{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:17:32Z","timestamp":1793143052813,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00381-021-05368-5","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T17:45:01Z","timestamp":1633455901000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum troponin I: a potential biomarker of hypoxic-ischemic encephalopathy in term newborns"],"prefix":"10.1007","volume":"38","author":[{"given":"Zhen-E","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juma","family":"Mbugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"issue":"15","key":"5368_CR1","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"MD Seetha Shankaran","year":"2015","unstructured":"Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, Mcdonald SA, Donovan EF, Fanaroff AA, Poole WK et al (2015) Whole-body hypothermia for neonates with hypoxic\u2013ischemic encephalopathy. N Engl J Med 353(15):1574\u20131584","journal-title":"N Engl J Med"},{"issue":"6","key":"5368_CR2","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","volume":"100","author":"RC Vannucci","year":"1997","unstructured":"Vannucci RC, Perlman JM (1997) Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 100(6):1004\u20131014","journal-title":"Pediatrics"},{"key":"5368_CR3","doi-asserted-by":"publisher","unstructured":"Kurinczuk JJ, White-Koning M, Badawi N (2010) Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev [Internet] 86(6):329\u201338. Available from: https:\/\/doi.org\/10.1016\/j.earlhumdev.2010.05.010","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"issue":"6640","key":"5368_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1136\/bmj.297.6640.24","volume":"297","author":"VJ Ruth","year":"1988","unstructured":"Ruth VJ, Raivio KO (1988) Perinatal brain damage: predictive value of metabolic acidosis and the Apgar score. BMJ 297(6640):24\u201327","journal-title":"BMJ"},{"key":"5368_CR5","doi-asserted-by":"publisher","unstructured":"Jones R, Heep A, Odd D(2018) Biochemical and clinical predictors of hypoxic\u2013ischemic encephalopathy after perinatal asphyxia. J Matern Neonatal Med [Internet] 31(6):791\u20136. Available from: https:\/\/doi.org\/10.1080\/14767058.2017.1297790","DOI":"10.1080\/14767058.2017.1297790"},{"issue":"6","key":"5368_CR6","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/0002-9378(92)91728-S","volume":"167","author":"T Murphy Goodwin","year":"1992","unstructured":"Murphy Goodwin T, Belai I, Hernandez P, Durand M, Paul RH (1992) Asphyxial complications in the term newborn with severe umbilical acidemia. Am J Obstet Gynecol 167(6):1506\u20131512","journal-title":"Am J Obstet Gynecol"},{"key":"5368_CR7","doi-asserted-by":"publisher","unstructured":"Sarnat HB, Sarnat MS (1976) Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol [Internet]. 33(10):696\u2013705. Available from: https:\/\/doi.org\/10.1001\/archneur.1976.00500100030012","DOI":"10.1001\/archneur.1976.00500100030012"},{"issue":"5","key":"5368_CR8","first-page":"295","volume":"32","author":"HB Sarnat","year":"1977","unstructured":"Sarnat HB, Sarnat MS (1977) Neonatal encephalopathy following fetal distress. Obstet Gynecol 32(5):295\u2013297","journal-title":"Obstet Gynecol"},{"issue":"6","key":"5368_CR9","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/s41390-020-01143-5","volume":"88","author":"A Mrelashvili","year":"2020","unstructured":"Mrelashvili A, Russ JB, Ferriero DM, Wusthoff CJ (2020) The Sarnat score for neonatal encephalopathy: looking back and moving forward. Pediatr Res 88(6):824\u2013825. https:\/\/doi.org\/10.1038\/s41390-020-01143-5","journal-title":"Pediatr Res"},{"issue":"1\u20134","key":"5368_CR10","first-page":"59","volume":"39","author":"D Neurosci","year":"2017","unstructured":"Neurosci D, Ahearne CE, Chang Y, Walsh BH, Boylan GB, Murray M (2017) Cord blood IL-16 Is associated with 3-year neurodevelopmental outcomes in perinatal asphyxia and hypoxic-ischaemic encephalopathy. Dev Neurosci 39(1\u20134):59\u201365","journal-title":"Dev Neurosci"},{"key":"5368_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1824-7288-36-63","volume":"36","author":"G Distefano","year":"2010","unstructured":"Distefano G, Pratic\u00f2 AD (2010) Actualities on molecular pathogenesis and repairing processes of cerebral damage in perinatal hypoxic-ischemic encephalopathy. Ital J Pediatr 36:63","journal-title":"Ital J Pediatr"},{"issue":"1","key":"5368_CR12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.pedneo.2016.05.001","volume":"58","author":"V Chaparro-Huerta","year":"2017","unstructured":"Chaparro-Huerta V, Flores-Soto ME, Merin Sigala ME, Barrera de Le\u00f3n JC, de Lemus-Varela M, L, Torres-Mendoza BM de G et al (2017) Proinflammatory cytokines, enolase and S-100 as early biochemical indicators of hypoxic-ischemic encephalopathy following perinatal asphyxia in newborns. Pediatr Neonatol 58(1):70\u201376","journal-title":"Pediatr Neonatol"},{"issue":"3","key":"5368_CR13","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.braindev.2005.06.006","volume":"28","author":"H Aly","year":"2006","unstructured":"Aly H, Khashaba MT, El-Ayouty M, El-Sayed O, Hasanein BM (2006) IL-1\u03b2, IL-6 and TNF-\u03b1 and outcomes of neonatal hypoxic ischemic encephalopathy. Brain Dev 28(3):178\u2013182","journal-title":"Brain Dev"},{"issue":"1","key":"5368_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40560-017-0246-8","volume":"5","author":"AL Vijayan","year":"2017","unstructured":"Vijayan AL, Ravindran S, Saikant R, Lakshmi S, Kartik R, Manoj G (2017) Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care 5(1):1\u20137","journal-title":"J Intensive Care"},{"issue":"1","key":"5368_CR15","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.eururo.2014.03.040","volume":"66","author":"W Weidner","year":"2014","unstructured":"Weidner W, Wagenlehner FME (2014) Re: Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Eur Urol 66(1):178","journal-title":"Eur Urol"},{"issue":"1","key":"5368_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s11845-016-1457-z","volume":"186","author":"HH Liu","year":"2017","unstructured":"Liu HH, Zhang MW, Guo JB, Li J, Su L (2017) Procalcitonin and C-reactive protein in early diagnosis of sepsis caused by either Gram-negative or Gram-positive bacteria. Ir J Med Sci 186(1):207\u2013212","journal-title":"Ir J Med Sci"},{"issue":"6","key":"5368_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1515\/JPM.2006.109","volume":"34","author":"A Kordek","year":"2006","unstructured":"Kordek A, Torb\u00e9 A, Czajka R (2006) Maternal venous procalcitonin levels do not correlate with umbilical cord blood and venous blood concentrations in the neonate. J Perinat Med 34(6):462\u2013465","journal-title":"J Perinat Med"},{"key":"5368_CR18","unstructured":"Pavcnik-Arnol M, Bonac-Tuma B, Derganc M (2008) Serum procalcitonin and C-reactive protein in neonates with hypoxic-ishemic encephalopathy and intracranial hemorrhage. Arch Dis Child [Internet] 93:pw146."},{"issue":"14","key":"5368_CR19","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1055\/s-0036-1583192","volume":"33","author":"J Saito","year":"2016","unstructured":"Saito J, Shibasaki J, Shimokaze T, Kishigami M, Ohyama M, Hoshino R et al (2016) Temporal relationship between serum levels of interleukin-6 and C-reactive protein in therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. Am J Perinatol 33(14):1401\u20131406","journal-title":"Am J Perinatol"},{"key":"5368_CR20","doi-asserted-by":"crossref","unstructured":"Wan B, Pan X, Ma J, Luo Y, Liu J, Zhao G (2019) Umbilical cord blood troponin I, myoglobin and CK\u2011MB in neonatal hypoxic ischemic encephalopathy and the clinical significance. Exp Ther Med 545\u201350.","DOI":"10.3892\/etm.2019.8248"},{"issue":"1","key":"5368_CR21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1651-2227.2011.02432.x","volume":"101","author":"AT Shastri","year":"2012","unstructured":"Shastri AT, Samarasekara S, Muniraman H, Clarke P (2012) Cardiac troponin i concentrations in neonates with hypoxic-ischaemic encephalopathy. Acta Paediatr Int J Paediatr 101(1):26\u201329","journal-title":"Acta Paediatr Int J Paediatr"},{"issue":"17","key":"5368_CR22","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.3390\/jcm10174010","volume":"10","author":"IC Lee","year":"2021","unstructured":"Lee IC, Yu CS, Wong SH, Lue KH (2021) Troponin I levels in neonatal hypoxic-ischemic encephalopathy are related to cardiopulmonary comorbidity and neurodevelopmental outcomes. J Clin Med 10(17):4010","journal-title":"J Clin Med"},{"issue":"14","key":"5368_CR23","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","volume":"361","author":"DV Azzopardi","year":"2009","unstructured":"Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E et al (2009) Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 361(14):1349\u20131358","journal-title":"N Engl J Med"},{"issue":"5","key":"5368_CR24","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41390-018-0142-5","volume":"84","author":"SY Ahn","year":"2018","unstructured":"Ahn SY, Chang YS, Kim YE, Sung SI, Sung DK, Park WS (2018) Mesenchymal stem cells transplantation attenuates brain injury and enhances bacterial clearance in Escherichia coli meningitis in newborn rats. Pediatr Res 84(5):778\u2013785","journal-title":"Pediatr Res"},{"issue":"3","key":"5368_CR25","first-page":"527","volume":"31","author":"E Hisamuddin","year":"2015","unstructured":"Hisamuddin E, Hisam A, Wahid S, Raza G (2015) Validity of c-reactive protein (CRP) for diagnosis of neonatal sepsis. Pakistan J Med Sci 31(3):527\u2013531","journal-title":"Pakistan J Med Sci"},{"issue":"2","key":"5368_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1136\/adc.2009.174367","volume":"95","author":"S McWilliam","year":"2010","unstructured":"McWilliam S, Riordan A (2010) How to use: C-reactive protein. Arch Dis Child Educ Pract Ed 95(2):55\u201358","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"5368_CR27","doi-asserted-by":"crossref","unstructured":"Rubia Khalak AM, Roberto P. Santos2 (2018) Use of a single C\u2011reactive protein level in decision\u2011making during neonatal sepsis evaluation. J Clin Neonatol 7(Number 3):146\u201350.","DOI":"10.4103\/jcn.JCN_32_18"},{"issue":"2","key":"5368_CR28","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1136\/archdischild-2013-304367","volume":"99","author":"S Rath","year":"2014","unstructured":"Rath S, Narasimhan R, Lumsden C (2014) C-reactive protein (CRP) responses in neonates with hypoxic ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 99(2):2014\u20132015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"3","key":"5368_CR29","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1651-2227.2000.tb01334.x","volume":"89","author":"S da Silva","year":"2000","unstructured":"da Silva S, Hennebert N, Denis R, Wayenberg JL (2000) Clinical value of a single postnatal lactate measurement after intrapartum asphyxia. Acta Paediatr Int J Paediatr 89(3):320\u2013323","journal-title":"Acta Paediatr Int J Paediatr"},{"issue":"1","key":"5368_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/fn.76.1.F15","volume":"76","author":"SA Deshpande","year":"1997","unstructured":"Deshpande SA, Ward Platt MP (1997) Association between blood lactate and acid-base status and mortality in ventilated babies. Arch Dis Child Fetal Neonatal Ed 76(1):15\u201321","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"1","key":"5368_CR31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/sj.jp.7211023","volume":"24","author":"S Shah","year":"2004","unstructured":"Shah S, Tracy M, Smyth J (2004) Postnatal lactate as an early predictor of short-term outcome after intrapartum asphyxia. J Perinatol 24(1):16\u201320","journal-title":"J Perinatol"},{"issue":"1","key":"5368_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/ped.12438","volume":"57","author":"Y Yamamoto","year":"2015","unstructured":"Yamamoto Y, Ibara S, Tokuhisa T, Hirakawa E, Yoneda S, Kobayashi K et al (2015) Calcium concentration in hypoxic-ischemic encephalopathy during hypothermia. Pediatr Int 57(1):64\u201367","journal-title":"Pediatr Int"},{"issue":"3","key":"5368_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpeds.2013.10.067","volume":"164","author":"LF Chalak","year":"2014","unstructured":"Chalak LF, S\u00e1nchez PJ, Adams-Huet B, Laptook AR, Heyne RJ, Rosenfeld CR (2014) Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr 164(3):1\u20138","journal-title":"J Pediatr"},{"issue":"3","key":"5368_CR34","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1542\/peds.2004-1587","volume":"117","author":"CM Gebauer","year":"2006","unstructured":"Gebauer CM, Knuepfer M, Robel-Tillig E, Pulzer F, Vogtmann C (2006) Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming. Pediatrics 117(3):843\u2013850","journal-title":"Pediatrics"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-021-05368-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-021-05368-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-021-05368-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T06:04:43Z","timestamp":1643090683000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-021-05368-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["5368"],"URL":"https:\/\/doi.org\/10.1007\/s00381-021-05368-5","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]},"assertion":[{"value":"18 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Institutional Review Board of Children\u2019s Hospital of Chongqing Medical University. Due to the retrospective nature of the study, the informed consent was waived off by Institutional Review Board of Children\u2019s Hospital of Chongqing Medical University because waiving off could not pose any risks, neither violate the rights and welfare of the subjects (patients). All procedures performed in this study were in accordance with the ethical standards of the Institutional Review Board of Children\u2019s Hospital of Chongqing Medical University and conducted in accordance with the principles as defined in the Declaration of Helsinki and International Conference on Harmonization Good Clinical Practice guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Approved by the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}