{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:47:01Z","timestamp":1790077621020,"version":"4.0.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00381-015-2873-5","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T06:37:14Z","timestamp":1439879834000},"page":"2269-2276","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Reference values for cerebral blood flow velocities in critically ill, sedated children"],"prefix":"10.1007","volume":"31","author":[{"given":"Nicole Fortier","family":"O\u2019Brien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"2873_CR1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3171\/jns.1982.57.6.0769","volume":"57","author":"R Aaslid","year":"1988","unstructured":"Aaslid R, Markwalder TM, Nornes H (1988) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57:769\u2013774","journal-title":"J Neurosurg"},{"key":"2873_CR2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000121192","volume":"26","author":"PD Adelson","year":"1997","unstructured":"Adelson PD, Clyde B, Kochanek PM, Wisniewski SR, Marion DW, Yonas H (1997) Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report. Pediatr Neurosurg 26:200\u2013207","journal-title":"Pediatr Neurosurg"},{"key":"2873_CR3","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/s00381-011-1476-z","volume":"27","author":"PD Adelson","year":"2011","unstructured":"Adelson PD, Srinivas R, Chang Y, Bell M, Kochanek PM (2011) Cerebrovascular response in children following severe traumatic brain injury. Childs Nerv Syst 27:1465\u20131476","journal-title":"Childs Nerv Syst"},{"key":"2873_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/jnnp.58.2.153","volume":"58","author":"PM Sharples","year":"1995","unstructured":"Sharples PM, Matthews DS, Eyre JA (1995) Cerebral blood flow and metabolism in children with severe head injuries. Part 2: cerebrovascular resistance and its determinants. J Neurol Neurosurg Psychiatry 58:153\u2013159","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2873_CR5","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00134-003-2057-8","volume":"30","author":"F Trabold","year":"2004","unstructured":"Trabold F, Meyer PG, Blanot S, Carli PA, Orliaguet GA (2004) The prognostic value of transcranial Doppler studies in children with moderate and severe head injury. Intensive Care Med 30:108\u2013112","journal-title":"Intensive Care Med"},{"key":"2873_CR6","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1097\/CCM.0000000000000745","volume":"43","author":"NF O\u2019Brien","year":"2015","unstructured":"O\u2019Brien NF, Maa T, Yeates KO (2015) The epidemiology of vasospasm in children with moderate-to-severe traumatic brain injury. Crit Care Med 43:674\u2013685","journal-title":"Crit Care Med"},{"key":"2873_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00381-004-1016-1","volume":"21","author":"PG Meyer","year":"2005","unstructured":"Meyer PG, Ducrocq S, Rackelbom T, Orliaguet G, Renier D, Carli P (2005) Surgical evacuation of acute subdural hematoma improves cerebral hemodynamics in children: a transcranial Doppler evaluation. Childs Nerv Syst 21:133\u2013137","journal-title":"Childs Nerv Syst"},{"key":"2873_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.surneu.2009.02.012","volume":"72","author":"AA Figaji","year":"2009","unstructured":"Figaji AA, Zwane E, Fieggen AG, Siesjo P, Peter JC (2009) Transcranial Doppler pulsatility index is not a reliable indicator of intracranial pressure in children with severe traumatic brain injury. Surg Neurol 72:389\u2013394","journal-title":"Surg Neurol"},{"key":"2873_CR9","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s00381-010-1367-8","volume":"27","author":"JR Melo","year":"2011","unstructured":"Melo JR, Di Rocco F, Blanot S (2011) Transcranial Doppler can predict intracranial hypertension in children with severe traumatic brain injuries. Childs Nerv Syst 27:979\u2013984","journal-title":"Childs Nerv Syst"},{"key":"2873_CR10","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1056\/NEJM199202273260905","volume":"326","author":"R Adams","year":"1992","unstructured":"Adams R, McKie V, Nichols F (1992) The use of transcranial ultrasonography to predict stroke in sickle cell disease. N Engl J Med 326:605\u2013610","journal-title":"N Engl J Med"},{"key":"2873_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1056\/NEJM199807023390102","volume":"339","author":"RJ Adams","year":"1998","unstructured":"Adams RJ, McKie VC, Hsu L (1998) Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 339:5\u201311","journal-title":"N Engl J Med"},{"key":"2873_CR12","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.ultrasmedbio.2009.04.024","volume":"10","author":"PH Leliefeld","year":"2009","unstructured":"Leliefeld PH, Gooskens RH, Peters R, Tulleken C, Kappelle L, Han K, Regli L, Hanlo P (2009) New transcranial Doppler index in infants with hydrocephalus: transsystolic time in clinical practice. Ultr Med Biol 10:1601\u20131606","journal-title":"Ultr Med Biol"},{"key":"2873_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/00004424-200202000-00006","volume":"37","author":"A Okten","year":"2002","unstructured":"Okten A, Ahmetoglu A, Dilber E (2002) Cranial Doppler ultrasonography as a predictor of neurologic sequelae in infants with bacterial meningitis. Investig Radiol 37:86\u201390","journal-title":"Investig Radiol"},{"key":"2873_CR14","first-page":"1698","volume":"26","author":"LH Lowe","year":"2005","unstructured":"Lowe LH, Morello FP, Jackson MA, Lasky A (2005) Application of transcranial Doppler sonography in children with acute neurologic events due to primary cerebral and West Nile vasculitis. AJNR Am J Neuroradiol 26:1698\u20131701","journal-title":"AJNR Am J Neuroradiol"},{"key":"2873_CR15","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1097\/CCM.0000000000000298","volume":"42","author":"R Kumar","year":"2014","unstructured":"Kumar R, Singhi S, Singhi P, Jayashree M, Bansal A, Bhatti A (2014) Randomized controlled trial comparing cerebral perfusion pressure-targeted therapy versus intracranial pressure-targeted therapy for raised intracranial pressure due to acute CNS infections in children. Crit Care Med 42:1775\u20131787","journal-title":"Crit Care Med"},{"key":"2873_CR16","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1136\/adc.63.6.606","volume":"63","author":"H Bode","year":"1988","unstructured":"Bode H, Wais U (1988) Age dependence of flow velocities in basal cerebral arteries. Arch Dis Childhood 63:606\u2013611","journal-title":"Arch Dis Childhood"},{"key":"2873_CR17","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1203\/01.PDR.0000179405.30737.0F","volume":"58","author":"MS Vavilala","year":"2005","unstructured":"Vavilala MS, Kinkaid M, Muangman SL (2005) Gender differences in cerebral blood flow velocity and autoregulation between anterior and posterior circulation in healthy children. Pediatr Res 58:574\u2013578","journal-title":"Pediatr Res"},{"key":"2873_CR18","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1542\/peds.2006-2110","volume":"119","author":"N Tontisirin","year":"2007","unstructured":"Tontisirin N, Muangman SL, Suz P, Pihoker C, Fisk D, Moore A, Lam AM, Vavilala MS (2007) Early childhood gender differences in anterior and posterior cerebral blood flow velocity and autoregulation. Pediatrics 119:e610\u2013e615","journal-title":"Pediatrics"},{"key":"2873_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/bja\/ael169","volume":"97","author":"A Conti","year":"2006","unstructured":"Conti A, Iacopino DG, Fodale V, Micalizzi S, Penna O, Santamaria LB (2006) Cerebral haemodynamic changes during propofol-remifentanil or sevoflurane anesthesia: transcranial Doppler study under bispectral index monitoring. Br J of Anaesth 97:333\u2013339","journal-title":"Br J of Anaesth"},{"key":"2873_CR20","doi-asserted-by":"crossref","unstructured":"Werner C, Hoffman WE, Baughman VL, Albrecht RF, Schulte am Esch J (1991) Effects of sufentanil on cerebral blood flow, cerebral blood flow velocity, and metabolism in dogs. Anesth Analg 72:177\u2013181","DOI":"10.1213\/00000539-199102000-00006"},{"key":"2873_CR21","doi-asserted-by":"crossref","unstructured":"Paris A, Scholz J, von Knobelsdorff G, Tonner PH, Schulte am Esch J (1998) The effect of remifentanil on cerebral blood flow velocity. Anesth Analg 87:569\u2013573","DOI":"10.1213\/00000539-199809000-00013"},{"key":"2873_CR22","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/01.aco.0000189879.67092.12","volume":"18","author":"W Heinke","year":"2005","unstructured":"Heinke W, Koelsch S (2005) The effects of anesthetics on brain activity and cognitive function. Curr Opin Anaesthesiol 18:625\u2013631","journal-title":"Curr Opin Anaesthesiol"},{"key":"2873_CR23","doi-asserted-by":"crossref","unstructured":"Werner C, Kochs E, Dietz R, Schulte am Esch J (1990) The effect of positive end expiratory pressure on the blood flow velocity in the basal cerebral arteries during general anesthesia. Anasth Intensivther Notfallmed 25:331\u2013334","DOI":"10.1055\/s-2007-1001076"},{"key":"2873_CR24","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1097\/01.CCM.0000181732.37319.DF","volume":"33","author":"E Muench","year":"2005","unstructured":"Muench E, Bauhuf C, Roth H, Horn P, Phillips M, Marquetant N, Quintel M, Vajkoczy P (2005) Effects of positive end-expiratory pressure on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation. Crit Care Med 33:2367\u20132372","journal-title":"Crit Care Med"},{"key":"2873_CR25","first-page":"293","volume":"23","author":"SI Merkel","year":"1997","unstructured":"Merkel SI, Voepel-Lewis T, Shayevitz JR, Malviya S (1997) The FLACC: a behavioral scale for scoring postoperative pain in young children. Pediatr Nurs 23:293\u2013297","journal-title":"Pediatr Nurs"},{"key":"2873_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4037\/ajcc2010624","volume":"19","author":"T Voepel-Lewis","year":"2010","unstructured":"Voepel-Lewis T, Zanotti J, Dammeyer JA, Merkel S (2010) Reliability and validity of the face, legs, activity, consolability behavioral tool in assessing acute pain in critically ill patients. Am J Crit Care 19:55\u201361","journal-title":"Am J Crit Care"},{"key":"2873_CR27","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1161\/01.STR.19.12.1466","volume":"19","author":"LM Brass","year":"1988","unstructured":"Brass LM, Pavlakis SG, DeVivo D, Piomelli S, Mohr JP (1988) Transcranial Doppler measurements of the middle cerebral artery. Effect of hematocrit. Stroke 19:1466\u20131469","journal-title":"Stroke"},{"key":"2873_CR28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1213\/00000539-199802000-00020","volume":"86","author":"N Bruder","year":"1998","unstructured":"Bruder N, Cohen B, Pellissier D, Francois G (1998) The effect of hemodilution on cerebral blood flow velocity in anesthetized patients. Anesth Analg 86:320\u2013324","journal-title":"Anesth Analg"},{"key":"2873_CR29","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1161\/01.STR.0000071526.45277.44","volume":"34","author":"MY Tseng","year":"2003","unstructured":"Tseng MY, Al-Rawi PG, Pickard JD, Rasulo FA, Kirkpatrick PJ (2003) Effect of hypertonic saline on cerebral blood flow in poor-grade patients with subarachnoid hemorrhage. Stroke 34:1389\u20131396","journal-title":"Stroke"},{"key":"2873_CR30","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1213\/00000539-199411000-00011","volume":"79","author":"HP Haring","year":"1994","unstructured":"Haring HP, Hormann CH, Schalow S, Benzer A (1994) Continuous positive airway pressure breathing increases cerebral blood flow velocity in humans. Anesth Analg 79:883\u2013885","journal-title":"Anesth Analg"},{"key":"2873_CR31","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1213\/00000539-200102000-00026","volume":"92","author":"RA Bowie","year":"2001","unstructured":"Bowie RA, O\u2019Connor PJ, Hardman JG, Mahajan RP (2001) The effect of continuous positive pressure on cerebral blood flow velocity in awake volunteers. Anesth Analg 92:415\u2013417","journal-title":"Anesth Analg"},{"key":"2873_CR32","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1213\/00000539-199006000-00008","volume":"70","author":"MH Zornow","year":"1990","unstructured":"Zornow MH, Fleischer JE, Scheller MS, Nakakimura K, Drummond JC (1990) Dexmedetomidine, an \u02512-adrenergic agonist reduces cerebral blood flow in the isoflurane-anesthetized dog. Anesth Analg 70:624\u2013630","journal-title":"Anesth Analg"},{"key":"2873_CR33","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/jcbfm.1993.45","volume":"13","author":"MH Zornow","year":"1993","unstructured":"Zornow MH, Maze M, Dyck B, Shafer SL (1993) Dexmedetomidine decreases cerebral blood flow velocities in humans. J Cerebral Blood Flow and Metabolism 13:350\u2013353","journal-title":"J Cerebral Blood Flow and Metabolism"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-015-2873-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-015-2873-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-015-2873-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-015-2873-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:52:17Z","timestamp":1744159937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-015-2873-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["2873"],"URL":"https:\/\/doi.org\/10.1007\/s00381-015-2873-5","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]},"assertion":[{"value":"15 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}