{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:20:53Z","timestamp":1786980053260,"version":"build-2736575974"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00381-020-04588-5","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T03:02:42Z","timestamp":1587092562000},"page":"2109-2112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Successful treatment of hemorrhagic brainstem cavernous malformation with hematoma evacuation and postoperative propranolol"],"prefix":"10.1007","volume":"36","author":[{"given":"Jessa E.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Wittenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Greenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corbett","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"4588_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1227\/NEU.0b013e3181ff9cde","volume":"68","author":"AA Abla","year":"2011","unstructured":"Abla AA, Lekovic GP, Turner JD, de Oliveira JG, Porter R, Spetzler RF (2011) Advances in the treatment and outcome of brainstem cavernous malformation surgery: a single-center case series of 300 surgically treated patients. Neurosurgery 68:403\u2013414","journal-title":"Neurosurgery"},{"key":"4588_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/0009922813492885","volume":"53","author":"I Berti","year":"2014","unstructured":"Berti I, Marchetti F, Skabar A, Zennaro F, Zanon D, Ventura A (2014) Propranolol for cerebral cavernous angiomatosis: a magic bullet. Clin Pediatr 53:189\u2013190","journal-title":"Clin Pediatr"},{"key":"4588_CR3","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1542\/peds.2012-1691","volume":"131","author":"BA Drolet","year":"2013","unstructured":"Drolet BA, Frommelt PC, Chamlin SL, Haggstrom A, Bauman NM, Chiu YE, Chun RH, Garzon MC, Holland KE, Liberman L, MacLellan-Tobert S, Mancini AJ, Metry D, Puttgen KB, Seefeldt M, Sidbury R, Ward KM, Blei F, Baselga E, Cassidy L, Darrow DH, Joachim S, Kwon EK, Martin K, Perkins J, Siegel DH, Boucek RJ, Frieden IJ (2013) Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics 131:128\u2013140","journal-title":"Pediatrics"},{"key":"4588_CR4","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1038\/s41598-018-22787-8","volume":"8","author":"Y Ji","year":"2018","unstructured":"Ji Y, Chen S, Wang Q, Xiang B, Xu Z, Zhong L, Yang K, Lu G, Qiu L (2018) Intolerable side effects during propranolol therapy for infantile hemangioma: frequency, risk factors and management. Sci Rep 8:4264","journal-title":"Sci Rep"},{"key":"4588_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pediatrneurol.2016.01.018","volume":"59","author":"E Kang","year":"2016","unstructured":"Kang E, Friedman N, Mamoun I, Tamburro J, Golden A (2016) Beta blockade as treatment for intracranial infantile hemangioma: case report and literature review. Pediatr Neurol 59:13\u201317","journal-title":"Pediatr Neurol"},{"key":"4588_CR6","first-page":"169","volume":"12","author":"BW Kim","year":"2010","unstructured":"Kim BW, Lee JW, Huh SK, Lee KC (2010) Clinical analysis of microsurgery for brainstem cavernous malformations: surgical indications, optimal approaches, and clinical outcomes. Korean J Cerebrovasc Surg 12:169\u2013176","journal-title":"Korean J Cerebrovasc Surg"},{"key":"4588_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.vph.2010.08.002","volume":"53","author":"S Lamy","year":"2010","unstructured":"Lamy S, Lachambre MP, Lord-Dufour S, Beliveau R (2010) Propranolol suppresses angiogenesis in vitro: inhibition of proliferation, migration, and differentiation of endothelial cells. Vasc Pharmacol 53:200\u2013208","journal-title":"Vasc Pharmacol"},{"key":"4588_CR8","doi-asserted-by":"crossref","unstructured":"Leaute-Lebreze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Ta\u00efeb A (2008) Propranolol for severe hemangiomas of infancy. N Engl J Med 358:2649\u20132651","DOI":"10.1056\/NEJMc0708819"},{"key":"4588_CR9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1177\/0883073810363917","volume":"25","author":"M Moschovi","year":"2010","unstructured":"Moschovi M, Alexiou GA, Tourkantoni N, Prodromous N (2010) Propranolol treatment for a giant infantile brain cavernoma. J Child Neurol 25:263\u2013655","journal-title":"J Child Neurol"},{"key":"4588_CR10","unstructured":"Shephard MJ, Bugarini A, Edwards NA, Lu J, Zhang Q, Wu T, Zhuang Z, Chittiboina P (2019) Repurposing propranolol as an antitumor agent in von Hippel-Lindau disease. JNS 131:993\u20131345"},{"key":"4588_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1365-2133.2010.09848.x","volume":"163","author":"CH Storch","year":"2010","unstructured":"Storch CH, Hoeger PH (2010) Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action. Br J Dermatol 163:269\u2013274","journal-title":"Br J Dermatol"},{"key":"4588_CR12","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3171\/2017.1.JNS161693","volume":"128","author":"A Tumturk","year":"2018","unstructured":"Tumturk A, Li Y, Turan Y, Cikla U, Iskandar BJ, Baskaya MK (2018) Emergency resection of brainstem cavernous malformations. JNS 128:1273\u20131603","journal-title":"JNS"},{"key":"4588_CR13","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.wneu.2015.11.003","volume":"88","author":"JM Zabramski","year":"2016","unstructured":"Zabramski JM, Kalani MYS, Filippidis AS, Spetzler RF (2016) Propranolol treatment of cavernous malformations with symptomatic hemorrhage. World Neurosurg 88:631\u2013639","journal-title":"World Neurosurg"},{"key":"4588_CR14","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/neuros\/nyw139","volume":"81","author":"HA Zaidi","year":"2017","unstructured":"Zaidi HA, Mooney MA, Levitt MR, Dru A, Abla A, Spetzler R (2017) Impact of timing of intervention among 397 consecutively treated brainstem cavernous malformations. Neurosurgery 81:620\u2013626","journal-title":"Neurosurgery"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04588-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-020-04588-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04588-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:20:49Z","timestamp":1666351249000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-020-04588-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["4588"],"URL":"https:\/\/doi.org\/10.1007\/s00381-020-04588-5","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]},"assertion":[{"value":"10 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors do not have any conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}