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Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (<jats:italic>n<\/jats:italic>\u2009=\u200910) or conventional EMB (<jats:italic>n<\/jats:italic>\u2009=\u200910). There were no major complications in the micro-EMB group (0\/10), compared to six major complications in the EMB group (6\/10; <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Survival analysis further highlighted these differences (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). There were significantly higher volumes of pericardial effusion in the EMB group (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB.<\/jats:p>","DOI":"10.1007\/s00380-021-01995-9","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T11:02:44Z","timestamp":1637665364000},"page":"697-704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety evaluation of high-risk myocardial micro-biopsy in a swine model"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-8293","authenticated-orcid":false,"given":"Arvin","family":"Chireh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Sandell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikard","family":"Grankvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"L\u00f6vljung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"al-Saadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Arnberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Settergren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Holmin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"1995_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.carpath.2011.10.001","volume":"21","author":"O Leone","year":"2012","unstructured":"Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d\u2019Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL (2012) 2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. 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The other authors report no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No human studies were carried out by the authors for this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human subjects\/informed consent statement"}},{"value":"The work had prior ethical approval from the local ethics committee (Stockholms Norra Djurf\u00f6rs\u00f6ksetiska N\u00e4mnd, Stockholm, Sweden) and was conducted in accordance with local and national ethical guidelines, as well as the ARRIVE guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal studies"}}]}}