{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:16:55Z","timestamp":1762377415426,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100021128","name":"Hyogo Science and Technology Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100021128","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grant-in-Aid for Young Scientists from the Ministry of Education, Culture, Sports, Science and Technology of Japan.","award":["20K17081"],"award-info":[{"award-number":["20K17081"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["22K08205"],"award-info":[{"award-number":["22K08205"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s00380-023-02302-4","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T18:04:00Z","timestamp":1692900240000},"page":"1422-1430","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma cystine\/methionine ratio is associated with left ventricular diastolic function in patients with heart disease"],"prefix":"10.1007","volume":"38","author":[{"given":"Junko","family":"Asakura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-4513","authenticated-orcid":false,"given":"Manabu","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nishimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Iino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seimi","family":"Satomi-Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Toh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"2302_CR1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012199","volume":"9","author":"MR MacDonald","year":"2020","unstructured":"MacDonald MR, Tay WT, Teng TK, Anand I, Ling LH, Yap J, Tromp J, Wander GS, Naik A, Ngarmukos T, Siswanto BB, Hung CL, Richards AM, Lam CSP, dagger A-Fi and investigatorsdagger A-F (2020) Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: outcomes in the ASIAN-HF registry. J Am Heart Assoc 9:e012199","journal-title":"J Am Heart Assoc"},{"key":"2302_CR2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.recesp.2021.11.027","volume":"75","author":"TA McDonagh","year":"2022","unstructured":"McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Piepoli MF, Price S, Rosano GMC, Ruschitzka F, Skibelund AK, Group ESCSD (2022) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. Rev Esp Cardiol (Engl Ed) 75:523","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2302_CR3","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","volume":"143","author":"SS Virani","year":"2021","unstructured":"Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Cheng S, Delling FN, Elkind MSV, Evenson KR, Ferguson JF, Gupta DK, Khan SS, Kissela BM, Knutson KL, Lee CD, Lewis TT, Liu J, Loop MS, Lutsey PL, Ma J, Mackey J, Martin SS, Matchar DB, Mussolino ME, Navaneethan SD, Perak AM, Roth GA, Samad Z, Satou GM, Schroeder EB, Shah SH, Shay CM, Stokes A, VanWagner LB, Wang NY, Tsao CW, American Heart Association Council on E (2021) Prevention statistics C and stroke statistics S. Heart disease and stroke statistics-2021 update: a report from the American Heart Association. Circulation 143:e254\u2013e743","journal-title":"Circulation"},{"key":"2302_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcmg.2017.08.007","volume":"11","author":"RS Vasan","year":"2018","unstructured":"Vasan RS, Xanthakis V, Lyass A, Andersson C, Tsao C, Cheng S, Aragam J, Benjamin EJ, Larson MG (2018) Epidemiology of left ventricular systolic dysfunction and heart failure in the Framingham study: an echocardiographic study over 3 decades. JACC Cardiovasc Imaging 11:1\u201311","journal-title":"JACC Cardiovasc Imaging"},{"key":"2302_CR5","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.amjcard.2018.07.012","volume":"122","author":"MG Del Buono","year":"2018","unstructured":"Del Buono MG, Buckley L, Abbate A (2018) Primary and secondary diastolic dysfunction in heart failure with preserved ejection fraction. Am J Cardiol 122:1578\u20131587","journal-title":"Am J Cardiol"},{"key":"2302_CR6","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1001\/jamacardio.2021.1825","volume":"6","author":"CJ Rush","year":"2021","unstructured":"Rush CJ, Berry C, Oldroyd KG, Rocchiccioli JP, Lindsay MM, Touyz RM, Murphy CL, Ford TJ, Sidik N, McEntegart MB, Lang NN, Jhund PS, Campbell RT, McMurray JJV, Petrie MC (2021) Prevalence of coronary artery disease and coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction. JAMA Cardiol 6:1130\u20131143","journal-title":"JAMA Cardiol"},{"key":"2302_CR7","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","volume":"324","author":"R Clarke","year":"1991","unstructured":"Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I (1991) Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 324:1149\u20131155","journal-title":"N Engl J Med"},{"key":"2302_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJM199707243370403","volume":"337","author":"O Nygard","year":"1997","unstructured":"Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337:230\u2013236","journal-title":"N Engl J Med"},{"key":"2302_CR9","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","author":"C Homocysteine Studies","year":"2002","unstructured":"Homocysteine Studies C (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015\u20132022","journal-title":"JAMA"},{"key":"2302_CR10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000095344","volume":"107","author":"HT May","year":"2007","unstructured":"May HT, Alharethi R, Anderson JL, Muhlestein JB, Reyna SP, Bair TL, Horne BD, Kfoury AG, Carlquist JF, Renlund DG (2007) Homocysteine levels are associated with increased risk of congestive heart failure in patients with and without coronary artery disease. Cardiology 107:178\u2013184","journal-title":"Cardiology"},{"key":"2302_CR11","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1001\/jama.289.10.1251","volume":"289","author":"RS Vasan","year":"2003","unstructured":"Vasan RS, Beiser A, D\u2019Agostino RB, Levy D, Selhub J, Jacques PF, Rosenberg IH, Wilson PW (2003) Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA 289:1251\u20131257","journal-title":"JAMA"},{"key":"2302_CR12","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.ehj.2004.01.008","volume":"25","author":"J Sundstrom","year":"2004","unstructured":"Sundstrom J, Sullivan L, Selhub J, Benjamin EJ, D\u2019Agostino RB, Jacques PF, Rosenberg IH, Levy D, Wilson PW, Vasan RS, Framingham Heart S (2004) Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study. Eur Heart J 25:523\u2013530","journal-title":"Eur Heart J"},{"issue":"5","key":"2302_CR13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s00380-021-01964-2","volume":"37","author":"LS Rallidis","year":"2022","unstructured":"Rallidis LS, Katsimardos A, Kosmas N, Rallidi T, Zapantiotis D, Varounis C, Kountouri A (2022) Differential prognostic value of resistin for cardiac death in patients with coronary artery disease according to the presence of metabolic syndrome. Heart Vessels 37(5):713\u2013719","journal-title":"Heart Vessels"},{"key":"2302_CR14","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1007\/s00380-021-01877-0","volume":"36","author":"M Takahara","year":"2021","unstructured":"Takahara M, Iida O, Soga Y, Kodama A, Terashi H, Azuma N (2021) Impact of homocysteine levels on mortality risk in patients with chronic limb-threatening ischemia undergoing revascularization. Heart Vessels 36:1825\u20131829","journal-title":"Heart Vessels"},{"key":"2302_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","volume":"29","author":"SF Nagueh","year":"2016","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD (2016) Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging. J Am Soc Echocardiogr 29:277\u2013314","journal-title":"J Am Soc Echocardiogr"},{"key":"2302_CR16","doi-asserted-by":"publisher","first-page":"H749","DOI":"10.1152\/ajpheart.00692.2021","volume":"322","author":"S Yoshikawa","year":"2022","unstructured":"Yoshikawa S, Nagao M, Toh R, Shinohara M, Iino T, Irino Y, Nishimori M, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI (2022) Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling. Am J Physiol Heart Circ Physiol 322:H749\u2013H761","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2302_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/0006-2944(76)90049-1","volume":"15","author":"K Yagi","year":"1976","unstructured":"Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15:212\u2013216","journal-title":"Biochem Med"},{"key":"2302_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0304-4157(84)90014-5","volume":"779","author":"S Bannai","year":"1984","unstructured":"Bannai S (1984) Transport of cystine and cysteine in mammalian cells. Biochim Biophys Acta 779:289\u2013306","journal-title":"Biochim Biophys Acta"},{"key":"2302_CR19","first-page":"111","volume":"56","author":"KS McCully","year":"1969","unstructured":"McCully KS (1969) Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 56:111\u2013128","journal-title":"Am J Pathol"},{"key":"2302_CR20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006716","volume":"96","author":"JL Luo","year":"2017","unstructured":"Luo JL, Chien KL, Hsu HC, Su TC, Lin HJ, Chen PC, Chen MF, Lee YT (2017) Association between plasma homocysteine concentration and the risk of all-cause death in adults with diastolic dysfunction in a community: a 13-year cohort study. Medicine (Baltimore) 96:e6716","journal-title":"Medicine (Baltimore)"},{"key":"2302_CR21","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.21037\/atm-21-5602","volume":"9","author":"Y Shi","year":"2021","unstructured":"Shi Y, Zhao L, Zhang Y, Qin Q, Cong H, Guo Z (2021) Homocysteine promotes cardiac fibrosis by regulating the Akt\/FoxO3 pathway. Ann Transl Med 9:1732","journal-title":"Ann Transl Med"},{"key":"2302_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015602","volume":"9","author":"M Raad","year":"2020","unstructured":"Raad M, AlBadri A, Wei J, Mehta PK, Maughan J, Gadh A, Thomson L, Jones DP, Quyyumi AA, Pepine CJ, Bairey Merz CN (2020) Oxidative stress is associated with diastolic dysfunction in women with ischemia with no obstructive coronary artery disease. J Am Heart Assoc 9:e015602","journal-title":"J Am Heart Assoc"},{"key":"2302_CR23","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/S0735-1097(98)00101-6","volume":"31","author":"M Keith","year":"1998","unstructured":"Keith M, Geranmayegan A, Sole MJ, Kurian R, Robinson A, Omran AS, Jeejeebhoy KN (1998) Increased oxidative stress in patients with congestive heart failure. J Am Coll Cardiol 31:1352\u20131356","journal-title":"J Am Coll Cardiol"},{"key":"2302_CR24","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/eurheartj\/14.11.1493","volume":"14","author":"J McMurray","year":"1993","unstructured":"McMurray J, Chopra M, Abdullah I, Smith WE, Dargie HJ (1993) Evidence of oxidative stress in chronic heart failure in humans. Eur Heart J 14:1493\u20131498","journal-title":"Eur Heart J"},{"key":"2302_CR25","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/cvr\/cvy038","volume":"114","author":"O Sorop","year":"2018","unstructured":"Sorop O, Heinonen I, van Kranenburg M, van de Wouw J, de Beer VJ, Nguyen ITN, Octavia Y, van Duin RWB, Stam K, van Geuns RJ, Wielopolski PA, Krestin GP, van den Meiracker AH, Verjans R, van Bilsen M, Danser AHJ, Paulus WJ, Cheng C, Linke WA, Joles JA, Verhaar MC, van der Velden J, Merkus D, Duncker DJ (2018) Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening. Cardiovasc Res 114:954\u2013964","journal-title":"Cardiovasc Res"},{"key":"2302_CR26","doi-asserted-by":"publisher","first-page":"13005","DOI":"10.1021\/bi001088w","volume":"39","author":"E Mosharov","year":"2000","unstructured":"Mosharov E, Cranford MR, Banerjee R (2000) The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry 39:13005\u201313011","journal-title":"Biochemistry"},{"key":"2302_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114510","volume":"214","author":"XX Chen","year":"2022","unstructured":"Chen XX, Wu Y, Ge X, Lei L, Niu LY, Yang QZ, Zheng L (2022) In vivo imaging of heart failure with preserved ejection fraction by simultaneous monitoring of cardiac nitric oxide and glutathione using a three-channel fluorescent probe. Biosens Bioelectron 214:114510","journal-title":"Biosens Bioelectron"},{"key":"2302_CR28","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/j.tiv.2011.05.011","volume":"25","author":"MC Garcia","year":"2011","unstructured":"Garcia MC, Amankwa-Sakyi M, Flynn TJ (2011) Cellular glutathione in fatty liver in vitro models. Toxicol In Vitro 25:1501\u20131506","journal-title":"Toxicol In Vitro"},{"key":"2302_CR29","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.exer.2004.06.029","volume":"79","author":"C Persa","year":"2004","unstructured":"Persa C, Pierce A, Ma Z, Kabil O, Lou MF (2004) The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system. Exp Eye Res 79:875\u2013886","journal-title":"Exp Eye Res"},{"key":"2302_CR30","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neuro.2007.09.010","volume":"29","author":"R Deth","year":"2008","unstructured":"Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M (2008) How environmental and genetic factors combine to cause autism: a redox\/methylation hypothesis. Neurotoxicology 29:190\u2013201","journal-title":"Neurotoxicology"},{"key":"2302_CR31","doi-asserted-by":"publisher","first-page":"35785","DOI":"10.1074\/jbc.M602799200","volume":"281","author":"V Vitvitsky","year":"2006","unstructured":"Vitvitsky V, Thomas M, Ghorpade A, Gendelman HE, Banerjee R (2006) A functional transsulfuration pathway in the brain links to glutathione homeostasis. J Biol Chem 281:35785\u201335793","journal-title":"J Biol Chem"},{"key":"2302_CR32","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1159\/000093680","volume":"24","author":"M Righetti","year":"2006","unstructured":"Righetti M, Serbelloni P, Milani S, Ferrario G (2006) Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Blood Purif 24:379\u2013386","journal-title":"Blood Purif"},{"issue":"5","key":"2302_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22090","volume":"31","author":"J Sun","year":"2017","unstructured":"Sun J, Wen S, Zhou J, Ding S (2017) Association between malnutrition and hyperhomocysteine in Alzheimer\u2019s disease patients and diet intervention of betaine. J Clin Lab Anal 31(5):e22090","journal-title":"J Clin Lab Anal"},{"key":"2302_CR34","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1536\/ihj.20-593","volume":"62","author":"P Cao","year":"2021","unstructured":"Cao P, Zhang W, Wang G, Zhao X, Gao N, Liu Z, Xu R (2021) Low dose of folic acid can ameliorate hyperhomocysteinemia-induced cardiac fibrosis and diastolic dysfunction in spontaneously hypertensive rats. Int Heart J 62:627\u2013635","journal-title":"Int Heart J"},{"key":"2302_CR35","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1177\/1747493015616512","volume":"11","author":"JH Park","year":"2016","unstructured":"Park JH, Saposnik G, Ovbiagele B, Markovic D, Towfighi A (2016) Effect of B-vitamins on stroke risk among individuals with vascular disease who are not on antiplatelets: a meta-analysis. Int J Stroke 11:206\u2013211","journal-title":"Int J Stroke"},{"key":"2302_CR36","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/S1474-4422(17)30180-1","volume":"16","author":"JD Spence","year":"2017","unstructured":"Spence JD, Yi Q, Hankey GJ (2017) B vitamins in stroke prevention: time to reconsider. Lancet Neurol 16:750\u2013760","journal-title":"Lancet Neurol"},{"issue":"8","key":"2302_CR37","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003768","volume":"5","author":"Y Li","year":"2016","unstructured":"Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB (2016) Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Heart Assoc 5(8):e003768","journal-title":"J Am Heart Assoc"},{"key":"2302_CR38","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1161\/STROKEAHA.110.578906","volume":"41","author":"R Cui","year":"2010","unstructured":"Cui R, Iso H, Date C, Kikuchi S, Tamakoshi A and Japan Collaborative Cohort Study G (2010) Dietary folate and vitamin b6 and B12 intake in relation to mortality from cardiovascular diseases: Japan collaborative cohort study. Stroke 41:1285\u20131289","journal-title":"Stroke"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-023-02302-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-023-02302-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-023-02302-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T07:04:28Z","timestamp":1698303868000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-023-02302-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["2302"],"URL":"https:\/\/doi.org\/10.1007\/s00380-023-02302-4","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"type":"print","value":"0910-8327"},{"type":"electronic","value":"1615-2573"}],"subject":[],"published":{"date-parts":[[2023,8,24]]},"assertion":[{"value":"25 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Manabu Nagao and Ryuji Toh belong to the Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine which was established by an endowment fund from Sysmex Corporation, Japan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}