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It is\u00a0hypothesized that loss of integrity of the cerebellar output tracts results in a cerebello-cerebral \u201cdiaschisis\u201d and reduced function of supratentorial areas of\u00a0the brain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a systematic review of the literature according to the PRISMA guidelines, in order to evaluate the evidence for hypoperfusion or\u00a0hypofunction in the cerebral hemispheres in patients with ppCMS. Articles were selected based on the predefined eligibility criteria and quality assessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Five studies were included, consisting of three prospective cohort studies, one retrospective cohort study and one retrospective case control study. Arterial\u00a0spin labelling (ASL) perfusion MRI, dynamic susceptibility contrast (DSC) perfusion MRI and single photon emission computed tomography (SPECT)\u00a0were used to measure the cerebral and cerebellar tissue perfusion or metabolic activity. Reduced cerebral perfusion was predominantly demonstrated in the\u00a0frontal lobe.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This systematic review shows that, after posterior fossa tumour resection, cerebral perfusion is reduced in ppCMS patients compared to patients without\u00a0ppCMS. Well-powered prospective studies, including preoperative imaging, are needed to ascertain the cause and role of hypoperfusion in the\u00a0pathophysiology of the syndrome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00381-021-05225-5","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T22:02:24Z","timestamp":1624312944000},"page":"2743-2751","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery\u2014a systematic review"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-9659","authenticated-orcid":false,"given":"Narjes","family":"Ahmadian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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