{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:35:40Z","timestamp":1772915740452,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s00381-006-0129-0","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T18:49:08Z","timestamp":1149792548000},"page":"867-873","source":"Crossref","is-referenced-by-count":64,"title":["Hypothalamic hamartomas\u2014clinical, neuropathological and surgical aspects"],"prefix":"10.1007","volume":"22","author":[{"given":"Wirginia","family":"Maixner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,6,9]]},"reference":[{"key":"129_CR1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1684\/j.1950-6945.2003.tb00010.x","volume":"5","author":"F Andermann","year":"2003","unstructured":"Andermann F, Arzimanoglou A, Berkovic SF (2003) Hypothalamic hamartoma and epilepsy: the pathway of discovery. Epileptic Disord 5:173\u2013175","journal-title":"Epileptic Disord"},{"key":"129_CR2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3171\/jns.1999.91.2.0212","volume":"91","author":"K Arita","year":"1999","unstructured":"Arita K, Ikawa F, Kurisu K, Sumida M, Harada K, Uozumi T, Monden S, Yoshida J, Nishi Y (1999) The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg 91:212\u2013220","journal-title":"J Neurosurg"},{"issue":"Pt 4","key":"129_CR3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/brain\/116.4.757","volume":"116","author":"S Arroyo","year":"1993","unstructured":"Arroyo S, Lesser RP, Gordon B, Uematsu S, Hart J, Schwerdt P, Andreasson K, Fisher RS (1993) Mirth, laughter and gelastic seizures. Brain 116(Pt 4):757\u2013780","journal-title":"Brain"},{"key":"129_CR4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1684\/j.1950-6945.2003.tb00012.x","volume":"5","author":"AA Arzimanoglou","year":"2003","unstructured":"Arzimanoglou AA, Hirsch E, Aicardi J (2003) Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions. Epileptic Disord 5:187\u2013199","journal-title":"Epileptic Disord"},{"key":"129_CR5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ana.410230502","volume":"23","author":"SF Berkovic","year":"1988","unstructured":"Berkovic SF, Andermann F, Melanson D, Ethier RE, Feindel W, Gloor P (1988) Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging. Ann Neurol 23:429\u2013439","journal-title":"Ann Neurol"},{"key":"129_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1997.tb01072.x","volume":"38","author":"SF Berkovic","year":"1997","unstructured":"Berkovic SF, Kuzniecky RI, Andermann F (1997) Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature. Epilepsia 38:1\u20133","journal-title":"Epilepsia"},{"key":"129_CR7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.0013-9580.2005.68303.x","volume":"46","author":"EA Boudreau","year":"2005","unstructured":"Boudreau EA, Liow K, Frattali CM, Wiggs E, Turner JT, Feuillan P, Sato S, Patsalides A, Patronas N, Biesecker LG, Theodore WH (2005) Hypothalamic hamartomas and seizures: distinct natural history of isolated and Pallister-Hall syndrome cases. Epilepsia 46:42\u201347","journal-title":"Epilepsia"},{"key":"129_CR8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1212\/WNL.43.4.747","volume":"43","author":"GD Cascino","year":"1993","unstructured":"Cascino GD, Andermann F, Berkovic SF, Kuzniecky RI, Sharbrough FW, Keene DL, Bladin PF, Kelly PJ, Olivier A, Feindel W (1993) Gelastic seizures and hypothalamic hamartomas: evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology 43:747\u2013750","journal-title":"Neurology"},{"key":"129_CR9","first-page":"506","volume":"100","author":"JU Choi","year":"2004","unstructured":"Choi JU, Yang KH, Kim TG, Chang JH, Chang JW, Lee BI, Kim DS (2004) Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 100:506\u2013511","journal-title":"J Neurosurg"},{"key":"129_CR10","first-page":"341","volume-title":"Epilepsy: a comprehensive textbook","author":"D Coulter","year":"1997","unstructured":"Coulter D (1997) Thalamocortical anatomy and physiology. In: Engel J, Pedley T (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven, Philadelphia, pp 341\u2013351"},{"key":"129_CR11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2176\/nmc.43.61","volume":"43","author":"O Delalande","year":"2003","unstructured":"Delalande O, Fohlen M (2003) Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo) 43:61\u201368","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"129_CR12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/088307380001500611","volume":"15","author":"MP DiFazio","year":"2000","unstructured":"DiFazio MP, Davis RG (2000) Utility of early single photon emission computed tomography (SPECT) in neonatal gelastic epilepsy associated with hypothalamic hamartoma. J Child Neurol 15:414\u2013417","journal-title":"J Child Neurol"},{"key":"129_CR13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1684\/j.1950-6945.2003.tb00021.x","volume":"5","author":"M Fohlen","year":"2003","unstructured":"Fohlen M, Lellouch A, Delalande O (2003) Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patients. Epileptic Disord 5:267\u2013273","journal-title":"Epileptic Disord"},{"key":"129_CR14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1212\/WNL.57.1.43","volume":"57","author":"CM Frattali","year":"2001","unstructured":"Frattali CM, Liow K, Craig GH, Korenman LM, Makhlouf F, Sato S, Biesecker LG, Theodore WH (2001) Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology 57:43\u201346","journal-title":"Neurology"},{"key":"129_CR15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1212\/01.WNL.0000049457.05670.7D","volume":"60","author":"JL Freeman","year":"2003","unstructured":"Freeman JL, Harvey AS, Rosenfeld JV, Wrennall JA, Bailey CA, Berkovic SF (2003) Generalized epilepsy in hypothalamic hamartoma: evolution and postoperative resolution. Neurology 60:762\u2013767","journal-title":"Neurology"},{"key":"129_CR16","first-page":"450","volume":"25","author":"JL Freeman","year":"2004","unstructured":"Freeman JL, Coleman LT, Wellard RM, Kean MJ, Rosenfeld JV, Jackson GD, Berkovic SF, Harvey AS (2004) MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 25:450\u2013462","journal-title":"AJNR Am J Neuroradiol"},{"key":"129_CR17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1684\/j.1950-6945.2003.tb00020.x","volume":"5","author":"AS Harvey","year":"2003","unstructured":"Harvey AS, Freeman JL, Berkovic SF, Rosenfeld JV (2003) Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord 5:257\u2013265","journal-title":"Epileptic Disord"},{"key":"129_CR18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/000992289203100804","volume":"31","author":"P Iannetti","year":"1992","unstructured":"Iannetti P, Chessa L, Raucci U, Basile LA, Fantozzi LM, Bozzao L (1992) Gelastic epilepsy. A clinical contribution. Clin Pediatr (Phila) 31:467\u2013470","journal-title":"Clin Pediatr (Phila)"},{"key":"129_CR19","first-page":"447","volume-title":"Paediatric epilepsy syndromes and their surgical treatment","author":"P Kahane","year":"1997","unstructured":"Kahane P, Munari C, Minotti L (1997) The role of the hypothalamic hamartoma in the genesis of gelastic and dacrystic seizures. In: Tuxhorn I, Hothausen H, Boenigk K (eds) Paediatric epilepsy syndromes and their surgical treatment. John Libbey, London, pp 447\u2013461"},{"key":"129_CR20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.spen.2005.04.002","volume":"12","author":"JF Kerrigan","year":"2005","unstructured":"Kerrigan JF, Ng YT, Chung S, Rekate HL (2005) The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol 12:119\u2013131","journal-title":"Semin Pediatr Neurol"},{"key":"129_CR21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ana.410420111","volume":"42","author":"R Kuzniecky","year":"1997","unstructured":"Kuzniecky R, Guthrie B, Mountz J, Bebin M, Faught E, Gilliam F, Liu HG (1997) Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsy. Ann Neurol 42:60\u201367","journal-title":"Ann Neurol"},{"key":"129_CR22","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1046\/j.1528-1157.2003.66902.x","volume":"44","author":"AJ Leal","year":"2003","unstructured":"Leal AJ, Moreira A, Robalo C, Ribeiro C (2003) Different electroclinical manifestations of the epilepsy associated with hamartomas connecting to the middle or posterior hypothalamus. Epilepsia 44:1191\u20131195","journal-title":"Epilepsia"},{"key":"129_CR23","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/BF00263190","volume":"7","author":"HR Machado","year":"1991","unstructured":"Machado HR, Hoffman HJ, Hwang PA (1991) Gelastic seizures treated by resection of a hypothalamic hamartoma. Childs Nerv Syst 7:462\u2013465","journal-title":"Childs Nerv Syst"},{"key":"129_CR24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00004691-198907000-00002","volume":"6","author":"F Morrell","year":"1989","unstructured":"Morrell F (1989) Varieties of human secondary epileptogenesis. J Clin Neurophysiol 6:227\u2013275","journal-title":"J Clin Neurophysiol"},{"key":"129_CR25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1684\/j.1950-6945.2003.tb00013.x","volume":"5","author":"N Mullatti","year":"2003","unstructured":"Mullatti N (2003) Hypothalamic hamartoma in adults. Epileptic Disord 5:201\u2013204","journal-title":"Epileptic Disord"},{"key":"129_CR26","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1046\/j.1528-1157.2003.04103.x","volume":"44","author":"N Mullatti","year":"2003","unstructured":"Mullatti N, Selway R, Nashef L, Elwes R, Honavar M, Chandler C, Morris R, Jarosz J, Buchanan C, Polkey C (2003) The clinical spectrum of epilepsy in children and adults with hypothalamic hamartoma. Epilepsia 44:1310\u20131319","journal-title":"Epilepsia"},{"key":"129_CR27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0013-4694(95)00063-5","volume":"95","author":"C Munari","year":"1995","unstructured":"Munari C, Kahane P, Francione S, Hoffmann D, Tassi L, Cusmai R, Vigevano F, Pasquier B, Betti OO (1995) Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol 95:154\u2013160","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"129_CR28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0887-8994(00)00170-3","volume":"23","author":"JV Murphy","year":"2000","unstructured":"Murphy JV, Wheless JW, Schmoll CM (2000) Left vagal nerve stimulation in six patients with hypothalamic hamartomas. Pediatr Neurol 23:167\u2013168","journal-title":"Pediatr Neurol"},{"key":"129_CR29","first-page":"78","volume":"102","author":"YT Ng","year":"2005","unstructured":"Ng YT, Kerrigan JF, Prenger EC, White WL, Rekate HL (2005) Successful resection of a hypothalamic hamartoma and a Rathke cleft cyst. Case report. J Neurosurg 102:78\u201380","journal-title":"J Neurosurg"},{"key":"129_CR30","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1528-1157.1994.tb02470.x","volume":"35","author":"S Nishio","year":"1994","unstructured":"Nishio S, Morioka T, Fukui M, Goto Y (1994) Surgical treatment of intractable seizures due to hypothalamic hamartoma. Epilepsia 35:514\u2013519","journal-title":"Epilepsia"},{"key":"129_CR31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/jnnp.30.2.166","volume":"30","author":"DW Northfield","year":"1967","unstructured":"Northfield DW, Russell DS (1967) Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumour. J Neurol Neurosurg Psychiatry 30:166\u2013173","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"129_CR32","first-page":"177","volume":"120","author":"J Paillas","year":"1969","unstructured":"Paillas J, Roger J, Toga M (1969) Hamartoma of the hypothalamus. Clinical, radiological and histological study. Results of excision. Rev Neurol 120:177\u2013194","journal-title":"Rev Neurol"},{"key":"129_CR33","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1212\/WNL.58.9.1338","volume":"58","author":"A Palmini","year":"2002","unstructured":"Palmini A, Chandler C, Andermann F, Costa Da Costa J, Paglioli-Neto E, Polkey C, Rosenblatt B, Montes J, Martinez JV, Farmer JP, Sinclair B, Aronyk K, Paglioli E, Coutinho L, Raupp S, Portuguez M (2002) Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy. Neurology 58:1338\u20131347","journal-title":"Neurology"},{"key":"129_CR34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1684\/j.1950-6945.2003.tb00019.x","volume":"5","author":"A Palmini","year":"2003","unstructured":"Palmini A, Paglioli-Neto E, Montes J, Farmer JP (2003) The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypotheses. Epileptic Disord 5:249\u2013255","journal-title":"Epileptic Disord"},{"key":"129_CR35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1528-1167.2005.52804.x","volume":"46","author":"A Palmini","year":"2005","unstructured":"Palmini A, Van Paesschen W, Dupont P, Van Laere K, Van Driel G (2005) Status gelasticus after temporal lobectomy: ictal FDG\u2013PET findings and the question of dual pathology involving hypothalamic hamartomas. Epilepsia 46:1313\u20131316","journal-title":"Epilepsia"},{"key":"129_CR36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1684\/j.1950-6945.2003.tb00023.x","volume":"5","author":"CE Polkey","year":"2003","unstructured":"Polkey CE (2003) Resective surgery for hypothalamic hamartoma. Epileptic Disord 5:281\u2013286","journal-title":"Epileptic Disord"},{"key":"129_CR37","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1227\/00006123-198502000-00012","volume":"16","author":"M Sato","year":"1985","unstructured":"Sato M, Ushio Y, Arita N, Mogami H (1985) Hypothalamic hamartoma: report of two cases. Neurosurgery 16:198\u2013206","journal-title":"Neurosurgery"},{"key":"129_CR38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1528-1157.1999.tb00707.x","volume":"40","author":"S Striano","year":"1999","unstructured":"Striano S, Meo R, Bilo L, Cirillo S, Nocerino C, Ruosi P, Striano P, Estraneo A (1999) Gelastic epilepsy: symptomatic and cryptogenic cases. Epilepsia 40:294\u2013302","journal-title":"Epilepsia"},{"key":"129_CR39","first-page":"429","volume-title":"Paediatric epilepsy syndromes and their surgical management","author":"C Tassinari","year":"1997","unstructured":"Tassinari C, Riguzzi P, Rizzi R (1997) Gelastic seizures. In: Tuxhorn I, Holthausen H, Boenigk K (eds) Paediatric epilepsy syndromes and their surgical management. John Libbey, London, pp 429\u2013446"},{"key":"129_CR40","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/00004583-200106000-00015","volume":"40","author":"AA Weissenberger","year":"2001","unstructured":"Weissenberger AA, Dell ML, Liow K, Theodore W, Frattali CM, Hernandez D, Zametkin AJ (2001) Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings. J Am Acad Child Adolesc Psychiatry 40:696\u2013703","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"129_CR41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ana.20580","volume":"58","author":"J Wu","year":"2005","unstructured":"Wu J, Xu L, Kim do Y, Rho JM, St John PA, Lue LF, Coons S, Ellsworth K, Nowak L, Johnson E, Rekate H, Kerrigan JF (2005) Electrophysiological properties of human hypothalamic hamartomas. Ann Neurol 58:371\u2013382","journal-title":"Ann Neurol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-006-0129-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-006-0129-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-006-0129-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T08:11:25Z","timestamp":1736410285000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-006-0129-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,9]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["129"],"URL":"https:\/\/doi.org\/10.1007\/s00381-006-0129-0","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,9]]}}}