{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:22:16Z","timestamp":1784575336105,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010909","name":"Young Scientists Fund","doi-asserted-by":"publisher","award":["81701277"],"award-info":[{"award-number":["81701277"]}],"id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00381-021-05146-3","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T09:02:48Z","timestamp":1617008568000},"page":"2545-2555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2"],"prefix":"10.1007","volume":"37","author":[{"given":"Yi","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"5146_CR1","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.prp.2018.12.021","volume":"215","author":"F Chen","year":"2019","unstructured":"Chen F, Qi S, Zhang X, Wu J, Yang X, Wang R (2019) miR-23a-3p suppresses cell proliferation in oral squamous cell carcinomas by targeting FGF2 and correlates with a better prognosis: miR-23a-3p inhibits OSCC growth by targeting FGF2. Pathol Res Pract 215:660\u2013667","journal-title":"Pathol Res Pract"},{"key":"5146_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s005350300007","volume":"38","author":"Y Cui","year":"2003","unstructured":"Cui Y, Walter B (2003) Influence of albumin binding on the substrate transport mediated by human hepatocyte transporters OATP2 and OATP8. J Gastroenterol 38:60\u201368","journal-title":"J Gastroenterol"},{"key":"5146_CR3","doi-asserted-by":"publisher","first-page":"11996","DOI":"10.1038\/ncomms11996","volume":"7","author":"L Dai","year":"2016","unstructured":"Dai L, Cui X, Zhang X, Cheng L, Liu Y, Yang Y, Fan P, Wang Q, Lin Y, Zhang J, Li C, Mao Y, Wang Q, Su X, Zhang S, Peng Y, Yang H, Hu X, Yang J, Huang M, Xiang R, Yu D, Zhou Z, Wei Y, Deng H (2016) SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin. Nat Commun 7:11996","journal-title":"Nat Commun"},{"key":"5146_CR4","doi-asserted-by":"publisher","first-page":"9331","DOI":"10.3892\/mmr.2017.7808","volume":"16","author":"Y Dong","year":"2017","unstructured":"Dong Y, Li T, Li Y, Ren S, Fan J, Weng X (2017) MicroRNA-23a-3p inhibitor decreases osteonecrosis incidence in a rat model. Mol Med Rep 16:9331\u20139336","journal-title":"Mol Med Rep"},{"issue":"3","key":"5146_CR5","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/wsbm.125","volume":"3","author":"DM Glubb","year":"2011","unstructured":"Glubb DM, Innocenti F (2011) Mechanisms of genetic regulation in gene expression: examples from drug metabolizing enzymes and transporters. Wiley Interdiscip Rev Syst Biol Med 3(3):299\u2013313","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"1","key":"5146_CR6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1179\/174313209X408954","volume":"32","author":"Y Guo","year":"2010","unstructured":"Guo Y, Jiang L (2010) Drug transporters are altered in brain,liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. Neurol Res 32(1):106\u2013112","journal-title":"Neurol Res"},{"key":"5146_CR7","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1080\/01616412.2016.1173324","volume":"38","author":"Y Guo","year":"2016","unstructured":"Guo Y, Jiang L (2016) Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells. Neurol Res 38:634\u2013639","journal-title":"Neurol Res"},{"key":"5146_CR8","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s12072-012-9379-y","volume":"7","author":"M Hidaka","year":"2013","unstructured":"Hidaka M, Takatsuki M, Okudaira S, Soyama A, Muraoka I, Tanaka T, Yamaguchi I, Hara T, Miyaaki H, Ichikawa T, Hayashi T, Sakamoto I, Nakao K, Kuroki T, Kanematsu T, Eguchi S (2013) The expression of transporter OATP2\/OATP8 decreases in undetectable hepatocellular carcinoma by Gd-EOB-MRI in the explanted cirrhotic liver. Hepatol Int 7:655\u2013661","journal-title":"Hepatol Int"},{"key":"5146_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1124\/jpet.104.068056","volume":"311","author":"M Hirano","year":"2004","unstructured":"Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004) Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139\u2013146","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"5146_CR10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.2174\/13894501113149990183","volume":"14","author":"L Hong","year":"2013","unstructured":"Hong L, Yang Z, Ma J, Fan D (2013) Function of miRNA in controlling drug resistance of human cancers. Curr Drug Targets 14(10):1118\u20131127","journal-title":"Curr Drug Targets"},{"key":"5146_CR11","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.bbrc.2016.06.071","volume":"478","author":"L Kang","year":"2016","unstructured":"Kang L, Yang C, Song Y, Liu W, Wang K, Li S, Zhang Y (2016) MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes. Biochem Biophys Res Commun 478:467\u2013473","journal-title":"Biochem Biophys Res Commun"},{"key":"5146_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jpsychires.2018.12.007","volume":"110","author":"HK Kim","year":"2019","unstructured":"Kim HK, Tyryshkin K, Elmi N, Dharsee M, Evans KR, Good J, Javadi M, McCormack S, Vaccarino AL, Zhang X, Andreazza AC, Feilotter H (2019) Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment. J Psychiatr Res 110:38\u201344","journal-title":"J Psychiatr Res"},{"issue":"6","key":"5146_CR13","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","volume":"51","author":"P Kwan","year":"2010","unstructured":"Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Mosh\u00e9 SL, Perucca E, Wiebe S, French J (2010) Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 51(6):1069\u20131077","journal-title":"Epilepsia."},{"key":"5146_CR14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1080\/15384101.2019.1691763","volume":"19","author":"Z Li","year":"2020","unstructured":"Li Z, Xu R, Zhu X, Li Y, Wang Y, Xu W (2020) MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice. Cell Cycle 19:24\u201338","journal-title":"Cell Cycle"},{"key":"5146_CR15","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1210\/jc.2017-01909","volume":"103","author":"J Lozano-Bartolome","year":"2018","unstructured":"Lozano-Bartolome J, Llaurado G, Portero-Otin M, Altuna-Coy A et al (2018) Altered expression of miR-181a-5p and miR-23a-3p is associated with obesity and TNFalpha-induced insulin resistance. J Clin Endocrinol Metab 103:1447\u20131458","journal-title":"J Clin Endocrinol Metab"},{"key":"5146_CR16","doi-asserted-by":"publisher","first-page":"945","DOI":"10.7150\/thno.30516","volume":"9","author":"M Ma","year":"2019","unstructured":"Ma M, Dai J, Tang H, Xu T, Yu S, Si L, Cui C, Sheng X, Chi Z, Mao L, Wu X, Yang L, Yu H, Li S, Lian B, Tang B, Wang X, Yan X, Bai X, Zhou L, Kong Y, Guo J (2019) MicroRNA-23a-3p inhibits mucosal melanoma growth and progression through targeting adenylate cyclase 1 and attenuating cAMP and MAPK pathways. Theranostics. 9:945\u2013960","journal-title":"Theranostics."},{"key":"5146_CR17","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1212\/01.wnl.0000224880.35053.26","volume":"67","author":"UK Misra","year":"2006","unstructured":"Misra UK, Kalita J, Patel R (2006) Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology. 67:340\u2013342","journal-title":"Neurology."},{"key":"5146_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2019.03.016","volume":"285","author":"AS Moghaddam","year":"2019","unstructured":"Moghaddam AS, Afshari JT, Esmaeili SA, Saburi E, Joneidi Z, Momtazi-Borojeni AA (2019) Cardioprotective microRNAs: lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease. Atherosclerosis. 285:1\u20139","journal-title":"Atherosclerosis."},{"key":"5146_CR19","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.biopha.2018.11.065","volume":"110","author":"J Quan","year":"2019","unstructured":"Quan J, Pan X, Li Y, Hu Y, Tao L, Li Z, Zhao L, Wang J, Li H, Lai Y, Zhou L, Lin C, Gui Y, Ye J, Zhang F, Lai Y (2019) MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC. Biomed Pharmacother 110:656\u2013666","journal-title":"Biomed Pharmacother"},{"key":"5146_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jpba.2009.11.029","volume":"52","author":"FS Sarr","year":"2010","unstructured":"Sarr FS, Andre C, Guillaume YC (2010) A novel biochromatographic Oatp2 column to study the transmembrane transport of statins. J Pharm Biomed Anal 52:93\u201398","journal-title":"J Pharm Biomed Anal"},{"key":"5146_CR21","doi-asserted-by":"publisher","first-page":"6497","DOI":"10.1074\/jbc.M109081200","volume":"277","author":"M Sasaki","year":"2002","unstructured":"Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y (2002) Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2\/SLC21A6) and multidrug resistance-associated protein 2 (MRP2\/ABCC2). J Biol Chem 277:6497\u20136503","journal-title":"J Biol Chem"},{"key":"5146_CR22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.brainres.2011.02.073","volume":"1387","author":"YJ Song","year":"2011","unstructured":"Song YJ, Tian XB, Zhang S, Zhang YX, Li X, Li D, Cheng Y, Zhang JN, Kang CS, Zhao W (2011) Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a\/b. Brain Res 1387:134\u2013140","journal-title":"Brain Res"},{"key":"5146_CR23","doi-asserted-by":"crossref","unstructured":"Sui DM, Xie Q, Yi WJ, Gupta S et al (2016) Resveratrol protects against sepsis-associated encephalopathy and inhibits the NLRP3\/IL-1beta axis in microglia. Mediat Inflamm 1045657","DOI":"10.1155\/2016\/1045657"},{"issue":"5","key":"5146_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3109\/00207454.2015.1038710","volume":"126","author":"GX Wang","year":"2016","unstructured":"Wang GX, Wang DW, Liu Y, Ma YH (2016) Intractable epilepsy and the P-glycoprotein hypothesis. Int J Neurosci 126(5):385\u2013392","journal-title":"Int J Neurosci"},{"key":"5146_CR25","doi-asserted-by":"publisher","first-page":"40438","DOI":"10.1038\/srep40438","volume":"7","author":"L Wang","year":"2017","unstructured":"Wang L, Zhou MT, Chen CY, Yin W, Wen DX, Cheung CW, Yang LQ, Yu WF (2017) Increased renal clearance of rocuronium compensates for chronic loss of bile excretion, via upregulation of Oatp2. Sci Rep 7:40438","journal-title":"Sci Rep"},{"key":"5146_CR26","doi-asserted-by":"publisher","first-page":"21120","DOI":"10.18632\/oncotarget.4229","volume":"6","author":"YC Wen","year":"2015","unstructured":"Wen YC, Lee WJ, Tan P, Yang SF, Hsiao M, Lee LM, Chien MH (2015) By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer. Oncotarget. 6:21120\u201321136","journal-title":"Oncotarget."},{"key":"5146_CR27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1528-1167.2011.03338.x","volume":"53","author":"HS White","year":"2012","unstructured":"White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M (2012) A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia. 53:134\u2013146","journal-title":"Epilepsia."},{"issue":"8","key":"5146_CR28","first-page":"500","volume":"39","author":"HM Xiao","year":"2013","unstructured":"Xiao HM, Liao JX, Jiang L (2013) The expression of miR-146a-5p and miR-23a-3p in the serum of children with intractable epilepsy. Chin J Nerv Ment Dis 39(8):500\u2013503 (article in China)","journal-title":"Chin J Nerv Ment Dis"},{"key":"5146_CR29","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bcp.2015.08.094","volume":"98","author":"D Yu","year":"2015","unstructured":"Yu D, Green B, Tolleson WH, Jin Y, Mei N, Guo Y, Deng H, Pogribny I, Ning B (2015) MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells. Biochem Pharmacol 98:215\u2013223","journal-title":"Biochem Pharmacol"},{"key":"5146_CR30","doi-asserted-by":"crossref","unstructured":"Zhang B, Zhao N, Jia L, Peng K et al (2019) Seminal plasma exosomes: promising biomarkers for identification of male and pseudo-males in Cynoglossus semilaevis. Mar Biotechnol (NY)","DOI":"10.1007\/s10126-019-09881-2"},{"key":"5146_CR31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.brainres.2014.09.055","volume":"1592","author":"H Zhao","year":"2014","unstructured":"Zhao H, Tao Z, Wang R, Liu P, Yan F, Li J, Zhang C, Ji X, Luo Y (2014) MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion. Brain Res 1592:65\u201372","journal-title":"Brain Res"},{"key":"5146_CR32","first-page":"524","volume":"29","author":"L Zhu","year":"2013","unstructured":"Zhu L, Jin L, Jiang R, Wang Q et al (2013) Correlations between miRNAs and TGF-beta1 in tumor microenvironment of esophageal squamous cell cancer. Chin J Cell Mol Immunol 29:524\u2013528 (article in China)","journal-title":"Chin J Cell Mol Immunol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-021-05146-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-021-05146-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-021-05146-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T18:09:40Z","timestamp":1628186980000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-021-05146-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["5146"],"URL":"https:\/\/doi.org\/10.1007\/s00381-021-05146-3","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"9 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were approved by the Institutional Animal Care and Use Committees of Chongqing Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication is not applicable in this study; no individual person\u2019s data was used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no potential conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}