{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:32:39Z","timestamp":1780626759782,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00381-022-05543-2","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T17:02:36Z","timestamp":1651510956000},"page":"1357-1364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of intravenous levetiracetam versus phenytoin in convulsive status epilepticus and acute repetitive seizures in children"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-7746","authenticated-orcid":false,"given":"Mehmet Tolga","family":"K\u00f6le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-2454","authenticated-orcid":false,"given":"Safiye G\u00fcnes","family":"Sager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-2118","authenticated-orcid":false,"given":"Hatice","family":"Zeynel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-7280","authenticated-orcid":false,"given":"Yakup","family":"\u00c7a\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-7778","authenticated-orcid":false,"given":"Yasemin","family":"Ak\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"issue":"1","key":"5543_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3345\/kjp.2016.59.1.35","volume":"59","author":"YJ Lee","year":"2016","unstructured":"Lee YJ, Yum MS, Kim EH, Ko TS (2016) Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures. Korean J Pediatr 59(1):35\u201339. https:\/\/doi.org\/10.3345\/kjp.2016.59.1.35","journal-title":"Korean J Pediatr"},{"key":"5543_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107289","volume":"111","author":"GE Besli","year":"2020","unstructured":"Besli GE, Yuksel Karatoprak E, Yilmaz S (2020) Efficacy and safety profile of intravenous levetiracetam versus phenytoin in convulsive status epilepticus and acute repetitive seizures in children. Epilepsy Behav 111:107289. https:\/\/doi.org\/10.1016\/j.yebeh.2020.107289","journal-title":"Epilepsy Behav"},{"issue":"2","key":"5543_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1212\/CON.0000000000000716","volume":"25","author":"S Vanhaerents","year":"2019","unstructured":"Vanhaerents S, Gerard EE (2019) Epilepsy emergencies: status epilepticus, acute repetitive seizures, and autoimmune encephalitis. Contin Lifelong Learn Neurol 25(2):454\u2013476. https:\/\/doi.org\/10.1212\/CON.0000000000000716","journal-title":"Contin Lifelong Learn Neurol"},{"issue":"10186","key":"5543_CR4","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/S0140-6736(19)30724-X","volume":"393","author":"MD Lyttle","year":"2019","unstructured":"Lyttle MD, Rainford NEA, Gamble C et al (2019) Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet 393(10186):2125\u20132134. https:\/\/doi.org\/10.1016\/S0140-6736(19)30724-X","journal-title":"Lancet"},{"key":"5543_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/epi.14515","volume":"59","author":"C Sculier","year":"2018","unstructured":"Sculier C, Ga\u00ednza-Lein M, S\u00e1nchez Fern\u00e1ndez I, Loddenkemper T (2018) Long-term outcomes of status epilepticus: a critical assessment. Epilepsia 59:155\u2013169. https:\/\/doi.org\/10.1111\/epi.14515","journal-title":"Epilepsia"},{"key":"5543_CR6","unstructured":"Erkek N, \u00d6zt\u00fcrk N, \u015eevketo\u011flu E et al (2020) \u00c7ocuk Acil T\u0131p ve Yo\u011fun Bak\u0131m Derne\u011fi Status Epileptikus Tedavi Protokol\u00fc. J Pediatr Emerg Intensive Care Med 7(Suppl-1):64\u201371. https:\/\/cms.galenos.com.tr\/Uploads\/Article_41608\/CAYD-7-64.pdf"},{"key":"5543_CR7","doi-asserted-by":"publisher","unstructured":"Glauser T, Shinnar S, Gloss D et al (2016) Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: Report of the guideline committee of the American epilepsy society. Epilepsy Curr 16(1):48\u201361. https:\/\/doi.org\/10.5698\/1535-7597-16.1.48","DOI":"10.5698\/1535-7597-16.1.48"},{"key":"5543_CR8","doi-asserted-by":"publisher","unstructured":"Shorvon S (2012) Clinical trials in acute repetitive seizures and status epilepticus. In: Epileptic Disorders 14(2):138\u2013147. https:\/\/doi.org\/10.1684\/epd.2012.0514","DOI":"10.1684\/epd.2012.0514"},{"issue":"10","key":"5543_CR9","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.4103\/jfmpc.jfmpc_750_19","volume":"8","author":"G Wani","year":"2019","unstructured":"Wani G, Imran A, Dhawan N, Gupta A, Giri J (2019) Levetiracetam versus phenytoin in children with status epilepticus. J Fam Med Prim Care 8(10):3367\u20133371. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_750_19","journal-title":"J Fam Med Prim Care"},{"issue":"7","key":"5543_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.seizure.2012.05.010","volume":"21","author":"A McTague","year":"2012","unstructured":"McTague A, Kneen R, Kumar R, Spinty S, Appleton R (2012) Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: experience from a children\u2019s hospital. Seizure 21(7):529\u2013534. https:\/\/doi.org\/10.1016\/j.seizure.2012.05.010","journal-title":"Seizure"},{"issue":"10","key":"5543_CR11","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1007\/s00415-009-5166-7","volume":"256","author":"S Berning","year":"2009","unstructured":"Berning S, Boesebeck F, Van Baalen A, Kellinghaus C (2009) Intravenous levetiracetam as treatment for status epilepticus. J Neurol 256(10):1634\u20131642. https:\/\/doi.org\/10.1007\/s00415-009-5166-7","journal-title":"J Neurol"},{"issue":"5","key":"5543_CR12","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1177\/0883073807302612","volume":"22","author":"A Trabacca","year":"2007","unstructured":"Trabacca A, Profice P, Costanza MC, Gesualdi M, De Rinaldis M (2007) Levetiracetam in nonconvulsive status epilepticus in childhood: a case report. J Child Neurol 22(5):639\u2013641. https:\/\/doi.org\/10.1177\/0883073807302612","journal-title":"J Child Neurol"},{"issue":"10","key":"5543_CR13","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1111\/epi.13121","volume":"56","author":"E Trinka","year":"2015","unstructured":"Trinka E, Cock H, Hesdorffer D, a, (2015) A definition and classification of status epilepticus - report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 56(10):1515\u20131523. https:\/\/doi.org\/10.1111\/epi.13121","journal-title":"Epilepsia"},{"key":"5543_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.seizure.2018.05.013","volume":"68","author":"S Jafarpour","year":"2019","unstructured":"Jafarpour S, Hirsch LJ, Ga\u00ednza-Lein M, Kellinghaus C, Detyniecki K (2019) Seizure cluster: definition, prevalence, consequences, and management. Seizure 68:9\u201315. https:\/\/doi.org\/10.1016\/j.seizure.2018.05.013","journal-title":"Seizure"},{"issue":"10186","key":"5543_CR15","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/S0140-6736(19)30722-6","volume":"393","author":"SR Dalziel","year":"2019","unstructured":"Dalziel SR, Borland ML, Furyk J et al (2019) Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. Lancet 393(10186):2135\u20132145. https:\/\/doi.org\/10.1016\/S0140-6736(19)30722-6","journal-title":"Lancet"},{"issue":"2","key":"5543_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/PEC.0b013e318196ea6e","volume":"25","author":"S Lewena","year":"2009","unstructured":"Lewena S, Pennington V, Acworth J et al (2009) Emergency management of pediatric convulsive status epilepticus: a multicenter study of 542 patients. Pediatr Emerg Care 25(2):83\u201387. https:\/\/doi.org\/10.1097\/PEC.0b013e318196ea6e","journal-title":"Pediatr Emerg Care"},{"issue":"4","key":"5543_CR17","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3988\/jcn.2019.15.4.468","volume":"15","author":"N Noureen","year":"2019","unstructured":"Noureen N, Khan S, Khursheed A et al (2019) Clinical efficacy and safety of injectable levetiracetam versus phenytoin as second-line therapy in the management of generalized convulsive status epilepticus in children: an open-label randomized controlled trial. J Clin Neurol 15(4):468\u2013472. https:\/\/doi.org\/10.3988\/jcn.2019.15.4.468","journal-title":"J Clin Neurol"},{"key":"5543_CR18","doi-asserted-by":"publisher","first-page":"I5464","DOI":"10.1136\/bmj.l5464","volume":"367","author":"R Cook","year":"2019","unstructured":"Cook R, Davidson P, Martin R (2019) Levetiracetam is a useful alternative to phenytoin for epileptic seizures in children. BMJ 367:I5464. https:\/\/doi.org\/10.1136\/bmj.l5464","journal-title":"BMJ"},{"issue":"2","key":"5543_CR19","doi-asserted-by":"publisher","first-page":"158","DOI":"10.4103\/jpn.JPN_126_17","volume":"13","author":"K Singh","year":"2018","unstructured":"Singh K, Aggarwal A, Faridi MMA, Sharma S (2018) IV levetiracetam versus IV phenytoin in childhood seizures: a randomized controlled trial. J Pediatr Neurosci 13(2):158\u2013164. https:\/\/doi.org\/10.4103\/jpn.JPN_126_17","journal-title":"J Pediatr Neurosci"},{"issue":"4","key":"5543_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.seizure.2013.12.001","volume":"23","author":"U Yilmaz","year":"2014","unstructured":"Yilmaz U, Yilmaz TS, Dizdarer G, Akinci G, G\u00fczel O, Tekgul H (2014) Efficacy and tolerability of the first antiepileptic drug in children with newly diagnosed idiopathic epilepsy. Seizure 23(4):252\u2013259. https:\/\/doi.org\/10.1016\/j.seizure.2013.12.001","journal-title":"Seizure"},{"issue":"4","key":"5543_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4274\/tnd.34635","volume":"23","author":"E Alt\u0131ndag","year":"2017","unstructured":"Alt\u0131ndag E, Erdo\u011fan FF, Tezer I, Ozkara C (2017) Management and early treatment of status epilepticus in adults and children. Turk J Neurol 23(4):155\u2013161","journal-title":"Turk J Neurol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-022-05543-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-022-05543-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-022-05543-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T09:06:12Z","timestamp":1656407172000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-022-05543-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["5543"],"URL":"https:\/\/doi.org\/10.1007\/s00381-022-05543-2","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,30]]},"assertion":[{"value":"25 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Ethics Committee of the hospital on October 27, 2021. (Registration Number: 2021\/514\/212\/13). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}