{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:14:57Z","timestamp":1790691297279,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"DOI":"10.1007\/s00380-026-02734-8","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T15:35:54Z","timestamp":1784475354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and outcomes of isolated severe functional tricuspid regurgitation in a real-world setting"],"prefix":"10.1007","author":[{"given":"Mina","family":"Tsukuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7039","authenticated-orcid":false,"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Noiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsunamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kintsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Hisamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terunobu","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Otake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"2734_CR1","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1161\/CIRCULATIONAHA.118.038946","volume":"140","author":"G Benfari","year":"2019","unstructured":"Benfari G, Antoine C, Miller WL, Thapa P, Topilsky Y, Rossi A, Michelena HI, Pislaru S, Enriquez-Sarano M (2019) Excess mortality associated with functional tricuspid regurgitation complicating heart failure with reduced ejection fraction. Circulation 140:196\u2013206","journal-title":"Circulation"},{"key":"2734_CR2","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.echo.2022.04.003","volume":"35","author":"S Offen","year":"2022","unstructured":"Offen S, Playford D, Strange G, Stewart S, Celermajer DS (2022) Adverse prognostic impact of even mild or moderate tricuspid regurgitation: insights from the national echocardiography database of australia. J Am Soc Echocardiogr 35:810\u2013817","journal-title":"J Am Soc Echocardiogr"},{"key":"2734_CR3","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.jchf.2023.07.020","volume":"11","author":"RT Hahn","year":"2023","unstructured":"Hahn RT, Brener MI, Cox ZL, Pinney S, Lindenfeld J (2023) Tricuspid regurgitation management for heart failure. JACC Heart Fail 11:1084\u20131102","journal-title":"JACC Heart Fail"},{"key":"2734_CR4","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1056\/NEJMra2216709","volume":"388","author":"RT Hahn","year":"2023","unstructured":"Hahn RT (2023) Tricuspid regurgitation. N Engl J Med 388:1876\u20131891","journal-title":"N Engl J Med"},{"key":"2734_CR5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jcmg.2018.06.014","volume":"12","author":"Y Topilsky","year":"2019","unstructured":"Topilsky Y, Maltais S, Medina Inojosa J, Oguz D, Michelena H, Maalouf J, Mahoney DW, Enriquez-Sarano M (2019) Burden of tricuspid regurgitation in patients diagnosed in the community setting. JACC Cardiovasc Imaging 12:433\u2013442","journal-title":"JACC Cardiovasc Imaging"},{"key":"2734_CR6","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1093\/eurheartj\/ehw229","volume":"37","author":"JL d\u2019Arcy","year":"2016","unstructured":"d\u2019Arcy JL, Coffey S, Loudon MA, Kennedy A, Pearson-Stuttard J, Birks J, Frangou E, Farmer AJ, Mant D, Wilson J, Myerson SG, Prendergast BD (2016) Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study. Eur Heart J 37:3515\u20133522","journal-title":"Eur Heart J"},{"key":"2734_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jjcc.2024.04.001","volume":"84","author":"X Ning","year":"2024","unstructured":"Ning X, Xu H, Cao J, Li N, Wang W, Qiao F, Han L, Lu F, Xu Z (2024) Transcatheter tricuspid valve interventions: Current devices and clinical evidence. J Cardiol 84:73\u201379","journal-title":"J Cardiol"},{"key":"2734_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jjcc.2025.03.009","volume":"86","author":"A Sugiura","year":"2025","unstructured":"Sugiura A, Tanaka T, Kavsur R, Ozturk C, Vogelhuber J, Silaschi M, Weber M, Zimmer S, Nickenig G (2025) Tricuspid regurgitation: Innovation, current landscape, and future perspective of transcatheter tricuspid valve interventions. J Cardiol 86:119\u2013126","journal-title":"J Cardiol"},{"key":"2734_CR9","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1253\/circj.CJ-24-0991","volume":"89","author":"H Yokota","year":"2025","unstructured":"Yokota H, Tanaka H, Fujimoto W, Nagano T, Odajima S, Takemoto M, Kuroda K, Yamashita S, Imanishi J, Iwasaki M, Todoroki T, Okuda M, Konishi A, Shinohara M, Nagao M, Toh R, Nishimura K, Otake H (2025) Impact of tricuspid regurgitation from a population-based chronic heart failure registry in Japan-insights from the KUNIUMI registry chronic cohort. Circ J 89:1555\u20131565","journal-title":"Circ J"},{"key":"2734_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.echo.2020.08.018","volume":"34","author":"G Spinka","year":"2021","unstructured":"Spinka G, Bartko PE, Heitzinger G, Prausmuller S, Pavo N, Frey MK, Arfsten H, Genger M, Hengstenberg C, Hulsmann M, Goliasch G (2021) Natural course of nonsevere secondary tricuspid regurgitation. J Am Soc Echocardiogr 34:13\u201319","journal-title":"J Am Soc Echocardiogr"},{"key":"2734_CR11","first-page":"1323","volume":"100","author":"M Gercek","year":"2022","unstructured":"Gercek M, Irimie AA, Gercek M, Fox H, Fortmeier V, Rudolph TK, Rudolph V, Friedrichs KP (2022) Cognitive function in late-stage HFpEF patients with tricuspid regurgitation undergoing transcatheter tricuspid valve intervention. Catheter Cardiovasc Interv 100:1323\u20131330","journal-title":"Catheter Cardiovasc Interv"},{"key":"2734_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2026.02.043","author":"T Nagano","year":"2026","unstructured":"Nagano T, Tanaka H, Fujimoto W, Yokota H, Odajima S, Fujii C, Tsunamoto H, Noiri J, Kuroda K, Yamashita S, Imanishi J, Iwasaki M, Todoroki T, Okuda M, Konishi A, Shinohara M, Nagao M, Toh R, Nishimura K, Otake H (2026) Association of tricuspid regurgitation severity with activities of daily living and dementia in patients with heart failure: Insight from the KUNIUMI registry chronic cohort. J Card Fail. https:\/\/doi.org\/10.1016\/j.cardfail.2026.02.043","journal-title":"J Card Fail"},{"key":"2734_CR13","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","volume":"30","author":"WA Zoghbi","year":"2017","unstructured":"Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, Hahn RT, Han Y, Hung J, Lang RM, Little SH, Shah DJ, Shernan S, Thavendiranathan P, Thomas JD, Weissman NJ (2017) Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the american society of echocardiography developed in collaboration with the society for cardiovascular magnetic resonance. J Am Soc Echocardiogr 30:303\u2013371","journal-title":"J Am Soc Echocardiogr"},{"key":"2734_CR14","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1093\/ehjci\/jeac015","volume":"23","author":"LE Sade","year":"2022","unstructured":"Sade LE, Muraru D, Marsan NA, Agricola E, Stankovic I, Donal E (2022) How to assess severe tricuspid regurgitation by echocardiography? Eur Heart J Cardiovasc Imaging 23:1273\u20131276","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2734_CR15","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00380-024-02405-6","volume":"39","author":"M Kinoshita","year":"2024","unstructured":"Kinoshita M, Saito M, Inoue K, Tasaka T, Nakagawa H, Fujimoto K, Sato S, Nishimura K, Ikeda S, Sumimoto T, Yamaguchi O (2024) Incremental value of tricuspid annular enlargement to progressive tricuspid regurgitation in patients with longstanding persistent atrial fibrillation. Heart Vessels 39:795\u2013802","journal-title":"Heart Vessels"},{"key":"2734_CR16","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1161\/CIRCULATIONAHA.125.074560","volume":"152","author":"SJ Park","year":"2025","unstructured":"Park SJ, Kim M, Son J, Jo HH, Kim GY, Kim J, Sun BJ, Kim EK, Lee S, Yoo JS, Yun SC, Jung SH, Song JM, Kang DH (2025) Long-term outcomes of early surgery versus conventional treatment for asymptomatic severe mitral regurgitation: a propensity analysis. Circulation 152:1209\u20131217","journal-title":"Circulation"},{"key":"2734_CR17","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ejcts.2009.02.063","volume":"36","author":"F Chenot","year":"2009","unstructured":"Chenot F, Montant P, Vancraeynest D, Pasquet A, Gerber B, Noirhomme PH, El Khoury G, Vanoverschelde JL (2009) Long-term clinical outcome of mitral valve repair in asymptomatic severe mitral regurgitation. Eur J Cardiothorac Surg 36:539\u2013545","journal-title":"Eur J Cardiothorac Surg"},{"key":"2734_CR18","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","volume":"380","author":"MJ Mack","year":"2019","unstructured":"Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo M, Kapadia SR, Malaisrie SC, Cohen DJ, Pibarot P, Leipsic J, Hahn RT, Blanke P, Williams MR, McCabe JM, Brown DL, Babaliaros V, Goldman S, Szeto WY, Genereux P, Pershad A, Pocock SJ, Alu MC, Webb JG, Smith CR, Investigators P (2019) Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med 380:1695\u20131705","journal-title":"N Engl J Med"},{"key":"2734_CR19","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","volume":"380","author":"JJ Popma","year":"2019","unstructured":"Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O\u2019Hair D, Bajwa T, Heiser JC, Merhi W, Kleiman NS, Askew J, Sorajja P, Rovin J, Chetcuti SJ, Adams DH, Teirstein PS, Zorn GL 3rd, Forrest JK, Tchetche D, Resar J, Walton A, Piazza N, Ramlawi B, Robinson N, Petrossian G, Gleason TG, Oh JK, Boulware MJ, Qiao H, Mugglin AS, Reardon MJ, Evolut Low Risk Trial I (2019) Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients. N Engl J Med 380:1706\u20131715","journal-title":"N Engl J Med"},{"key":"2734_CR20","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/j.jacc.2019.01.024","volume":"73","author":"LT Yang","year":"2019","unstructured":"Yang LT, Michelena HI, Scott CG, Enriquez-Sarano M, Pislaru SV, Schaff HV, Pellikka PA (2019) Outcomes in chronic hemodynamically significant aortic regurgitation and limitations of current guidelines. J Am Coll Cardiol 73:1741\u20131752","journal-title":"J Am Coll Cardiol"},{"key":"2734_CR21","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/ehjci\/jeaa205","volume":"22","author":"JM Vieitez","year":"2021","unstructured":"Vieitez JM, Monteagudo JM, Mahia P, Perez L, Lopez T, Marco I, Perone F, Gonzalez T, Sitges M, Bouzas A, Gonzalez-Salvado V, Li CH, Alonso D, Carrasco F, Adeba A, de la Hera JM, Fernandez-Golfin C, Zamorano JL (2021) New insights of tricuspid regurgitation: a large-scale prospective cohort study. Eur Heart J Cardiovasc Imaging 22:196\u2013202","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2734_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/AC.67.5.2174129","volume":"67","author":"P De Meester","year":"2012","unstructured":"De Meester P, Van De Bruaene A, Herijgers P, Voigt JU, Budts W (2012) Tricuspid valve regurgitation: prevalence and relationship with different types of heart disease. Acta Cardiol 67:549\u2013556","journal-title":"Acta Cardiol"},{"key":"2734_CR23","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.jtcvs.2017.09.141","volume":"155","author":"BJ Kelly","year":"2018","unstructured":"Kelly BJ, Ho Luxford JM, Butler CG, Huang CC, Wilusz K, Ejiofor JI, Rawn JD, Fox JA, Shernan SK, Muehlschlegel JD (2018) Severity of tricuspid regurgitation is associated with long-term mortality. J Thorac Cardiovasc Surg 155:1032\u20131038 e1032","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2734_CR24","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s00380-025-02523-9","volume":"40","author":"T Nagai","year":"2025","unstructured":"Nagai T, Horinouchi H, Hirotsugu T, Ikari Y (2025) Evaluation of intrarenal vein flow patterns during routine echocardiography. Heart Vessels 40:837\u2013845","journal-title":"Heart Vessels"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-026-02734-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-026-02734-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-026-02734-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:41:47Z","timestamp":1790646107000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-026-02734-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":24,"alternative-id":["2734"],"URL":"https:\/\/doi.org\/10.1007\/s00380-026-02734-8","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"17 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Hidekazu Tanaka received remuneration from AstraZeneca plc, Ono Pharmaceutical Company, Limited. Pfizer Inc, Otsuka Pharmaceutical Co., Ltd., Daiichi Sankyo Company, Limited, Eli Lilly and Company, Boehringer Ingelheim GmbH, Abbott Japan LLC, and Novartis International AG. The remaining authors have no conflicts of interest to declare.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}