{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:21:33Z","timestamp":1770888093926,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T00:00:00Z","timestamp":1350950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s00381-012-1918-2","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T05:32:54Z","timestamp":1350883974000},"page":"281-287","source":"Crossref","is-referenced-by-count":12,"title":["Neurophysiologic intraoperative monitoring in children with Down syndrome"],"prefix":"10.1007","volume":"29","author":[{"given":"Akash J.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Agadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Fulkerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris D.","family":"Glover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Jea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,23]]},"reference":[{"key":"1918_CR1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/00000542-198104000-00007","volume":"54","author":"HH Ali","year":"1981","unstructured":"Ali HH, Savarese JJ, Lebowitz PW, Ramsey FM (1981) Twitch, tetanus and train-of-four as indices of recovery from nondepolarizing neuromuscular blockade. Anesthesiology 54:294\u2013297","journal-title":"Anesthesiology"},{"key":"1918_CR2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S1388-2457(98)00049-2","volume":"110","author":"G Andersson","year":"1999","unstructured":"Andersson G, Ohlin A (1999) Spatial facilitation of motor evoked responses in monitoring during spinal surgery. Clin Neurophysiol 110:720\u2013724","journal-title":"Clin Neurophysiol"},{"key":"1918_CR3","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1097\/00006123-199806000-00074","volume":"42","author":"JR Balzer","year":"1998","unstructured":"Balzer JR, Rose RD, Welch WC, Sclabassi RJ (1998) Simultaneous somatosensory evoked potential and electromyographic recordings during lumbosacral decompression and instrumentation. Neurosurgery 42:1318\u20131324, discussion 1324\u20131315","journal-title":"Neurosurgery"},{"key":"1918_CR4","doi-asserted-by":"crossref","unstructured":"Booke JS, Banta JV, Bunke FJ, Pelletier C (1993) Somatosensory evoked potential monitoring during Cotrel-Dubousset instrumentation. Report of a case. Spine (Phila Pa 1976) 18: 518\u2013521","DOI":"10.1097\/00007632-199303010-00017"},{"key":"1918_CR5","doi-asserted-by":"crossref","unstructured":"Bouchard JA, Bohlman HH, Biro C (1996) Intraoperative improvements of somatosensory evoked potentials: correlation to clinical outcome in surgery for cervical spondylitic myelopathy. Spine (Phila Pa 1976) 21: 589\u2013594","DOI":"10.1097\/00007632-199603010-00011"},{"key":"1918_CR6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1460-9592.1998.00282.x","volume":"8","author":"RJ Bray","year":"1998","unstructured":"Bray RJ (1998) Propofol infusion syndrome in children. Paediatr Anaesth 8:491\u2013499","journal-title":"Paediatr Anaesth"},{"key":"1918_CR7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/WNP.0b013e31802ed2d4","volume":"24","author":"X Chen","year":"2007","unstructured":"Chen X, Sterio D, Ming X, Para DD, Butusova M, Tong T, Beric A (2007) Success rate of motor evoked potentials for intraoperative neurophysiologic monitoring: effects of age, lesion location, and preoperative neurologic deficits. J Clin Neurophysiol 24:281\u2013285","journal-title":"J Clin Neurophysiol"},{"key":"1918_CR8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10877-005-5097-5","volume":"18","author":"Z Chen","year":"2004","unstructured":"Chen Z (2004) The effects of isoflurane and propofol on intraoperative neurophysiological monitoring during spinal surgery. J Clin Monit Comput 18:303\u2013308","journal-title":"J Clin Monit Comput"},{"key":"1918_CR9","doi-asserted-by":"crossref","unstructured":"DiCindio S, Theroux M, Shah S, Miller F, Dabney K, Brislin RP, Schwartz D (2003) Multimodality monitoring of transcranial electric motor and somatosensory-evoked potentials during surgical correction of spinal deformity in patients with cerebral palsy and other neuromuscular disorders. Spine (Phila Pa 1976) 28: 1851\u20131855; discussion 1855\u20131856","DOI":"10.1097\/01.BRS.0000083202.62956.A8"},{"key":"1918_CR10","doi-asserted-by":"crossref","unstructured":"Frei FJ, Ryhult SE, Duitmann E, Hasler CC, Luetschg J, Erb TO (2007) Intraoperative monitoring of motor-evoked potentials in children undergoing spinal surgery. Spine (Phila Pa 1976) 32: 911\u2013917","DOI":"10.1097\/01.brs.0000259836.84151.75"},{"key":"1918_CR11","first-page":"339","volume":"75","author":"A Fudickar","year":"2009","unstructured":"Fudickar A, Bein B (2009) Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol 75:339\u2013344","journal-title":"Minerva Anestesiol"},{"key":"1918_CR12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3171\/2011.1.PEDS10255","volume":"7","author":"DH Fulkerson","year":"2011","unstructured":"Fulkerson DH, Satyan KB, Wilder LM, Riviello JJ, Stayer SA, Whitehead WE, Curry DJ, Dauser RC, Luerssen TG, Jea A (2011) Intraoperative monitoring of motor evoked potentials in very young children. J Neurosurg Pediatr 7:331\u2013337","journal-title":"J Neurosurg Pediatr"},{"key":"1918_CR13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3171\/jns.1985.63.2.0296","volume":"63","author":"HH Ginsburg","year":"1985","unstructured":"Ginsburg HH, Shetter AG, Raudzens PA (1985) Postoperative paraplegia with preserved intraoperative somatosensory evoked potentials. Case report. J Neurosurg 63:296\u2013300","journal-title":"J Neurosurg"},{"key":"1918_CR14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S1529-9430(03)00144-X","volume":"3","author":"M Gundanna","year":"2003","unstructured":"Gundanna M, Eskenazi M, Bendo J, Spivak J, Moskovich R (2003) Somatosensory evoked potential monitoring of lumbar pedicle screw placement for in situ posterior spinal fusion. Spine J 3:370\u2013376","journal-title":"Spine J"},{"key":"1918_CR15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00000542-199901000-00042","volume":"90","author":"SR Hays","year":"1999","unstructured":"Hays SR, Schwengel DA (1999) Transient hypotension as a complication of monitoring transcervical motor evoked potentials. Anesthesiology 90:314\u2013317","journal-title":"Anesthesiology"},{"key":"1918_CR16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00008506-200207000-00007","volume":"14","author":"S Inoue","year":"2002","unstructured":"Inoue S, Kawaguchi M, Kakimoto M, Sakamoto T, Kitaguchi K, Furuya H, Morimoto T, Sakaki T (2002) Amplitudes and intrapatient variability of myogenic motor evoked potentials to transcranial electrical stimulation during ketamine\/N2O- and propofol\/N2O-based anesthesia. J Neurosurg Anesthesiol 14:213\u2013217","journal-title":"J Neurosurg Anesthesiol"},{"key":"1918_CR17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1213\/00000539-199110000-00008","volume":"73","author":"CJ Kalkman","year":"1991","unstructured":"Kalkman CJ, Drummond JC, Ribberink AA (1991) Low concentrations of isoflurane abolish motor evoked responses to transcranial electrical stimulation during nitrous oxide\/opioid anesthesia in humans. Anesth Analg 73:410\u2013415","journal-title":"Anesth Analg"},{"key":"1918_CR18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00001503-199710000-00009","volume":"10","author":"CJ Kalkman","year":"1997","unstructured":"Kalkman CJ, Ubags LH (1997) Motor-evoked potential monitoring. Curr Opin Anesthesiol 10:327\u2013332","journal-title":"Curr Opin Anesthesiol"},{"key":"1918_CR19","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1365-2044.2007.05055.x","volume":"62","author":"PC Kam","year":"2007","unstructured":"Kam PC, Cardone D (2007) Propofol infusion syndrome. Anaesthesia 62:690\u2013701","journal-title":"Anaesthesia"},{"key":"1918_CR20","doi-asserted-by":"crossref","unstructured":"Kawaguchi M, Sakamoto T, Inoue S, Kakimoto M, Furuya H, Morimoto T, Sakaki T (2000) Low dose propofol as a supplement to ketamine-based anesthesia during intraoperative monitoring of motor-evoked potentials. Spine (Phila Pa 1976) 25: 974\u2013979","DOI":"10.1097\/00007632-200004150-00013"},{"key":"1918_CR21","doi-asserted-by":"crossref","unstructured":"Khan MH, Smith PN, Balzer JR, Crammond D, Welch WC, Gerszten P, Sclabassi RJ, Kang JD, Donaldson WF (2006) Intraoperative somatosensory evoked potential monitoring during cervical spine corpectomy surgery: experience with 508 cases. Spine (Phila Pa 1976) 31: E105-113","DOI":"10.1097\/01.brs.0000200163.71909.1f"},{"key":"1918_CR22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ana.410190105","volume":"19","author":"RP Lesser","year":"1986","unstructured":"Lesser RP, Raudzens P, Luders H, Nuwer MR, Goldie WD, Morris HH 3rd, Dinner DS, Klem G, Hahn JF, Shetter AG et al (1986) Postoperative neurological deficits may occur despite unchanged intraoperative somatosensory evoked potentials. Ann Neurol 19:22\u201325","journal-title":"Ann Neurol"},{"key":"1918_CR23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1213\/01.ane.0000226142.15746.b2","volume":"103","author":"JA Lieberman","year":"2006","unstructured":"Lieberman JA, Lyon R, Feiner J, Diab M, Gregory GA (2006) The effect of age on motor evoked potentials in children under propofol\/isoflurane anesthesia. Anesth Analg 103:316\u2013321, table of contents","journal-title":"Anesth Analg"},{"key":"1918_CR24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00004691-200210000-00005","volume":"19","author":"DB MacDonald","year":"2002","unstructured":"MacDonald DB (2002) Safety of intraoperative transcranial electrical stimulation motor evoked potential monitoring. J Clin Neurophysiol 19:416\u2013429","journal-title":"J Clin Neurophysiol"},{"key":"1918_CR25","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.1460-9592.2008.02704.x","volume":"18","author":"M Mahmoud","year":"2008","unstructured":"Mahmoud M, Spaeth J, Sadhasivam S (2008) Protection of tongue from injuries during transcranial motor-evoked potential monitoring. Paediatr Anaesth 18:902\u2013903","journal-title":"Paediatr Anaesth"},{"key":"1918_CR26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2106\/00004623-198971040-00019","volume":"71","author":"CL Nash Jr","year":"1989","unstructured":"Nash CL Jr, Brown RH (1989) Spinal cord monitoring. J Bone Joint Surg Am 71:627\u2013630","journal-title":"J Bone Joint Surg Am"},{"key":"1918_CR27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/bja\/aeg211","volume":"91","author":"N Nathan","year":"2003","unstructured":"Nathan N, Tabaraud F, Lacroix F, Moulies D, Viviand X, Lansade A, Terrier G, Feiss P (2003) Influence of propofol concentrations on multipulse transcranial motor evoked potentials. Br J Anaesth 91:493\u2013497","journal-title":"Br J Anaesth"},{"key":"1918_CR28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0387-7604(96)00552-9","volume":"19","author":"A Nezu","year":"1997","unstructured":"Nezu A, Kimura S, Uehara S, Kobayashi T, Tanaka M, Saito K (1997) Magnetic stimulation of motor cortex in children: maturity of corticospinal pathway and problem of clinical application. Brain Dev 19:176\u2013180","journal-title":"Brain Dev"},{"key":"1918_CR29","doi-asserted-by":"crossref","unstructured":"Parikh SN, Mehlman CT, Keith RW (2003) A third-degree burn caused by a neurogenic motor-evoked potential monitoring electrode during spinal surgery: a case report. Spine (Phila Pa 1976) 28: E21-24","DOI":"10.1097\/00007632-200301010-00028"},{"key":"1918_CR30","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S1388-2457(01)00529-6","volume":"112","author":"L Pelosi","year":"2001","unstructured":"Pelosi L, Stevenson M, Hobbs GJ, Jardine A, Webb JK (2001) Intraoperative motor evoked potentials to transcranial electrical stimulation during two anaesthetic regimens. Clin Neurophysiol 112:1076\u20131087","journal-title":"Clin Neurophysiol"},{"key":"1918_CR31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00381-002-0582-3","volume":"18","author":"F Sala","year":"2002","unstructured":"Sala F, Krzan MJ, Deletis V (2002) Intraoperative neurophysiological monitoring in pediatric neurosurgery: why, when, how? Childs Nerv Syst 18:264\u2013287","journal-title":"Childs Nerv Syst"},{"key":"1918_CR32","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3171\/jns.2002.96.3.0571","volume":"96","author":"KM Scheufler","year":"2002","unstructured":"Scheufler KM, Zentner J (2002) Total intravenous anesthesia for intraoperative monitoring of the motor pathways: an integral view combining clinical and experimental data. J Neurosurg 96:571\u2013579","journal-title":"J Neurosurg"},{"key":"1918_CR33","doi-asserted-by":"crossref","unstructured":"Sloan T (2010) Anesthesia and intraoperative neurophysiological monitoring in children. Childs Nerv Syst 26:227\u2013235","DOI":"10.1007\/s00381-009-1023-3"},{"key":"1918_CR34","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00004691-200210000-00006","volume":"19","author":"TB Sloan","year":"2002","unstructured":"Sloan TB, Heyer EJ (2002) Anesthesia for intraoperative neurophysiologic monitoring of the spinal cord. J Clin Neurophysiol 19:430\u2013443","journal-title":"J Clin Neurophysiol"},{"key":"1918_CR35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/01241398-198607000-00009","volume":"6","author":"EA Szalay","year":"1986","unstructured":"Szalay EA, Carollo JJ, Roach JW (1986) Sensitivity of spinal cord monitoring to intraoperative events. J Pediatr Orthop 6:437\u2013441","journal-title":"J Pediatr Orthop"},{"key":"1918_CR36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/bja\/79.5.590","volume":"79","author":"LH Ubags","year":"1997","unstructured":"Ubags LH, Kalkman CJ, Been HD, Drummond JC (1997) Differential effects of nitrous oxide and propofol on myogenic transcranial motor evoked responses during sufentanil anaesthesia. Br J Anaesth 79:590\u2013594","journal-title":"Br J Anaesth"},{"key":"1918_CR37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00006123-199807000-00058","volume":"43","author":"LH Ubags","year":"1998","unstructured":"Ubags LH, Kalkman CJ, Been HD (1998) Influence of isoflurane on myogenic motor evoked potentials to single and multiple transcranial stimuli during nitrous oxide\/opioid anesthesia. Neurosurgery 43:90\u201394, discussion 94\u201395","journal-title":"Neurosurgery"},{"key":"1918_CR38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/bja\/82.3.323","volume":"82","author":"EP Dongen van","year":"1999","unstructured":"van Dongen EP, ter Beek HT, Schepens MA, Morshuis WJ, de Boer A, Aarts LP, Boezeman EH (1999) Effect of nitrous oxide on myogenic motor potentials evoked by a six pulse train of transcranial electrical stimuli: a possible monitor for aortic surgery. Br J Anaesth 82:323\u2013328","journal-title":"Br J Anaesth"},{"key":"1918_CR39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1053-0770(99)90169-6","volume":"13","author":"EP Dongen van","year":"1999","unstructured":"van Dongen EP, ter Beek HT, Schepens MA, Morshuis WJ, Langemeijer HJ, Kalkman CJ, Boezeman EH (1999) The influence of nitrous oxide to supplement fentanyl\/low-dose propofol anesthesia on transcranial myogenic motor-evoked potentials during thoracic aortic surgery. J Cardiothorac Vasc Anesth 13:30\u201334","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1918_CR40","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1034\/j.1399-6576.2000.440705.x","volume":"44","author":"EP Dongen van","year":"2000","unstructured":"van Dongen EP, ter Beek HT, Aarts LP, Schepens MA, Morshuis WJ, Benning FJ, de Boer A, Boezeman EH (2000) The effect of two low-dose propofol infusions on the relationship between six-pulse transcranial electrical stimulation and the evoked lower extremity muscle response. Acta Anaesthesiol Scand 44:799\u2013803","journal-title":"Acta Anaesthesiol Scand"},{"key":"1918_CR41","doi-asserted-by":"crossref","unstructured":"Wilson-Holden TJ, Padberg AM, Lenke LG, Larson BJ, Bridwell KH, Bassett GS (1999) Efficacy of intraoperative monitoring for pediatric patients with spinal cord pathology undergoing spinal deformity surgery. Spine (Phila Pa 1976) 24: 1685\u20131692","DOI":"10.1097\/00007632-199908150-00010"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-012-1918-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-012-1918-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-012-1918-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T17:40:40Z","timestamp":1562262040000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-012-1918-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,23]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["1918"],"URL":"https:\/\/doi.org\/10.1007\/s00381-012-1918-2","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,23]]}}}