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Ryota Kobayashi has patent #Arterial stiffness augmentation inhibitor (2022\u2013204343) pending to Mitsui DM Sugar Co., Ltd. The other authors declare that they have no conflict of interest relevant to the content of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Teikyo University of Science (approval No.: 20A013). This study has been clinically registered with the University Hospital Medical Information Network Center (study No.: UMIN000045001).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Before the study began, all participants received a complete explanation of the study\u2019s purpose and methods before providing their written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}