{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:55:05Z","timestamp":1789829705418,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T00:00:00Z","timestamp":1469836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00381-016-3157-4","type":"journal-article","created":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T04:32:30Z","timestamp":1469853150000},"page":"2041-2045","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Pineal region tumors: a simplified management scheme"],"prefix":"10.1007","volume":"32","author":[{"given":"Mohamed A.","family":"Zaazoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana C.","family":"Goumnerova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,30]]},"reference":[{"issue":"Suppl 4","key":"3157_CR1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/nov189","volume":"17","author":"QT Ostrom","year":"2015","unstructured":"Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2015) CBTRUS Statistical Report: primary brain and central nervous system tumors diagnosed in the United States in 2008\u20132012. Neuro Oncol 17(Suppl 4):iv1\u2013iv62","journal-title":"Neuro Oncol"},{"key":"3157_CR2","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/cncr.21430","volume":"104","author":"TT Wong","year":"2005","unstructured":"Wong TT, Ho DM, Chang KP, Yen SH, Guo WY, Chang FC, Liang ML, Pan HC, Chung WY (2005) Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975-2004). Cancer 104:2156\u20132167","journal-title":"Cancer"},{"key":"3157_CR3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/A:1012721723387","volume":"54","author":"J Hirato","year":"2001","unstructured":"Hirato J, Nakazato Y (2001) Pathology of pineal region tumors. J Neurooncol 54:239\u2013249","journal-title":"J Neurooncol"},{"key":"3157_CR4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97\u2013109","journal-title":"Acta Neuropathol"},{"key":"3157_CR5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/jns.1985.63.2.0155","volume":"63","author":"MT Jennings","year":"1985","unstructured":"Jennings MT, Gelman R, Hochberg F (1985) Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg 63:155\u2013167","journal-title":"J Neurosurg"},{"key":"3157_CR6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/WCO.0b013e3283404ef1","volume":"23","author":"G Dhall","year":"2010","unstructured":"Dhall G, Khatua S, Finlay JL (2010) Pineal region tumors in children. Curr Opin Neurol 23:576\u2013582","journal-title":"Curr Opin Neurol"},{"key":"3157_CR7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nec.2011.05.003","volume":"22","author":"EJ Fontana","year":"2011","unstructured":"Fontana EJ, Garvin J, Feldstein N, Anderson RC (2011) Pediatric considerations for pineal tumor management. Neurosurg Clin N Am 22:395\u2013402, ix","journal-title":"Neurosurg Clin N Am"},{"key":"3157_CR8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s00381-012-1762-4","volume":"28","author":"I Qaddoumi","year":"2012","unstructured":"Qaddoumi I, Sane M, Li S, Kocak M, Pai-Panandiker A, Harreld J, Klimo P, Wright K, Broniscer A, Gajjar A (2012) Diagnostic utility and correlation of tumor markers in the serum and cerebrospinal fluid of children with intracranial germ cell tumors. Childs Nerv Syst 28:1017\u20131024","journal-title":"Childs Nerv Syst"},{"key":"3157_CR9","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1200\/JCO.1999.17.4.1212","volume":"17","author":"MC Baranzelli","year":"1999","unstructured":"Baranzelli MC, Kramar A, Bouffet E, Quintana E, Rubie H, Edan C, Patte C (1999) Prognostic factors in children with localized malignant nonseminomatous germ cell tumors. J Clin Oncol 17:1212","journal-title":"J Clin Oncol"},{"key":"3157_CR10","first-page":"1075","volume":"68","author":"GL Perkins","year":"2003","unstructured":"Perkins GL, Slater ED, Sanders GK, Prichard JG (2003) Serum tumor markers. Am Fam Physician 68:1075\u20131082","journal-title":"Am Fam Physician"},{"key":"3157_CR11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00428-010-0951-3","volume":"457","author":"D Lee","year":"2010","unstructured":"Lee D, Suh YL (2010) Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute. Virchows Arch 457:347\u2013357","journal-title":"Virchows Arch"},{"key":"3157_CR12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1634\/theoncologist.2000-0312","volume":"5","author":"RJ Packer","year":"2000","unstructured":"Packer RJ, Cohen BH, Cooney K (2000) Intracranial germ cell tumors. Oncologist 5:312\u2013320","journal-title":"Oncologist"},{"key":"3157_CR13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11060-005-9110-0","volume":"79","author":"N Luther","year":"2006","unstructured":"Luther N, Edgar MA, Dunkel IJ, Souweidane MM (2006) Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors. J Neurooncol 79:45\u201350","journal-title":"J Neurooncol"},{"key":"3157_CR14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3171\/jns.1997.86.3.0446","volume":"86","author":"M Matsutani","year":"1997","unstructured":"Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T (1997) Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 86:446\u2013455","journal-title":"J Neurosurg"},{"key":"3157_CR15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuchi.2013.12.008","volume":"61","author":"C Mottolese","year":"2015","unstructured":"Mottolese C, Szathamari A, Beuriat PA, Grassiot B, Simon E (2015) Neuroendoscopy and pineal tumors: a review of the literature and our considerations regarding its utility. Neurochirurgie 61:155\u2013159","journal-title":"Neurochirurgie"},{"key":"3157_CR16","doi-asserted-by":"crossref","unstructured":"Morgenstern PF, Souweidane MM (2013) Pineal region tumors: simultaneous endoscopic third ventriculostomy and tumor biopsy. World Neurosurg S18.e19","DOI":"10.1016\/j.wneu.2012.02.020"},{"key":"3157_CR17","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2011.2.FOCUS10301","volume":"30","author":"PF Morgenstern","year":"2011","unstructured":"Morgenstern PF, Osbun N, Schwartz TH, Greenfield JP, Tsiouris AJ, Souweidane MM (2011) Pineal region tumors: an optimal approach for simultaneous endoscopic third ventriculostomy and biopsy. Neurosurg Focus 30:E3","journal-title":"Neurosurg Focus"},{"key":"3157_CR18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nec.2011.05.007","volume":"22","author":"BC Kennedy","year":"2011","unstructured":"Kennedy BC, Bruce JN (2011) Surgical approaches to the pineal region. Neurosurg Clin N Am 22:367\u2013380, viii","journal-title":"Neurosurg Clin N Am"},{"key":"3157_CR19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3171\/2010.5.PEDS09112","volume":"6","author":"MM Souweidane","year":"2010","unstructured":"Souweidane MM, Krieger MD, Weiner HL, Finlay JL (2010) Surgical management of primary central nervous system germ cell tumors: proceedings from the Second International Symposium on Central Nervous System Germ Cell Tumors. J Neurosurg Pediatr 6:125\u2013130","journal-title":"J Neurosurg Pediatr"},{"key":"3157_CR20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/pbc.22468","volume":"55","author":"S Khatua","year":"2010","unstructured":"Khatua S, Dhall G, O\u2019Neil S, Jubran R, Villablanca JG, Marachelian A, Nastia A, Lavey R, Olch AJ, Gonzalez I, Gilles F, Nelson M, Panigrahy A, McComb G, Krieger M, Fan J, Sposto R, Finlay JL (2010) Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation. Pediatr Blood Cancer 55:42\u201346","journal-title":"Pediatr Blood Cancer"},{"key":"3157_CR21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1470-2045(05)70245-X","volume":"6","author":"SJ Rogers","year":"2005","unstructured":"Rogers SJ, Mosleh-Shirazi MA, Saran FH (2005) Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol 6:509\u2013519","journal-title":"Lancet Oncol"},{"key":"3157_CR22","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.3171\/foc.1998.5.1.10","volume":"5","author":"M Matsutani","year":"1998","unstructured":"Matsutani M, Ushio Y, Abe H, Yamashita J, Shibui S, Fujimaki T, Takakura K, Nomura K, Tanaka R, Fukui M, Yoshimoto T, Hayakawa T, Nagashima T, Kurisu K, Kayama T (1998) Combined chemotherapy and radiation therapy for central nervous system germ cell tumors: preliminary results of a Phase II study of the Japanese Pediatric Brain Tumor Study Group. Neurosurg Focus 5:e7","journal-title":"Neurosurg Focus"},{"key":"3157_CR23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuchi.2014.03.003","volume":"61","author":"D Frappaz","year":"2015","unstructured":"Frappaz D, Conter CF, Szathmari A, Valsijevic A, Mottolese C (2015) The management of pineal tumors as a model for a multidisciplinary approach in neuro-oncology. Neurochirurgie 61:208\u2013211","journal-title":"Neurochirurgie"},{"key":"3157_CR24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11060-009-9951-z","volume":"96","author":"AP Kyritsis","year":"2010","unstructured":"Kyritsis AP (2010) Management of primary intracranial germ cell tumors. J Neurooncol 96:143\u2013149","journal-title":"J Neurooncol"},{"key":"3157_CR25","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1634\/theoncologist.2008-0037","volume":"13","author":"ME Echevarria","year":"2008","unstructured":"Echevarria ME, Fangusaro J, Goldman S (2008) Pediatric central nervous system germ cell tumors: a review. Oncologist 13:690\u2013699","journal-title":"Oncologist"},{"key":"3157_CR26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11060-010-0238-1","volume":"101","author":"CY Kim","year":"2011","unstructured":"Kim CY, Choi JW, Lee JY, Kim SK, Wang KC, Park SH, Choe G, Ahn HS, Kim IH, Cho BK (2011) Intracranial growing teratoma syndrome: clinical characteristics and treatment strategy. J Neurooncol 101:109\u2013115","journal-title":"J Neurooncol"},{"key":"3157_CR27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3171\/jns.2000.93.2.0245","volume":"93","author":"S Oi","year":"2000","unstructured":"Oi S, Shibata M, Tominaga J, Honda Y, Shinoda M, Takei F, Tsugane R, Matsuzawa K, Sato O (2000) Efficacy of neuroendoscopic procedures in minimally invasive preferential management of pineal region tumors: a prospective study. J Neurosurg 93:245\u2013253","journal-title":"J Neurosurg"},{"key":"3157_CR28","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00401-014-1247-5","volume":"127","author":"S Fukushima","year":"2014","unstructured":"Fukushima S, Otsuka A, Suzuki T, Yanagisawa T, Mishima K, Mukasa A, Saito N, Kumabe T, Kanamori M, Tominaga T, Narita Y, Shibui S, Kato M, Shibata T, Matsutani M, Nishikawa R, Ichimura K (2014) Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas. Acta Neuropathol 127:911\u2013925","journal-title":"Acta Neuropathol"},{"key":"3157_CR29","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1349-7006.2004.tb03251.x","volume":"95","author":"Y Sakuma","year":"2004","unstructured":"Sakuma Y, Sakurai S, Oguni S, Satoh M, Hironaka M, Saito K (2004) c-kit gene mutations in intracranial germinomas. Cancer Sci 95:716\u2013720","journal-title":"Cancer Sci"},{"key":"3157_CR30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.nec.2011.04.002","volume":"22","author":"C Jackson","year":"2011","unstructured":"Jackson C, Jallo G, Lim M (2011) Clinical outcomes after treatment of germ cell tumors. Neurosurg Clin N Am 22:385\u2013394, viii","journal-title":"Neurosurg Clin N Am"},{"key":"3157_CR31","first-page":"173","volume":"104","author":"Y Kamakura","year":"2006","unstructured":"Kamakura Y, Hasegawa M, Minamoto T, Yamashita J, Fujisawa H (2006) C-kit gene mutation: common and widely distributed in intracranial germinomas. J Neurosurg 104:173\u2013180","journal-title":"J Neurosurg"},{"key":"3157_CR32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.nec.2011.05.004","volume":"22","author":"AJ Clark","year":"2011","unstructured":"Clark AJ, Sughrue ME, Aranda D, Parsa AT (2011) Contemporary management of pineocytoma. Neurosurg Clin N Am 22:403\u2013407, Ix","journal-title":"Neurosurg Clin N Am"},{"key":"3157_CR33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.nec.2011.05.001","volume":"22","author":"MC Tate","year":"2011","unstructured":"Tate MC, Rutkowski MJ, Parsa AT (2011) Contemporary management of pineoblastoma. Neurosurg Clin N Am 22:409\u2013412, Ix","journal-title":"Neurosurg Clin N Am"},{"key":"3157_CR34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10143-010-0287-0","volume":"34","author":"M Mandera","year":"2010","unstructured":"Mandera M, Marcol W, Kotulska K, Olakowska E, Golka D, Malinowska I, Pietrucha-Dutczak M, Olakowski M, Lewin-Kowalik J (2010) Childhood pineal parenchymal tumors: clinical and therapeutic aspects. Neurosurg Rev 34:191\u2013196","journal-title":"Neurosurg Rev"},{"key":"3157_CR35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11060-008-9589-2","volume":"89","author":"SW Gilheeney","year":"2008","unstructured":"Gilheeney SW, Saad A, Chi S, Turner C, Ullrich NJ, Goumnerova L, Scott RM, Marcus K, Lehman L, De Girolami U, Kieran MW (2008) Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. J Neurooncol 89:89\u201395","journal-title":"J Neurooncol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-016-3157-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-016-3157-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-016-3157-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T09:45:53Z","timestamp":1749030353000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-016-3157-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,30]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["3157"],"URL":"https:\/\/doi.org\/10.1007\/s00381-016-3157-4","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,30]]}}}