{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:58:26Z","timestamp":1771027106625,"version":"3.50.1"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2011,5,24]],"date-time":"2011-05-24T00:00:00Z","timestamp":1306195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00381-011-1488-8","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T06:32:43Z","timestamp":1306132363000},"page":"1211-1219","source":"Crossref","is-referenced-by-count":21,"title":["Neurosurgical treatment of tuberous sclerosis complex lesions"],"prefix":"10.1007","volume":"27","author":[{"given":"Ignacio","family":"Pascual-Castroviejo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,5,24]]},"reference":[{"key":"1488_CR1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2165\/00148581-200810050-00004","volume":"10","author":"DA Krueger","year":"2008","unstructured":"Krueger DA, Franz DN (2008) Current management of tuberous sclerosis complex. Pediatr Drugs 10:299\u2013313","journal-title":"Pediatr Drugs"},{"key":"1488_CR2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-211-69500-5_2","volume-title":"Neurocutaneous disorders. Phakomatosis and hamartoneoplastic syndromes","author":"I Pascual-Castroviejo","year":"2008","unstructured":"Pascual-Castroviejo I (2008) Vascular birthmarks of infancy: PHACE association (Pascual-Castroviejo type II syndrome and Cobb syndrome). In: Ruggieri M, Pascual-Castroviejo I, Di Rocco C (eds) Neurocutaneous disorders. Phakomatosis and hamartoneoplastic syndromes. Springer, Wien-New York, pp 19\u201349"},{"key":"1488_CR3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-211-69500-5_3","volume-title":"Neurocutaneous disorders. Phakomatosis and hamartoneoplastic syndromes","author":"M Ruggieri","year":"2008","unstructured":"Ruggieri M, Hupadhyaya M, Di Rocco C, Gabriele A, Pascual-Castroviejo I (2008) Neurofibromatosis type 1 and related disorders. In: Ruggieri M, Pascual-Castroviejo I, Di Rocco C (eds) Neurocutaneous disorders. Phakomatosis and hamartoneoplastic syndromes. Springer, Wien-New York, pp 51\u2013151"},{"key":"1488_CR4","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","volume":"355","author":"PB Crino","year":"2006","unstructured":"Crino PB, Nathanson KL, Henske EP (2006) The tuberous sclerosis complex. N Engl J Med 355:1345\u20131356","journal-title":"N Engl J Med"},{"key":"1488_CR5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00431-001-0903-7","volume":"161","author":"N Langkau","year":"2002","unstructured":"Langkau N, Martin N, Brandt R, Z\u00fcgge K, Quast S, Wiegele G et al (2002) TSC1 and TSC2 mutations in tuberous sclerosis, the associated phenotypes and a model to explain observed TSC1\/TSC2 frequency rations. Eur J Pediatr 161:393\u2013402","journal-title":"Eur J Pediatr"},{"key":"1488_CR6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0025-6196(12)61196-3","volume":"66","author":"CW Shepherd","year":"1991","unstructured":"Shepherd CW, G\u00f3mez MR, Lie JT, Crowson CS (1991) Causes of death in patients with tuberous sclerosis. Mayo Clin Proc 66:792\u2013796","journal-title":"Mayo Clin Proc"},{"key":"1488_CR7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/jnnp.66.3.370","volume":"66","author":"R Nabbout","year":"1999","unstructured":"Nabbout R, Santos M, Rolland Y, Delalande O, Dulac O, Chiron C (1999) Early diagnosis of subependymal giant cell astrocytoma in children with tuberous sclerosis. J Neurol Neurosurg Psychiatry 66:370\u2013375","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1488_CR8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1212\/01.WNL.0000142039.14522.1A","volume":"63","author":"S Goh","year":"2004","unstructured":"Goh S, Butler W, Thiele EA (2004) Subependymal giant cell tumors in tuberous sclerosis complex. Neurology 63:1457\u20131461","journal-title":"Neurology"},{"key":"1488_CR9","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1227\/00006123-197905000-00006","volume":"4","author":"CP Boesel","year":"1979","unstructured":"Boesel CP, Poulson GW, Kosnik EJ, Earle KM (1979) Brain hamartomas and tumors associated with tuberous sclerosis. Neurosurgery 4:410\u2013417","journal-title":"Neurosurgery"},{"key":"1488_CR10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.5694\/j.1326-5377.1975.tb82053.x","volume":"1","author":"JM Brown","year":"1975","unstructured":"Brown JM (1975) Tuberose sclerosis with malignant astrocytoma. Med J Aust 1:811\u2013814","journal-title":"Med J Aust"},{"key":"1488_CR11","unstructured":"Russell DS, Rubinstein LJ, Lumsden CE (1959) Tuberose sclerose (Bourneville's disease), subependymal giant-cell astrocytomas: tuberose sclerosis, spongio neuroblastoma and tuberose sclerosis. In: Russell DS, Rubenstein LJ, editor. Pathology of tumours of the nervous system. London: Edward Arnold, 29\u201330, 105\u2013106, 169"},{"key":"1488_CR12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.nrl.2010.02.001","volume":"25","author":"I Pascual-Castroviejo","year":"2010","unstructured":"Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, Via\u00f1o J, Carceller F, Hern\u00e1ndez-Moneo JL et al (2010) Astrocitoma subependimario de c\u00e9lulas gigantes en el complejo esclerosis tuberosa. Presentaci\u00f3n de ocho pacientes infantiles. Neurologia 25:314\u2013321","journal-title":"Neurologia"},{"key":"1488_CR13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/adc.2007.125880","volume":"93","author":"FJK O'Callaghan","year":"2008","unstructured":"O'Callaghan FJK, Martyn CN, Renowden S, Noakes M, Presdee D, Osborne JP (2008) Subependymal nodules, giant cell astrocytomas and the tuberous sclerosis complex: a population base study. Arch Dis Child 93:751\u2013754","journal-title":"Arch Dis Child"},{"key":"1488_CR14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF00341764","volume":"28","author":"DPE Kingsley","year":"1986","unstructured":"Kingsley DPE, Kendall BE, Fitz CR (1986) Tuberous sclerosis: a clinicoradiological evaluation of 110 cases with particular reference to atypical presentation. Neuroradiology 28:38\u201346","journal-title":"Neuroradiology"},{"key":"1488_CR15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01644066","volume":"3","author":"FJCS Hollanda","year":"1980","unstructured":"Hollanda FJCS, Hollanda GMP (1980) Tuberous sclerosis. Neurosurgical indications in interventricular tumors. Neurosurg Rev 3:139\u2013150","journal-title":"Neurosurg Rev"},{"key":"1488_CR16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00381-002-0700-2","volume":"19","author":"V Cuccia","year":"2003","unstructured":"Cuccia V, Zuccaro G, Sosa F, Monges J, Lubienieky F, Taratuto AL (2003) Subependymal giant cell astrocytoma in children with tuberous sclerosis. Childs Nerv Syst 19:232\u2013243","journal-title":"Childs Nerv Syst"},{"key":"1488_CR17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pediatrneurol.2006.08.009","volume":"36","author":"GP Raju","year":"2007","unstructured":"Raju GP, Urion DK, Sahin M (2007) Neonatal subependymal giant cell astrocytoma: new case and review of the literature. Pediatr Neurol 36:128\u2013131","journal-title":"Pediatr Neurol"},{"key":"1488_CR18","first-page":"1251","volume":"11","author":"RD Tien","year":"1990","unstructured":"Tien RD, Hesselink JR, Duberg A (1990) Rare subependymal giant-cell astrocytoma in a neonate with tuberous sclerosis. AJNR Am J Neuroradiol 11:1251\u20131252","journal-title":"AJNR Am J Neuroradiol"},{"key":"1488_CR19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000058432","volume":"36","author":"A Medhkour","year":"2002","unstructured":"Medhkour A, Traul D, Hussain N (2002) Neonatal subependymal giant cell astrocytoma. Pediatr Neurosurg 36:271\u2013274","journal-title":"Pediatr Neurosurg"},{"key":"1488_CR20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s002470050693","volume":"29","author":"LD Mirkin","year":"1999","unstructured":"Mirkin LD, Ey EH, Chaparro M (1999) Congenital subependymal giant cell astrocytoma: case report with prenatal ultrasonogram. Pediatr Radiol 29:776\u2013780","journal-title":"Pediatr Radiol"},{"key":"1488_CR21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1136\/adc.2005.081703","volume":"91","author":"N Hussain","year":"2006","unstructured":"Hussain N, Curran A, Pilling D, Malluci CL, Ladusans EJ, Alfirevic Z et al (2006) Congenital subependymal giant cell astrocytoma diagnosed on fetal MRI. Arch Dis Child 91:520","journal-title":"Arch Dis Child"},{"key":"1488_CR22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1212\/WNL.41.1.124","volume":"41","author":"JS Hahn","year":"1991","unstructured":"Hahn JS, Bejar R, Gladson CL (1991) Neonatal subependymal giant cell astrocytoma associated with tuberous sclerosis: MRI, CT and ultrasound correlation. Neurology 41:124\u2013128","journal-title":"Neurology"},{"key":"1488_CR23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1590\/S0004-282X2007000200023","volume":"65","author":"K Takata","year":"2007","unstructured":"Takata K, Gaspareto EL, Da Costa LC, Lucato LT, Reed UC, Matushita H et al (2007) Subependymal giant cell astrocytoma in patients with tuberous sclerosis: magnetic resonance imaging findings in ten cases. Arq Neuropsiquiatr 65:313\u2013316","journal-title":"Arq Neuropsiquiatr"},{"key":"1488_CR24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0887-8994(95)00123-W","volume":"13","author":"I Pascual-Castroviejo","year":"1995","unstructured":"Pascual-Castroviejo I, Patr\u00f3n M, Gutierrez M, Carceller F, Pascual-Pascual SI (1995) Tuberous sclerosis associated with histologically confirmed ocular and cerebral tumors. Pediatr Neurol 13:172\u2013174","journal-title":"Pediatr Neurol"},{"key":"1488_CR25","first-page":"99","volume":"8","author":"S Waga","year":"1977","unstructured":"Waga S, Yamamoto Y, Kojima T, Sakakura N (1977) Massive hemorrhage in tumor of tuberous sclerosis. Surg Neurol 8:99\u2013101","journal-title":"Surg Neurol"},{"key":"1488_CR26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1227\/01.NEU.0000249216.19591.5D","volume":"60","author":"S Ribaupierre De","year":"2007","unstructured":"De Ribaupierre S, Dorfm\u00fcller G, Bulteau C, Fohlen M, Pinard JM, Chiron E et al (2007) Subependymal giant-cell astrocytomas in pediatric tuberous sclerosis disease: when should we operate? Neurosurgery 60:83\u201389","journal-title":"Neurosurgery"},{"key":"1488_CR27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.33588\/rn.4907.2009164","volume":"49","author":"M Beltr\u00e1n-Mar\u00edn","year":"2009","unstructured":"Beltr\u00e1n-Mar\u00edn M, Riaguas-Almanara A, Mazas-Artasona LV, Vela-Mar\u00edn A, Mar\u00edn-Cardenas MA, Solanas-Alava S (2009) Neurocitoma central: hallazgos en tomograf\u00eda computarizada y resonancia magn\u00e9tica. Rev Neurol 49:383\u2013384","journal-title":"Rev Neurol"},{"key":"1488_CR28","first-page":"8","volume":"69","author":"L Bongiorni","year":"2009","unstructured":"Bongiorni L, Arroyo HA, Lubienicki F (2009) Complejo n\u00f3dulo subependymario-astrocytoma gigantocelular en ni\u00f1os con esclerosis tuberosa. Med B Aires 69:8\u201314","journal-title":"Med B Aires"},{"key":"1488_CR29","unstructured":"Genitori L, Donati PA, Giordano F, Mussa F, Sanzo M, Sardo L, et al. (2006) Neurosurgical strategies in the management of subependymal giant cell tumors in tuberous sclerosis complex. In: Curatolo P, Riva D (eds) Neurocutaneous syndromes in children. John Libbey Eurotext, 117\u2013138."},{"key":"1488_CR30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000120947","volume":"23","author":"C Rocco Di","year":"1995","unstructured":"Di Rocco C, Iannelli A, Marchese E (1995) On the treatment of subependymal giant cell astrocytoma and associated hydrocephalus in tuberous sclerosis. Pediatr Neurosurg 23:115\u2013121","journal-title":"Pediatr Neurosurg"},{"key":"1488_CR31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0303-8467(96)00028-5","volume":"98","author":"M Turgut","year":"1996","unstructured":"Turgut M, Akalan N, Ozgen T, Ruacans S, Erbengi A (1996) Subependymal giant cell astrocytoma associated with tuberous sclerosis. Diagnostic and surgical characteristics of five cases with unusual features. Clin Neurol Neurosurg 98:217\u2013221","journal-title":"Clin Neurol Neurosurg"},{"key":"1488_CR32","first-page":"274","volume":"27","author":"R Kumar","year":"2004","unstructured":"Kumar R, Singh V (2004) Subependymal giant cell astrocytoma: a report of five cases. Neurosurg Rev 27:274\u2013280","journal-title":"Neurosurg Rev"},{"key":"1488_CR33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/088307389801300405","volume":"13","author":"OA Torres","year":"1998","unstructured":"Torres OA, Roach ES, Delgado MR, Sparagana SP, Sheffield E, Swift D (1998) Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis. J Child Neurol 13:173\u2013177","journal-title":"J Child Neurol"},{"key":"1488_CR34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12519-010-0025-2","volume":"6","author":"M Berhouma","year":"2010","unstructured":"Berhouma M (2010) Management of subependymal giant cell tumors in tuberous sclerosis complex: the neurosurgeon's perspective. World J Pediatr 6:103\u2013110","journal-title":"World J Pediatr"},{"key":"1488_CR35","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.20784","volume":"59","author":"DN Franz","year":"2006","unstructured":"Franz DN, Leonard J, Tudor C, Chuck G, Care M, Sethuraman G et al (2006) Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 59:490\u2013498","journal-title":"Ann Neurol"},{"key":"1488_CR36","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1177\/0883073808321764","volume":"23","author":"MK Koenig","year":"2008","unstructured":"Koenig MK, Butler IJ, Northrup H (2008) Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex. J Child Neurol 23:1238\u20131239","journal-title":"J Child Neurol"},{"key":"1488_CR37","doi-asserted-by":"crossref","unstructured":"Moavero R, Pinci M, Bombardieri R, Curately P (2011) The management of subependymal giant cell tumors in tuberous sclerosis: a clinician perspective. Child's Nerv Syst. (in press)","DOI":"10.1007\/s00381-011-1406-0"},{"key":"1488_CR38","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJMoa1001671","volume":"363","author":"DA Krueger","year":"2010","unstructured":"Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P et al (2010) Everolimus for subependymal giant-cell astrocytoma in tuberous sclerosis. N Engl J Med 363:1801\u20131811","journal-title":"N Engl J Med"},{"key":"1488_CR39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3171\/2010.7.PEDS10221","volume":"6","author":"A Birca","year":"2010","unstructured":"Birca A, Mercier C, Major P (2010) Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. J Neurosurg Pediatr 6:381\u2013384","journal-title":"J Neurosurg Pediatr"},{"key":"1488_CR40","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1158\/0008-5472.CAN-04-4058","volume":"65","author":"B Dasgupta","year":"2005","unstructured":"Dasgupta B, Yi Y, Chen DY, Weber JD, Gutman DH (2005) Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis1-associated human and mouse brain tumors. Cancer Res 65:2755\u20132760","journal-title":"Cancer Res"},{"key":"1488_CR41","first-page":"265","volume":"27","author":"GB Pellizzi","year":"1901","unstructured":"Pellizzi GB (1901) Contributo allo studio dell \u00b4idiozia. Riv Sper Freniatr 27:265\u2013269","journal-title":"Riv Sper Freniatr"},{"key":"1488_CR42","unstructured":"Scheithauer BW, Reagan TJ (1999) Neuropathology. In: Rodriguez G\u00f3mez M, Sanpson JR, Whittemore VH (eds) Tuberous sclerosis complex. Developmental perspectives in psychiatry. 3rd edition. New York-Oxford. Oxford University Press, 101\u2013144"},{"key":"1488_CR43","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0387-7604(01)00304-7","volume":"23","author":"M Mizuguchi","year":"2001","unstructured":"Mizuguchi M, Takashima S (2001) Neuropathology of tuberous sclerosis. Brain Dev 23:508\u2013515","journal-title":"Brain Dev"},{"key":"1488_CR44","first-page":"9","volume-title":"Tuberous sclerosis","author":"MR Gomez","year":"1988","unstructured":"Gomez MR (1988) Criteria for the diagnosis. In: Gomez MR (ed) Tuberous sclerosis, 2nd edn. Raven, New York, pp 9\u201319","edition":"2"},{"key":"1488_CR45","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/088307380001501003","volume":"15","author":"S Jozwiak","year":"2000","unstructured":"Jozwiak S, Schwartz RA, Janniger CK, Bielicka-Cymerman J (2000) Usefulness of diagnostic criteria of tuberous sclerosis complex in pediatric patients. J Child Neurol 15:652\u2013659","journal-title":"J Child Neurol"},{"key":"1488_CR46","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/08830738050200040901","volume":"20","author":"P Curatolo","year":"2005","unstructured":"Curatolo P, Bombardieri R, Verdecchia M, Seri (2005) Intractable seizures in tuberous sclerosis complex: from molecular pathogenesis to the rationale for treatment. J Child Neurol 20:318\u2013325","journal-title":"J Child Neurol"},{"key":"1488_CR47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1528-1167.2007.01035.x","volume":"48","author":"GL Holmes","year":"2007","unstructured":"Holmes GL, Stafstrom CE, Tuberous Sclerosis Study Group (2007) Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia 48:617\u2013630","journal-title":"Epilepsia"},{"key":"1488_CR48","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/08830738040190090801","volume":"19","author":"EA Thiele","year":"2004","unstructured":"Thiele EA (2004) Managing epilepsy in tuberous sclerosis complex. J Child Neurol 19:680\u2013686","journal-title":"J Child Neurol"},{"key":"1488_CR49","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0387-7604(01)00300-X","volume":"23","author":"P Curatolo","year":"2001","unstructured":"Curatolo P, Seri S, Verdecchia M, Bombardieri R (2001) Infantile spasms in tuberous sclerosis complex. Brain Dev 23:502\u2013507","journal-title":"Brain Dev"},{"key":"1488_CR50","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0387-7604(87)80047-5","volume":"9","author":"N Yamamoto","year":"1987","unstructured":"Yamamoto N, Watanabe K, Negoro T, Matsumoto A, Mizyazaki S, Kumagai R et al (1987) Long-term prognosis of tuberous sclerosis with epilepsy in children. Brain Dev 9:292\u2013295","journal-title":"Brain Dev"},{"key":"1488_CR51","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/316951","volume":"68","author":"SL Dabora","year":"2001","unstructured":"Dabora SL, Jozwiak S, Franz DN, Roberts PS, Nieto A, Chung J et al (2001) Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 68:64\u201380","journal-title":"Am J Hum Genet"},{"key":"1488_CR52","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3174\/ajnr.A1972","volume":"31","author":"HP Gama","year":"2010","unstructured":"Gama HP, da Rocha AJ, Valerio RM, da Silva CJ, Garc\u00eda LA (2010) Hippocampal abnormalities in an MB imaging series of patients with tuberous sclerosis. AJNR Am J Neuroradiol 31:1059\u20131062","journal-title":"AJNR Am J Neuroradiol"},{"key":"1488_CR53","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s00415-010-5535-2","volume":"257","author":"A Gallagher","year":"2010","unstructured":"Gallagher A, Grant EP, Madan N, Jarrett DY, Lyczkowski DA, Thiele EA (2010) MRI findings reveal three different types of tubers in patients with tuberous sclerosis complex. J Neurol 257:1373\u20131381","journal-title":"J Neurol"},{"key":"1488_CR54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/088307389701200203","volume":"12","author":"M Goodman","year":"1997","unstructured":"Goodman M, Lamm SH, Engel A, Shepherd CW, Houser OW, Gomez MR (1997) Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex. J Child Neurol 12:85\u201390","journal-title":"J Child Neurol"},{"key":"1488_CR55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1528-1167.2010.02892.x","volume":"52","author":"M Kaczorowska","year":"2011","unstructured":"Kaczorowska M, Jurkiewiez E, Domanska-Pakiela D, Syczewska M, Lojszczyk B, Chmielewski D et al (2011) Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex. Epilepsia 52:22\u201327","journal-title":"Epilepsia"},{"key":"1488_CR56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neurad.2009.12.006","volume":"37","author":"G Ertan","year":"2010","unstructured":"Ertan G, Arulrajah S, Tekes A, Jordan L, Huisman TA (2010) Cerebellar abnormality in children and young adults with tuberous sclerosis complex: MR and diffusion weighted imaging findings. J Neuroradiol 37:231\u2013238","journal-title":"J Neuroradiol"},{"key":"1488_CR57","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.clinph.2010.01.010","volume":"121","author":"A Heide Van der","year":"2010","unstructured":"Van der Heide A, van Huffelen AC, Spetgens WP, Ferrier CH, van Nieuwenhnizen O, Jansen FE (2010) Identification of epileptogenic zone in patients with tuberous sclerosis: concordance of interictal and ictal epileptiform activity. Clin Neurophysiol 121:842\u2013847","journal-title":"Clin Neurophysiol"},{"key":"1488_CR58","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1055\/s-2007-985368","volume":"38","author":"N Matsuo","year":"2007","unstructured":"Matsuo N, Imamura A, Ito R, Sugawara K, Takahashi Y, Kondo N (2007) The correlation between 1H-MR spectroscopy and clinical manifestation with tuberous sclerosis complex. Neuropediatrics 38:126\u2013129","journal-title":"Neuropediatrics"},{"key":"1488_CR59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1179\/016164107X163996","volume":"29","author":"Z Yapici","year":"2007","unstructured":"Yapici Z, Dortcan N, Baykan BB, Okan F, Dincer A, Baykal C et al (2007) Neurological aspects of tuberous sclerosis in relation to MRI\/MR spectroscopy findings in children with epilepsy. Neurol Res 29:449\u2013454","journal-title":"Neurol Res"},{"key":"1488_CR60","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.eplepsyres.2009.09.001","volume":"87","author":"A Gallagher","year":"2009","unstructured":"Gallagher A, Chu-Shore CJ, Montenegro MA, Major P, Costello DJ, Lyczkowski DA et al (2009) Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex. Epilepsy Res 87:197\u2013202","journal-title":"Epilepsy Res"},{"key":"1488_CR61","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1528-1167.2007.01486.x","volume":"49","author":"J Jacobs","year":"2008","unstructured":"Jacobs J, Rohr A, Moeller F, Boor R, Kobayashi E, Le Van MP et al (2008) Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG-fMRI. Epilepsia 49:816\u2013825","journal-title":"Epilepsia"},{"key":"1488_CR62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1080\/02841850701477686","volume":"48","author":"E Widjaja","year":"2007","unstructured":"Widjaja E, Wilkinson ID, Griffiths PD (2007) Magnetic resonance perfusion imaging in malformations of cortical development. Acta Radiol 48:907\u2013917","journal-title":"Acta Radiol"},{"key":"1488_CR63","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3171\/2009.7.PEDS09198","volume":"4","author":"I Sugiyama","year":"2009","unstructured":"Sugiyama I, Imai K, Yamaguchi Y, Ochi A, Akizuki Y, Go C et al (2009) Localization of epileptic foci in children with intractable epilepsy secondary to multiple cortical tubers by using synthetic aperture magnetometry kurtosis. J Neurosurg Pediatr 4:515\u2013522","journal-title":"J Neurosurg Pediatr"},{"key":"1488_CR64","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1528-1167.2008.01814.x","volume":"50","author":"P Major","year":"2009","unstructured":"Major P, Rakowski S, Simon MV, Cheng ML, Escandar E, Baron J et al (2009) Are cortical tubers epileptogenic? Evidence from electrocorticography. Epilepsia 50:147\u2013154","journal-title":"Epilepsia"},{"key":"1488_CR65","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.seizure.2007.03.001","volume":"16","author":"FE Jansen","year":"2007","unstructured":"Jansen FE, Van Huffelen AC, Van Rijen PC, Leijten FS, Jennekens-Schinkel A, Gosselaar P et al (2007) Epilepsy surgery in tuberous sclerosis: the Dutch experience. Seizure 16:445\u2013453","journal-title":"Seizure"},{"key":"1488_CR66","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1111\/j.1528-1167.2010.02669.x","volume":"51","author":"S Liang","year":"2010","unstructured":"Liang S, Li A, Zhal M, Jiang H, Yu S, Meng X et al (2010) Epilepsy surgery in tuberous sclerosis complex: emphasis on surgical candidate and neuropsychology. Epilepsia 51:2316\u20132321","journal-title":"Epilepsia"},{"key":"1488_CR67","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1212\/WNL.0b013e3181ce5d9e","volume":"74","author":"JY Wu","year":"2010","unstructured":"Wu JY, Salamon N, Kirsch HE, Mantle MM, Nagarajan SS, Kurelowech L et al (2010) Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex. Neurology 74:392\u2013398","journal-title":"Neurology"},{"key":"1488_CR68","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/adc.2003.026815","volume":"89","author":"FJK O'Callaghan","year":"2004","unstructured":"O'Callaghan FJK, Harris T, Joinson C, Bolton P, Noakes M, Presdee D et al (2004) The relation of infantile spasms, tubers, and intelligence in tuberous sclerosis complex. Arch Dis Child 89:530\u2013533","journal-title":"Arch Dis Child"},{"key":"1488_CR69","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/08830738040190090601","volume":"19","author":"P Prather","year":"2004","unstructured":"Prather P, de Vries PJ (2004) Behavioral and cognitive aspects of tuberous sclerosis complex. J Child Neurol 19:666\u2013674","journal-title":"J Child Neurol"},{"key":"1488_CR70","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1212\/01.wnl.0000168908.78118.99","volume":"65","author":"S Goh","year":"2005","unstructured":"Goh S, Kwiatkowski DJ, Dorer DJ, Thiele EA (2005) Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex. Neurology 65:235\u2013238","journal-title":"Neurology"},{"key":"1488_CR71","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/j.1528-1167.2009.02493.x","volume":"51","author":"YA Moshel","year":"2010","unstructured":"Moshel YA, Elliott R, Teutonico F, Sellin J, Carlson C, Devinsky O et al (2010) Do tubers contain function? Resection of epileptogenic foci in perirolandic cortex in children with tuberous sclerosis complex. Epilepsia 51:1242\u20131251","journal-title":"Epilepsia"},{"key":"1488_CR72","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/08830738040190090901","volume":"19","author":"HL Weiner","year":"2004","unstructured":"Weiner HL, Ferraris N, La Joie J, Miles D, Devinsky O (2004) Epilepsy surgery for children with tuberous sclerosis complex. J Child Neurol 19:687\u2013689","journal-title":"J Child Neurol"},{"key":"1488_CR73","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejpn.2007.07.002","volume":"12","author":"IJ Chou","year":"2008","unstructured":"Chou IJ, Lin KL, Wong AM, Wang HS, Chou ML, Humg PC (2008) Neuroimaging correlation with neurological severity in tuberous sclerosis complex. Eur J Pediatr Neurol 12:108\u2013112","journal-title":"Eur J Pediatr Neurol"},{"key":"1488_CR74","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.yebeh.2009.08.018","volume":"16","author":"RE Elliott","year":"2009","unstructured":"Elliott RE, Carlson C, Kalhorn SP, Moshel YA, Weiner HL, Devinsky O, Doyle WK (2009) Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery. Epilepsy Behav 16:454\u2013460","journal-title":"Epilepsy Behav"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-011-1488-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-011-1488-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-011-1488-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T19:25:29Z","timestamp":1741202729000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-011-1488-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,24]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["1488"],"URL":"https:\/\/doi.org\/10.1007\/s00381-011-1488-8","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,24]]}}}