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To address this limitation, a meta-analysis comparing the early and late outcomes of SAVR plus CABG with i-SAVR was performed. Electronic databases from January 2000 to November 2021 were screened. Studies reporting early-term and long-term comparison between the two treatments in patients over 75\u00a0years were analyzed. The primary endpoints were in-hospital\/30-day mortality and overall long-term survival. The pooled odd ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated for in-early outcome and long-term survival, respectively. Random-effect model was used in all analyses. Forty-four retrospective observational studies reporting on 74,560 patients (i-SAVR\u2009=\u200936,062; SAVR\u2009+\u2009CABG\u2009=\u200938,498) were included for comparison. The pooled analysis revealed that i-SAVR was significantly associated with lower rate of early mortality compared to SAVR plus CABG (OR\u2009=\u20090.70, 95% CI 0.66\u20130.75; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and with lower incidence of postoperative acute renal failure (OR\u2009=\u20090.65; 95% CI 0.50\u20130.91; <jats:italic>p<\/jats:italic>\u2009=\u20090.02), need for dialysis (OR\u2009=\u20090.65; 95% CI 0.50\u20130.86; <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and prolonged mechanical ventilation (OR\u2009=\u20090.57; 95% CI 0.42\u20130.77; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Twenty-two studies reported data of long-term follow-up. No differences were reported between the two groups in long-term survival (HR\u2009=\u20090.95; 95% CI\u2009 0.87\u20131.03; <jats:italic>p<\/jats:italic>\u2009=\u20090.23). CABG added to SAVR is associated with worse early outcomes in terms of early mortality, postoperative acute renal failure, and prolonged mechanical ventilation. Long-term survival was comparable between the two treatments.<\/jats:p>","DOI":"10.1007\/s00380-022-02073-4","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T07:03:00Z","timestamp":1652079780000},"page":"1647-1661","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The early and long-term outcomes of coronary artery bypass grafting added to aortic valve replacement compared to isolated aortic valve replacement in elderly patients: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"37","author":[{"given":"Stefano","family":"D\u2019Alessandro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Tuttolomondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurmeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hernandez-Vaquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pattuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Gallingani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-6134","authenticated-orcid":false,"given":"Francesco","family":"Formica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"2073_CR1","unstructured":"https:\/\/appsso.eurostat.ec.europa.eu\/nui\/show.do?dataset=demo_pjan&lang=en (21\/11\/2021)"},{"key":"2073_CR2","unstructured":"https:\/\/www.jchs.harvard.edu\/sites\/default\/files\/jchs housing_americas_older_adults_2014-ch2_0.pdf. 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