{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:00:55Z","timestamp":1781845255467,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901524"],"award-info":[{"award-number":["81901524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313579"],"award-info":[{"award-number":["2018A030313579"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20191015"],"award-info":[{"award-number":["20191015"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Medical Scientific Research Foundation of Guangdong Province","award":["A2020252"],"award-info":[{"award-number":["A2020252"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00381-020-04690-8","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T06:15:35Z","timestamp":1594793735000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neuroprotective effects of icariin in neonatal hypoxia-ischemic brain damage via its anti-apoptotic property"],"prefix":"10.1007","volume":"37","author":[{"given":"Mengxia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"issue":"7","key":"4690_CR1","first-page":"E99","volume":"5","author":"J Nair","year":"2018","unstructured":"Nair J, Kumar VHS (2018) Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates. Children (Basel) 5(7):E99","journal-title":"Children (Basel)"},{"issue":"3","key":"4690_CR2","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.clp.2016.04.012","volume":"43","author":"A Pappas","year":"2016","unstructured":"Pappas A, Korzeniewski SJ (2016) Long-term cognitive outcomes of birth asphyxia and the contribution of identified perinatal asphyxia to cerebral palsy. Clin Perinatol 43(3):559\u2013572","journal-title":"Clin Perinatol"},{"key":"4690_CR3","first-page":"44","volume":"44","author":"GS Shah","year":"2005","unstructured":"Shah GS, Singh R, Das BK (2005) Outcome of newborns with birth asphyxia. JNMA J Nepal Med Assoc 44:44\u201346","journal-title":"JNMA J Nepal Med Assoc"},{"issue":"3","key":"4690_CR4","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.clp.2016.04.007","volume":"43","author":"RM McAdams","year":"2016","unstructured":"McAdams RM, Juul SE (2016) Neonatal encephalopathy: update on therapeutic hypothermia and other novel therapeutics. Clin Perinatol 43(3):485\u2013500","journal-title":"Clin Perinatol"},{"issue":"4","key":"4690_CR5","first-page":"1910","volume":"8","author":"Z Wei","year":"2016","unstructured":"Wei Z, Wang M, Hong M, Diao S, Liu A, Huang Y, Yu Q, Peng Z (2016) Icariin exerts estrogen-like activity in ameliorating EAE via mediating estrogen receptor \u03b2, modulating HPA function and glucocorticoid receptor expression. Am J Transl Res 8(4):1910\u20131918","journal-title":"Am J Transl Res"},{"key":"4690_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.intimp.2015.11.035","volume":"30","author":"D Xiong","year":"2016","unstructured":"Xiong D, Deng Y, Huang B, Yin C, Liu B, Shi J, Gong Q (2016) Icariin attenuates cerebral ischemia-reperfusion injury through inhibition of inflammatory response mediated by NF-\u03baB, PPAR\u03b1 and PPAR\u03b3 in rats. Int Immunopharmacol 30:157\u2013162","journal-title":"Int Immunopharmacol"},{"key":"4690_CR7","doi-asserted-by":"crossref","first-page":"4343084","DOI":"10.1155\/2016\/4343084","volume":"2016","author":"ZT Mo","year":"2016","unstructured":"Mo ZT, Li WN, Zhai YR, Gong QH (2016) Icariin attenuates OGD\/R-induced autophagy via Bcl-2-dependent cross talk between apoptosis and autophagy in PC12 cells. Evid Based Complement Alternat Med 2016:4343084","journal-title":"Evid Based Complement Alternat Med"},{"issue":"11","key":"4690_CR8","first-page":"20188","volume":"8","author":"Z Wei","year":"2015","unstructured":"Wei Z, Deng X, Hong M, Su Q, Liu A, Huang Y, Yu Q, Peng Z (2015) Icariin has synergistic effects with methylprednisolone to ameliorate EAE via modulating HPA function, promoting anti-inflammatory and anti-apoptotic effects. Int J Clin Exp Med 8(11):20188\u201320197","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"4690_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice 3rd","year":"1981","unstructured":"Rice JE 3rd, Vannucci RC, Brierley JB (1981) The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9(2):131\u2013141","journal-title":"Ann Neurol"},{"issue":"1","key":"4690_CR10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/01.STR.0000047101.87575.3C","volume":"34","author":"C Manabat","year":"2003","unstructured":"Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM (2003) Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke 34(1):207\u2013213","journal-title":"Stroke"},{"issue":"3","key":"4690_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1385\/MN:34:3:249","volume":"34","author":"H Zhao","year":"2006","unstructured":"Zhao H, Sapolsky RM (2006) Steinberg GK. Phosphoinositide-3-kinase\/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34(3):249\u2013270","journal-title":"Mol Neurobiol"},{"issue":"1\u20133","key":"4690_CR12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ejphar.2010.05.012","volume":"642","author":"CQ Xu","year":"2010","unstructured":"Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC (2010) Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K\/Akt and NF-kappaB signaling pathway. Eur J Pharmacol 642(1\u20133):146\u2013153","journal-title":"Eur J Pharmacol"},{"key":"4690_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ejphar.2018.10.006","volume":"842","author":"J Jin","year":"2019","unstructured":"Jin J, Wang H, Hua X, Chen D, Huang C, Chen Z (2019) An outline for thepharmacological effect of icariin in the nervous system. Eur J Pharmacol 842:20\u201332","journal-title":"Eur J Pharmacol"},{"issue":"19","key":"4690_CR14","first-page":"1637","volume":"118","author":"L Li","year":"2005","unstructured":"Li L, Zhou QX, Shi JS (2005) Protective effects of icariin on neurons injured by cerebral ischemia\/reperfusion. Chin Med J 118(19):1637\u20131643","journal-title":"Chin Med J"},{"issue":"5","key":"4690_CR15","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/ptr.2276","volume":"22","author":"M Zheng","year":"2008","unstructured":"Zheng M, Qu L, Lou Y (2008) Effects of icariin combined with Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat. Phytother Res 22(5):597\u2013604","journal-title":"Phytother Res"},{"issue":"1","key":"4690_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13041-018-0389-0","volume":"11","author":"JM Jia","year":"2018","unstructured":"Jia JM, Peng C, Wang Y, Zheng J, Ge WP (2018) Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force. Mol Brain 11(1):47","journal-title":"Mol Brain"},{"issue":"9","key":"4690_CR17","doi-asserted-by":"publisher","first-page":"5962","DOI":"10.1007\/s12035-015-9488-4","volume":"53","author":"B Xu","year":"2016","unstructured":"Xu B, Xiao AJ, Chen W, Turlova E, Liu R, Barszczyk A, Sun CLF, Liu L, Tymianski M, Feng ZP (2016) Neuroprotective effects of a PSD-95 inhibitor in neonatal hypoxic-ischemic brain injury. Mol Neurobiol 53(9):5962\u20135970","journal-title":"Mol Neurobiol"},{"issue":"1","key":"4690_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3390\/md13010029","volume":"13","author":"AJ Xiao","year":"2014","unstructured":"Xiao AJ, Chen W, Xu B, Liu R, Turlova E, Barszczyk A, Sun CL, Liu L, Deurloo M, Wang GL (2014) Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury. Mar Drugs 13(1):29\u201347","journal-title":"Mar Drugs"},{"issue":"9","key":"4690_CR19","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1177\/0883073809338212","volume":"24","author":"H Hagberg","year":"2009","unstructured":"Hagberg H, Mallard C, Rousset CI (2009) Apoptotic mechanisms in the immature brain: involvement of mitochondria. J Child Neurol 24(9):1141\u20131146","journal-title":"J Child Neurol"},{"issue":"4","key":"4690_CR20","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.2042-7158.2010.01241.x","volume":"63","author":"YH Song","year":"2011","unstructured":"Song YH, Cai H, Gu N, Qian CF, Cao SP, Zhao ZM (2011) Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure. J Pharm Pharmacol 63(4):541\u2013549","journal-title":"J Pharm Pharmacol"},{"issue":"23","key":"4690_CR21","first-page":"2727","volume":"33","author":"L Li","year":"2008","unstructured":"Li L, Wang XM (2008) Progress of pharmacological research on icariin. Zhongguo Zhong Yao Za Zhi 33(23):2727\u20132732","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"4690_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ica.2017.05.060","volume":"466","author":"DG Pruitt","year":"2017","unstructured":"Pruitt DG, Bullock KM, Banks WA, Jelliss PA (2017) Development of rhenacarborane complexes as central nervous system (CNS) drug delivery agents. Inorg Chim Acta 466:139\u2013144","journal-title":"Inorg Chim Acta"},{"issue":"23","key":"4690_CR23","first-page":"8509","volume":"22","author":"YJ Zhao","year":"2018","unstructured":"Zhao YJ, Nai Y, Li SY, Zheng YH (2018) Retigabine protects the blood-brain barrier by regulating tight junctions between cerebral vascular endothelial cells in cerebral ischemia-reperfusion rats. Eur Rev Med Pharmacol Sci 22(23):8509\u20138518","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1\u20133","key":"4690_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s12011-011-9272-x","volume":"147","author":"H Yang","year":"2012","unstructured":"Yang H, Xu Z, Liu W, Wei Y, Deng Y, Xu B (2012) Efect of grape seed pranthocyanidin extracts on methylmercury-induced neurotoxicity in rats. Biol Trace Elem Res 147(1\u20133):156\u2013164","journal-title":"Biol Trace Elem Res"},{"key":"4690_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neuroscience.2015.02.053","volume":"294","author":"B Liu","year":"2015","unstructured":"Liu B, Xu C, Wu X, Liu F, Du Y, Sun J, Tao J, Dong J (2015) Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation. Neuroscience 294:193\u2013205","journal-title":"Neuroscience"},{"key":"4690_CR26","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S1995-7645(14)60303-5","volume":"8","author":"XM Liu","year":"2015","unstructured":"Liu XM, Feng Y, Li AM (2015) Efect of G-CSF and TPO on HIBD in neonatal rats. Asian Pac J Trop Med 8:132\u2013136","journal-title":"Asian Pac J Trop Med"},{"issue":"6","key":"4690_CR27","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1017\/S1461145713001533","volume":"17","author":"F Jin","year":"2014","unstructured":"Jin F, Gong QH, Xu YS, Wang LN, Jin H, Li F, Li LS, Ma YM, Shi JS (2014) Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP\/PS1 transgenic mice by stimulation of NO\/cGMP signalling. Int J Neuropsychopharmacol 17(6):871\u2013881","journal-title":"Int J Neuropsychopharmacol"},{"key":"4690_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.phymed.2016.12.017","volume":"25","author":"WF Chen","year":"2017","unstructured":"Chen WF, Wu L, Du ZR, Chen L, Xu AL, Chen XH, Teng JJ, Wong MS (2017) Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: involvement of PI3K\/Akt and MEK\/ERK signaling pathways. Phytomedicine 25:93\u201399","journal-title":"Phytomedicine"},{"issue":"1\u20132","key":"4690_CR29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuropharm.2010.03.017","volume":"59","author":"HR Zhu","year":"2010","unstructured":"Zhu HR, Wang ZY, Zhu XL, Wu XX, Li EG, Xu Y (2010) Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 59(1\u20132):70\u201376","journal-title":"Neuropharmacology"},{"issue":"1\u20133","key":"4690_CR30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejphar.2009.03.033","volume":"609","author":"L Wang","year":"2009","unstructured":"Wang L, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y (2009) Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol 609(1\u20133):40\u201344","journal-title":"Eur J Pharmacol"},{"key":"4690_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13041-015-0102-5","volume":"8","author":"W Chen","year":"2015","unstructured":"Chen W, Xu B, Xiao A, Liu L, Fang X, Liu R, Turlova E, Barszczyk A, Zhong X, Sun CL, Britto LR, Feng ZP, Sun HS (2015) TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury. Mol Brain 8:11","journal-title":"Mol Brain"},{"issue":"14","key":"4690_CR32","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.3109\/14767058.2013.878694","volume":"27","author":"H Kilicdag","year":"2014","unstructured":"Kilicdag H, Daglioglu YK, Erdogan S, Zorludemir S (2014) Effects of caffeine on neuronal apoptosis in neonatal hypoxic-ischemic brain injury. J Matern Fetal Neonatal Med 27(14):1470\u20131475","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"4690_CR33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0304-3940(97)13426-7","volume":"223","author":"RS Sidhu","year":"1997","unstructured":"Sidhu RS, Tuor UI, Del Bigio MR (1997) Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats. Neurosci Lett 223(2):129\u2013132","journal-title":"Neurosci Lett"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04690-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-020-04690-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04690-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T03:01:21Z","timestamp":1723258881000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-020-04690-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["4690"],"URL":"https:\/\/doi.org\/10.1007\/s00381-020-04690-8","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"27 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}