{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:24:34Z","timestamp":1790839474150,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00381-018-3927-2","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T06:47:38Z","timestamp":1532674058000},"page":"2431-2440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Time to diagnosis of pediatric brain tumors: a report from the Pediatric Hematology and Oncology Center in Rabat, Morocco"],"prefix":"10.1007","volume":"34","author":[{"given":"Fatima Zahra","family":"Boutahar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarra","family":"Benmiloud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"El Kababri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Kili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Khorassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazik","family":"Allali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Qaddoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-273X","authenticated-orcid":false,"given":"Laila","family":"Hessissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"3927_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1750-3639.2003.tb00036.x","volume":"13","author":"DD Armstrong","year":"2003","unstructured":"Armstrong DD, Giangaspero F (2003) Pediatric brain tumors: introduction. Brain Pathol 13:373\u2013375","journal-title":"Brain Pathol"},{"key":"3927_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/archneur.56.4.421","volume":"56","author":"RJ Packer","year":"1999","unstructured":"Packer RJ (1999) Brain tumors in children. Arch Neurol 56:421\u2013425","journal-title":"Arch Neurol"},{"key":"3927_CR3","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s003810050270","volume":"14","author":"CH Rickert","year":"1998","unstructured":"Rickert CH (1998) Epidemiological features of brain tumors in the first 3 years of life. Childs Nerv Syst 14:547\u2013550","journal-title":"Childs Nerv Syst"},{"key":"3927_CR4","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1002\/cncr.22849","volume":"110","author":"T Dang-Tan","year":"2007","unstructured":"Dang-Tan T, Franco EL (2007) Diagnosis delays in childhood cancer: a review. Cancer 110:703\u2013713","journal-title":"Cancer"},{"key":"3927_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00431-008-0755-5","volume":"168","author":"K Kukal","year":"2009","unstructured":"Kukal K, Dobrovoljac M, Boltshauser E, Ammann RA, Grotzer MA (2009) Does diagnostic delay result in decreased survival in paediatric brain tumours? Eur J Pediatr 168:303\u2013310","journal-title":"Eur J Pediatr"},{"key":"3927_CR6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/00006123-200208000-00012","volume":"51","author":"V Mehta","year":"2002","unstructured":"Mehta V, Chapman A, McNeely PD, Walling S, Howes WJ (2002) Latency between symptom onset and diagnosis of pediatric brain tumors: an eastern Canadian geographic study. Neurosurgery 51:365\u2013372","journal-title":"Neurosurgery"},{"key":"3927_CR7","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1136\/adc.2009.162057","volume":"95","author":"S Wilne","year":"2010","unstructured":"Wilne S, Koller K, Collier J, Kennedy C, Grundy R, Walker D (2010) The diagnosis of brain tumours in children: a guideline to assist healthcare professionals in the assessment of children who may have a brain tumour. Arch Dis Child 95:534\u2013539","journal-title":"Arch Dis Child"},{"key":"3927_CR8","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1007\/s00381-011-1479-9","volume":"27","author":"I Quaddoumi","year":"2011","unstructured":"Quaddoumi I, Unal E, Diez B et al (2011) Web-based survey of resources for treatement and long term follow up for children with brain tumors in developing countries. Childs Nerv Syst 27:1957\u20131961","journal-title":"Childs Nerv Syst"},{"key":"3927_CR9","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/adc.2005.090266","volume":"91","author":"SH Wilne","year":"2006","unstructured":"Wilne SH, Ferris RC, Nathwani A, Kennedy CR (2006) The presenting features of brain tumours: a review of 200 cases. Arch Dis Child 91:502\u2013506","journal-title":"Arch Dis Child"},{"key":"3927_CR10","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s00381-010-1097-y","volume":"26","author":"M Karkouri","year":"2010","unstructured":"Karkouri M, Zafad S, Khattab M et al (2010) Epidemiologic profile of pediatric brain tumors in Morocco. Childs Nerv Syst 26:1021\u20131027","journal-title":"Childs Nerv Syst"},{"key":"3927_CR11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97\u2013109","journal-title":"Acta Neuropathol"},{"key":"3927_CR12","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00431-002-1088-4","volume":"161","author":"M Dobrovoljac","year":"2002","unstructured":"Dobrovoljac M, Hengartner H, Boltshauser E, Grotzer MA (2002) Delay in the diagnosis of paediatric brain tumours. Eur J Pediatr 161:663\u2013667","journal-title":"Eur J Pediatr"},{"key":"3927_CR13","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1177\/0883073807308692","volume":"23","author":"BC Reulecke","year":"2008","unstructured":"Reulecke BC, Erker CG, Fiedler BJ, Niederstadt TU, Kurlemann G (2008) Brain tumors in children: initial symptoms and their influence on the time span between symptom onset and diagnosis. J Child Neurol 23:178\u2013183","journal-title":"J Child Neurol"},{"key":"3927_CR14","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00381-007-0323-8","volume":"23","author":"L Dorner","year":"2007","unstructured":"Dorner L, Fritsch MJ, Stark AM, Mehdorn HM (2007) Posterior fossa tumors in children: how long does it take to establish the diagnosis? Childs Nerv Syst 23:887\u2013890","journal-title":"Childs Nerv Syst"},{"key":"3927_CR15","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1136\/adc.74.2.148","volume":"74","author":"J Edgeworth","year":"1996","unstructured":"Edgeworth J, Bullock P, Bailey A, Gallagher A, Crouchman M (1996) Why are brain tumours still being missed? Arch Dis Child 74:148\u2013151","journal-title":"Arch Dis Child"},{"key":"3927_CR16","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S1470-2045(07)70207-3","volume":"8","author":"S Wilne","year":"2007","unstructured":"Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D (2007) Presentation of childhood CNS tumours: a systematic review and meta analysis. Lancet Oncol 8:685\u2013695","journal-title":"Lancet Oncol"},{"key":"3927_CR17","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00381-015-2670-1","volume":"31","author":"A Arnautovic","year":"2015","unstructured":"Arnautovic A, Billups C, Broniscer A, Gajjar A, Boop F, Qaddoumi I et al (2015) Delayed diagnosis of childhood low-grade glioma: causes, consequences and potential solutions. Childs Nerv Syst 31:1067\u20131077","journal-title":"Childs Nerv Syst"},{"key":"3927_CR18","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0022-3476(05)80287-2","volume":"119","author":"BH Pollock","year":"1991","unstructured":"Pollock BH, Krischer JP, Vietti TJ (1991) Interval between symptom onset and diagnosis of pediatric solid tumors. J Pediatr 119:725\u2013732","journal-title":"J Pediatr"},{"key":"3927_CR19","first-page":"684","volume":"140","author":"LE Flores","year":"1986","unstructured":"Flores LE, Williams DL, Bell BA, O'Brien M, Ragab AH (1986) Delay in the diagnosis of pediatric brain tumors. Am J Dis Child 140:684\u2013686","journal-title":"Am J Dis Child"},{"key":"3927_CR20","unstructured":"Brasme J, Grill J, Doz F, et al (2010) Diagnosis delay of medulloblastoma in children: distribution, determinants and consequences in a population-based study. 14th International Symposium on Pediatric Neuro-Oncology, Vienna [abstract]"},{"key":"3927_CR21","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/S0140-6736(00)04130-1","volume":"357","author":"M Dixon-Woods","year":"2001","unstructured":"Dixon-Woods M, Findlay M, Young B, Cox H, Heney D (2001) Parents\u2019 accounts of obtaining a diagnosis of childhood cancer. Lancet 357:670\u2013674","journal-title":"Lancet"},{"key":"3927_CR22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bulcan.2016.11.002","volume":"104","author":"S Tatencloux","year":"2017","unstructured":"Tatencloux S, Mosseri V, Papillard-Mar\u00e9chal S, Mesples B, Pellegrino B, Belloy M, Jim\u00e8nez I, Algret N, Levy D, Michon J, Orbach D (2017) Parcours pr\u00e9diagnostique des enfants et adolescents atteints de tumeurs solides. Bull Cancer 104:128\u2013138","journal-title":"Bull Cancer"},{"key":"3927_CR23","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<874::AID-CNCR26>3.0.CO;2-R","volume":"78","author":"EC Halperin","year":"1996","unstructured":"Halperin EC, Friedman HS (1996) Is there a correlation between duration of presenting symptoms and stage of medulloblastoma at the time of diagnosis? Cancer 78:874\u2013880","journal-title":"Cancer"},{"key":"3927_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00431-011-1485-7","volume":"171","author":"S Wilne","year":"2012","unstructured":"Wilne S, Collier J, Kennedy C, Jenkins A, Grout J, Mackie S, Koller K, Grundy R, Walker D (2012) Progression from first symptom to diagnosis in childhood brain tumours. Eur J Pediatr 171:87\u201393","journal-title":"Eur J Pediatr"},{"key":"3927_CR25","doi-asserted-by":"publisher","first-page":"f5844","DOI":"10.1136\/bmj.f5844","volume":"347","author":"SH Wilne","year":"2013","unstructured":"Wilne SH, Dineen RA, Dommett RM, Chu TP, Walker DA (2013) Identifying brain tumours in children and young adults. BMJ 347:f5844","journal-title":"BMJ"},{"key":"3927_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1001\/archpedi.1982.03970380033008","volume":"136","author":"PJ Honig","year":"1982","unstructured":"Honig PJ, Charney EB (1982) Children with brain tumor headaches. Am J Dis Child 136:121\u2013124","journal-title":"Am J Dis Child"},{"key":"3927_CR27","first-page":"99","volume":"136","author":"CF Barlow","year":"1982","unstructured":"Barlow CF (1982) Headaches and brain tumors. Am J Dis Child 136:99\u2013100","journal-title":"Am J Dis Child"},{"key":"3927_CR28","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1200\/JCO.1995.13.7.1687","volume":"13","author":"BH Cohen","year":"1995","unstructured":"Cohen BH, Zeltzer PM, Boyett JM, Geyer JR, Allen JC, Finlay JL, McGuire-Cullen P, Milstein JM, Rorke LB, Stanley P (1995) Prognostic factors and treatment results for supratentorial primitive neuroectodermal tumors in children using radiation and chemotherapy: a Children\u2019s Cancer group randomized trial. J Clin Oncol 13:1687\u20131696","journal-title":"J Clin Oncol"},{"key":"3927_CR29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1227\/00006123-199510000-00008","volume":"37","author":"IF Pollack","year":"1995","unstructured":"Pollack IF, Gerszten PC, Martinez AJ, Lo KH, Shultz B, Albright AL, Janosky J, Deutsch M (1995) Intracranial ependymomas of childhood: long-term outcome and prognostic factors. Neurosurgery 37:655\u2013666","journal-title":"Neurosurgery"},{"key":"3927_CR30","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1200\/JCO.1999.17.3.832","volume":"17","author":"PM Zeltzer","year":"1999","unstructured":"Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, Allen JC, Stevens KR, Stanley P, Li H, Wisoff JH, Geyer JR, McGuire-Cullen P, Stehbens JA, Shurin SB, Packer RJ (1999) Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children\u2019s Cancer group 921 randomized phase III study. J Clin Oncol 17:832\u2013845","journal-title":"J Clin Oncol"},{"key":"3927_CR31","doi-asserted-by":"publisher","first-page":"e33415","DOI":"10.1371\/journal.pone.0033415","volume":"7","author":"JF Brasme","year":"2012","unstructured":"Brasme JF, Grill J, Doz F, Lacour B, Valteau-Couanet D, Gaillard S, Delalande O, Aghakhani N, Puget S, Chalumeau M (2012) Long time to diagnosis of medulloblastoma in children is not associated with decreased survival or with worse neurological outcome. PLoS One 7:e33415","journal-title":"PLoS One"},{"key":"3927_CR32","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1002\/cncr.24663","volume":"115","author":"I Qaddoumi","year":"2009","unstructured":"Qaddoumi I, Sultan I, Gajjar A (2009) Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the surveillance, epidemiology, and end results database. Cancer 115:5761\u20135770","journal-title":"Cancer"},{"key":"3927_CR33","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/neuonc\/nov187","volume":"18","author":"HeadSmart Be Brain Tumour Aware","year":"2016","unstructured":"HeadSmart Be Brain Tumour Aware (2016) A new clinical guideline from the Royal College of Paediatrics and Child Health with a national awareness campaign accelerates brain tumor diagnosis in UK children\u2014 HeadSmart: Be Brain TumourAware. Neuro Oncol 18:445\u2013454","journal-title":"Neuro Oncol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-018-3927-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-018-3927-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-018-3927-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T19:07:50Z","timestamp":1564168070000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-018-3927-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,27]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3927"],"URL":"https:\/\/doi.org\/10.1007\/s00381-018-3927-2","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,27]]},"assertion":[{"value":"15 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work was supported by ALSAC and the National Institutes of Health [CA21765 to I. Qaddoumi].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no potential conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}