{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:10:11Z","timestamp":1785449411357,"version":"3.56.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00381-020-04766-5","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:02:54Z","timestamp":1594677774000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of intraventricular fibrinolytic therapy for post-intraventricular hemorrhagic hydrocephalus in extreme low birth weight infants: a preliminary clinical study"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-1332","authenticated-orcid":false,"given":"Young-Soo","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Kyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"4766_CR1","doi-asserted-by":"publisher","first-page":"e1130","DOI":"10.1542\/peds.2005-2724","volume":"118","author":"S Kusuda","year":"2006","unstructured":"Kusuda S, Fujimura M, Sakuma I, Aotani H, Kabe K, Itani Y, Ichiba H, Matsunami K, Nishida H, Neonatal Research Network J (2006) Morbidity and mortality of infants with very low birth weight in Japan: center variation. Pediatrics 118:e1130\u2013e1138","journal-title":"Pediatrics"},{"key":"4766_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1542\/peds.2006-1416","volume":"119","author":"D Wilson-Costello","year":"2007","unstructured":"Wilson-Costello D, Friedman H, Minich N, Siner B, Taylor G, Schluchter M, Hack M (2007) Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000-2002. Pediatrics 119:37\u201345","journal-title":"Pediatrics"},{"key":"4766_CR3","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1177\/0883073809339361","volume":"24","author":"AJ du Plessis","year":"2009","unstructured":"du Plessis AJ (2009) The role of systemic hemodynamic disturbances in prematurity-related brain injury. J Child Neurol 24:1127\u20131140","journal-title":"J Child Neurol"},{"key":"4766_CR4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","volume":"126","author":"BJ Stoll","year":"2010","unstructured":"Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Schibler K, Carlo WA, Kennedy KA, Poindexter BB, Finer NN, Ehrenkranz RA, Duara S, Sanchez PJ, O\u2019Shea TM, Goldberg RN, Van Meurs KP, Faix RG, Phelps DL, Frantz ID 3rd, Watterberg KL, Saha S, Das A, Higgins RD, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N (2010) Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 126:443\u2013456","journal-title":"Pediatrics"},{"key":"4766_CR5","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"LA Papile","year":"1978","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H (1978) Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 92:529\u2013534","journal-title":"J Pediatr"},{"key":"4766_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/ana.410250202","volume":"25","author":"JJ Volpe","year":"1989","unstructured":"Volpe JJ (1989) Intraventricular hemorrhage in the premature infant--current concepts. Part II. Ann Neurol 25:109\u2013116","journal-title":"Ann Neurol"},{"key":"4766_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/ana.410250103","volume":"25","author":"JJ Volpe","year":"1989","unstructured":"Volpe JJ (1989) Intraventricular hemorrhage in the premature infant--current concepts. Part I. Ann Neurol 25:3\u201311","journal-title":"Ann Neurol"},{"key":"4766_CR8","doi-asserted-by":"publisher","first-page":"e1167","DOI":"10.1542\/peds.2007-0423","volume":"121","author":"I Adams-Chapman","year":"2008","unstructured":"Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R, Network NR (2008) Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics 121:e1167\u2013e1177","journal-title":"Pediatrics"},{"key":"4766_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1159\/000331797","volume":"101","author":"AJ Brouwer","year":"2012","unstructured":"Brouwer AJ, van Stam C, Uniken Venema M, Koopman C, Groenendaal F, de Vries LS (2012) Cognitive and neurological outcome at the age of 5-8 years of preterm infants with post-hemorrhagic ventricular dilatation requiring neurosurgical intervention. Neonatology 101:210\u2013216","journal-title":"Neonatology"},{"key":"4766_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3171\/2015.7.PEDS15140","volume":"17","author":"EA Christian","year":"2016","unstructured":"Christian EA, Jin DL, Attenello F, Wen T, Cen S, Mack WJ, Krieger MD, McComb JG (2016) Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000-2010. J Neurosurg Pediatr 17:260\u2013269","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR11","doi-asserted-by":"crossref","unstructured":"McClugage SG, Laskay NMB, Donahue BN, Arynchyna A, Zimmerman K, Aban IB, Alford EN, Peralta-Carcelen M, Blount JP, Rozzelle CJ, Johnston JM, Rocque BG (2020) Functional outcomes at 2 years of age following treatment for posthemorrhagic hydrocephalus of prematurity: what do we know at the time of consult? J Neurosurg Pediatr:1\u20139","DOI":"10.3171\/2019.12.PEDS19381"},{"key":"4766_CR12","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3171\/2014.11.PEDS14364","volume":"15","author":"JA Radic","year":"2015","unstructured":"Radic JA, Vincer M, McNeely PD (2015) Outcomes of intraventricular hemorrhage and posthemorrhagic hydrocephalus in a population-based cohort of very preterm infants born to residents of Nova Scotia from 1993 to 2010. J Neurosurg Pediatr 15:580\u2013588","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR13","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3171\/2010.5.PEDS1010","volume":"6","author":"DD Limbrick Jr","year":"2010","unstructured":"Limbrick DD Jr, Mathur A, Johnston JM, Munro R, Sagar J, Inder T, Park TS, Leonard JL, Smyth MD (2010) Neurosurgical treatment of progressive posthemorrhagic ventricular dilation in preterm infants: a 10-year single-institution study. J Neurosurg Pediatr 6:224\u2013230","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR14","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00381-019-04127-x","volume":"35","author":"P Valdez Sandoval","year":"2019","unstructured":"Valdez Sandoval P, Hernandez Rosales P, Quinones Hernandez DG, Chavana Naranjo EA, Garcia Navarro V (2019) Intraventricular hemorrhage and posthemorrhagic hydrocephalus in preterm infants: diagnosis, classification, and treatment options. Childs Nerv Syst 35:917\u2013927","journal-title":"Childs Nerv Syst"},{"key":"4766_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3171\/2014.7.PEDS13552","volume":"14","author":"JY Wang","year":"2014","unstructured":"Wang JY, Amin AG, Jallo GI, Ahn ES (2014) Ventricular reservoir versus ventriculosubgaleal shunt for posthemorrhagic hydrocephalus in preterm infants: infection risks and ventriculoperitoneal shunt rate. J Neurosurg Pediatr 14:447\u2013454","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3171\/2009.2.PEDS08400","volume":"4","author":"JC Wellons","year":"2009","unstructured":"Wellons JC, Shannon CN, Kulkarni AV, Simon TD, Riva-Cambrin J, Whitehead WE, Oakes WJ, Drake JM, Luerssen TG, Walker ML, Kestle JR, Hydrocephalus Clinical Research N (2009) A multicenter retrospective comparison of conversion from temporary to permanent cerebrospinal fluid diversion in very low birth weight infants with posthemorrhagic hydrocephalus. J Neurosurg Pediatr 4:50\u201355","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR17","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3171\/2014.2.PEDS13397","volume":"13","author":"M Schulz","year":"2014","unstructured":"Schulz M, Buhrer C, Pohl-Schickinger A, Haberl H, Thomale UW (2014) Neuroendoscopic lavage for the treatment of intraventricular hemorrhage and hydrocephalus in neonates. J Neurosurg Pediatr 13:626\u2013635","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR18","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00381-019-04077-4","volume":"35","author":"UW Thomale","year":"2019","unstructured":"Thomale UW, Cinalli G, Kulkarni AV, Al-Hakim S, Roth J, Schaumann A, Buhrer C, Cavalheiro S, Sgouros S, Constantini S, Bock HC (2019) TROPHY registry study design: a prospective, international multicenter study for the surgical treatment of posthemorrhagic hydrocephalus in neonates. Childs Nerv Syst 35:613\u2013619","journal-title":"Childs Nerv Syst"},{"key":"4766_CR19","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1007\/s00381-018-3897-4","volume":"34","author":"RH Han","year":"2018","unstructured":"Han RH, McKinnon A, CreveCoeur TS, Baksh BS, Mathur AM, Smyser CD, Strahle JM, Olsen MA, Limbrick DD Jr (2018) Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study. Childs Nerv Syst 34:2203\u20132213","journal-title":"Childs Nerv Syst"},{"key":"4766_CR20","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1007\/s00381-015-2865-5","volume":"31","author":"JY Wang","year":"2015","unstructured":"Wang JY, Jackson EM, Jallo GI, Ahn ES (2015) Shunt revision requirements after posthemorrhagic hydrocephalus of prematurity: insight into the time course of shunt dependency. Childs Nerv Syst 31:2123\u20132130","journal-title":"Childs Nerv Syst"},{"key":"4766_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3171\/2017.1.PEDS16496","volume":"20","author":"JC Wellons 3rd","year":"2017","unstructured":"Wellons JC 3rd, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni AV, Limbrick DD Jr, Whitehead W, Browd S, Rozzelle C, Simon TD, Tamber MS, Oakes WJ, Drake J, Luerssen TG, Kestle J, Hydrocephalus Clinical Research N (2017) Shunting outcomes in posthemorrhagic hydrocephalus: results of a Hydrocephalus Clinical Research Network prospective cohort study. J Neurosurg Pediatr 20:19\u201329","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR22","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1111\/j.1651-2227.2002.tb02834.x","volume":"91","author":"K Savman","year":"2002","unstructured":"Savman K, Blennow M, Hagberg H, Tarkowski E, Thoresen M, Whitelaw A (2002) Cytokine response in cerebrospinal fluid from preterm infants with posthaemorrhagic ventricular dilatation. Acta Paediatr 91:1357\u20131363","journal-title":"Acta Paediatr"},{"key":"4766_CR23","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1203\/00006450-200102000-00013","volume":"49","author":"K Savman","year":"2001","unstructured":"Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A (2001) Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation. Pediatr Res 49:208\u2013212","journal-title":"Pediatr Res"},{"key":"4766_CR24","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1007\/s00381-016-3217-9","volume":"32","author":"D Szpecht","year":"2016","unstructured":"Szpecht D, Wiak K, Braszak A, Szymankiewicz M, Gadzinowski J (2016) Role of selected cytokines in the etiopathogenesis of intraventricular hemorrhage in preterm newborns. Childs Nerv Syst 32:2097\u20132103","journal-title":"Childs Nerv Syst"},{"key":"4766_CR25","doi-asserted-by":"publisher","first-page":"F229","DOI":"10.1136\/adc.2010.190173","volume":"97","author":"A Whitelaw","year":"2012","unstructured":"Whitelaw A, Aquilina K (2012) Management of posthaemorrhagic ventricular dilatation. Arch Dis Child Fetal Neonatal Ed 97:F229\u2013F223","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"4766_CR26","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1542\/peds.111.4.759","volume":"111","author":"A Whitelaw","year":"2003","unstructured":"Whitelaw A, Pople I, Cherian S, Evans D, Thoresen M (2003) Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapy. Pediatrics 111:759\u2013765","journal-title":"Pediatrics"},{"key":"4766_CR27","doi-asserted-by":"publisher","first-page":"e1071","DOI":"10.1542\/peds.2006-2841","volume":"119","author":"A Whitelaw","year":"2007","unstructured":"Whitelaw A, Evans D, Carter M, Thoresen M, Wroblewska J, Mandera M, Swietlinski J, Simpson J, Hajivassiliou C, Hunt LP, Pople I (2007) Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid. Pediatrics 119:e1071\u2013e1078","journal-title":"Pediatrics"},{"key":"4766_CR28","doi-asserted-by":"publisher","first-page":"e852","DOI":"10.1542\/peds.2009-1960","volume":"125","author":"A Whitelaw","year":"2010","unstructured":"Whitelaw A, Jary S, Kmita G, Wroblewska J, Musialik-Swietlinska E, Mandera M, Hunt L, Carter M, Pople I (2010) Randomized trial of drainage, irrigation and fibrinolytic therapy for premature infants with posthemorrhagic ventricular dilatation: developmental outcome at 2 years. Pediatrics 125:e852\u2013e858","journal-title":"Pediatrics"},{"key":"4766_CR29","first-page":"2056","volume":"34","author":"YS Park","year":"2018","unstructured":"Park YS, Kim TK, Nakase H (2018) 46(th) Annual Meeting of International Society for Pediatric Neurosurgery, Tel Aviv, ISRAEL, 7-11 October, 2018. Childs Nerv Syst 34:2056\u20132057","journal-title":"Childs Nerv Syst"},{"key":"4766_CR30","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1111\/j.1651-2227.2010.01830.x","volume":"99","author":"MJ Brouwer","year":"2010","unstructured":"Brouwer MJ, de Vries LS, Pistorius L, Rademaker KJ, Groenendaal F, Benders MJ (2010) Ultrasound measurements of the lateral ventricles in neonates: why, how and when? A systematic review. Acta Paediatr 99:1298\u20131306","journal-title":"Acta Paediatr"},{"key":"4766_CR31","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1055\/s-0030-1254550","volume":"27","author":"M El-Dib","year":"2010","unstructured":"El-Dib M, Massaro AN, Bulas D, Aly H (2010) Neuroimaging and neurodevelopmental outcome of premature infants. Am J Perinatol 27:803\u2013818","journal-title":"Am J Perinatol"},{"issue":"Suppl 1","key":"4766_CR32","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3171\/2014.7.PEDS14322","volume":"14","author":"CA Mazzola","year":"2014","unstructured":"Mazzola CA, Choudhri AF, Auguste KI, Limbrick DD Jr, Rogido M, Mitchell L, Flannery AM, Pediatric Hydrocephalus Systematic R, Evidence-Based Guidelines Task F (2014) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: management of posthemorrhagic hydrocephalus in premature infants. J Neurosurg Pediatr 14(Suppl 1):8\u201323","journal-title":"J Neurosurg Pediatr"},{"key":"4766_CR33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1136\/adc.67.1_Spec_No.12","volume":"67","author":"A Whitelaw","year":"1992","unstructured":"Whitelaw A, Rivers RP, Creighton L, Gaffney P (1992) Low dose intraventricular fibrinolytic treatment to prevent posthaemorrhagic hydrocephalus. Arch Dis Child 67:12\u201314","journal-title":"Arch Dis Child"},{"key":"4766_CR34","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1159\/000121207","volume":"26","author":"RJ Hudgins","year":"1997","unstructured":"Hudgins RJ, Boydston WR, Hudgins PA, Morris R, Adler SM, Gilreath CL (1997) Intrathecal urokinase as a treatment for intraventricular hemorrhage in the preterm infant. Pediatr Neurosurg 26:281\u2013287","journal-title":"Pediatr Neurosurg"},{"key":"4766_CR35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0887-8994(97)00130-6","volume":"17","author":"AR Hansen","year":"1997","unstructured":"Hansen AR, Volpe JJ, Goumnerova LC, Madsen JR (1997) Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. Pediatr Neurol 17:213\u2013217","journal-title":"Pediatr Neurol"},{"key":"4766_CR36","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3171\/2015.3.PEDS14630","volume":"16","author":"JH Badhiwala","year":"2015","unstructured":"Badhiwala JH, Hong CJ, Nassiri F, Hong BY, Riva-Cambrin J, Kulkarni AV (2015) Treatment of posthemorrhagic ventricular dilation in preterm infants: a systematic review and meta-analysis of outcomes and complications. J Neurosurg Pediatr 16:545\u2013555","journal-title":"J Neurosurg Pediatr"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04766-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-020-04766-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-020-04766-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:21:34Z","timestamp":1626135694000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-020-04766-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["4766"],"URL":"https:\/\/doi.org\/10.1007\/s00381-020-04766-5","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]},"assertion":[{"value":"31 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}