{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:29:45Z","timestamp":1792549785855,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00381-021-05169-w","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T01:02:37Z","timestamp":1618707757000},"page":"2001-2009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Syndrome-related outcomes following posterior vault distraction osteogenesis"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-0827","authenticated-orcid":false,"given":"Cassio Eduardo","family":"Raposo-Amaral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri Moresco","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Denadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto","family":"Raposo-Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Ghizoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"5169_CR1","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1097\/PRS.0b013e31820a64b6","volume":"127","author":"KA Allam","year":"2011","unstructured":"Allam KA, Wan DC, Khwanngern K, Kawamoto HK, Tanna N, Perry A, Bradley JP (2011) Treatment of Apert syndrome: a long-term follow-up study. Plast Reconstr Surg 127:1601\u20131611. https:\/\/doi.org\/10.1097\/PRS.0b013e31820a64b6","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR2","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1097\/SCS.0000000000004353","volume":"29","author":"M Asaad","year":"2018","unstructured":"Asaad M, Goyal S, Klement KA, Denny AD (2018) Improvement of color vision following posterior cranial vault distraction for Crouzon syndrome. J Craniofac Surg 29:868\u2013870. https:\/\/doi.org\/10.1097\/SCS.0000000000004353","journal-title":"J Craniofac Surg"},{"key":"5169_CR3","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/SCS.0b013e318240ff49","volume":"23","author":"M Choi","year":"2012","unstructured":"Choi M, Flores RL, Havlik RJ (2012) Volumetric analysis of anterior versus posterior cranial vault expansion in patients with syndromic craniosynostosis. J Craniofac Surg 23:455\u2013458. https:\/\/doi.org\/10.1097\/SCS.0b013e318240ff49","journal-title":"J Craniofac Surg"},{"key":"5169_CR4","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1097\/SCS.0000000000005285","volume":"30","author":"F Chouairi","year":"2019","unstructured":"Chouairi F, Torabi SJ, Alperovich M (2019) National 30-day outcomes for posterior cranial vault distraction. J Craniofac Surg 30:761\u2013766. https:\/\/doi.org\/10.1097\/SCS.0000000000005285","journal-title":"J Craniofac Surg"},{"key":"5169_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santibanes E, Pekolj J, Slankamenac K, Bassi C, Graf R, Vonlanthen R, Padbury R, Cameron JL, Makuuchi M (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 250:187\u2013196. https:\/\/doi.org\/10.1097\/SLA.0b013e3181b13ca2","journal-title":"Ann Surg"},{"key":"5169_CR6","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s00381-012-1802-0","volume":"28","author":"CA Derderian","year":"2012","unstructured":"Derderian CA, Bastidas N, Bartlett SP (2012) Posterior cranial vault expansion using distraction osteogenesis. Childs Nerv Syst 28:1551\u20131556. https:\/\/doi.org\/10.1007\/s00381-012-1802-0","journal-title":"Childs Nerv Syst"},{"key":"5169_CR7","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1097\/PRS.0000000000001294","volume":"135","author":"CA Derderian","year":"2015","unstructured":"Derderian CA, Wink JD, McGrath JL, Collinsworth A, Bartlett SP, Taylor JA (2015) Volumetric changes in cranial vault expansion: comparison of fronto-orbital advancement and posterior cranial vault distraction osteogenesis. Plast Reconstr Surg 135:1665\u20131672. https:\/\/doi.org\/10.1097\/PRS.0000000000001294","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR8","doi-asserted-by":"publisher","first-page":"422","DOI":"10.2119\/2007-00027.Fanganiello","volume":"13","author":"RD Fanganiello","year":"2007","unstructured":"Fanganiello RD, Sertie AL, Reis EM, Yeh E, Oliveira NA, Bueno DF, Kerkis I, Alonso N, Cavalheiro S, Matsushita H, Freitas R, Verjovski-Almeida S, Passos-Bueno MR (2007) Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells. Mol Med 13:422\u2013442. https:\/\/doi.org\/10.2119\/2007-00027.Fanganiello","journal-title":"Mol Med"},{"key":"5169_CR9","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1097\/PRS.0b013e3182729f42","volume":"131","author":"JA Fearon","year":"2013","unstructured":"Fearon JA, Podner C (2013) Apert syndrome: evaluation of a treatment algorithm. Plast Reconstr Surg 131:132\u2013142. https:\/\/doi.org\/10.1097\/PRS.0b013e3182729f42","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jcms.2014.11.023","volume":"43","author":"JM Florisson","year":"2015","unstructured":"Florisson JM, Barmpalios G, Lequin M, van Veelen ML, Bannink N, Hayward RD, Mathijssen IM (2015) Venous hypertension in syndromic and complex craniosynostosis: the abnormal anatomy of the jugular foramen and collaterals. J Craniomaxillofac Surg 43:312\u2013318. https:\/\/doi.org\/10.1016\/j.jcms.2014.11.023","journal-title":"J Craniomaxillofac Surg"},{"key":"5169_CR11","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1097\/PRS.0b013e31828bd541","volume":"131","author":"JA Goldstein","year":"2013","unstructured":"Goldstein JA, Paliga JT, Wink JD, Low DW, Bartlett SP, Taylor JA (2013) A craniometric analysis of posterior cranial vault distraction osteogenesis. Plast Reconstr Surg 131:1367\u20131375. https:\/\/doi.org\/10.1097\/PRS.0b013e31828bd541","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR12","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1097\/PRS.0000000000006041","volume":"144","author":"LO Lin","year":"2019","unstructured":"Lin LO, Zhang RS, Hoppe IC, Paliga JT, Swanson JW, Bartlett SP, Taylor JA (2019) Onset and resolution of Chiari malformations and hydrocephalus in syndromic craniosynostosis following posterior vault distraction. Plast Reconstr Surg 144:932\u2013940. https:\/\/doi.org\/10.1097\/PRS.0000000000006041","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR13","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1097\/PRS.0b013e31818458f0","volume":"122","author":"DD Marucci","year":"2008","unstructured":"Marucci DD, Dunaway DJ, Jones BM, Hayward RD (2008) Raised intracranial pressure in Apert syndrome. Plast Reconstr Surg 122:1162\u20131168; discussion 1169-1170. https:\/\/doi.org\/10.1097\/PRS.0b013e31818458f0","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR14","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1097\/SCS.0000000000005496","volume":"30","author":"DM Mazzaferro","year":"2019","unstructured":"Mazzaferro DM, Ter Maaten NS, Wes AM, Naran S, Bartlett SP, Taylor JA (2019) A Craniometric analysis of the posterior cranial base after posterior vault distraction. J Craniofac Surg 30:1692\u20131695. https:\/\/doi.org\/10.1097\/SCS.0000000000005496","journal-title":"J Craniofac Surg"},{"key":"5169_CR15","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1097\/SCS.0000000000003458","volume":"28","author":"K McMillan","year":"2017","unstructured":"McMillan K, Lloyd M, Evans M, White N, Nishikawa H, Rodrigues D, Sharp M, Noons P, Solanki G, Dover S (2017) Experiences in performing posterior calvarial distraction. J Craniofac Surg 28:664\u2013669. https:\/\/doi.org\/10.1097\/SCS.0000000000003458","journal-title":"J Craniofac Surg"},{"key":"5169_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00381-019-04059-6","volume":"35","author":"A Mondal","year":"2019","unstructured":"Mondal A, Rodriguez-Florez N, O'Hara J, Ong J, Jeelani NUO, Dunaway DJ, James G (2019) Lack of association of cranial lacunae with intracranial hypertension in children with Crouzon syndrome and Apert syndrome: a 3D morphometric quantitative analysis. Childs Nerv Syst 35:501\u2013507. https:\/\/doi.org\/10.1007\/s00381-019-04059-6","journal-title":"Childs Nerv Syst"},{"key":"5169_CR17","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00381-011-1563-1","volume":"27","author":"D Nowinski","year":"2011","unstructured":"Nowinski D, Saiepour D, Leikola J, Messo E, Nilsson P, Enblad P (2011) Posterior cranial vault expansion performed with rapid distraction and time-reduced consolidation in infants with syndromic craniosynostosis. Childs Nerv Syst 27:1999\u20132003. https:\/\/doi.org\/10.1007\/s00381-011-1563-1","journal-title":"Childs Nerv Syst"},{"key":"5169_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1055\/s-0034-1390169","volume":"28","author":"J Ong","year":"2014","unstructured":"Ong J, Harshbarger RJ 3rd, Kelley P, George T (2014) Posterior cranial vault distraction osteogenesis: evolution of technique. Semin Plast Surg 28:163\u2013178. https:\/\/doi.org\/10.1055\/s-0034-1390169","journal-title":"Semin Plast Surg"},{"key":"5169_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/SCS.0000000000004098","volume":"29","author":"C Park","year":"2018","unstructured":"Park C, Wormald J, Miranda BH, Ong J, Hare A, Eccles S (2018) Perioperative blood loss and transfusion in craniosynostosis surgery. J Craniofac Surg 29:112\u2013115. https:\/\/doi.org\/10.1097\/SCS.0000000000004098","journal-title":"J Craniofac Surg"},{"key":"5169_CR20","doi-asserted-by":"publisher","first-page":"e2230","DOI":"10.1097\/GOX.0000000000002230","volume":"7","author":"CE Raposo-Amaral","year":"2019","unstructured":"Raposo-Amaral CE, Denadai R, do Monte Lameiro TM, de Oliveira YM, Raposo-Amaral CA (2019) Hand function in Apert syndrome. Plast Reconstr Surg Glob Open 7:e2230. https:\/\/doi.org\/10.1097\/GOX.0000000000002230","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"5169_CR21","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1097\/PRS.0000000000004815","volume":"142","author":"CE Raposo-Amaral","year":"2018","unstructured":"Raposo-Amaral CE, Denadai R, Furlan P, Raposo-Amaral CA (2018) Treatment of Apert hand syndrome: strategies for achieving a five-digit hand. Plast Reconstr Surg 142:972\u2013982. https:\/\/doi.org\/10.1097\/PRS.0000000000004815","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR22","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002788","volume":"8","author":"CE Raposo-Amaral","year":"2020","unstructured":"Raposo-Amaral CE, Denadai R, Maximo G, Raposo-Amaral CA, Ghizoni E (2020) Pfeiffer syndrome: a therapeutic algorithm based on a modified grading scale. Plast Reconstr Surg Glob Open 8:e2788. https:\/\/doi.org\/10.1097\/GOX.0000000000002788","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"5169_CR23","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1097\/SCS.0000000000006105","volume":"31","author":"CE Raposo-Amaral","year":"2020","unstructured":"Raposo-Amaral CE, Denadai R, Oliveira YM, Ghizoni E, Raposo-Amaral CA (2020) Apert syndrome management: changing treatment algorithm. J Craniofac Surg 31:648\u2013652. https:\/\/doi.org\/10.1097\/SCS.0000000000006105","journal-title":"J Craniofac Surg"},{"key":"5169_CR24","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1097\/PRS.0000000000006646","volume":"145","author":"CE Raposo-Amaral","year":"2020","unstructured":"Raposo-Amaral CE, Denadai R, Zanco GL, Ghizoni E, Raposo-Amaral CA (2020) Long-term follow-up on bone stability and complication rate after monobloc advancement in syndromic craniosynostosis. Plast Reconstr Surg 145:1025\u20131034. https:\/\/doi.org\/10.1097\/PRS.0000000000006646","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR25","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3171\/jns.1982.57.3.0370","volume":"57","author":"D Renier","year":"1982","unstructured":"Renier D, Sainte-Rose C, Marchac D, Hirsch JF (1982) Intracranial pressure in craniostenosis. J Neurosurg 57:370\u2013377. https:\/\/doi.org\/10.3171\/jns.1982.57.3.0370","journal-title":"J Neurosurg"},{"key":"5169_CR26","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1097\/SCS.0000000000002661","volume":"27","author":"Y Sakamoto","year":"2016","unstructured":"Sakamoto Y, Miwa T, Nakajima H, Yoshida K, Kishi K (2016) A new technique for posterior distraction in craniosynostosis: the double-door technique. J Craniofac Surg 27:950\u2013952. https:\/\/doi.org\/10.1097\/SCS.0000000000002661","journal-title":"J Craniofac Surg"},{"key":"5169_CR27","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00381-010-1353-1","volume":"27","author":"WS Serlo","year":"2011","unstructured":"Serlo WS, Ylikontiola LP, Lahdesluoma N, Lappalainen OP, Korpi J, Verkasalo J, Sandor GK (2011) Posterior cranial vault distraction osteogenesis in craniosynostosis: estimated increases in intracranial volume. Childs Nerv Syst 27:627\u2013633. https:\/\/doi.org\/10.1007\/s00381-010-1353-1","journal-title":"Childs Nerv Syst"},{"key":"5169_CR28","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1097\/SCS.0000000000002739","volume":"27","author":"A Shimizu","year":"2016","unstructured":"Shimizu A, Komuro Y, Shimoji K, Miyajima M, Arai H (2016) Quantitative analysis of change in intracranial volume after posterior cranial vault distraction. J Craniofac Surg 27:1135\u20131138. https:\/\/doi.org\/10.1097\/SCS.0000000000002739","journal-title":"J Craniofac Surg"},{"key":"5169_CR29","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/PRS.0b013e318200ab83","volume":"127","author":"DM Steinbacher","year":"2011","unstructured":"Steinbacher DM, Skirpan J, Puchala J, Bartlett SP (2011) Expansion of the posterior cranial vault using distraction osteogenesis. Plast Reconstr Surg 127:792\u2013801. https:\/\/doi.org\/10.1097\/PRS.0b013e318200ab83","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR30","doi-asserted-by":"publisher","first-page":"829e","DOI":"10.1097\/PRS.0000000000002127","volume":"137","author":"JW Swanson","year":"2016","unstructured":"Swanson JW, Samra F, Bauder A, Mitchell BT, Taylor JA, Bartlett SP (2016) An algorithm for managing syndromic craniosynostosis using posterior vault distraction osteogenesis. Plast Reconstr Surg 137:829e\u2013841e. https:\/\/doi.org\/10.1097\/PRS.0000000000002127","journal-title":"Plast Reconstr Surg"},{"key":"5169_CR31","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00381-019-04448-x","volume":"36","author":"JW Swanson","year":"2020","unstructured":"Swanson JW, Xu W, Ying GS, Pan W, Lang SS, Heuer GG, Bartlett SP, Taylor JA (2020) Intracranial pressure patterns in children with craniosynostosis utilizing optical coherence tomography. Childs Nerv Syst 36:535\u2013544. https:\/\/doi.org\/10.1007\/s00381-019-04448-x","journal-title":"Childs Nerv Syst"},{"key":"5169_CR32","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1097\/SCS.0000000000004473","volume":"29","author":"NS Ter Maaten","year":"2018","unstructured":"Ter Maaten NS, Mazzaferro DM, Wes AM, Naran S, Bartlett SP, Taylor JA (2018) Craniometric analysis of frontal cranial morphology following posterior vault distraction. J Craniofac Surg 29:1169\u20131173. https:\/\/doi.org\/10.1097\/SCS.0000000000004473","journal-title":"J Craniofac Surg"},{"key":"5169_CR33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/BF00301758","volume":"11","author":"DN Thompson","year":"1995","unstructured":"Thompson DN, Harkness W, Jones B, Gonsalez S, Andar U, Hayward R (1995) Subdural intracranial pressure monitoring in craniosynostosis: its role in surgical management. Childs Nerv Syst 11:269\u2013275. https:\/\/doi.org\/10.1007\/BF00301758","journal-title":"Childs Nerv Syst"},{"key":"5169_CR34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00381-008-0758-6","volume":"25","author":"N White","year":"2009","unstructured":"White N, Evans M, Dover MS, Noons P, Solanki G, Nishikawa H (2009) Posterior calvarial vault expansion using distraction osteogenesis. Childs Nerv Syst 25:231\u2013236. https:\/\/doi.org\/10.1007\/s00381-008-0758-6","journal-title":"Childs Nerv Syst"},{"key":"5169_CR35","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/SCS.0b013e31819b9429","volume":"20","author":"N White","year":"2009","unstructured":"White N, Marcus R, Dover S, Solanki G, Nishikawa H, Millar C, Carver ED (2009) Predictors of blood loss in fronto-orbital advancement and remodeling. J Craniofac Surg 20:378\u2013381. https:\/\/doi.org\/10.1097\/SCS.0b013e31819b9429","journal-title":"J Craniofac Surg"},{"key":"5169_CR36","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.jcms.2012.02.018","volume":"40","author":"A Wiberg","year":"2012","unstructured":"Wiberg A, Magdum S, Richards PG, Jayamohan J, Wall SA, Johnson D (2012) Posterior calvarial distraction in craniosynostosis - an evolving technique. J Craniomaxillofac Surg 40:799\u2013806. https:\/\/doi.org\/10.1016\/j.jcms.2012.02.018","journal-title":"J Craniomaxillofac Surg"},{"key":"5169_CR37","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1097\/PRS.0b013e3181a3f391","volume":"123","author":"RH Woods","year":"2009","unstructured":"Woods RH, Ul-Haq E, Wilkie AO, Jayamohan J, Richards PG, Johnson D, Lester T, Wall SA (2009) Reoperation for intracranial hypertension in TWIST1-confirmed Saethre-Chotzen syndrome: a 15-year review. Plast Reconstr Surg 123:1801\u20131810. https:\/\/doi.org\/10.1097\/PRS.0b013e3181a3f391","journal-title":"Plast Reconstr Surg"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-021-05169-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-021-05169-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-021-05169-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T19:09:59Z","timestamp":1623092999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-021-05169-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,18]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["5169"],"URL":"https:\/\/doi.org\/10.1007\/s00381-021-05169-w","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,18]]},"assertion":[{"value":"27 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no personal financial or institutional interest in any of the drugs, materials, or devices described in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All subjects enrolled in this study completed consent forms signed by the patients\u2019 parents in accordance with the Declaration of Helsinki of 1975, as\u00a0amended in 1983.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}