{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:20:54Z","timestamp":1786980054851,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00381-019-04157-5","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T07:03:03Z","timestamp":1559199783000},"page":"1357-1362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Minimizing transfusion in sagittal craniosynostosis surgery: the Children\u2019s Hospital of Minnesota Protocol"],"prefix":"10.1007","volume":"35","author":[{"given":"Paul J.","family":"Escher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wheelwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Petronio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam","family":"Kebriaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivakumar","family":"Chinnadurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Tibesar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"4157_CR1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/SCS.0000000000003717","volume":"28","author":"HA Aljaaly","year":"2017","unstructured":"Aljaaly HA, Aldekhayel SA, Diaz-Abele J, Karunanayka M, Gilardino MS (2017) Effect of erythropoietin on transfusion requirements for craniosynostosis surgery in children. J Craniofac Surg 28:1315\u20131319","journal-title":"J Craniofac Surg"},{"key":"4157_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/cc13965","volume":"18","author":"S Beno","year":"2014","unstructured":"Beno S, Ackery AD, Callum J, Rizoli S (2014) Tranexamic acid in pediatric trauma: why not? Crit Care 18:313","journal-title":"Crit Care"},{"key":"4157_CR3","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1097\/PRS.0000000000002049","volume":"137","author":"CS Bergquist","year":"2016","unstructured":"Bergquist CS, Nauta AC, Selden NR, Kuang AA (2016) Age at the time of surgery and maintenance of head size in nonsyndromic sagittal craniosynostosis. Plast Reconstr Surg 137:1557\u20131565","journal-title":"Plast Reconstr Surg"},{"issue":"8","key":"4157_CR4","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.jpedsurg.2008.10.112","volume":"44","author":"R Bierer","year":"2009","unstructured":"Bierer R, Roohl M, Ohls RK (2009) Erythopoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery. J Pediatr Surg 44(8):1540\u20131545","journal-title":"J Pediatr Surg"},{"issue":"1","key":"4157_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/SCS.0b013e3182646ab8","volume":"24","author":"JW Chan","year":"2013","unstructured":"Chan JW, Stewart CL, Stalder MW, St Hilaire H, McBride L, Moses MH (2013) Endoscope-assisted open repair of craniosynostosis: a comparison of perioperative cost and risk. J Craniofac Surg 24(1):170\u2013174","journal-title":"J Craniofac Surg"},{"key":"4157_CR6","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1097\/ALN.0b013e318210f9e3","volume":"114","author":"C Dadure","year":"2011","unstructured":"Dadure C, Sauter M, Bringuier S, Bigorre M, RAux O, Rochette A, Canaud N, Capdevila X (2011) Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery. Anesthesiology 114:856\u2013861","journal-title":"Anesthesiology"},{"key":"4157_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3171\/2009.3.PEDS08355","volume":"4","author":"F DiRocco","year":"2009","unstructured":"DiRocco F, Arnaud E, Renier D (2009) Evolution in the frequency of nonsyndromic craniosynostosis. J Neurosurg Pediatr 4:21\u201325","journal-title":"J Neurosurg Pediatr"},{"issue":"3","key":"4157_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/00008506-199907000-00002","volume":"11","author":"LW Faberowski","year":"1999","unstructured":"Faberowski LW, Black S, Mickle JP (1999) Blood loss and transfusion practice in the perioperative management of craniosynostosis repair. J Neurosurg Anesthesiol 11(3):167\u2013172","journal-title":"J Neurosurg Anesthesiol"},{"key":"4157_CR9","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1097\/00006534-200206000-00002","volume":"109","author":"JA Fearon","year":"2002","unstructured":"Fearon JA, Weinthal J (2002) The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children. Plast Reconstr Surg 109:2190\u20132196","journal-title":"Plast Reconstr Surg"},{"key":"4157_CR10","first-page":"679","volume":"24","author":"SM Goobie","year":"2014","unstructured":"Goobie SM, Haas T (2014) Bleeding management for pediatric craniotomies and craniofacial surgery. Pediatr Anesth 24:679\u2013689","journal-title":"Pediatr Anesth"},{"issue":"4","key":"4157_CR11","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1097\/ALN.0b013e318210fd8f","volume":"114","author":"SM Goobie","year":"2011","unstructured":"Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF (2011) Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 114(4):862\u2013871","journal-title":"Anesthesiology"},{"key":"4157_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1056\/NEJM199703273361307","volume":"336","author":"LT Goodnough","year":"1997","unstructured":"Goodnough LT, Monk TG, Adriole GL (1997) Erythropoietin therapy. N Engl J Med 336:933\u2013938","journal-title":"N Engl J Med"},{"issue":"4","key":"4157_CR13","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3171\/jns.1998.88.4.0704","volume":"88","author":"MA Helfaer","year":"1998","unstructured":"Helfaer MA, Carson BS, James CS, Gate J, Della-Lana D, Vander Kolk C (1998) Increased hematocrit and decreased transfusion requirements in children given erythropoietin before undergoing craniofacial surgery. J Neurosurg 88(4):704\u2013708","journal-title":"J Neurosurg"},{"key":"4157_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/anae.12910","volume":"70","author":"BJ Hunt","year":"2015","unstructured":"Hunt BJ (2015) The current place of tranexamic acid in the management of bleeding. Anaesthesia 70:50\u201353","journal-title":"Anaesthesia"},{"issue":"1","key":"4157_CR15","first-page":"138","volume":"27","author":"A Kucuk","year":"2017","unstructured":"Kucuk A, Tumturk A, Gergin IS, Oral S, Gorkem SB, Kurtsoy A, Madenoglu H, Oktem IS (2017) The management of blood loss in non-syndromic craniosynostosis patients undergoing barrel stave osteotomy. Turk Neurosurg 27(1):138\u2013141","journal-title":"Turk Neurosurg"},{"issue":"4","key":"4157_CR16","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1177\/229255031502300413","volume":"23","author":"JP Martin","year":"2015","unstructured":"Martin JP, Wang JS, Hanna KR, Stovall MM, Lin KY (2015) Use of tranexamic acid in craniosynostosis surgery. Plast Surg 23(4):247\u2013251","journal-title":"Plast Surg"},{"key":"4157_CR17","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/bja\/71.6.854","volume":"71","author":"P Meyer","year":"1993","unstructured":"Meyer P, Renier D, Arnaud E, Jarreau MM, Charron B, Buy E, Buisson C, Barrier G (1993) Blood loss during repair of craniosynostosis. Br J Anaesth 71:854\u2013857","journal-title":"Br J Anaesth"},{"key":"4157_CR18","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/01.prs.0000416232.89764.55","volume":"130","author":"S Naran","year":"2012","unstructured":"Naran S, Cladis F, Fearon J, Bradley J, Michelotti B, Cooper G, Cray J, Katchikian H, Grunwaldt L, Pollack IF, Losee J (2012) Safety of preoperative erythropoietin in surgical calvarial remodeling: an 8 year retrospective review and analysis. Plast Reconstr Surg 130:301\u2013305","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"4157_CR19","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/MOO.0b013e328355a869","volume":"20","author":"H Okada","year":"2012","unstructured":"Okada H, Gosain AK (2012) Current approaches to management of nonsyndromic craniosynostosis. Curr Opin Otolaryngol Head Neck Surg 20(4):310\u2013317","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"5","key":"4157_CR20","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.jcms.2013.07.018","volume":"42","author":"M Pagnoni","year":"2014","unstructured":"Pagnoni M, Fadda MT, Spalice A, Amodeo G, Ursitti F, Mitro V, Iannetti G (2014) Surgical timing of craniosynostosis: what to do and when. J Craniomaxillofac Surg 42(5):513\u2013519","journal-title":"J Craniomaxillofac Surg"},{"issue":"3","key":"4157_CR21","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/CCM.0000000000000176","volume":"42","author":"RI Parker","year":"2014","unstructured":"Parker RI (2014) Transfusion in critically ill children: indications, risks, and challenges. Crit Care Med 42(3):675\u2013690","journal-title":"Crit Care Med"},{"issue":"4","key":"4157_CR22","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.surg.2016.06.006","volume":"160","author":"LD Rothermel","year":"2016","unstructured":"Rothermel LD, Lipman JM (2016) Estimation of blood loss is inaccurate and unreliable. Surgery 160(4):946\u2013953","journal-title":"Surgery"},{"key":"4157_CR23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/SCS.0b013e3182710232","volume":"24","author":"G Song","year":"2013","unstructured":"Song G, Yang P, Zhu S, Luo E, Feng G, Hu J, Li J, Li Y (2013) Tranexamic acid reducing blood transfusion in children ungergoing craniosynostosis surgery. J Craniofac Surg 24:299\u2013303","journal-title":"J Craniofac Surg"},{"key":"4157_CR24","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1097\/SCS.0b013e3181b09c4a","volume":"20","author":"JF Teichgraeber","year":"2009","unstructured":"Teichgraeber JF, Baumgartner JE, Waller AL, Reis SM, Stafford MT, Hollinger LE (2009) Microscopic minimally invasive approach to nonsyndromic craniosynostosis. J Craniofac Surg 20:1492\u20131500","journal-title":"J Craniofac Surg"},{"key":"4157_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1517\/14712598.2014.858116","volume":"14","author":"DH Tran","year":"2014","unstructured":"Tran DH, Wong GT, Chee YE, Irwin MG (2014) Effectiveness and safety of erythropoiesis stimulating agent use in the perioperative period. Expert Opin Biol Ther 14:51\u201361","journal-title":"Expert Opin Biol Ther"},{"key":"4157_CR26","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1007\/s003810050306","volume":"14","author":"F Velardi","year":"1998","unstructured":"Velardi F, DiChirico A, DiRocco C, Fundar\u00e8 C, Genovese O, Rendeli C, Menichella G, Serafini R, Piastra M, Viola L, Pietrini D, Pusateri A, Stoppa F (1998) \u201cNo allogeneic blood transfusion\u201d protocol for the surgical correction of craniosynostosis. Childs Nerv Syst 14:732\u2013739","journal-title":"Childs Nerv Syst"},{"key":"4157_CR27","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s003810050459","volume":"15","author":"F Velardi","year":"1999","unstructured":"Velardi F, DiChirico A, DiRocco C (1999) Blood salvage in craniosynostosis surgery. Childs Nerv Syst 15:695\u2013710","journal-title":"Childs Nerv Syst"},{"key":"4157_CR28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1097\/ALN.0b013e3182449fc8","volume":"116","author":"E Vergnaud","year":"2012","unstructured":"Vergnaud E, Vecchione A, Blanot S, di Rocco F, Arnaud E, Renier D, Meyer P (2012) Reducing blood losses and transfusion requirements in craniosynostosis surgery: an endless quest? Anesthesiology 116:733\u2013734","journal-title":"Anesthesiology"},{"key":"4157_CR29","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/SCS.0000000000001108","volume":"26","author":"N White","year":"2015","unstructured":"White N, Bayliss S, Lib D, Moore D (2015) Systematic review of interventions for minimizing perioperative blood transfusion for surgery for craniosynostosis. J Craniofac Surg 26:26\u201336","journal-title":"J Craniofac Surg"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-019-04157-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00381-019-04157-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-019-04157-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T19:08:32Z","timestamp":1590692912000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00381-019-04157-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,30]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["4157"],"URL":"https:\/\/doi.org\/10.1007\/s00381-019-04157-5","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,30]]},"assertion":[{"value":"31 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}