{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:03:59Z","timestamp":1780394639666,"version":"3.54.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"DOI":"10.1007\/s00380-026-02684-1","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:12:55Z","timestamp":1780387975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of prosthetic heart valve-associated subclinical intravascular hemolysis on endothelium and cardiovascular system: a retrospective cohort study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-4710","authenticated-orcid":false,"given":"Yakup Yunus","family":"Yamanturk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3605-9365","authenticated-orcid":false,"given":"Cagdas","family":"Ozdol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-9113","authenticated-orcid":false,"given":"Kerim","family":"Esenboga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-0691","authenticated-orcid":false,"given":"Demet Menekse Gerede","family":"Uludag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"issue":"13","key":"2684_CR1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1622","volume":"106","author":"R van Wijk","year":"2005","unstructured":"van Wijk R, van Solinge WW (2005) The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis. Blood 106(13):4034","journal-title":"Blood"},{"issue":"2","key":"2684_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0098-2997(96)88344-0","volume":"17","author":"C Poyart","year":"1996","unstructured":"Poyart C, Wajcman H (1996) Hemolytic anemias due to hemoglobinopathies. Mol Aspects Med 17(2):129\u2013165","journal-title":"Mol Aspects Med"},{"issue":"10","key":"2684_CR3","doi-asserted-by":"publisher","first-page":"E169","DOI":"10.1002\/ajh.23800","volume":"89","author":"R Russo","year":"2014","unstructured":"Russo R, Gambale A, Langella C, Andolfo I, Unal S, Iolascon A (2014) Retrospective cohort study of 205 cases with congenital dyserythropoietic anemia type II: definition of clinical and molecular spectrum and identification of new diagnostic scores. Am J Hematol 89(10):E169-175","journal-title":"Am J Hematol"},{"issue":"19","key":"2684_CR4","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1182\/blood-2014-06-583021","volume":"124","author":"W Barcellini","year":"2014","unstructured":"Barcellini W, Fattizzo B, Zaninoni A, Giannotta JA, Lunghi M, Ferrari A, Boschetti C, Russo R, Duca L, Gaidano G, Giannarelli D, Fo\u00e0 R, Cortelezzi A, Rodeghiero F, De Stefano V, Girelli D, Notaro R, Iolascon A, Zanella A (2014) Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients. Blood 124(19):2930\u20132936","journal-title":"Blood"},{"issue":"6","key":"2684_CR5","first-page":"354","volume":"98","author":"J Phillips","year":"2018","unstructured":"Phillips J, Henderson AC (2018) Hemolytic anemia: evaluation and differential diagnosis. Am Fam Physician 98(6):354\u2013361","journal-title":"Am Fam Physician"},{"issue":"12","key":"2684_CR6","first-page":"533","volume":"58","author":"A Shah","year":"2004","unstructured":"Shah A (2004) Acquired hemolytic anemia. Indian J Med Sci 58(12):533\u2013536","journal-title":"Indian J Med Sci"},{"issue":"2","key":"2684_CR7","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.mcna.2016.09.008","volume":"101","author":"K Haley","year":"2017","unstructured":"Haley K (2017) Congenital hemolytic anemia. Med Clin North Am 101(2):361\u2013374","journal-title":"Med Clin North Am"},{"key":"2684_CR8","first-page":"661","volume-title":"Williams Hematology","author":"TI Coetzer","year":"2016","unstructured":"Coetzer TI (2016) Erythrocyte membrane disorders. In: Kaushansky K, Lichtman MA, Prchal JT, Levi MM, Press OW, Burns LJ, Caligiuri MA (eds) Williams Hematology, 9th edn. McGraw-Hill Education, New York, pp 661\u2013688","edition":"9"},{"issue":"Suppl 2","key":"2684_CR9","first-page":"S47","volume":"55","author":"WA Flegel","year":"2015","unstructured":"Flegel WA (2015) Pathogenesis and mechanisms of antibody-mediated hemolysis. Transfusion 55(Suppl 2):S47\u2013S58","journal-title":"Transfusion"},{"issue":"1","key":"2684_CR10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/(SICI)1096-8652(199609)53:1<22::AID-AJH5>3.0.CO;2-7","volume":"53","author":"H Nakakuma","year":"1996","unstructured":"Nakakuma H (1996) Mechanism of intravascular hemolysis in paroxysmal nocturnal hemoglobinuria. Am J Hematol 53(1):22\u201329","journal-title":"Am J Hematol"},{"issue":"11","key":"2684_CR11","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1182\/blood.2019000946","volume":"136","author":"M Risinger","year":"2020","unstructured":"Risinger M, Kalfa TA (2020) Red cell membrane disorders: structure meets function. Blood 136(11):1250\u20131261","journal-title":"Blood"},{"key":"2684_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00119","volume":"10","author":"CB Crayne","year":"2019","unstructured":"Crayne CB, Albeituni S, Nichols KE, Cron RQ (2019) The immunology of macrophage activation syndrome. Front Immunol 10:119","journal-title":"Front Immunol"},{"issue":"13","key":"2684_CR13","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","volume":"293","author":"RP Rother","year":"2005","unstructured":"Rother RP, Bell L, Hillmen P, Gladwin MT (2005) The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 293(13):1653\u20131662","journal-title":"JAMA"},{"key":"2684_CR14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3389\/fphys.2014.00379","volume":"5","author":"V Jeney","year":"2014","unstructured":"Jeney V, Balla G, Balla J (2014) Red blood cell, hemoglobin and heme in the progression of atherosclerosis. Front Physiol 5:379","journal-title":"Front Physiol"},{"issue":"3","key":"2684_CR15","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1172\/JCI89741","volume":"127","author":"GJ Kato","year":"2017","unstructured":"Kato GJ, Steinberg MH, Gladwin MT (2017) Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest 127(3):750\u2013760","journal-title":"J Clin Invest"},{"issue":"3","key":"2684_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.toxlet.2005.03.004","volume":"157","author":"S Kumar","year":"2005","unstructured":"Kumar S, Bandyopadhyay U (2005) Free heme toxicity and its detoxification systems in human. Toxicol Lett 157(3):175\u2013188","journal-title":"Toxicol Lett"},{"issue":"1","key":"2684_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1183\/09031936.00134410","volume":"39","author":"GH Fonseca","year":"2012","unstructured":"Fonseca GH, Souza R, Salemi VM, Jardim CV, Gualandro SF (2012) Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease. Eur Respir J 39(1):112\u2013118","journal-title":"Eur Respir J"},{"issue":"1","key":"2684_CR18","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1056\/NEJMoa1005565","volume":"365","author":"F Parent","year":"2011","unstructured":"Parent F, Bachir D, Inamo J, Lionnet F, Driss F, Loko G, Habibi A, Bennani S, Savale L, Adnot S, Maitre B, Ya\u00efci A, Hajji L, O\u2019Callaghan DS, Clerson P, Girot R, Galacteros F, Simonneau G (2011) A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med 365(1):44\u201353","journal-title":"N Engl J Med"},{"issue":"12","key":"2684_CR19","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1001\/jama.2012.358","volume":"307","author":"A Mehari","year":"2012","unstructured":"Mehari A, Gladwin MT, Tian X, Machado RF, Kato GJ (2012) Mortality in adults with sickle cell disease and pulmonary hypertension. JAMA 307(12):1254\u20131256","journal-title":"JAMA"},{"issue":"3","key":"2684_CR20","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.113.002124","volume":"129","author":"G Derchi","year":"2014","unstructured":"Derchi G, Galanello R, Bina P, Cappellini MD, Piga A, Lai ME, Tavazzi D, Tognoni G, Fiorelli G, Maggio A (2014) Prevalence and risk factors for pulmonary arterial hypertension in a large group of beta-thalassemia patients using right heart catheterization: a Webthal study. Circulation 129(3):338\u2013345","journal-title":"Circulation"},{"issue":"1","key":"2684_CR21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022","volume":"61","author":"M Humbert","year":"2023","unstructured":"Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, Ferreira DS, Ghofrani HA, Giannakoulas G, Kiely DG, Mayer E, Meszaros G, Nagavci B, Olsson KM, Pepke-Zaba J, Quint JK, R\u00e5degran G, Simonneau G, Sitbon O, Tonia T, Toshner M, Vachiery JL, Vonk Noordegraaf A, Delcroix M, Rosenkranz S (2023) 2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 61(1):2200879","journal-title":"Eur Respir J"},{"issue":"9","key":"2684_CR22","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.3390\/ijms23094763","volume":"23","author":"J Gonzales","year":"2022","unstructured":"Gonzales J, Holbert K, Czysz K, George J, Fernandes C, Fraidenburg DR (2022) Hemin-induced endothelial dysfunction and endothelial to mesenchymal transition in the pathogenesis of pulmonary hypertension due to chronic hemolysis. Int J Mol Sci 23(9):4763","journal-title":"Int J Mol Sci"},{"key":"2684_CR23","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2023-0103","author":"C Gils","year":"2023","unstructured":"Gils C, Hansen DL, Nybo M, Frederiksen H (2023) Elevated hemolysis index is associated with higher risk of cardiovascular diseases. Clin Chem Lab Med. https:\/\/doi.org\/10.1515\/cclm-2023-0103","journal-title":"Clin Chem Lab Med"},{"issue":"2","key":"2684_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1182\/blood-2017-02-767624","volume":"130","author":"O Niss","year":"2017","unstructured":"Niss O, Fleck R, Makue F, Alsaied T, Desai P, Towbin JA, Malik P, Taylor MD, Quinn CT (2017) Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia. Blood 130(2):205\u2013213","journal-title":"Blood"},{"issue":"6","key":"2684_CR25","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1182\/blood-2005-06-2373","volume":"107","author":"GJ Kato","year":"2006","unstructured":"Kato GJ, McGowan V, Machado RF, Little JA, Taylor J 6th, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM Jr, Gladwin MT (2006) Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 107(6):2279\u20132285","journal-title":"Blood"},{"issue":"10","key":"2684_CR26","first-page":"188","volume":"4","author":"V Bhaskar","year":"2016","unstructured":"Bhaskar V, Joshi C (2016) Effect of sickle cell disease on cardiovascular system: a 4.5 years autopsy study conducted in a tertiary care center of Central India. Int J Sci Study 4(10):188\u2013192","journal-title":"Int J Sci Study"},{"issue":"4","key":"2684_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/ejh.12346","volume":"93","author":"C Mu\u00f1oz-Linares","year":"2014","unstructured":"Mu\u00f1oz-Linares C, Ojeda E, For\u00e9s R, Pastrana M, Cabero M, Morillo D, Bautista G, Ba\u00f1os I, Monteser\u00edn C, Bravo P, Jaro E, Cedena T, Steegmann JL, Villegas A, Cabrera JR (2014) Paroxysmal nocturnal hemoglobinuria: a single Spanish center\u2019s experience over the last 40 years. Eur J Haematol 93(4):309\u2013319","journal-title":"Eur J Haematol"},{"issue":"3","key":"2684_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033442","volume":"7","author":"B Z\u00f6ller","year":"2012","unstructured":"Z\u00f6ller B, Li X, Sundquist J, Sundquist K (2012) Risk of subsequent coronary heart disease in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden. PLoS ONE 7(3):e33442","journal-title":"PLoS ONE"},{"key":"2684_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.781839","volume":"9","author":"Y Guo","year":"2022","unstructured":"Guo Y, Zhao H, Lin Z, Ye T, Xu D, Zeng Q (2022) Heme in cardiovascular diseases: a ubiquitous dangerous molecule worthy of vigilance. Front Cell Dev Biol 9:781839","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"2684_CR30","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002272","volume":"4","author":"KT Sawicki","year":"2015","unstructured":"Sawicki KT, Shang M, Wu R, Chang HC, Khechaduri A, Sato T, Kamide C, Liu T, Naga Prasad SV, Ardehali H (2015) Increased heme levels in the heart lead to exacerbated ischemic injury. J Am Heart Assoc 4(8):e002272","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"2684_CR31","first-page":"1273","volume":"137","author":"AV Menon","year":"2021","unstructured":"Menon AV, Liu J, Tsai HP, Zeng L, Yang S, Asnani A, Abdallah H, Abdellatif M, Arumugam S, Arumugam TV, Shah P, Scherrer-Crosbie M, Shapiro NI, Signore S, Singh N, Umapathy NS, Yuan C, Zhao D, Zhou X, Ardehali H (2021) Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease. Blood 137(9):1273\u20131283","journal-title":"Blood"},{"issue":"5","key":"2684_CR32","doi-asserted-by":"publisher","first-page":"H1133","DOI":"10.1152\/ajpheart.00306.2023","volume":"325","author":"J Hurtado","year":"2023","unstructured":"Hurtado J, Sellak H, Joseph G, Lewis CV, Naudin CR, Garcia S, Wodicka JR, Archer DR, Taylor WR (2023) Accelerated atherosclerosis in beta-thalassemia. Am J Physiol Heart Circ Physiol 325(5):H1133\u2013H1143","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"2684_CR33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/clc.4960210604","volume":"21","author":"R Maraj","year":"1998","unstructured":"Maraj R, Jacobs LE, Ioli A, Kotler MN (1998) Evaluation of hemolysis in patients with prosthetic heart valves. Clin Cardiol 21(6):387\u2013392","journal-title":"Clin Cardiol"},{"issue":"3","key":"2684_CR34","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1067\/mtc.2002.120337","volume":"123","author":"G Mecozzi","year":"2002","unstructured":"Mecozzi G, Milano AD, De Carlo M, Sorrentino F, Pratali S, Nardi C, Bortolotti U (2002) Intravascular hemolysis in patients with new-generation prosthetic heart valves: a prospective study. J Thorac Cardiovasc Surg 123(3):550\u2013556","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"2684_CR35","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1182\/blood-2005-06-2373","volume":"107","author":"GJ Kato","year":"2006","unstructured":"Kato GJ et al (2006) Lactate dehydrogenase as a biomarker of hemolysis and tissue injury. Blood 107(6):2279\u20132285","journal-title":"Blood"},{"issue":"18","key":"2684_CR36","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/j.jacc.2021.03.295","volume":"77","author":"A Cannata","year":"2021","unstructured":"Cannata A, Cantoni S, Sciortino A, Bruschi G, Russo CF (2021) Mechanical hemolysis complicating transcatheter interventions for valvular heart disease: JACC state-of-the-art review. J Am Coll Cardiol 77(18):2323\u20132334","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"2684_CR37","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/S0003-4975(97)00313-5","volume":"63","author":"O Lund","year":"1997","unstructured":"Lund O, Emmertsen K, Nielsen TT, Jensen FT, Fl\u00f8 C, Pilegaard HK, Rasmussen BS, Hansen OK, Kristensen LH (1997) Impact of size mismatch and left ventricular function on performance of the St. Jude disc valve after aortic valve replacement. Ann Thorac Surg 63(5):1227\u20131234","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"2684_CR38","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.athoracsur.2005.09.045","volume":"81","author":"M Josa","year":"2006","unstructured":"Josa M, Castell\u00e1 M, Par\u00e9 C, Bedini JL, Carta\u00f1\u00e1 R, Mestres CA, Pomar JL, Mulet J (2006) Hemolysis in mechanical bileaflet prostheses: experience with the Bicarbon valve. Ann Thorac Surg 81(4):1291\u20131296","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"2684_CR39","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.athoracsur.2006.08.010","volume":"83","author":"GM Palatianos","year":"2007","unstructured":"Palatianos GM, Laczkovics AM, Simon P, Pomar JL, Birnbaum DE, Greve HH, Haverich A (2007) Multicentered European study on safety and effectiveness of the On-X prosthetic heart valve: intermediate follow-up. Ann Thorac Surg 83(1):40\u201346","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"2684_CR40","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1136\/thx.34.6.746","volume":"34","author":"RH Falk","year":"1979","unstructured":"Falk RH, Mackinnon J, Wainscoat J, Melikian V, Bignell AH (1979) Intravascular haemolysis after valve replacement: comparative study between Starr-Edwards (ball valve) and Bj\u00f6rk-Shiley (disc valve) prosthesis. Thorax 34(6):746\u2013748","journal-title":"Thorax"},{"issue":"8","key":"2684_CR41","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/ajh.21446","volume":"84","author":"M Olnes","year":"2009","unstructured":"Olnes M, Chi A, Haney C, May R, Minniti C, Taylor J 6th, Kato GJ (2009) Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea. Am J Hematol 84(8):530\u2013532","journal-title":"Am J Hematol"},{"key":"2684_CR42","doi-asserted-by":"publisher","DOI":"10.1177\/10742484221132671","volume":"27","author":"E El-Khateeb","year":"2022","unstructured":"El-Khateeb E, El-Haggar SM, El-Razaky O, El-Shanshory MR, Mostafa TM (2022) Randomized clinical and biochemical study comparing the effect of L-arginine and sildenafil in beta thalassemia major children with high tricuspid regurgitant jet velocity. J Cardiovasc Pharmacol Ther 27:10742484221132671","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"6","key":"2684_CR43","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00585-2019","volume":"54","author":"L Savale","year":"2019","unstructured":"Savale L, Habibi A, Lionnet F, Maitre B, Cottin V, Jais X, Montani D, Roubille C, Bourdin A, Ma\u00eetre B, Maitre J, Dufour N, Weatherald J, Rousselot P, Eyries M, Sitbon O, Simonneau G, Adnot S, O\u2019Callaghan DS (2019) Clinical phenotypes and outcomes of precapillary pulmonary hypertension of sickle cell disease. Eur Respir J 54(6):1900585","journal-title":"Eur Respir J"},{"issue":"9","key":"2684_CR44","doi-asserted-by":"crossref","first-page":"E315","DOI":"10.1002\/ajh.26243","volume":"96","author":"AJ van Vuren","year":"2021","unstructured":"van Vuren AJ, Minniti CP, Mendelsohn L, Baird JH, Kato GJ, van Beers EJ (2021) Lactate dehydrogenase to carboxyhemoglobin ratio as a biomarker of heme release to heme processing is associated with higher tricuspid regurgitant jet velocity and early death in sickle cell disease. Am J Hematol 96(9):E315\u2013E318","journal-title":"Am J Hematol"},{"key":"2684_CR45","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.rmed.2018.02.020","volume":"137","author":"A Haw","year":"2018","unstructured":"Haw A, Palevsky HI (2018) Pulmonary hypertension in chronic hemolytic anemias: pathophysiology and treatment. Respir Med 137:191\u2013200","journal-title":"Respir Med"},{"issue":"5","key":"2684_CR46","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018394","volume":"10","author":"MV Genuardi","year":"2021","unstructured":"Genuardi MV, Shpilsky D, Handen A, VanSpeybroeck G, Canterbury A, Lu M, Shapero K, Nieves RA, Thoma F, Mulukutla SR, Cavalcante JL, Chan SY (2021) Increased mortality in patients with preoperative and persistent postoperative pulmonary hypertension undergoing mitral valve surgery for mitral regurgitation: a cohort study. J Am Heart Assoc 10(5):e018394","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"2684_CR47","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s00380-015-0700-2","volume":"31","author":"S Briongos Figuero","year":"2016","unstructured":"Briongos Figuero S, Moya Mur JL, Garc\u00eda-Lled\u00f3 A, Centella T, Salido L, Ace\u00f1a Navarro \u00c1, Garc\u00eda Mart\u00edn A, Garc\u00eda-Andrade I, Oliva E, Zamorano JL (2016) Predictors of persistent pulmonary hypertension after mitral valve replacement. Heart Vessels 31(7):1091\u20131099","journal-title":"Heart Vessels"},{"issue":"1","key":"2684_CR48","first-page":"1","volume":"17","author":"MC Walls","year":"2008","unstructured":"Walls MC, Cimino N, Bolling SF, Bach DS (2008) Persistent pulmonary hypertension after mitral valve surgery: does surgical procedure affect outcome? J Heart Valve Dis 17(1):1\u20139","journal-title":"J Heart Valve Dis"},{"issue":"1","key":"2684_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89713-3","volume":"11","author":"D Peth\u0151","year":"2021","unstructured":"Peth\u0151 D, Hendrik Z, Nagy A, Beke L, Patsalos A, Nagy L, P\u00f3liska S, M\u00e9hes G, T\u00f3th C, Potor L, Eaton JW, Jacob HS, Balla G, Balla J, G\u00e1ll T (2021) Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression. Sci Rep 11(1):10435","journal-title":"Sci Rep"},{"issue":"1","key":"2684_CR50","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.30435","volume":"4","author":"HI Hyacinth","year":"2021","unstructured":"Hyacinth HI, Franceschini N, Seals SR, Irvin MR, Chaudhary N, Naik RP, Alonso A, Carty CL, Burke GL, Zakai NA, Winkler CA, David VA, Kopp JB, Judd SE, Adams RJ, Gee BE, Longstreth WT Jr, Egede L, Lackland DT, Greenberg CS, Taylor H, Manson JE, Key NS, Derebail VK, Kshirsagar AV, Folsom AR, Konety SH, Howard V, Allison M, Wilson JG, Correa A, Zhi D, Arnett DK, Howard G, Reiner AP, Cushman M, Safford MM (2021) Association of sickle cell trait with incidence of coronary heart disease among African American individuals. JAMA Netw Open 4(1):e2030435","journal-title":"JAMA Netw Open"},{"issue":"1","key":"2684_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/bjh.12342","volume":"162","author":"H Wang","year":"2013","unstructured":"Wang H, Luo W, Wang J, Guo C, Wolffe SL, Wang J, Sun EB, Bradley KN, Campbell AD, Eitzman DT (2013) Paradoxical protection from atherosclerosis and thrombosis in a mouse model of sickle cell disease. Br J Haematol 162(1):120\u2013129","journal-title":"Br J Haematol"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-026-02684-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-026-02684-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-026-02684-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:03:37Z","timestamp":1780391017000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-026-02684-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":51,"alternative-id":["2684"],"URL":"https:\/\/doi.org\/10.1007\/s00380-026-02684-1","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"8 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The named authors have no conflict of interest, financial or otherwise.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors confirm that written consent for submission and publication of this case report, including imaging and associated text, has been obtained from the patient\u2019s family in line with COPE guidance.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent publication"}},{"value":"This study was approved by the Ankara University Faculty of Medicine Ethics Committee on July 27, 2023 (Approval No: I07-447\u201323).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"N\/A","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial registration"}}]}}