{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:42:44Z","timestamp":1792460564690,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute myocardial infarction (AMI) is one of the most serious complications of coronary heart disease. Although morbidity and mortality have been decreasing year by year, acute coronary syndrome still has a high mortality rate and disability rate. To search for accurate and effective biomarkers, we explore the diagnostic and prognostic value of microRNAs (miRNAs) and the monocyte to high-density lipoprotein cholesterol ratio (MHR) in patients with AMI. By referring to the relevant literature, miR-486-5p, miR-451a and miR-21-5p were reportedly altered in the blood of patients with ischemic heart disease. These miRNAs were selected and validated in 40 AMI patients, 22 unstable angina pectoris (UAP) and 22 healthy groups (HC) by real-time fluorescent quantitative polymerase chain reaction (RT-qPCR). All patients with AMI underwent primary percutaneous coronary intervention (PCI) and were followed up 3\u00a0months after the operation. MHR and miR-451a expression were markedly elevated in plasma samples of AMI patients compared with the UAP and HC groups, but the expressions of miR-486-5p and miR-21-5p were significantly decreased. The expression level of miRNA-451a increased gradually among the three groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). However, the expression of miRNA-21-5p showed a downward trend (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). More importantly, MHR was significantly different before and after PCI in AMI patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Receiver operating characteristic (ROC) analysis indicated that MHR, miR-486-5p, miR-451a and miR-21-5p could diagnose and predict AMI. MiR-451a was a more reliable biomarker for AMI diagnosis among these miRNAs. Moreover, the combination of MHR and miRNAs had higher diagnostic value for AMI. We further demonstrated that miR-21-5p had a strong predictive ability for the occurrence of major adverse cardiovascular events (MACE) after 3\u00a0months. The results showed that circulating miR-486-5p, miR-451a, miR-21-5p and MHR may play critical roles in the early phase of AMI, and may be used as potential predictors for AMI diagnosis. Importantly, miR-451a was a more reliable biomarker in diagnosing AMI patients. Circulating miR-21-5p may be used as a predictor of MACE occurrence.\n                  <\/jats:p>","DOI":"10.1007\/s00380-022-02172-2","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T08:57:20Z","timestamp":1665392240000},"page":"318-331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Diagnostic and prognostic value of miR-486-5p, miR-451a, miR-21-5p and monocyte to high-density lipoprotein cholesterol ratio in patients with acute myocardial infarction"],"prefix":"10.1007","volume":"38","author":[{"given":"Liwenjing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenrong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"issue":"9","key":"2172_CR1","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","volume":"141","author":"SS Virani","year":"2020","unstructured":"Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW (2020) Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation 141(9):e139\u2013e596","journal-title":"Circulation"},{"issue":"17","key":"2172_CR2","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.jacc.2020.08.057","volume":"76","author":"S Kosugi","year":"2020","unstructured":"Kosugi S, Shinouchi K, Ueda Y, Abe H, Sogabe T, Ishida K, Mishima T, Ozaki T, Takayasu K, Iida Y, Ohashi T, Toriyama C, Nakamura M, Ueda Y, Sasaki S, Matsumura M, Iehara T, Date M, Ohnishi M, Uematsu M, Koretsune Y (2020) Clinical and angiographic features of patients with out-of-hospital cardiac arrest and acute myocardial infarction. J Am Coll Cardiol 76(17):1934\u20131943","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"2172_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3122\/jabfm.2015.02.140189","volume":"28","author":"JN Smith","year":"2015","unstructured":"Smith JN, Negrelli JM, Manek MB, Hawes EM, Viera AJ (2015) Diagnosis and management of acute coronary syndrome: an evidence-based update. J Am Board Fam Med 28(2):283\u2013293","journal-title":"J Am Board Fam Med"},{"key":"2172_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-6524-3_1","volume":"1509","author":"A Vishnoi","year":"2017","unstructured":"Vishnoi A, Rani S (2017) MiRNA biogenesis and regulation of diseases: an overview. Methods Mol Biol 1509:1\u201310","journal-title":"Methods Mol Biol"},{"issue":"30","key":"2172_CR5","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O\u2019Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105(30):10513\u201310518","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2172_CR6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","volume":"8","author":"MA Cortez","year":"2011","unstructured":"Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA (2011) MicroRNAs in body fluids\u2014the mix of hormones and biomarkers. Nat Rev Clin Oncol 8(8):467\u2013477","journal-title":"Nat Rev Clin Oncol"},{"issue":"1 Pt 2","key":"2172_CR7","first-page":"1233","volume":"113","author":"L Zhu","year":"2020","unstructured":"Zhu L, Li N, Sun L, Zheng D, Shao G (2020) Non-coding RNAs: the key detectors and regulators in cardiovascular disease. Genomics 113(1 Pt 2):1233\u20131246","journal-title":"Genomics"},{"issue":"9","key":"2172_CR8","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1073\/pnas.1000300107","volume":"107","author":"EM Small","year":"2010","unstructured":"Small EM, O\u2019Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD, Richardson JA, Olson EN (2010) Regulation of PI3-kinase\/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci USA 107(9):4218\u20134223","journal-title":"Proc Natl Acad Sci USA"},{"key":"2172_CR9","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.ejphar.2019.03.045","volume":"855","author":"HH Zhu","year":"2019","unstructured":"Zhu HH, Wang XT, Sun YH, He WK, Liang JB, Mo BH, Li L (2019) MicroRNA-486-5p targeting PTEN protects against coronary microembolization-induced cardiomyocyte apoptosis in rats by activating the PI3K\/AKT pathway. Eur J Pharmacol 855:244\u2013251","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"2172_CR10","first-page":"9154","volume":"8","author":"Z Su","year":"2015","unstructured":"Su Z, Zhao J, Rong Z, Geng W, Wang Z (2015) MiR-451, a potential prognostic biomarker and tumor suppressor for gastric cancer. Int J Clin Exp Pathol 8(8):9154\u20139160","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"2172_CR11","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.3892\/mmr.2016.5192","volume":"13","author":"J Xie","year":"2016","unstructured":"Xie J, Hu X, Yi C, Hu G, Zhou X, Jiang H (2016) MicroRNA-451 protects against cardiomyocyte anoxia\/reoxygenation injury by inhibiting high mobility group box 1 expression. Mol Med Rep 13(6):5335\u20135341","journal-title":"Mol Med Rep"},{"issue":"12","key":"2172_CR12","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.2217\/epi-2019-0036","volume":"11","author":"\u00d6 Berkan","year":"2019","unstructured":"Berkan \u00d6, Arslan S, Lalem T, Zhang L, \u015eahin N, Aydemir EI, Korkmaz \u00d6, E\u011filmez HR, \u00c7ekin N, Devaux Y (2019) Regulation of microRNAs in coronary atherosclerotic plaque. Epigenomics 11(12):1387\u20131397","journal-title":"Epigenomics"},{"key":"2172_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.yjmcc.2016.05.009","volume":"97","author":"A Bye","year":"2016","unstructured":"Bye A, R\u00f8sj\u00f8 H, Nauman J, Silva GJ, Follestad T, Omland T, Wisl\u00f8ff U (2016) Circulating microRNAs predict future fatal myocardial infarction in healthy individuals\u2014the HUNT study. J Mol Cell Cardiol 97:162\u2013168","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"2172_CR14","doi-asserted-by":"publisher","first-page":"6418","DOI":"10.1002\/jcp.26324","volume":"233","author":"SM Parizadeh","year":"2018","unstructured":"Parizadeh SM, Ferns GA, Ghandehari M, Hassanian SM, Ghayour-Mobarhan M, Parizadeh SMR, Avan A (2018) The diagnostic and prognostic value of circulating microRNAs in coronary artery disease: a novel approach to disease diagnosis of stable CAD and acute coronary syndrome. J Cell Physiol 233(9):6418\u20136424","journal-title":"J Cell Physiol"},{"key":"2172_CR15","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3389\/fphar.2020.00726","volume":"11","author":"CK Huang","year":"2020","unstructured":"Huang CK, B\u00e4r C, Thum T (2020) miR-21, mediator, and potential therapeutic target in the cardiorenal syndrome. Front Pharmacol 11:726","journal-title":"Front Pharmacol"},{"issue":"12","key":"2172_CR16","doi-asserted-by":"publisher","first-page":"9237","DOI":"10.1002\/jcp.27028","volume":"233","author":"S Ganjali","year":"2018","unstructured":"Ganjali S, Gotto AM Jr, Ruscica M, Atkin SL, Butler AE, Banach M, Sahebkar A (2018) Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol 233(12):9237\u20139246","journal-title":"J Cell Physiol"},{"issue":"20","key":"2172_CR17","doi-asserted-by":"publisher","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","volume":"138","author":"K Thygesen","year":"2018","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD (2018) Fourth universal definition of myocardial infarction (2018). Circulation 138(20):e618\u2013e651","journal-title":"Circulation"},{"issue":"10","key":"2172_CR18","first-page":"2681","volume":"91","author":"KA Chacko","year":"1995","unstructured":"Chacko KA (1995) Diagnosing and managing unstable angina. Circulation 91(10):2681\u20132682","journal-title":"Circulation"},{"issue":"3","key":"2172_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2020.100555","volume":"46","author":"R Solomon","year":"2021","unstructured":"Solomon R, Nowak R, Hudson M, Moyer M, Jacobsen G, McCord J (2021) Is duration of symptoms predictive of acute myocardial infarction? Curr Probl Cardiol 46(3):100555","journal-title":"Curr Probl Cardiol"},{"issue":"6","key":"2172_CR20","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00059-020-04943-x","volume":"45","author":"E Giannitsis","year":"2020","unstructured":"Giannitsis E, Gopi V (2020) Biomarkers for infarct diagnosis and rapid rule-out\/rule-in of acute myocardial infarction. Herz 45(6):509\u2013519","journal-title":"Herz"},{"issue":"7","key":"2172_CR21","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","volume":"129","author":"P Landgraf","year":"2007","unstructured":"Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Fo\u00e0 R, Schliwka J, Fuchs U, Novosel A, M\u00fcller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129(7):1401\u20131414","journal-title":"Cell"},{"issue":"12","key":"2172_CR22","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3390\/biomedicines8120552","volume":"8","author":"CM Ghantous","year":"2020","unstructured":"Ghantous CM, Kamareddine L, Farhat R, Zouein FA, Mondello S, Kobeissy F, Zeidan A (2020) Advances in cardiovascular biomarker discovery. Biomedicines 8(12):552","journal-title":"Biomedicines"},{"issue":"8","key":"2172_CR23","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1002\/jcla.23332","volume":"34","author":"X Wang","year":"2020","unstructured":"Wang X, Tian L, Sun Q (2020) Diagnostic and prognostic value of circulating miRNA-499 and miRNA-22 in acute myocardial infarction. J Clin Lab Anal 34(8):2410\u20132417","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"2172_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.amjcard.2017.03.264","volume":"120","author":"R De Rosa","year":"2017","unstructured":"De Rosa R, De Rosa S, Leistner D, Boeckel JN, Keller T, Fichtlscherer S, Dimmeler S, Zeiher AM (2017) Transcoronary concentration gradient of microRNA-133a and outcome in patients with coronary artery disease. Am J Cardiol 120(1):15\u201324","journal-title":"Am J Cardiol"},{"issue":"10","key":"2172_CR25","doi-asserted-by":"publisher","first-page":"e75872","DOI":"10.1371\/journal.pone.0075872","volume":"8","author":"Y Tu","year":"2013","unstructured":"Tu Y, Wan L, Fan Y, Wang K, Bu L, Huang T, Cheng Z, Shen B (2013) Ischemic postconditioning-mediated miRNA-21 protects against cardiac ischemia\/reperfusion injury via PTEN\/Akt pathway. PLoS\u00a0One 8(10):e75872","journal-title":"PLoS\u00a0One"},{"issue":"8","key":"2172_CR26","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.ajem.2016.05.031","volume":"34","author":"S Balta","year":"2016","unstructured":"Balta S, Celik T, Ozturk C, Kaya MG, Aparci M, Yildirim AO, Demir M, Kilic S, Aydin \u0130, Iyisoy A (2016) The relation between monocyte to HDL ratio and no-reflow phenomenon in the patients with acute ST-segment elevation myocardial infarction. Am J Emerg Med 34(8):1542\u20131547","journal-title":"Am J Emerg Med"},{"issue":"8","key":"2172_CR27","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s11255-014-0730-1","volume":"46","author":"M Kanbay","year":"2014","unstructured":"Kanbay M, Solak Y, Unal HU, Kurt YG, Gok M, Cetinkaya H, Karaman M, Oguz Y, Eyileten T, Vural A, Covic A, Goldsmith D, Turak O, Yilmaz MI (2014) Monocyte count\/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol 46(8):1619\u20131625","journal-title":"Int Urol Nephrol"},{"issue":"1","key":"2172_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cjca.2020.03.018","volume":"37","author":"X Yang","year":"2021","unstructured":"Yang X, Du X, Ma K, Li G, Liu Z, Rong W, Miao H, Zhu F, Cui Q, Wu S, Li Y, Du J (2021) Circulating miRNAs related to long-term adverse cardiovascular events in STEMI patients: a nested case-control study. Can J Cardiol 37(1):77\u201385","journal-title":"Can J Cardiol"},{"key":"2172_CR29","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3389\/fphys.2020.00691","volume":"11","author":"C Zhai","year":"2020","unstructured":"Zhai C, Li R, Hou K, Chen J, Alzogool M, Hu Y, Zhang J, Zhang Y, Wang L, Zhang R, Cong H (2020) Value of blood-based microRNAs in the diagnosis of acute myocardial infarction: a systematic review and meta-analysis. Front Physiol 11:691","journal-title":"Front Physiol"},{"issue":"1","key":"2172_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ncrna.2020.01.001","volume":"5","author":"AM ElKhouly","year":"2020","unstructured":"ElKhouly AM, Youness RA, Gad MZ (2020) MicroRNA-486-5p and microRNA-486-3p: multifaceted pleiotropic mediators in oncological and non-oncological conditions. Noncoding RNA Res 5(1):11\u201321","journal-title":"Noncoding RNA Res"},{"key":"2172_CR31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12872-015-0042-0","volume":"15","author":"R Zhang","year":"2015","unstructured":"Zhang R, Lan C, Pei H, Duan G, Huang L, Li L (2015) Expression of circulating miR-486 and miR-150 in patients with acute myocardial infarction. BMC Cardiovasc Disord 15:51","journal-title":"BMC Cardiovasc Disord"},{"issue":"3","key":"2172_CR32","doi-asserted-by":"publisher","first-page":"e00351","DOI":"10.1042\/BSR20160023","volume":"36","author":"T Wei","year":"2016","unstructured":"Wei T, Folkersen L, Ehrenborg E, Gabrielsen A (2016) MicroRNA 486-3P as a stability marker in acute coronary syndrome. Biosci Rep 36(3):e00351","journal-title":"Biosci Rep"},{"issue":"12","key":"2172_CR33","doi-asserted-by":"publisher","first-page":"e80738","DOI":"10.1371\/journal.pone.0080738","volume":"8","author":"J Ren","year":"2013","unstructured":"Ren J, Zhang J, Xu N, Han G, Geng Q, Song J, Li S, Zhao J, Chen H (2013) Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease. PLoS\u00a0One 8(12):e80738","journal-title":"PLoS\u00a0One"},{"issue":"8","key":"2172_CR34","doi-asserted-by":"publisher","first-page":"13649","DOI":"10.1002\/jcp.28045","volume":"234","author":"L Li","year":"2019","unstructured":"Li L, Li S, Wu M, Chi C, Hu D, Cui Y, Song J, Lee C, Chen H (2019) Early diagnostic value of circulating microRNAs in patients with suspected acute myocardial infarction. J Cell Physiol 234(8):13649\u201313658","journal-title":"J Cell Physiol"},{"issue":"1","key":"2172_CR35","doi-asserted-by":"publisher","first-page":"20549","DOI":"10.1038\/s41598-020-77539-4","volume":"10","author":"T Barbalata","year":"2020","unstructured":"Barbalata T, Zhang L, Dulceanu MD, Stancu CS, Devaux Y, Sima AV, Niculescu LS (2020) Regulation of microRNAs in high-fat diet induced hyperlipidemic hamsters. Sci Rep 10(1):20549","journal-title":"Sci Rep"},{"issue":"43","key":"2172_CR36","doi-asserted-by":"publisher","first-page":"29514","DOI":"10.1074\/jbc.M109.027896","volume":"284","author":"S Dong","year":"2009","unstructured":"Dong S, Cheng Y, Yang J, Li J, Liu X, Wang X, Wang D, Krall TJ, Delphin ES, Zhang C (2009) MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem 284(43):29514\u201329525","journal-title":"J Biol Chem"},{"issue":"21","key":"2172_CR37","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1152\/physiolgenomics.00020.2014","volume":"46","author":"X Xu","year":"2014","unstructured":"Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M, Ding X (2014) miR-21 In ischemia\/reperfusion injury: a double-edged sword? Physiol Genom 46(21):789\u2013797","journal-title":"Physiol Genom"},{"issue":"25","key":"2172_CR38","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.2174\/1381612823666170707165319","volume":"23","author":"Y Oyama","year":"2017","unstructured":"Oyama Y, Bartman CM, Gile J, Eckle T (2017) Circadian microRNAs in cardioprotection. Curr Pharm Des 23(25):3723\u20133730","journal-title":"Curr Pharm Des"},{"issue":"6","key":"2172_CR39","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/eurheartj\/ehq013","volume":"31","author":"GK Wang","year":"2010","unstructured":"Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW, Jing Q (2010) Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 31(6):659\u2013666","journal-title":"Eur Heart J"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-022-02172-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-022-02172-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-022-02172-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:16:06Z","timestamp":1675383366000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-022-02172-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["2172"],"URL":"https:\/\/doi.org\/10.1007\/s00380-022-02172-2","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,10]]},"assertion":[{"value":"10 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}