume":"167","author":"HF AlFaleh","year":"2013","unstructured":"AlFaleh HF, Alsuwaida AO, Ullah A, Hersi A, AlHabib KF, AlNemer K, AlSaif S, Taraben A, Kashour T, Balghith MA, Ahmed WH (2013) The prognostic impact of in-hospital worsening renal function in patients with acute coronary syndrome. Int J Cardiol 167:866\u2013870","journal-title":"Int J Cardiol"},{"key":"1837_CR4","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.ahj.2010.08.007","volume":"160","author":"AP Amin","year":"2010","unstructured":"Amin AP, Spertus JA, Reid KJ, Lan X, Buchanan DM, Decker C, Masoudi FA (2010) The prognostic importance of worsening renal function during an acute myocardial infarction on long-term mortality. Am Heart J 160:1065\u20131071","journal-title":"Am Heart J"},{"key":"1837_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.ahj.2004.09.055","volume":"150","author":"A Goldberg","year":"2005","unstructured":"Goldberg A, Hammerman H, Petcherski S, Zdorovyak A, Yalonetsky S, Kapeliovich M, Agmon Y, Markiewicz W, Aronson D (2005) Inhospital and 1-year mortality if patients who develop worsening renal function acute ST-elevation myocardial infarction. Am Heart J 150:330\u2013337","journal-title":"Am Heart J"},{"key":"1837_CR6","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.amjcard.2006.10.058","volume":"99","author":"R Latchamsetty","year":"2007","unstructured":"Latchamsetty R, Fang J, Kline-Rogers E, Mukherjee D, Otten RF, LaBounty TM, Emery MS, Eagle KM, Froehlich JB (2007) Prognostic value of transient and sustained increase in in-hospital creatinine on outcomes of patients admitted with acute coronary syndrome. Am J Cardiol 99:939\u2013942","journal-title":"Am J Cardiol"},{"key":"1837_CR7","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/ejhf.609","volume":"18","author":"K Damman","year":"2016","unstructured":"Damman K, Solomon SD, Pfeffer MA, Swedberg K, Yusuf S, Young JB, Rouleau JL, Granger CB, McMurray JJV (2016) Worsening renal function and outcome in heart failure patients with reduced and preserved ejection function and the impact of angiotensin receptor blocker treatment: data from the CHARM-study programme. Eur J Heart Fail 18:1508\u20131517","journal-title":"Eur J Heart Fail"},{"key":"1837_CR8","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1177\/2048872615589511","volume":"5","author":"A Palazzuoli","year":"2016","unstructured":"Palazzuoli A, Lombardi C, Ruocco G, Padeletti M, Nuti R, Metra M, Ronco C (2016) Chronic kidney disease and worsening renal function in acute heart failure: different phenotypes with similar prognostic impact? Eur Heart J Acute Cardiovasc Care 5:534\u2013548","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"1837_CR9","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1093\/eurheartj\/ehr238","volume":"32","author":"JE Blair","year":"2011","unstructured":"Blair JE, Pang PS, Schrier RW, Metra M, Traver B, Cook T, Campia U, Ambrosy A, Burnett JC Jr, Grinfeld L, Maggioni AP, Swedberg K, Udelson JE, Zannad F, Konstam MA, Gheorghiade M (2011) Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial. Eur Heart J 32:2563\u20132572","journal-title":"Eur Heart J"},{"key":"1837_CR10","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.cardfail.2010.02.001","volume":"16","author":"D Aronson","year":"2010","unstructured":"Aronson D, Burger AJ (2010) The relationship between transient and persistent worsening renal function and mortality in patients with acute decompensated heart failure. J Cardiac Fail 16:541\u2013547","journal-title":"J Cardiac Fail"},{"key":"1837_CR11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s00380-020-01672-3","volume":"36","author":"I Kubo","year":"2021","unstructured":"Kubo I, Izawa KP, Kajisa N, Ryu M, Akasaka H, Ogura A, Kanai M, Matsuzoe H, Matsumoto D (2021) Worsening renal function during hospitalization in elderly patients with heart failure: an independent factor of activities of daily living decline. Heart Vessels 36:76\u201384","journal-title":"Heart Vessels"},{"key":"1837_CR12","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ejheart.2008.01.011","volume":"10","author":"M Metra","year":"2008","unstructured":"Metra M, Nodari S, Parrinello G, Bordonali T, Bugatti S, Danesi R, Fontanella B, Lombardi C, Milani P, Verzura G, Cotter G, Dittrich H, Massie BM, Cas LD (2008) Worsening renal function in patients hospitalized for acute heart failure: clinical implications and prognostic significance. Eur J Heart Fail 10:188\u2013195","journal-title":"Eur J Heart Fail"},{"key":"1837_CR13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cardiores.2004.03.026","volume":"63","author":"N Hanna","year":"2004","unstructured":"Hanna N, Cardin S, Leung TK, Nattel S (2004) Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure. Cardiovasc Res 63:236\u2013244","journal-title":"Cardiovasc Res"},{"key":"1837_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1161\/01.CIR.102.2.203","volume":"102","author":"HL Hillege","year":"2000","unstructured":"Hillege HL, Girbes AR, de Kam PJ, Boomsma F, de Zeeuw D, Charlesworth A, Hampton JR, van Veldhuisen J (2000) Renal function, neurohormonal activation, and survival in patients with chronic heart failure. Circulation 102:203\u2013210","journal-title":"Circulation"},{"key":"1837_CR15","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.jacc.2008.05.068","volume":"53","author":"W Mullens","year":"2009","unstructured":"Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, Young JB, Tang WHW (2009) Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol 53:589\u2013596","journal-title":"J Am Coll Cardiol"},{"key":"1837_CR16","first-page":"713","volume":"5","author":"J Wright","year":"2009","unstructured":"Wright J, Hutchison A (2009) Cardiovascular disease in patients with chronic kidney disease. Vasc Health Risk Manag 5:713\u2013722","journal-title":"Vasc Health Risk Manag"},{"key":"1837_CR17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.106.678342","volume":"116","author":"EL Schiffrin","year":"2007","unstructured":"Schiffrin EL, Lipman ML, Mann JFE (2007) Chronic kidney disease effects on the cardiovascular system. Circulation 116:85\u201397","journal-title":"Circulation"},{"key":"1837_CR18","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1161\/01.CIR.0000027560.41358.B3","volume":"106","author":"J Al Suwaidi","year":"2002","unstructured":"Al Suwaidi J, Reddan DN, Williams K, Pieper KS, Harrington RA, Califf RM, Granger CB, Ohman EM, Holmes DR (2002) Prognostic implication of abnormalities in renal function in patient with acute coronary syndrome. Circulation 106:974\u2013980","journal-title":"Circulation"},{"key":"1837_CR19","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s00380-010-0061-9","volume":"26","author":"H Yagi","year":"2011","unstructured":"Yagi H, Kawai M, Komukai K, Ogawa T, Minai K, Nagoshi T, Ogawa K, Sekiyama H, Taniguchi I, Yoshimura M (2011) Impact of chronic kidney disease on the severity of initially diagnosed coronary artery disease and the patient prognosis in the Japanese population. Heart Vessels 26:370\u2013378","journal-title":"Heart Vessels"},{"key":"1837_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1053\/j.ajkd.2007.05.008","volume":"50","author":"A Levin","year":"2007","unstructured":"Levin A, Warnock DG, Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C (2007) Improving outcomes from acute kidney injury: report of an initiative. Am J Kidney Dis 50:1\u20134","journal-title":"Am J Kidney Dis"},{"key":"1837_CR21","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","volume":"375","author":"K Matsushita","year":"2010","unstructured":"Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT (2010) Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 375:2073\u20132081","journal-title":"Lancet"},{"key":"1837_CR22","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/ki.2011.280","volume":"80","author":"M Tonelli","year":"2011","unstructured":"Tonelli M, Klarenbach SW, Lloyd AM, James MT, Bello AK, Manns BJ, Hemmelgarn BR (2011) Higher estimated glomerular filtration rates may be associated with increased risk of adverse outcomes, especially with concomitant proteinuria. Kidney Int 80:1306\u20131314","journal-title":"Kidney Int"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-021-01837-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-021-01837-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-021-01837-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T03:32:38Z","timestamp":1629516758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-021-01837-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1837"],"URL":"https:\/\/doi.org\/10.1007\/s00380-021-01837-8","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"type":"print","value":"0910-8327"},{"type":"electronic","value":"1615-2573"}],"subject":[],"published":{"date-parts":[[2021,4,7]]},"assertion":[{"value":"10 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Shinshu University School of Medicine Ethics Committee, 2040.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"IRB information"}}]}}