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Moreover, we searched for SS cases with CNS vasculopathies from the same databases. We identified 7 related articles reporting 7 cases of CNS vasculopathies in SS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall rate of CNS vasculopathy in SS patients is 3.16% (n\u2009=\u20098\/253), where moyamoya disease (MMD) accounted for 1.97%. The mean age is 13.5\u00a0years (6\u201319\u00a0years), with equal gender distribution (M:F, 1:1). The most common presenting symptoms were headache and seizure followed by weakness or coma. Aneurysms were mostly located in the basilar artery, middle cerebral artery, and internal carotid artery, respectively. Regardless of the management approach, 50% of the cases sustained mild-moderate neurological deficit, 37.5% have died, and 12.5% sustained no deficit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high index of suspicion should be maintained in (SS) patients, and MMD should be part of the differential diagnosis. Prevalence of CNS vasculopathy in SS is 3.16% with a much higher prevalence of MMD compared to the general population. Screening for cerebral vasculopathy in SS is justifiable especially in centers that have good resources. Further data are still needed to identify the most appropriate management plan in these cases.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00381-021-05284-8","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:02:35Z","timestamp":1628028155000},"page":"3847-3860","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Central nervous system vasculopathy and Seckel syndrome: case illustration and systematic review"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0173-6701","authenticated-orcid":false,"given":"Osama","family":"Khojah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8037-0738","authenticated-orcid":false,"given":"Saeed","family":"Alamoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf","family":"Aldawsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-795X","authenticated-orcid":false,"given":"Mohammed","family":"Babgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Lary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"5284_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00438-015-1110-y","volume":"291","author":"P Khetarpal","year":"2016","unstructured":"Khetarpal P, Das S, Panigrahi I, Munshi A (2016) Primordial dwarfism: overview of clinical and genetic aspects. 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