{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:06:20Z","timestamp":1781129180736,"version":"3.54.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00381-020-04754-9","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T17:02:20Z","timestamp":1592672540000},"page":"2401-2408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Spinal manifestations of Neurofibromatosis type 1"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-4740","authenticated-orcid":false,"given":"Ben","family":"Shofty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Barzilai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morsi","family":"Khashan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Lidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Constantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,20]]},"reference":[{"key":"4754_CR1","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1097\/01.rct.0000163705.21892.23","volume":"29","author":"CS Restrepo","year":"2005","unstructured":"Restrepo CS, Riascos RF, Hatta AA, Rojas R (2005) Neurofibromatosis type 1: spinal manifestations of a systemic disease. J Comput Assist Tomogr 29:532\u2013539","journal-title":"J Comput Assist Tomogr"},{"key":"4754_CR2","doi-asserted-by":"crossref","unstructured":"NIH (1988) NIH consensus development conference. Neurofibromatosis Conference statement. Arch Neurl:575\u2013578","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"4754_CR3","doi-asserted-by":"publisher","first-page":"W99","DOI":"10.2214\/AJR.11.7811","volume":"199","author":"NB Patel","year":"2012","unstructured":"Patel NB, Stacy GS (2012) Musculoskeletal manifestations of neurofibromatosis type 1. AJR Am J Roentgenol 199:W99\u2013W106. https:\/\/doi.org\/10.2214\/AJR.11.7811","journal-title":"AJR Am J Roentgenol"},{"key":"4754_CR4","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/jid.2014.465","volume":"135","author":"E Uusitalo","year":"2015","unstructured":"Uusitalo E, Lepp\u00e4virta J, Koffert A, Suominen S, Vahtera J, Vahlberg T, P\u00f6yh\u00f6nen M, Peltonen J, Peltonen S (2015) Incidence and mortality of neurofibromatosis: a total population study in Finland. J Invest Dermatol 135:904\u2013906. https:\/\/doi.org\/10.1038\/jid.2014.465","journal-title":"J Invest Dermatol"},{"key":"4754_CR5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s002340050814","volume":"41","author":"SD Thakkar","year":"1999","unstructured":"Thakkar SD, Feigen U, Mautner VF (1999) Spinal tumours in neurofibromatosis type 1: an MRI study of frequency, multiplicity and variety. Neuroradiology 41:625\u2013629","journal-title":"Neuroradiology"},{"key":"4754_CR6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3171\/2010.9.SPINE09242","volume":"14","author":"FS Taleb","year":"2011","unstructured":"Taleb FS, Guha A, Arnold PM, Fehlings MG, Massicotte EM (2011) Surgical management of cervical spine manifestations of neurofibromatosis type 1: long-term clinical and radiological follow-up in 22 cases. J Neurosurg Spine 14:356\u2013366. https:\/\/doi.org\/10.3171\/2010.9.SPINE09242","journal-title":"J Neurosurg Spine"},{"key":"4754_CR7","first-page":"777","volume":"34","author":"O Goertz","year":"2014","unstructured":"Goertz O, Langer S, Uthoff D, Ring A, Stricker I, Tannapfel A, Steinau HU (2014) Diagnosis, treatment and survival of 65 patients with malignant peripheral nerve sheath tumors. Anticancer Res 34:777\u2013783","journal-title":"Anticancer Res"},{"key":"4754_CR8","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1093\/neuonc\/nou235","volume":"17","author":"B Weiss","year":"2015","unstructured":"Weiss B, Widemann BC, Wolters P, Dombi E, Vinks A, Cantor A, Perentesis J, Schorry E, Ullrich N, Gutmann DH, Tonsgard J, Viskochil D, Korf B, Packer RJ, Fisher MJ (2015) Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis clinical trials consortium phase II study. Neuro-oncology 17:596\u2013603. https:\/\/doi.org\/10.1093\/neuonc\/nou235","journal-title":"Neuro-oncology"},{"key":"4754_CR9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/neuonc\/now158","volume":"19","author":"RI Jakacki","year":"2017","unstructured":"Jakacki RI, Dombi E, Steinberg SM, Goldman S, Kieran MW, Ullrich NJ, Pollack IF, Goodwin A, Manley PE, Fangusaro J, Allen R, Widemann BC (2017) Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas. Neuro-oncology 19:289\u2013297. https:\/\/doi.org\/10.1093\/neuonc\/now158","journal-title":"Neuro-oncology"},{"key":"4754_CR10","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/pbc.25763","volume":"63","author":"MJ Ferguson","year":"2016","unstructured":"Ferguson MJ, Rhodes SD, Jiang L, Li X, Yuan J, Yang X, Zhang S, Vakili ST, Territo P, Hutchins G, Yang FC, Ingram DA, Clapp DW, Chen S (2016) Preclinical evidence for the use of sunitinib malate in the treatment of plexiform neurofibromas. Pediatr Blood Cancer 63:206\u2013213. https:\/\/doi.org\/10.1002\/pbc.25763","journal-title":"Pediatr Blood Cancer"},{"key":"4754_CR11","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1056\/NEJMoa1605943","volume":"375","author":"E Dombi","year":"2016","unstructured":"Dombi E, Baldwin A, Marcus LJ, Fisher MJ, Weiss B, Kim AR, Whitcomb P, Martin S, Aschbacher-Smith LE, Rizvi TA, Wu J, Ershler R, Wolters P, Therrien J, Glod J, Belasco JB, Schorry E, Brofferio A, Starosta AJ, Gillespie A, Doyle AL, Ratner N, Widemann BC (2016) Activity of selumetinib in neurofibromatosis type 1-related plexiform neurofibromas. N Engl J Med 375:2550\u20132560. https:\/\/doi.org\/10.1056\/NEJMoa1605943","journal-title":"N Engl J Med"},{"key":"4754_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/cge.12498","volume":"87","author":"M Ruggieri","year":"2015","unstructured":"Ruggieri M, Polizzi A, Spalice A, Salpietro V, Caltabiano R, D'Orazi V, Pavone P, Pirrone C, Magro G, Platania N, Cavallaro S, Muglia M, Nicita F (2015) The natural history of spinal neurofibromatosis: a critical review of clinical and genetic features. Clin Genet 87:401\u2013410. https:\/\/doi.org\/10.1111\/cge.12498","journal-title":"Clin Genet"},{"key":"4754_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11060-013-1293-1","volume":"116","author":"R Nguyen","year":"2014","unstructured":"Nguyen R, Jett K, Harris GJ, Cai W, Friedman JM, Mautner VF (2014) Benign whole body tumor volume is a risk factor for malignant peripheral nerve sheath tumors in neurofibromatosis type 1. J Neuro-Oncol 116:307\u2013313. https:\/\/doi.org\/10.1007\/s11060-013-1293-1","journal-title":"J Neuro-Oncol"},{"key":"4754_CR14","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/ajmg.a.36466","volume":"164A","author":"VL Merker","year":"2014","unstructured":"Merker VL, Bredella MA, Cai W, Kassarjian A, Harris GJ, Muzikansky A, Nguyen R, Mautner VF, Plotkin SR (2014) Relationship between whole-body tumor burden, clinical phenotype, and quality of life in patients with neurofibromatosis. Am J Med Genet A 164A:1431\u20131437. https:\/\/doi.org\/10.1002\/ajmg.a.36466","journal-title":"Am J Med Genet A"},{"key":"4754_CR15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1215\/15228517-2008-011","volume":"10","author":"V-F Mautner","year":"2008","unstructured":"Mautner V-F, Asuagbor FA, Dombi E, F\u00fcnsterer C, Kluwe L, Wenzel R, Widemann BC, Friedman JM (2008) Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. Neuro-oncology 10:593\u2013598. https:\/\/doi.org\/10.1215\/15228517-2008-011","journal-title":"Neuro-oncology"},{"key":"4754_CR16","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00701-015-2366-z","volume":"157","author":"L Pratt","year":"2015","unstructured":"Pratt L, Helfer D, Weizman L, Shofty B, Constantini S, Joskowicz L, Ben Bashat D, Ben-Sira L (2015) Tumor burden evaluation in NF1 patients with plexiform neurofibromas in daily clinical practice. Acta Neurochir 157:855\u2013861. https:\/\/doi.org\/10.1007\/s00701-015-2366-z","journal-title":"Acta Neurochir"},{"key":"4754_CR17","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/neuonc\/noy199","volume":"21","author":"L Well","year":"2019","unstructured":"Well L, Salamon J, Kaul MG, Farschtschi S, Herrmann J, Geier KI, Hagel C, Bockhorn M, Bannas P, Adam G, Mautner VF, Derlin T (2019) Differentiation of peripheral nerve sheath tumors in patients with neurofibromatosis type 1 using diffusion-weighted magnetic resonance imaging. Neuro-oncology 21:508\u2013516. https:\/\/doi.org\/10.1093\/neuonc\/noy199","journal-title":"Neuro-oncology"},{"key":"4754_CR18","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1007\/s00259-018-4227-5","volume":"46","author":"CP Reinert","year":"2019","unstructured":"Reinert CP, Schuhmann MU, Bender B, Gugel I, la Foug\u00e8re C, Sch\u00e4fer J, Gatidis S (2019) Comprehensive anatomical and functional imaging in patients with type I neurofibromatosis using simultaneous FDG-PET\/MRI. Eur J Nucl Med Mol Imaging 46:776\u2013787. https:\/\/doi.org\/10.1007\/s00259-018-4227-5","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4754_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2214\/ajr.180.2.1800413","volume":"180","author":"P-L Khong","year":"2003","unstructured":"Khong P-L, Goh WHS, Wong VCN, Fung CW, Ooi GC (2003) MR imaging of spinal tumors in children with neurofibromatosis 1. AJR Am J Roentgenol 180:413\u2013417. https:\/\/doi.org\/10.2214\/ajr.180.2.1800413","journal-title":"AJR Am J Roentgenol"},{"key":"4754_CR20","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/01.bsd.0000133466.97241.50","volume":"17","author":"M Ramachandran","year":"2004","unstructured":"Ramachandran M, Tsirikos AI, Lee J, Saifuddin A (2004) Whole-spine magnetic resonance imaging in patients with neurofibromatosis type 1 and spinal deformity. J Spinal Disord Tech 17:483\u2013491. https:\/\/doi.org\/10.1097\/01.bsd.0000133466.97241.50","journal-title":"J Spinal Disord Tech"},{"key":"4754_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/00007632-200001010-00013","volume":"25","author":"AA Durrani","year":"2000","unstructured":"Durrani AA, Crawford AH, Chouhdry SN, Saifuddin A, Morley TR (2000) Modulation of spinal deformities in patients with neurofibromatosis type 1. Spine 25:69\u201375. https:\/\/doi.org\/10.1097\/00007632-200001010-00013","journal-title":"Spine"},{"key":"4754_CR22","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1097\/00007632-199712010-00014","volume":"22","author":"HW Kim","year":"1997","unstructured":"Kim HW, Weinstein SL (1997) Spine update. The management of scoliosis in neurofibromatosis. Spine 22:2770\u20132776. https:\/\/doi.org\/10.1097\/00007632-199712010-00014","journal-title":"Spine"},{"key":"4754_CR23","doi-asserted-by":"crossref","unstructured":"Betz RR, Iorio R, Lombardi AV et al (1989) Scoliosis surgery in neurofibromatosis. Clin Orthop Relat Res:53\u201356","DOI":"10.1097\/00003086-198908000-00010"},{"key":"4754_CR24","doi-asserted-by":"crossref","unstructured":"Crawford AH (1989) Pitfalls of spinal deformities associated with neurofibromatosis in children. Clin Orthop Relat Res:29\u201342","DOI":"10.1097\/00003086-198908000-00007"},{"key":"4754_CR25","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1097\/01241398-199010040-00019","volume":"10","author":"JL Sirois","year":"1990","unstructured":"Sirois JL, Drennan JC (1990) Dystrophic spinal deformity in neurofibromatosis. J Pediatr Orthop 10:522\u2013526","journal-title":"J Pediatr Orthop"},{"key":"4754_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/BPO.0000000000001090","volume":"40","author":"R Tauchi","year":"2020","unstructured":"Tauchi R, Kawakami N, Castro MA, Ohara T, Saito T, Morishita K, Yamauchi I (2020) Long-term surgical outcomes after early definitive spinal fusion for early-onset scoliosis with neurofibromatosis type 1 at mean follow-up of 14 years. J Pediatr Orthop 40:42\u201347. https:\/\/doi.org\/10.1097\/BPO.0000000000001090","journal-title":"J Pediatr Orthop"},{"key":"4754_CR27","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00586-004-0829-7","volume":"14","author":"AI Tsirikos","year":"2005","unstructured":"Tsirikos AI, Saifuddin A, Noordeen MH (2005) Spinal deformity in neurofibromatosis type-1: diagnosis and treatment. Eur Spine J 14:427\u2013439. https:\/\/doi.org\/10.1007\/s00586-004-0829-7","journal-title":"Eur Spine J"},{"key":"4754_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/jmg.2006.045906","volume":"44","author":"RE Ferner","year":"2007","unstructured":"Ferner RE, Huson SM, Thomas N, Moss C, Willshaw H, Evans DG, Upadhyaya M, Towers R, Gleeson M, Steiger C, Kirby A (2007) Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. J Med Genet 44:81\u201388. https:\/\/doi.org\/10.1136\/jmg.2006.045906","journal-title":"J Med Genet"},{"key":"4754_CR29","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.3174\/ajnr.A5338","volume":"38","author":"M Mauda-Havakuk","year":"2017","unstructured":"Mauda-Havakuk M, Shofty B, Ben-Shachar S, Ben-Sira L, Constantini S, Bokstein F (2017) Spinal and paraspinal plexiform neurofibromas in patients with neurofibromatosis type 1: a novel scoring system for radiological-clinical correlation. Am J Neuroradiol 38:1869\u20131875. https:\/\/doi.org\/10.3174\/ajnr.A5338","journal-title":"Am J Neuroradiol"},{"key":"4754_CR30","first-page":"752","volume":"63","author":"ME McLaughlin","year":"2003","unstructured":"McLaughlin ME, Jacks T (2003) Progesterone receptor expression in neurofibromas. Cancer Res 63:752\u2013755","journal-title":"Cancer Res"},{"key":"4754_CR31","doi-asserted-by":"publisher","first-page":"e0232031","DOI":"10.1371\/journal.pone.0232031","volume":"15","author":"L Well","year":"2020","unstructured":"Well L, Jaeger A, Kehrer-Sawatzki H, Farschtschi S, Avanesov M, Sauer M, de Sousa MT, Bannas P, Derlin T, Adam G, Mautner VF, Salamon JM (2020) The effect of pregnancy on growth-dynamics of neurofibromas in Neurofibromatosis type 1. PLoS One 15:e0232031. https:\/\/doi.org\/10.1371\/journal.pone.0232031","journal-title":"PLoS One"},{"key":"4754_CR32","doi-asserted-by":"publisher","first-page":"e1143","DOI":"10.1016\/j.wneu.2019.11.124","volume":"134","author":"B Shofty","year":"2020","unstructured":"Shofty B, Mauda-Havakuk M, Ben-Sira L, Bokstein F, Lidar Z, Salame K, Korn A, Constantini S (2020) Surgical management of \u201ckissing\u201d spinal plexiform neurofibromas in neurofibromatosis type 1 patients. World Neurosurg 134:e1143\u2013e1147. https:\/\/doi.org\/10.1016\/j.wneu.2019.11.124","journal-title":"World Neurosurg"},{"key":"4754_CR33","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1212\/01.wnl.0000250332.89420.e6","volume":"68","author":"E Dombi","year":"2007","unstructured":"Dombi E, Solomon J, Gillespie AJ, Fox E, Balis FM, Patronas N, Korf BR, Babovic-Vuksanovic D, Packer RJ, Belasco J, Goldman S, Jakacki R, Kieran M, Steinberg SM, Widemann BC (2007) NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight. Neurology 68:643\u2013647. https:\/\/doi.org\/10.1212\/01.wnl.0000250332.89420.e6","journal-title":"Neurology"},{"key":"4754_CR34","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/jmg.2005.036319","volume":"43","author":"DGR Evans","year":"2006","unstructured":"Evans DGR, Birch JM, Ramsden RT et al (2006) Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes. J Med Genet 43:289\u2013294. https:\/\/doi.org\/10.1136\/jmg.2005.036319","journal-title":"J Med Genet"},{"key":"4754_CR35","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.21873\/anticanres.14136","volume":"40","author":"A Marjanska","year":"2020","unstructured":"Marjanska A, Galazka P, Wysocki M, Styczynski J (2020) New frontiers in therapy of peripheral nerve sheath tumors in patients with neurofibromatosis type 1: latest evidence and clinical implications. Anticancer Res 40:1817\u20131831. https:\/\/doi.org\/10.21873\/anticanres.14136","journal-title":"Anticancer Res"},{"key":"4754_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humpath.2017.05.010","volume":"67","author":"MM Miettinen","year":"2017","unstructured":"Miettinen MM, Antonescu CR, Fletcher CDM, Kim A, Lazar AJ, Quezado MM, Reilly KM, Stemmer-Rachamimov A, Stewart DR, Viskochil D, Widemann B, Perry A (2017) Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview. Hum Pathol 67:1\u201310. https:\/\/doi.org\/10.1016\/j.humpath.2017.05.010","journal-title":"Hum Pathol"},{"key":"4754_CR37","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1093\/neuonc\/noy013","volume":"20","author":"CS Higham","year":"2018","unstructured":"Higham CS, Dombi E, Rogiers A, Bhaumik S, Pans S, Connor SEJ, Miettinen M, Sciot R, Tirabosco R, Brems H, Baldwin A, Legius E, Widemann BC, Ferner RE (2018) The characteristics of 76 atypical neurofibromas as precursors to neurofibromatosis 1 associated malignant peripheral nerve sheath tumors. Neuro-oncology 20:818\u2013825. https:\/\/doi.org\/10.1093\/neuonc\/noy013","journal-title":"Neuro-oncology"},{"key":"4754_CR38","doi-asserted-by":"publisher","unstructured":"Akshintala S, Baldwin A, Liewehr DJ, Goodwin A, Blakeley JO, Gross AM, Steinberg SM, Dombi E, Widemann BC (2020) Longitudinal evaluation of peripheral nerve sheath tumors in neurofibromatosis type 1: growth analysis of plexiform neurofibromas and distinct nodular lesions. Neuro-oncology. https:\/\/doi.org\/10.1093\/neuonc\/noaa053","DOI":"10.1093\/neuonc\/noaa053"},{"key":"4754_CR39","doi-asserted-by":"publisher","unstructured":"Nelson CN, Dombi E, Rosenblum JS, Miettinen MM, Lehky TJ, Whitcomb PO, Hayes C, Scott G, Benzo S, Widemann BC, Chittiboina P (2019) Safe marginal resection of atypical neurofibromas in neurofibromatosis type 1. J Neurosurg:1\u201311. https:\/\/doi.org\/10.3171\/2019.7.JNS191353","DOI":"10.3171\/2019.7.JNS191353"},{"key":"4754_CR40","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6","volume":"57","author":"BS Ducatman","year":"1986","unstructured":"Ducatman BS, Scheithauer BW, Piepgras DG, Reiman HM, Ilstrup DM (1986) Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer 57:2006\u20132021","journal-title":"Cancer"},{"key":"4754_CR41","first-page":"1573","volume":"62","author":"RE Ferner","year":"2002","unstructured":"Ferner RE, Gutmann DH (2002) International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Cancer Res 62:1573\u20131577","journal-title":"Cancer Res"},{"key":"4754_CR42","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1136\/jmg.39.5.311","volume":"39","author":"DG Evans","year":"2002","unstructured":"Evans DG, Baser ME, McGaughran J, Sharif S, Howard E, Moran A (2002) Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 39:311\u2013314","journal-title":"J Med Genet"},{"key":"4754_CR43","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3171\/2012.9.JNS101610","volume":"118","author":"GP Dunn","year":"2013","unstructured":"Dunn GP, Spiliopoulos K, Plotkin SR, Hornicek FJ, Harmon DC, Delaney TF, Williams Z (2013) Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis type 1. J Neurosurg 118:142\u2013148. https:\/\/doi.org\/10.3171\/2012.9.JNS101610","journal-title":"J Neurosurg"},{"key":"4754_CR44","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3171\/2016.8.SPINE151548","volume":"26","author":"D Chou","year":"2017","unstructured":"Chou D, Bilsky MH, Luzzati A, Fisher CG, Gokaslan ZL, Rhines LD, Dekutoski MB, Fehlings MG, Ghag R, Varga P, Boriani S, Germscheid NM, Reynolds JJ, _ _ (2017) Malignant peripheral nerve sheath tumors of the spine: results of surgical management from a multicenter study. J Neurosurg Spine 26:291\u2013298. https:\/\/doi.org\/10.3171\/2016.8.SPINE151548","journal-title":"J Neurosurg Spine"},{"key":"4754_CR45","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/COC.0000000000000303","volume":"41","author":"AJ Bishop","year":"2018","unstructured":"Bishop AJ, Zagars GK, Torres KE, Bird JE, Feig BW, Guadagnolo BA (2018) Malignant peripheral nerve sheath tumors: a single institution\u2019s experience using combined surgery and radiation therapy. Am J Clin Oncol 41:465\u2013470. https:\/\/doi.org\/10.1097\/COC.0000000000000303","journal-title":"Am J Clin Oncol"},{"key":"4754_CR46","doi-asserted-by":"publisher","first-page":"bcr2012007266","DOI":"10.1136\/bcr-2012-007266","volume":"2012","author":"A Akhavan","year":"2012","unstructured":"Akhavan A, Binesh F, Ghannadi F, Navabii H (2012) Excellent response of malignant peripheral nerve sheath tumour of retroperitoneum to radiation therapy. BMJ Case Rep 2012:bcr2012007266. https:\/\/doi.org\/10.1136\/bcr-2012-007266","journal-title":"BMJ Case Rep"},{"key":"4754_CR47","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3171\/2015.1.SPINE14910","volume":"23","author":"D-W Shin","year":"2015","unstructured":"Shin D-W, Sohn M-J, Kim H-S, Lee DJ, Jeon SR, Hwang YJ, Jho EH (2015) Clinical analysis of spinal stereotactic radiosurgery in the treatment of neurogenic tumors. J Neurosurg Spine 23:429\u2013437. https:\/\/doi.org\/10.3171\/2015.1.SPINE14910","journal-title":"J Neurosurg Spine"},{"key":"4754_CR48","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3171\/jns.1996.85.6.1036","volume":"85","author":"S Constantini","year":"1996","unstructured":"Constantini S, Houten J, Miller DC, Freed D, Ozek MM, Rorke LB, Allen JC, Epstein FJ (1996) Intramedullary spinal cord tumors in children under the age of 3 years. J Neurosurg 85:1036\u20131043. https:\/\/doi.org\/10.3171\/jns.1996.85.6.1036","journal-title":"J Neurosurg"},{"key":"4754_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3171\/spi.2000.93.2.0183","volume":"93","author":"S Constantini","year":"2000","unstructured":"Constantini S, Miller DC, Allen JC, Rorke LB, Freed D, Epstein FJ (2000) Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults. J Neurosurg 93:183\u2013193. https:\/\/doi.org\/10.3171\/spi.2000.93.2.0183","journal-title":"J Neurosurg"},{"key":"4754_CR50","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/BF01411560","volume":"139","author":"T Yagi","year":"1997","unstructured":"Yagi T, Ohata K, Haque M, Hakuba A (1997) Intramedullary spinal cord tumour associated with neurofibromatosis type 1. Acta Neurochir 139:1055\u20131060. https:\/\/doi.org\/10.1007\/BF01411560","journal-title":"Acta Neurochir"},{"key":"4754_CR51","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.radcr.2020.02.033","volume":"15","author":"T Uchi","year":"2020","unstructured":"Uchi T, Inaoka T, Kitamura N, Ishikawa R, Nakatsuka T, Kasuya S, Tokuyama W, Hiruta N, Takahashi H, Terada H (2020) Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient. Radiol Case Rep 15:784\u2013788. https:\/\/doi.org\/10.1016\/j.radcr.2020.02.033","journal-title":"Radiol Case Rep"},{"key":"4754_CR52","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/00006123-199601000-00009","volume":"38","author":"M Lee","year":"1996","unstructured":"Lee M, Rezai AR, Freed D, Epstein FJ (1996) Intramedullary spinal cord tumors in neurofibromatosis. Neurosurgery 38:32\u201337. https:\/\/doi.org\/10.1097\/00006123-199601000-00009","journal-title":"Neurosurgery"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04754-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-020-04754-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04754-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T23:20:30Z","timestamp":1624144830000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-020-04754-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,20]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["4754"],"URL":"https:\/\/doi.org\/10.1007\/s00381-020-04754-9","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,20]]},"assertion":[{"value":"16 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}