{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:20:46Z","timestamp":1776133246802,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00381-022-05447-1","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T18:02:42Z","timestamp":1643652162000},"page":"1615-1619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Solid-variant aneurysmal bone cysts in the craniofacial skeleton: the role of genomic analysis"],"prefix":"10.1007","volume":"38","author":[{"given":"William A.","family":"Lambert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus J.","family":"Bookland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belachew","family":"Tessema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Balarezo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-2201","authenticated-orcid":false,"given":"David S.","family":"Hersh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"5447_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12178-016-9371-6","volume":"9","author":"HY Park","year":"2016","unstructured":"Park HY, Yang SK, Sheppard WL, Hegde V, Zoller SD, Nelson SD, Federman N, Bernthal NM (2016) Current management of aneurysmal bone cysts. Curr Rev Musculoskelet Med 9:435\u2013444","journal-title":"Curr Rev Musculoskelet Med"},{"key":"5447_CR2","doi-asserted-by":"crossref","unstructured":"Leithner A, Windhager R, Lang S, Haas OA, Kainberger F, Kotz R (1999) Aneurysmal bone cyst. A population based epidemiologic study and literature review. Clin Orthop Relat Res 176\u2013179","DOI":"10.1097\/00003086-199906000-00023"},{"key":"5447_CR3","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1097\/01202412-200411000-00008","volume":"13","author":"J Cottalorda","year":"2004","unstructured":"Cottalorda J, Kohler R, Sales de Gauzy J, Chotel F, Mazda K, Lefort G, Louahem D, Bourelle S, Dimeglio A (2004) Epidemiology of aneurysmal bone cyst in children: a multicenter study and literature review. J Pediatr Orthop B 13:389\u2013394","journal-title":"J Pediatr Orthop B"},{"key":"5447_CR4","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1002\/1097-0142(19880601)61:11<2291::AID-CNCR2820611125>3.0.CO;2-V","volume":"61","author":"V Martinez","year":"1988","unstructured":"Martinez V, Sissons HA (1988) Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer 61:2291\u20132304","journal-title":"Cancer"},{"key":"5447_CR5","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/S0002-9440(10)63432-3","volume":"165","author":"AM Oliveira","year":"2004","unstructured":"Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, Gebhardt MC, Rosenberg AE, Fletcher JA (2004) USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 165:1773\u20131780","journal-title":"Am J Pathol"},{"key":"5447_CR6","doi-asserted-by":"publisher","first-page":"37111","DOI":"10.1074\/jbc.M110.175133","volume":"285","author":"AW Lau","year":"2010","unstructured":"Lau AW, Pringle LM, Quick L, Riquelme DN, Ye Y, Oliveira AM, Chou MM (2010) TRE17\/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem 285:37111\u201337120","journal-title":"J Biol Chem"},{"key":"5447_CR7","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00402-006-0223-5","volume":"127","author":"J Cottalorda","year":"2007","unstructured":"Cottalorda J, Bourelle S (2007) Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg 127:105\u2013114","journal-title":"Arch Orthop Trauma Surg"},{"key":"5447_CR8","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s00402-007-0477-6","volume":"128","author":"B Saccomanni","year":"2008","unstructured":"Saccomanni B (2008) Aneurysmal bone cyst of spine: a review of literature. Arch Orthop Trauma Surg 128:1145\u20131147","journal-title":"Arch Orthop Trauma Surg"},{"key":"5447_CR9","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.2214\/ajr.180.6.1801681","volume":"180","author":"H Ilaslan","year":"2003","unstructured":"Ilaslan H, Sundaram M, Unni KK (2003) Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. AJR Am J Roentgenol 180:1681\u20131687","journal-title":"AJR Am J Roentgenol"},{"key":"5447_CR10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1177\/0003489418757251","volume":"127","author":"N Saez","year":"2018","unstructured":"Saez N, Sharma GK, Barnes CH, Lu Y, Hsu FP, Huoh KC, Djalilian HR, Lin HW (2018) Solid variant of aneurysmal bone cyst of the temporal bone. Ann Otol Rhinol Laryngol 127:285\u2013290","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"5447_CR11","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.ijporl.2004.05.001","volume":"68","author":"V Perrotti","year":"2004","unstructured":"Perrotti V, Rubini C, Fioroni M, Piattelli A (2004) Solid aneurysmal bone cyst of the mandible. Int J Pediatr Otorhinolaryngol 68:1339\u20131344","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"5447_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/BF03000693","volume":"50","author":"VK Kataria","year":"1998","unstructured":"Kataria VK, Bhansali SK, Mehta BS (1998) A solid variant of aneurysmal bone cyst of maxilla. Indian J Otolaryngol Head Neck Surg 50:379\u2013381","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"5447_CR13","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1002\/1097-0142(19830615)51:12<2278::AID-CNCR2820511219>3.0.CO;2-Y","volume":"51","author":"NG Sanerkin","year":"1983","unstructured":"Sanerkin NG, Mott MG, Roylance J (1983) An unusual intraosseous lesion with fibroblastic, osteoclastic, osteoblastic, aneurysmal and fibromyxoid elements. \u201cSolid\u201d variant of aneurysmal bone cyst. Cancer 51:2278\u20132286","journal-title":"Cancer"},{"key":"5447_CR14","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/pin.12941","volume":"70","author":"J Zhou","year":"2020","unstructured":"Zhou J, Zheng S, Zhou L, Yong X, Zhang Y, QinXia ZW, Wang C (2020) Pathologic evaluation of the solid variant of aneurysmal bone cysts with USP6 rearrangement with an emphasis on the frequent diagnostic pitfalls. Pathol Int 70:502\u2013512","journal-title":"Pathol Int"},{"key":"5447_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/1752-1947-5-261","volume":"5","author":"G Al-Shamy","year":"2011","unstructured":"Al-Shamy G, Relyea K, Adesina A, Whitehead WE, Curry DJ, Luerssen TG, Jea A (2011) Solid variant of aneurysmal bone cyst of the thoracic spine: a case report. J Med Case Rep 5:261","journal-title":"J Med Case Rep"},{"key":"5447_CR16","doi-asserted-by":"crossref","unstructured":"Suzuki M, Satoh T, Nishida J, Kato S, Toba T, Honda T, Masuda T (2004) Solid variant of aneurysmal bone cyst of the cervical spine. Spine (Phila Pa 1976) 29:E376\u2013E381","DOI":"10.1097\/01.brs.0000137053.08152.a6"},{"key":"5447_CR17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00586-012-2548-9","volume":"22","author":"C Karampalis","year":"2013","unstructured":"Karampalis C, Lenthall R, Boszczyk B (2013) Solid variant of aneurysmal bone cyst on the cervical spine of a child: case report, differential diagnosis and treatment rationale. Eur Spine J 22:523\u2013531","journal-title":"Eur Spine J"},{"key":"5447_CR18","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1002\/1097-0142(19920615)69:12<2921::AID-CNCR2820691210>3.0.CO;2-E","volume":"69","author":"AM Vergel De Dios","year":"1992","unstructured":"Vergel De Dios AM, Bond JR, Shives TC, McLeod RA, Unni KK (1992) Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer 69:2921\u20132931","journal-title":"Cancer"},{"key":"5447_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1052-5149(03)00040-6","volume":"13","author":"MF Mafee","year":"2003","unstructured":"Mafee MF, Yang G, Tseng A, Keiler L, Andrus K (2003) Fibro-osseous and giant cell lesions, including brown tumor of the mandible, maxilla, and other craniofacial bones. Neuroimaging Clin N Am 13:525\u2013540","journal-title":"Neuroimaging Clin N Am"},{"key":"5447_CR20","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/gcc.22469","volume":"56","author":"K Ogura","year":"2017","unstructured":"Ogura K, Hosoda F, Nakamura H, Hama N, Totoki Y, Yoshida A, Ohashi S, Rokutan H, Takai E, Yachida S, Kawai A, Tanaka S, Shibata T (2017) Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone. Genes Chromosom Cancer 56:711\u2013718","journal-title":"Genes Chromosomes Cancer"},{"key":"5447_CR21","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.hoc.2015.06.004","volume":"29","author":"BJ Rollins","year":"2015","unstructured":"Rollins BJ (2015) Genomic alterations in Langerhans cell histiocytosis. Hematol Oncol Clin North Am 29:839\u2013851","journal-title":"Hematol Oncol Clin North Am"},{"key":"5447_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.humpath.2017.11.018","volume":"76","author":"HR Li","year":"2018","unstructured":"Li HR, Tai CF, Huang HY, Jin YT, Chen YT, Yang SF (2018) USP6 gene rearrangement differentiates primary paranasal sinus solid aneurysmal bone cyst from other giant cell-rich lesions: report of a rare case. Hum Pathol 76:117\u2013121","journal-title":"Hum Pathol"},{"key":"5447_CR23","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1158\/0008-5472.CAN-03-2827","volume":"64","author":"AM Oliveira","year":"2004","unstructured":"Oliveira AM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N, Bridge JA, Perez-Atayde AR, Fletcher JA (2004) USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res 64:1920\u20131923","journal-title":"Cancer Res"},{"key":"5447_CR24","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1038\/sj.onc.1208506","volume":"24","author":"AM Oliveira","year":"2005","unstructured":"Oliveira AM, Perez-Atayde AR, Dal Cin P, Gebhardt MC, Chen CJ, Neff JR, Demetri GD, Rosenberg AE, Bridge JA, Fletcher JA (2005) Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oncogene 24:3419\u20133426","journal-title":"Oncogene"},{"key":"5447_CR25","doi-asserted-by":"publisher","first-page":"851","DOI":"10.5858\/arpa.2020-0336-OA","volume":"145","author":"JK Dermawan","year":"2021","unstructured":"Dermawan JK, Cheng YW, Tu ZJ, Meyer A, Habeeb O, Zou Y, Goldblum JR, Billings SD, Kilpatrick SE, Reith JD, Shurtleff SA, Farkas DH, Rubin BP, Azzato EM (2021) Diagnostic utility of a custom 34-gene anchored multiplex PCR-based next-generation sequencing fusion panel for the diagnosis of bone and soft tissue neoplasms with identification of novel USP6 fusion partners in aneurysmal bone cysts. Arch Pathol Lab Med 145:851\u2013863","journal-title":"Arch Pathol Lab Med"},{"key":"5447_CR26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cancergen.2018.07.001","volume":"228\u2013229","author":"D \u0160ekoranja","year":"2018","unstructured":"\u0160ekoranja D, Bo\u0161tjan\u010di\u010d E, Salapura V, Mav\u010di\u010d B, Pi\u017eem J (2018) Primary aneurysmal bone cyst with a novel SPARC-USP6 translocation identified by next-generation sequencing. Cancer Genet 228\u2013229:12\u201316","journal-title":"Cancer Genet"},{"key":"5447_CR27","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00256-018-3135-x","volume":"48","author":"W Song","year":"2019","unstructured":"Song W, Suurmeijer AJH, Bollen SM, Cleton-Jansen AM, Bov\u00e9e J, Kroon HM (2019) Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature. Skeletal Radiol 48:1059\u20131067","journal-title":"Skeletal Radiol"},{"key":"5447_CR28","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/gcc.22836","volume":"59","author":"D \u0160ekoranja","year":"2020","unstructured":"\u0160ekoranja D, Zupan A, Mav\u010di\u010d B, Martin\u010di\u010d D, Salapura V, Snoj \u017d, Limpel Novak AK, Pi\u017eem J (2020) Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst. Genes Chromosom Cancer 59:357\u2013365","journal-title":"Genes Chromosomes Cancer"},{"key":"5447_CR29","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.humpath.2014.01.020","volume":"45","author":"NP Agaram","year":"2014","unstructured":"Agaram NP, LeLoarer FV, Zhang L, Hwang S, Athanasian EA, Hameed M, Antonescu CR (2014) USP6 gene rearrangements occur preferentially in giant cell reparative granulomas of the hands and feet but not in gnathic location. Hum Pathol 45:1147\u20131152","journal-title":"Hum Pathol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-022-05447-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-022-05447-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-022-05447-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T09:07:18Z","timestamp":1658826438000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-022-05447-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["5447"],"URL":"https:\/\/doi.org\/10.1007\/s00381-022-05447-1","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"30 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}