{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:24:26Z","timestamp":1787102666363,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009337","name":"Saitama Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009337","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00380-026-02661-8","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:52:10Z","timestamp":1771876330000},"page":"626-633","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac sympathetic nerve activity following mitral transcatheter edge-to-edge repair verified by 123I-metaiodobezylguanidine (MIBG) scintigraphy among disproportionate secondary mitral regurgitation"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0890-5688","authenticated-orcid":false,"given":"Takahide","family":"Arai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yodo","family":"Gatate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunobu","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohji","family":"Matsusaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiei","family":"Kuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"1","key":"2661_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jcmg.2009.07.014","volume":"3","author":"I Carrio","year":"2010","unstructured":"Carrio I, Cowie MR, Yamazaki J, Udelson J, Camici PG (2010) Cardiac sympathetic imaging with mIBG in heart failure. JACC Cardiovasc Imaging 3(1):92\u2013100","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"2661_CR2","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/S0735-1097(02)02855-3","volume":"41","author":"S Kasama","year":"2003","unstructured":"Kasama S, Toyama T, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, Kurabayashi M (2003) Effect of spironolactone on cardiac sympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy. J Am Coll Cardiol 41(4):574\u2013581","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"2661_CR3","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/eurheartj\/ehn113","volume":"29","author":"HJ Verberne","year":"2008","unstructured":"Verberne HJ, Brewster LM, Somsen GA, van Eck-Smit BL (2008) Prognostic value of myocardial 123I-metaiodobenzylguanidine (MIBG) parameters in patients with heart failure: a systematic review. Eur Heart J 29(9):1147\u20131159","journal-title":"Eur Heart J"},{"issue":"7","key":"2661_CR4","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jcmg.2013.02.007","volume":"6","author":"T Nakata","year":"2013","unstructured":"Nakata T, Nakajima K, Yamashina S, Yamada T, Momose M, Kasama S, Matsui T, Matsuo S, Travin MI, Jacobson AF (2013) A pooled analysis of multicenter cohort studies of (123)I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging 6(7):772\u2013784","journal-title":"JACC Cardiovasc Imaging"},{"issue":"22","key":"2661_CR5","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1056\/NEJMoa2300213","volume":"388","author":"GW Stone","year":"2023","unstructured":"Stone GW, Abraham WT, Lindenfeld J, Kar S, Grayburn PA, Lim DS, Mishell JM, Whisenant B, Rinaldi M, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Marx SO, Cohen DJ, Asch FM, Mack MJ, Investigators C (2023) Five-Year Follow-up after transcatheter repair of secondary mitral regurgitation. N Engl J Med 388(22):2037\u20132048","journal-title":"N Engl J Med"},{"issue":"2","key":"2661_CR6","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1002\/ehf2.13266","volume":"8","author":"K Fukuda","year":"2021","unstructured":"Fukuda K, Hasegawa S, Kawamura T, Waratani N, Hirata K, Higashimori A, Yokoi Y (2021) Changes in cardiac sympathetic nerve activity on (123) I-metaiodobenzylguanidine scintigraphy after MitraClip therapy. ESC Heart Fail 8(2):1590\u20131595","journal-title":"ESC Heart Fail"},{"issue":"2","key":"2661_CR7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","volume":"12","author":"PA Grayburn","year":"2019","unstructured":"Grayburn PA, Sannino A, Packer M (2019) Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials. JACC Cardiovasc Imaging 12(2):353\u2013362","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"2661_CR8","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jcmg.2020.05.042","volume":"14","author":"M Orban","year":"2021","unstructured":"Orban M, Karam N, Lubos E, Kalbacher D, Braun D, Deseive S, Neuss M, Butter C, Praz F, Kassar M, Petrescu A, Pfister R, Iliadis C, Unterhuber M, Lurz P, Thiele H, Baldus S, von Bardeleben RS, Blankenberg S, Massberg S, Windecker S, Hausleiter J, Euro SMRI (2021) Impact of proportionality of secondary mitral regurgitation on outcome after transcatheter mitral valve repair. JACC Cardiovasc Imaging 14(4):715\u2013725","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"2661_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00392-013-0614-x","volume":"103","author":"P Boekstegers","year":"2014","unstructured":"Boekstegers P, Hausleiter J, Baldus S, von Bardeleben RS, Beucher H, Butter C, Franzen O, Hoffmann R, Ince H, Kuck KH, Rudolph V, Schafer U, Schillinger W, Wunderlich N, Germany Society of Cardiology Working Group on Interventional Cardiology Focus Group on Interventional Mitral Valve T (2014) Percutaneous interventional mitral regurgitation treatment using the Mitra-Clip system. Clin Res Cardiol 103(2):85\u201396","journal-title":"Clin Res Cardiol"},{"issue":"1","key":"2661_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s12350-010-9313-4","volume":"18","author":"K Okuda","year":"2011","unstructured":"Okuda K, Nakajima K, Hosoya T, Ishikawa T, Konishi T, Matsubara K, Matsuo S, Kinuya S (2011) Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging. J Nucl Cardiol 18(1):82\u201389","journal-title":"J Nucl Cardiol"},{"issue":"5","key":"2661_CR11","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1007\/s12350-014-9916-2","volume":"21","author":"K Nakajima","year":"2014","unstructured":"Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, Kinuya S (2014) Multicenter cross-calibration of I-123 Metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations. J Nucl Cardiol 21(5):970\u2013978","journal-title":"J Nucl Cardiol"},{"issue":"9","key":"2661_CR12","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1097\/MNM.0b013e32833c3ac4","volume":"31","author":"S Kasama","year":"2010","unstructured":"Kasama S, Toyama T, Sumino H, Kumakura H, Takayama Y, Minami K, Ichikawa S, Matsumoto N, Sato Y, Kurabayashi M (2010) Serial cardiac 123I-metaiodobenzylguanidine scintigraphic studies are more useful for predicting cardiac death than one-time scan in patients with chronic heart failure: sub-analysis of our previous report. Nucl Med Commun 31(9):807\u2013813","journal-title":"Nucl Med Commun"},{"issue":"9","key":"2661_CR13","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s00259-014-2759-x","volume":"41","author":"K Nakajima","year":"2014","unstructured":"Nakajima K, Nakata T, Yamada T, Yamashina S, Momose M, Kasama S, Matsui T, Matsuo S, Travin MI, Jacobson AF (2014) A prediction model for 5-year cardiac mortality in patients with chronic heart failure using (1)(2)(3)I-metaiodobenzylguanidine imaging. Eur J Nucl Med Mol Imaging 41(9):1673\u20131682","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"2661_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.17996\/anc.23-00008","volume":"10","author":"R Egi","year":"2024","unstructured":"Egi R, Fukushima K, Matsusaka Y, Yamane T, Seto A, Matsunari I, Nakajima Y, Nakano S, Kuji I (2024) Cardiac sympathetic nerve function in patients with severe aortic stenosis prior and after transcatheter aortic valve implantation: evaluation by 5-Year risk model. Ann Nucl Cardiol 10(1):6\u201315","journal-title":"Ann Nucl Cardiol"},{"issue":"1","key":"2661_CR15","first-page":"56","volume":"17","author":"G Treglia","year":"2013","unstructured":"Treglia G, Stefanelli A, Bruno I, Giordano A (2013) Clinical usefulness of myocardial innervation imaging using Iodine-123-meta-iodobenzylguanidine scintigraphy in evaluating the effectiveness of Pharmacological treatments in patients with heart failure: an overview. Eur Rev Med Pharmacol Sci 17(1):56\u201368","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"20","key":"2661_CR16","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","volume":"55","author":"AF Jacobson","year":"2010","unstructured":"Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, Agostini D, Weiland F, Chandna H, Narula J, Investigators A-H (2010) Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView myocardial imaging for risk evaluation in heart Failure) study. J Am Coll Cardiol 55(20):2212\u20132221","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2661_CR17","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1007\/s00380-025-02550-6","volume":"40","author":"Y Fukuda","year":"2025","unstructured":"Fukuda Y, Nishio Y, Miyazaki H, Okada Y, Ueda H, Takahashi S, Nakano Y (2025) Prolonged corrected QT interval is associated with cardiac sympathetic nervous function overactivity in patients with severe aortic stenosis: assessment by 123I-metaiodobenzylguanidine myocardial scintigraphy. Heart Vessels 40(11):1048\u20131057","journal-title":"Heart Vessels"},{"issue":"11","key":"2661_CR18","first-page":"1796","volume":"46","author":"A Cohen-Solal","year":"2005","unstructured":"Cohen-Solal A, Rouzet F, Berdeaux A, Le Guludec D, Abergel E, Syrota A, Merlet P (2005) Effects of carvedilol on myocardial sympathetic innervation in patients with chronic heart failure. J Nucl Med 46(11):1796\u20131803","journal-title":"J Nucl Med"},{"key":"2661_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-025-02592-w","author":"J Takahashi","year":"2025","unstructured":"Takahashi J, Fukumoto Y (2025) Improvements of cardiac function and metabolic parameters by sodium-glucose cotransporter 2 inhibitors with no significant effects on sympathetic or parasympathetic activity in chronic heart failure. Heart Vessels. https:\/\/doi.org\/10.1007\/s00380-025-02592-w","journal-title":"Heart Vessels"},{"issue":"2","key":"2661_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.amjcard.2015.04.025","volume":"116","author":"F D\u2019Ascenzo","year":"2015","unstructured":"D\u2019Ascenzo F, Moretti C, Marra WG, Montefusco A, Omede P, Taha S, Castagno D, Gaemperli O, Taramasso M, Frea S, Pidello S, Rudolph V, Franzen O, Braun D, Giannini C, Ince H, Perl L, Zoccai G, Marra S, D\u2019Amico M, Maisano F, Rinaldi M, Gaita F (2015) Meta-analysis of the usefulness of Mitraclip in patients with functional mitral regurgitation. Am J Cardiol 116(2):325\u2013331","journal-title":"Am J Cardiol"},{"key":"2661_CR21","first-page":"100804","volume":"34","author":"M Spieker","year":"2021","unstructured":"Spieker M, Marpert J, Afzal S, Scheiber D, Bonner F, Horn P, Kelm M, Westenfeld R (2021) Extent and determinants of left ventricular reverse remodeling in patients with secondary mitral regurgitation undergoing MitraClip implantation. Int J Cardiol Heart Vasc 34:100804","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2661_CR22","doi-asserted-by":"crossref","unstructured":"Markus B, Kreutz J, Chatzis G, Syntila S, Kuchenbuch J, Mueller C, Choukeir M, Schieffer B, Patsalis N (2024) Mitral Valve Transcatheter Edge-to-edge repair (MV-TEER) in patients with secondary mitral regurgitation improves hemodynamics, enhances renal function, and optimizes quality of life in patients with advanced renal insufficiency. Biomedicines 12(11):2642","DOI":"10.3390\/biomedicines12112648"},{"key":"2661_CR23","doi-asserted-by":"publisher","first-page":"1454986","DOI":"10.1155\/2017\/1454986","volume":"2017","author":"A Koratala","year":"2017","unstructured":"Koratala A, Kazory A (2017) Natriuretic peptides as biomarkers for congestive states: the cardiorenal divergence. Dis Markers 2017:1454986","journal-title":"Dis Markers"},{"issue":"1","key":"2661_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10741-024-10442-6","volume":"30","author":"LA Ammar","year":"2025","unstructured":"Ammar LA, Massoud GP, Chidiac C, Booz GW, Altara R, Zouein FA (2025) BNP and NT-proBNP as prognostic biomarkers for the prediction of adverse outcomes in HFpEF patients: a systematic review and meta-analysis. Heart Fail Rev 30(1):45\u201354","journal-title":"Heart Fail Rev"},{"issue":"3","key":"2661_CR25","doi-asserted-by":"publisher","first-page":"100153","DOI":"10.1016\/j.shj.2022.100153","volume":"7","author":"H Yokoyama","year":"2023","unstructured":"Yokoyama H, Shishido K, Mizuno S, Yamanaka F, Saito S (2023) Early effect of transcatheter mitral valve repair on cardiac sympathetic nerve activity. Struct Heart 7(3):100153","journal-title":"Struct Heart"},{"issue":"4","key":"2661_CR26","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1007\/s12350-020-02501-w","volume":"29","author":"M Pontico","year":"2022","unstructured":"Pontico M, Brunotti G, Conte M, Corica F, Cosma L, De Angelis C, De Feo MS, Lazri J, Matto A, Montebello M, Di Rocco A, Frantellizzi V, Farcomeni A, De Vincentis G (2022) The prognostic value of (123)I-mIBG SPECT cardiac imaging in heart failure patients: a systematic review. J Nucl Cardiol 29(4):1799\u20131809","journal-title":"J Nucl Cardiol"},{"issue":"24","key":"2661_CR27","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","volume":"379","author":"JF Obadia","year":"2018","unstructured":"Obadia JF, Messika-Zeitoun D, Leurent G, Iung B, Bonnet G, Piriou N, Lefevre T, Piot C, Rouleau F, Carrie D, Nejjari M, Ohlmann P, Leclercq F, Saint Etienne C, Teiger E, Leroux L, Karam N, Michel N, Gilard M, Donal E, Trochu JN, Cormier B, Armoiry X, Boutitie F, Maucort-Boulch D, Barnel C, Samson G, Guerin P, Vahanian A, Mewton N, Investigators M-F (2018) Percutaneous repair or medical treatment for secondary mitral regurgitation. N Engl J Med 379(24):2297\u20132306","journal-title":"N Engl J Med"},{"issue":"3","key":"2661_CR28","doi-asserted-by":"publisher","first-page":"100284","DOI":"10.1016\/j.shj.2024.100284","volume":"8","author":"A Moonen","year":"2024","unstructured":"Moonen A, Cao J, Celermajer DS, Ng MKC (2024) Mitral regurgitation proportionality in functional mitral regurgitation and outcomes after mitral valve transcatheter Edge-to-Edge repair: a systematic review and meta-analysis. Struct Heart 8(3):100284","journal-title":"Struct Heart"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-026-02661-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-026-02661-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-026-02661-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:33:45Z","timestamp":1787099625000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-026-02661-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2661"],"URL":"https:\/\/doi.org\/10.1007\/s00380-026-02661-8","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"1 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors report no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}