{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:21:48Z","timestamp":1763018508642,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00380-022-02051-w","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T19:04:55Z","timestamp":1647543895000},"page":"1489-1495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Resistive reserve ratio and microvascular resistance reserve in patients with coronary vasospastic angina"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3574-0685","authenticated-orcid":false,"given":"Yuichi","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"2051_CR1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","volume":"135","author":"CN Bairey Merz","year":"2017","unstructured":"Bairey Merz CN, Pepine CJ, Walsh MN, Fleg JL (2017) Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade. Circulation 135:1075\u20131092","journal-title":"Circulation"},{"key":"2051_CR2","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1016\/j.jacc.2018.09.006","volume":"72","author":"TJ Ford","year":"2018","unstructured":"Ford TJ, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Yii E, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz RM, Oldroyd KG, Berry C (2018) Stratified medical therapy using invasive coronary function testing in angina: the CorMicA Trial. J Am Coll Cardiol 72:2841\u20132855","journal-title":"J Am Coll Cardiol"},{"key":"2051_CR3","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1093\/eurheartj\/ehaa503","volume":"41","author":"V Kunadian","year":"2020","unstructured":"Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas AHEM, Prescott E, Karam N, Appelman Y, Fraccaro C, Louise Buchanan G, Manzo-Silberman S, Al-Lamee R, Regar E, Lansky A, Abbott JD, Badimon L, Duncker DJ, Mehran R, Capodanno D, Baumbach A (2020) An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology and Microcirculation endorsed by Coronary Vasomotor Disorders International Study Group. Eur Heart J 41:3504\u20133520","journal-title":"Eur Heart J"},{"key":"2051_CR4","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1097\/MCA.0000000000000721","volume":"30","author":"Y Saito","year":"2019","unstructured":"Saito Y, Kitahara H, Nishi T, Fujimoto Y, Kobayashi Y (2019) Decreased resting coronary flow and impaired endothelial function in patients with vasospastic angina. Coron Artery Dis 30:291\u2013296","journal-title":"Coron Artery Dis"},{"key":"2051_CR5","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1016\/j.jacc.2019.08.1056","volume":"74","author":"A Suda","year":"2019","unstructured":"Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Ikeda S, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H (2019) Coronary functional abnormalities in patients with angina and nonobstructive coronary artery disease. J Am Coll Cardiol 74:2350\u20132360","journal-title":"J Am Coll Cardiol"},{"key":"2051_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ijcard.2021.09.003","volume":"343","author":"G Pirozzolo","year":"2021","unstructured":"Pirozzolo G, Mart\u00ednez Pereyra V, Hubert A, Guenther F, Sechtem U, Bekeredjian R, Mahrholdt H, Ong P, Seitz A (2021) Coronary artery spasm and impaired myocardial perfusion in patients with ANOCA: predictors from a multimodality study using stress CMR and acetylcholine testing. Int J Cardiol 343:5\u201311","journal-title":"Int J Cardiol"},{"key":"2051_CR7","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1253\/circj.CJ-08-0393","volume":"72","author":"A Takagi","year":"2008","unstructured":"Takagi A, Arai K, Hosaka M, Komatsu Y, Gunnji K, Tanimoto K, Ishizuka N, Tsurumi Y, Hagiwara N (2008) Noninvasive prediction of angiographic spasm provocation using trans-thoracic Doppler echocardiography in patients with coronary spastic angina. Circ J 72:1640\u20131644","journal-title":"Circ J"},{"key":"2051_CR8","doi-asserted-by":"publisher","first-page":"H478","DOI":"10.1152\/ajpheart.00593.2014","volume":"308","author":"K Yamanaga","year":"2015","unstructured":"Yamanaga K, Tsujita K, Komura N, Kaikita K, Sakamoto K, Miyazaki T, Saito M, Ishii M, Tabata N, Akasaka T, Sato K, Horio E, Arima Y, Kojima S, Tayama S, Nakamura S, Hokimoto S, Ogawa H (2015) Single-wire pressure and flow velocity measurement for quantifying microvascular dysfunction in patients with coronary vasospastic angina. Am J Physiol Heart Circ Physiol 308:H478\u2013H484","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2051_CR9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008126","volume":"12","author":"TJ Ford","year":"2019","unstructured":"Ford TJ, Yii E, Sidik N, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, McCartney P, Corcoran D, Collison D, Rush C, Stanley B, McConnachie A, Sattar N, Touyz RM, Oldroyd KG, Berry C (2019) Ischemia and no obstructive coronary artery disease: prevalence and correlates of coronary vasomotion disorders. Circ Cardiovasc Interv 12:e008126","journal-title":"Circ Cardiovasc Interv"},{"key":"2051_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ijcard.2021.02.079","volume":"333","author":"RE Konst","year":"2021","unstructured":"Konst RE, Damman P, Pellegrini D, Hartzema-Meijer MJ, van Uden BJC, Jansen TPJ, Brandsma J, Vart P, Gehlmann H, Maas AHEM, van Royen N, Elias-Smale SE (2021) Vasomotor dysfunction in patients with angina and nonobstructive coronary artery disease is dominated by vasospasm. Int J Cardiol 333:14\u201320","journal-title":"Int J Cardiol"},{"key":"2051_CR11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008505","volume":"13","author":"AM Maznyczka","year":"2020","unstructured":"Maznyczka AM, Oldroyd KG, Greenwood JP, McCartney PJ, Cotton J, Lindsay M, McEntegart M, Rocchiccioli JP, Good R, Robertson K, Eteiba H, Watkins S, Shaukat A, Petrie CJ, Murphy A, Petrie MC, Berry C (2020) Comparative significance of invasive measures of microvascular injury in acute myocardial infarction. Circ Cardiovasc Interv 13:e008505","journal-title":"Circ Cardiovasc Interv"},{"key":"2051_CR12","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015846","volume":"9","author":"SH Lee","year":"2020","unstructured":"Lee SH, Lee JM, Park J, Choi KH, Hwang D, Doh JH, Nam CW, Shin ES, Hoshino M, Murai T, Yonetsu T, Mej\u00eda-Renter\u00eda H, Kakuta T, Escaned J, International Collaboration of Comprehensive Physiologic Assessment Investigators (2020) Prognostic implications of resistive reserve ratio in patients with coronary artery disease. J Am Heart Assoc 9:e015846","journal-title":"J Am Heart Assoc"},{"key":"2051_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020464","volume":"10","author":"T Toya","year":"2021","unstructured":"Toya T, Ahmad A, Corban MT, \u04e6zcan I, Sara JD, Sebaali F, Escaned J, Lerman LO, Lerman A (2021) Risk stratification of patients with nonobstructive coronary artery disease using resistive reserve ratio. J Am Heart Assoc 10:e020464","journal-title":"J Am Heart Assoc"},{"key":"2051_CR14","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.jacc.2021.08.017","volume":"78","author":"B De Bruyne","year":"2021","unstructured":"De Bruyne B, Pijls NHJ, Gallinoro E, Candreva A, Fournier S, Keulards DCJ, Sonck J, Van\u2019t Veer M, Barbato E, Bartunek J, Vanderheyden M, Wyffels E, De Vos A, El Farissi M, Tonino PAL, Muller O, Collet C, Fearon WF (2021) Microvascular resistance reserve for assessment of coronary microvascular function: JACC technology corner. J Am Coll Cardiol 78:1541\u20131549","journal-title":"J Am Coll Cardiol"},{"key":"2051_CR15","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.jacc.2021.08.028","volume":"78","author":"TPJ Jansen","year":"2021","unstructured":"Jansen TPJ, Konst RE, Elias-Smale SE, van den Oord SC, Ong P, de Vos AMJ, van de Hoef TP, Paradies V, Smits PC, van Royen N, Damman P (2021) Assessing microvascular dysfunction in angina with unobstructed coronary arteries: JACC review topic of the week. J Am Coll Cardiol 78:1471\u20131479","journal-title":"J Am Coll Cardiol"},{"key":"2051_CR16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/MCA.0000000000000874","volume":"31","author":"Y Saito","year":"2020","unstructured":"Saito Y, Kitahara H, Nishi T, Fujimoto Y, Kobayashi Y (2020) Systemic endothelial dysfunction in patients with vasospastic and microvascular angina: serum uric acid as a marker of reactive hyperemia index. Coron Artery Dis 31:565\u2013566","journal-title":"Coron Artery Dis"},{"key":"2051_CR17","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1253\/circj.CJ-66-0098","volume":"78","author":"JCS Joint Working Group","year":"2014","unstructured":"JCS Joint Working Group (2014) Guidelines for diagnosis and treatment of patients with vasospastic angina (Coronary Spastic Angina) (JCS 2013). Circ J 78:2779\u20132801","journal-title":"Circ J"},{"key":"2051_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s12928-020-00720-z","volume":"36","author":"S Suzuki","year":"2021","unstructured":"Suzuki S, Kaikita K, Yamamoto E, Jinnouchi H, Tsujita K (2021) Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease. Cardiovasc Interv Ther 36:39\u201351","journal-title":"Cardiovasc Interv Ther"},{"key":"2051_CR19","doi-asserted-by":"publisher","first-page":"4344","DOI":"10.1007\/s12325-021-01854-z","volume":"38","author":"T Matsumoto","year":"2021","unstructured":"Matsumoto T, Saito Y, Saito K, Tateishi K, Kato K, Kitahara H, Kobayashi Y (2021) Relation between cancer and vasospastic angina. Adv Ther 38:4344\u20134353","journal-title":"Adv Ther"},{"key":"2051_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijcard.2018.06.108","volume":"269","author":"K Tateishi","year":"2018","unstructured":"Tateishi K, Saito Y, Kitahara H, Shoji T, Kadohira T, Nakayama T, Fujimoto Y, Kobayashi Y (2018) Safety and usefulness of acetylcholine provocation test in patients with no culprit lesions on emergency coronary angiography. Int J Cardiol 269:27\u201330","journal-title":"Int J Cardiol"},{"key":"2051_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ijcard.2017.07.002","volume":"248","author":"Y Saito","year":"2017","unstructured":"Saito Y, Kitahara H, Shoji T, Tokimasa S, Nakayama T, Sugimoto K, Fujimoto Y, Kobayashi Y (2017) Relation between severity of myocardial bridge and vasospasm. Int J Cardiol 248:34\u201338","journal-title":"Int J Cardiol"},{"key":"2051_CR22","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1253\/circj.CJ-16-0344","volume":"80","author":"Y Saito","year":"2016","unstructured":"Saito Y, Kitahara H, Shoji T, Tokimasa S, Nakayama T, Sugimoto K, Fujimoto Y, Kobayashi Y (2016) Intracoronary acetylcholine provocation testing\u2014omission of the 20-\u00b5g dose is feasible in patients without coronary artery spasm in the other coronary artery. Circ J 80:1820\u20131823","journal-title":"Circ J"},{"key":"2051_CR23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s12928-019-00624-7","volume":"35","author":"S Sueda","year":"2020","unstructured":"Sueda S, Kohno H (2020) Transitional changes of acetylcholine spasm provocation test procedures. Cardiovasc Interv Ther 35:321\u2013326","journal-title":"Cardiovasc Interv Ther"},{"key":"2051_CR24","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s12928-018-0559-0","volume":"34","author":"Y Kawase","year":"2019","unstructured":"Kawase Y, Matsuo H, Akasaka T, Shiono Y, Tanaka N, Amano T, Kozuma K, Nakamura M, Yokoi H, Kobayashi Y, Ikari Y (2019) Clinical use of physiological lesion assessment using pressure guidewires: an expert consensus document of the Japanese Association of Cardiovascular Intervention and Therapeutics. Cardiovasc Interv Ther 34:85\u201396","journal-title":"Cardiovasc Interv Ther"},{"key":"2051_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/MCA.0000000000000594","volume":"29","author":"T Nishi","year":"2018","unstructured":"Nishi T, Kitahara H, Saito Y, Nishi T, Nakayama T, Fujimoto Y, Matsumiya G, Kobayashi Y (2018) Invasive assessment of microvascular function in patients with valvular heart disease. Coron Artery Dis 29:223\u2013229","journal-title":"Coron Artery Dis"},{"key":"2051_CR26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jcin.2012.08.019","volume":"6","author":"AS Yong","year":"2013","unstructured":"Yong AS, Layland J, Fearon WF, Ho M, Shah MG, Daniels D, Whitbourn R, Macisaac A, Kritharides L, Wilson A, Ng MK (2013) Calculation of the index of microcirculatory resistance without coronary wedge pressure measurement in the presence of epicardial stenosis. JACC Cardiovasc Interv 6:53\u201358","journal-title":"JACC Cardiovasc Interv"},{"key":"2051_CR27","doi-asserted-by":"publisher","first-page":"701","DOI":"10.4244\/EIJV12I6A114","volume":"12","author":"M van \u2018t Veer","year":"2016","unstructured":"van \u2018t Veer M, Adjedj J, Wijnbergen I, T\u00f3th GG, Rutten MC, Barbato E, van Nunen LX, Pijls NH, De Bruyne B (2016) Novel monorail infusion catheter for volumetric coronary blood flow measurement in humans: in vitro validation. EuroIntervention 12:701\u2013707","journal-title":"EuroIntervention"},{"key":"2051_CR28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005361","volume":"10","author":"WF Fearon","year":"2017","unstructured":"Fearon WF, Kobayashi Y (2017) Invasive assessment of the coronary microvasculature: the index of microcirculatory resistance. Circ Cardiovasc Interv 10:e005361","journal-title":"Circ Cardiovasc Interv"},{"key":"2051_CR29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1161\/CIRCINTERVENTIONS.112.000180","volume":"6","author":"J Layland","year":"2013","unstructured":"Layland J, Carrick D, McEntegart M, Ahmed N, Payne A, McClure J, Sood A, McGeoch R, MacIsaac A, Whitbourn R, Wilson A, Oldroyd K, Berry C (2013) Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction. Circ Cardiovasc Interv 6:231\u2013236","journal-title":"Circ Cardiovasc Interv"},{"key":"2051_CR30","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.jacc.2015.12.053","volume":"67","author":"JM Lee","year":"2016","unstructured":"Lee JM, Jung JH, Hwang D, Park J, Fan Y, Na SH, Doh JH, Nam CW, Shin ES, Koo BK (2016) Coronary flow reserve and microcirculatory resistance in patients with intermediate coronary stenosis. J Am Coll Cardiol 67:1158\u20131169","journal-title":"J Am Coll Cardiol"},{"key":"2051_CR31","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1007\/s00380-020-01616-x","volume":"35","author":"S Sueda","year":"2020","unstructured":"Sueda S (2020) Pharmacological spasm provocation testing in 2500 patients: provoked spasm incidence, complications and cardiac events. Heart Vessels 35:1368\u20131377","journal-title":"Heart Vessels"},{"key":"2051_CR32","first-page":"2565","volume":"38","author":"JF Beltrame","year":"2017","unstructured":"Beltrame JF, Crea F, Kaski JC, Ogawa H, Ong P, Sechtem U, Shimokawa H, Bairey Merz CN, Coronary Vasomotion Disorders International Study Group (COVADIS) (2017) International standardization of diagnostic criteria for vasospastic angina. Eur Heart J 38:2565\u20132568","journal-title":"Eur Heart J"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-022-02051-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-022-02051-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-022-02051-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T10:06:02Z","timestamp":1659521162000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-022-02051-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2051"],"URL":"https:\/\/doi.org\/10.1007\/s00380-022-02051-w","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"type":"print","value":"0910-8327"},{"type":"electronic","value":"1615-2573"}],"subject":[],"published":{"date-parts":[[2022,3,17]]},"assertion":[{"value":"26 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}