{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:51:30Z","timestamp":1776462690413,"version":"3.51.2"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00381-019-04050-1","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T11:19:30Z","timestamp":1547464770000},"page":"565-567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Apert syndrome without craniosynostosis"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-6157","authenticated-orcid":false,"given":"Diego","family":"de \u00c2ngelis Ramos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamilton","family":"Matushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Dante","family":"Cardeal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa N\u00f3brega Gambarra","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"issue":"3","key":"4050_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/SAP.0b013e3181b0bb53","volume":"64","author":"DS Lee","year":"2010","unstructured":"Lee DS, Chung KC (2010) Eugene Apert and his contributions to plastic surgery. Ann Plast Surg 64(3):362\u2013365","journal-title":"Ann Plast Surg"},{"issue":"3","key":"4050_CR2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3171\/jns.1999.90.3.0443","volume":"90","author":"E Lajeunie","year":"1999","unstructured":"Lajeunie E, Cameron R, El Ghouzzi V, de Parseval N, Journeau P, Gonzales M et al (1999) Clinical variability in patients with Apert\u2019s syndrome. J Neurosurg 90(3):443\u2013447","journal-title":"J Neurosurg"},{"issue":"5","key":"4050_CR3","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/ajmg.1320420505","volume":"42","author":"MM Cohen Jr","year":"1992","unstructured":"Cohen MM Jr, Kreiborg S, Lammer EJ, Cordero JF, Mastroiacovo P, Erickson JD et al (1992) Birth prevalence study of the Apert syndrome. Am J Med Genet 42(5):655\u2013659","journal-title":"Am J Med Genet"},{"issue":"1","key":"4050_CR4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ng0596-48","volume":"13","author":"DM Moloney","year":"1996","unstructured":"Moloney DM, Slaney SR, Oldridge M, Wall SA, Sahlin P, Stenman G, Wilkie AOM (1996) Exclusive paternal origin of new mutations in Apert syndrome. Nat Genet 13(1):48\u201353","journal-title":"Nat Genet"},{"issue":"10\u201311","key":"4050_CR5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s003810000320","volume":"16","author":"D Renier","year":"2000","unstructured":"Renier D, Lajeunie E, Arnaud E, Marchac D (2000) Management of craniosynostoses. Childs Nerv Syst 16(10\u201311):645\u2013658","journal-title":"Childs Nerv Syst"},{"issue":"6","key":"4050_CR6","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1097\/MOP.0000000000000542","volume":"29","author":"AO Wilkie","year":"2017","unstructured":"Wilkie AO, Johnson D, Wall SA (2017) Clinical genetics of craniosynostosis. Curr Opin Pediatr 29(6):622\u2013628","journal-title":"Curr Opin Pediatr"},{"issue":"1","key":"4050_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00001665-199601000-00008","volume":"7","author":"A Avantaggiato","year":"1996","unstructured":"Avantaggiato A, Carinci F, Curioni C (1996) Apert\u2019s syndrome: cephalometric evaluation and considerations on pathogenesis. J Craniofac Surg 7(1):23\u201331","journal-title":"J Craniofac Surg"},{"issue":"1","key":"4050_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/ajmg.1320350108","volume":"35","author":"MM Cohen Jr","year":"1990","unstructured":"Cohen MM Jr, Kreiborg S (1990) The central nervous system in the Apert syndrome. Am J Med Genet 35(1):36\u201345","journal-title":"Am J Med Genet"},{"issue":"3","key":"4050_CR9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/ng0795-357","volume":"10","author":"GA Bellus","year":"1995","unstructured":"Bellus GA, McIntosh I, Smith EA, Aylsworth AS, Kaitila I, Horton WA, Greenhaw GA, Hecht JT, Francomano CA (1995) A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat Genet 10(3):357\u2013359","journal-title":"Nat Genet"},{"issue":"6494","key":"4050_CR10","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/371252a0","volume":"371","author":"F Rousseau","year":"1994","unstructured":"Rousseau F, Bonaventure J, Legeai-Mallet L, Pelet A, Rozet J-M, Maroteaux P, Merrer ML, Munnich A (1994) Mutations in the gene encoding fibroblast growth factor receptor 3 in achondroplasia. Nature 371(6494):252\u2013254","journal-title":"Nature"},{"issue":"2","key":"4050_CR11","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","volume":"78","author":"R Shiang","year":"1994","unstructured":"Shiang R, Thompson LM, Zhu Y-Z, Church DM, Fielder TJ, Bocian M, Winokur ST, Wasmuth JJ (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78(2):335\u2013342","journal-title":"Cell"},{"issue":"4","key":"4050_CR12","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1242\/dev.113.4.1419","volume":"113","author":"A Orr-Urtreger","year":"1991","unstructured":"Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P (1991) Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113(4):1419\u20131434","journal-title":"Development"},{"issue":"3","key":"4050_CR13","doi-asserted-by":"publisher","first-page":"e209","DOI":"10.1097\/SCS.0b013e31824de344","volume":"23","author":"S Coomaralingam","year":"2012","unstructured":"Coomaralingam S, Roth P (2012) Apert syndrome in a newborn infant without craniosynostosis. J Craniofac Surg 23(3):e209\u2013ee11","journal-title":"J Craniofac Surg"},{"issue":"5","key":"4050_CR14","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1097\/01.PRS.0000111593.96440.30","volume":"113","author":"JP Connolly","year":"2004","unstructured":"Connolly JP, Gruss J, Seto ML, Whelan MF, Ellenbogen R, Weiss A, Buchman SR, Cunningham ML (2004) Progressive postnatal craniosynostosis and increased intracranial pressure. Plast Reconstr Surg 113(5):1313\u20131323","journal-title":"Plast Reconstr Surg"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-019-04050-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-019-04050-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-019-04050-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T05:35:46Z","timestamp":1662788146000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-019-04050-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,14]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["4050"],"URL":"https:\/\/doi.org\/10.1007\/s00381-019-04050-1","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,14]]},"assertion":[{"value":"11 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}