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From January 2021 to December 2022, patients admitted to a university hospital who underwent trans-femoral TAVI were consecutively recruited. We measured short physical performance battery (SPPB) pre and post-TAVI, and non-lying time from post-operative days 3\u20135. HAFD was defined as at least 1 point decrease in SPPB during pre and post-TAVI. Among 75 patients (47 female, mean age of 84.5\u00a0years) enrolled, 14 patients were classified as having HAFD. Non-lying time was significantly shorter in the HAFD group than in the non-HAFD group (371\u00a0min vs. 539\u00a0min, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Receiver-operating characteristic analysis determined an optimal cut-off value of 477\u00a0min for differentiating the patients more likely to experience HAFD (sensitivity, 75%; specificity, 92%; area under the curve, 0.798). The non-lying time could be one of the associated factors of HAFD in older patients with TAVI. Non-lying time of about 480\u00a0min (8\u00a0h) during hospitalization may be an initial target for preventing HAFD.<\/jats:p>","DOI":"10.1007\/s00380-023-02326-w","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:03:19Z","timestamp":1697436199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical impact of non-lying time on hospital-associated functional decline in older patients undergoing transcatheter aortic valve implantation"],"prefix":"10.1007","author":[{"given":"Yuji","family":"Kono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Mukaino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Senju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Otaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"2326_CR1","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1152\/japplphysiol.00811.2018","volume":"126","author":"ZS Mahmassani","year":"2019","unstructured":"Mahmassani ZS, Reidy PT, McKenzie AI, Stubben C, Howard MT, Drummond MJ (2019) Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. 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