{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:14:14Z","timestamp":1771258454242,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008678","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Although intrathecal baclofen (ITB) therapy is an effective treatment for spasticity, it has several disadvantages and a risk of complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We present six pediatric patients who suffered from unusual mechanical failures of intrathecal baclofen pump systems.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>With these case-vignettes, we provide a systematic approach on how to interpret the symptoms of ITB complications and an advice which further diagnostic and therapeutic steps to follow. We underline the seriousness of baclofen overdose, underdosing or withdrawal.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00381-021-05154-3","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:14:54Z","timestamp":1617920094000},"page":"2597-2604","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unusual mechanical failures of intrathecal baclofen pump systems: symptoms, signs, and trouble shooting"],"prefix":"10.1007","volume":"37","author":[{"given":"Janina","family":"Gburek-Augustat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Bernhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Sorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gr\u00e4fe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Siekmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Nestler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Merkenschlager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"5154_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1472-6904-4-6","volume":"4","author":"I Mohammed","year":"2004","unstructured":"Mohammed I, Hussain A (2004) Intrathecal baclofen withdrawal syndrome- a life-threatening complication of baclofen pump: a case report. BMC Clin Pharmacol 4:6. https:\/\/doi.org\/10.1186\/1472-6904-4-6","journal-title":"BMC Clin Pharmacol"},{"key":"5154_CR2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1017\/s0012162201001190","volume":"43","author":"AL Albright","year":"2001","unstructured":"Albright AL, Barry MJ, Shafton DH, Ferson SS (2001) Intrathecal baclofen for generalized dystonia. Dev Med Child Neurol 43:652\u2013657. https:\/\/doi.org\/10.1017\/s0012162201001190","journal-title":"Dev Med Child Neurol"},{"key":"5154_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00112-009-2038-2","volume":"157","author":"W Voss","year":"2009","unstructured":"Voss W, Gad D, M\u00fccke K-H, Christen H-J (2009) Intrathekale Baclofentherapie: Palliativma\u00dfnahme bei spastischen und dystonen Bewegungsst\u00f6rungen. Monatsschrift f\u00fcr Kinderheilkunde 157:1\u20139. https:\/\/doi.org\/10.1007\/s00112-009-2038-2","journal-title":"Monatsschrift f\u00fcr Kinderheilkunde"},{"issue":"11","key":"5154_CR4","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1007\/s00702-015-1425-1","volume":"122","author":"D Dressler","year":"2015","unstructured":"Dressler D, Berweck S, Chatzikalfas A, Ebke M, Frank B, Hesse S, Huber M, Krauss JK, M\u00fccke KH, Nolte A, Oelmann HD, Sch\u00f6nle PW, Schmutzler M, Pickenbrock H, Van der Ven C, Veelken N, Vogel M, Vogt T, Saberi FA (2015 Nov) Intrathecal baclofen therapy in Germany: proceedings of the IAB-interdisciplinary working group for movement disorders consensus meeting. J Neural Transm (Vienna) 122(11):1573\u20131579. https:\/\/doi.org\/10.1007\/s00702-015-1425-1","journal-title":"J Neural Transm (Vienna)"},{"issue":"3","key":"5154_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/10790268.2006.11753880","volume":"29","author":"Y Tunali","year":"2006","unstructured":"Tunali Y, Hanimoglu H, Tanriverdi T, Hanci L, Hanci M (2006) Intrathecal baclofen toxicity and deep coma in minutes. J Spinal Cord Med 29(3):237\u2013239. https:\/\/doi.org\/10.1080\/10790268.2006.11753880","journal-title":"J Spinal Cord Med"},{"issue":"11","key":"5154_CR6","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1177\/0883073818785074","volume":"33","author":"G Winter","year":"2018","unstructured":"Winter G, Beni-Adani L, Ben-Pazi H (2018 Oct) Intrathecal baclofen therapy-practical approach: clinical benefits and complication management. J Child Neurol 33(11):734\u2013741. https:\/\/doi.org\/10.1177\/0883073818785074","journal-title":"J Child Neurol"},{"issue":"3","key":"5154_CR7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3171\/2013.11.PEDS13253","volume":"13","author":"F Motta","year":"2014","unstructured":"Motta F, Antonello CE (2014) Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience. J Neurosurg Pediatr 13(3):301\u2013306. https:\/\/doi.org\/10.3171\/2013.11.PEDS13253","journal-title":"J Neurosurg Pediatr"},{"issue":"1","key":"5154_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000070870","volume":"39","author":"JL Gooch","year":"2003","unstructured":"Gooch JL, Oberg WA, Grams B, Ward LA, Walker ML (2003) Complications of intrathecal baclofen pumps in children. Pediatr Neurosurg 39(1):1\u20136. https:\/\/doi.org\/10.1159\/000070870","journal-title":"Pediatr Neurosurg"},{"issue":"4","key":"5154_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/PEC.0000000000001090","volume":"33","author":"SM Woolf","year":"2017","unstructured":"Woolf SM, Baum CR (2017) Baclofen pumps: uses and complications. Pediatr Emerg Care 33(4):271\u2013275. https:\/\/doi.org\/10.1097\/PEC.0000000000001090","journal-title":"Pediatr Emerg Care"},{"issue":"5","key":"5154_CR10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/ner.12258","volume":"18","author":"J Riordan","year":"2015","unstructured":"Riordan J, Murphy P (2015) Intrathecal pump: an abrupt intermittent pump failure. 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Consent for treatment was given by the parents or caregivers and are in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and Consent to participate"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}