{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:50:47Z","timestamp":1777693847441,"version":"3.51.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Poznan University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Horner syndrome (HS) manifests in unilateral ptosis, miosis, enophthalmos, and anhedonia. It is most commonly caused by trauma or surgical procedures, but can also occur in pediatric patients as a result of tumors, especially neuroblastoma (NBL). The objective of this study was to analyze the incidence of HS in patients diagnosed with NBL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective analysis of data collected at the Department of Pediatric Oncology, Hematology, and Transplantology from 2004 to 2019 was performed. The study group included 119 patients younger than 18\u00a0years old, with 62 girls and 57 boys. All of them were diagnosed with a neuroblastic tumor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the 119 patients, eight children (6.72%) were diagnosed with HS associated with NBL. Three of these patients presented to the clinic with HS, whereas HS developed after the surgical procedure to remove the tumor in four patients. The adrenal gland was the most frequent localization of the tumor. However, HS occurred more frequently in patients with mediastinum tumors. As a presenting symptom, HS occurred in 2 of 11 cases (18.18%) with mediastinum localization. All of the patients with HS were younger than 2\u00a0years old.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Investigation of the cause of isolated HS is crucial because it can be the first symptom of NBL. However, the surgical procedure itself increases the risk of HS as a complication of NBL treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00381-020-04966-z","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T23:02:45Z","timestamp":1605049365000},"page":"1243-1247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence of Horner syndrome associated with neuroblastic disease"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-1005","authenticated-orcid":false,"given":"Katarzyna","family":"Kuchalska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Bare\u0142kowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-4035","authenticated-orcid":false,"given":"Katarzyna","family":"Derwich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Jo\u0144czyk-Potoczna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-4583","authenticated-orcid":false,"given":"Anna","family":"Gotz-Wi\u0119ckowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"4966_CR1","first-page":"686","volume-title":"Taylor and Hoyt\u2019s pediatric ophthalmology and strabismus","author":"SR Lambert","year":"2017","unstructured":"Lambert SR (2017) Taylor and Hoyt\u2019s pediatric ophthalmology and strabismus, 5th edn. Elsevier, Edinburgh, pp 686\u2013688","edition":"5"},{"key":"4966_CR2","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1001\/archophthalmol.2010.6","volume":"128","author":"SJ Smith","year":"2010","unstructured":"Smith SJ, Diehl N, Leavitt JA, Mohney BG (2010) Incidence of pediatric Horner syndrome and the risk of neuroblastoma: a population-based study. Arch Ophthalmol 128:324\u2013329","journal-title":"Arch Ophthalmol"},{"key":"4966_CR3","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ajo.2009.11.027","volume":"149","author":"SJ Smith","year":"2010","unstructured":"Smith SJ, Diehl N, Smith BD, Mohney BG (2010) Incidence, ocular manifestations, and survival in children with neuroblastoma: a population-based study. 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Ophthalmology 91:936\u2013940","journal-title":"Ophthalmology"},{"key":"4966_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ajo.2020.01.023","volume":"213","author":"S Graef","year":"2020","unstructured":"Graef S, Irwin MS, Wan MJ (2020) Incidence and prognostic role of the ocular manifestations of neuroblastoma in children. Am J Ophthalmol 213:145\u2013152","journal-title":"Am J Ophthalmol"},{"key":"4966_CR7","doi-asserted-by":"publisher","unstructured":"Nutt R, McLoone E, George S, O\u2019Gallagher M (2020) Atypical Horner\u2019s syndrome: frequency, features and aetiology in a paediatric population. Eye (Lond). https:\/\/doi.org\/10.1038\/s41433-020-0967-0","DOI":"10.1038\/s41433-020-0967-0"},{"key":"4966_CR8","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/WNO.0000000000000844","volume":"40","author":"MA Sabbagh","year":"2019","unstructured":"Sabbagh MA, De Lott LB, Trobe JD (2019) Causes of Horner syndrome: a study of 318 patients. J Neuroophthalmol 40:362\u2013369. https:\/\/doi.org\/10.1097\/WNO.0000000000000844","journal-title":"J Neuroophthalmol"},{"key":"4966_CR9","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s00247-015-3341-9","volume":"45","author":"N Kadom","year":"2015","unstructured":"Kadom N, Rosman NP, Jubouri S, Trofimova A, Egloff AM, Zein WM (2015) Neuroimaging experience in pediatric Horner syndrome. Pediatr Radiol 45:1535\u20131543","journal-title":"Pediatr Radiol"},{"key":"4966_CR10","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1136\/archdischild-2019-317007","volume":"104","author":"S Braungart","year":"2019","unstructured":"Braungart S, Craigie RJ, Farrelly P, Losty PD (2019) Paediatric Horner\u2019s syndrome: is investigation for underlying malignancy always required? 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