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Kusunose), an AMED grant (JP22uk1024007 to K. Kusunose), and Edwards Lifesciences Japan LLC. The funding sources had no role in the design and conduct of the study, the collection, management, analysis, or interpretation of the data, the preparation, review, or approval of the manuscript, or the decision to submit the manuscript for publication.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Ethics Committee of Medical and Health Research Involving Human Subjects in Ryukyu University Hospital. (IRB; No. 21000132).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}