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Normative reference values were obtained through bootstrap analysis. Main outcome was the association between peripapillary total retinal thickness (TRT) and total retinal volume (TRV) and appearance on fundoscopy. Signs and symptoms suggestive of ICH, including skull growth arrest, fingerprinting, and headache, were scored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty-four healthy controls and 93 isolated sagittal synostosis patients were included. Normative cut-off values for mean TRT are\u2009&lt;\u2009256\u00a0\u03bcm and\u2009&gt;\u2009504\u00a0\u03bcm and for mean TRV\u2009&lt;\u20090.21 mm\n                      <jats:sup>3<\/jats:sup>\n                      and\u2009&gt;\u20090.39 mm\n                      <jats:sup>3<\/jats:sup>\n                      . TRT was increased in 16 (17%) and TRV in 15 (16%) of 93 patients, compared to only 4 patients with papilledema on fundoscopy (4%). Both parameters were associated with papilledema on fundoscopy (OR\u2009=\u200916.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02, and OR\u2009=\u200918.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Skull growth arrest was significantly associated with abnormal OCT parameters (OR\u2009=\u200913.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The established cut-off points can be applied to screen for ICH in pediatrics. The present study detected abnormalities with OCT more frequent than with fundoscopy, which were associated with skull growth arrest. Therefore, a combination of OCT, fundoscopy, and skull growth arrest can improve clinical decision-making in craniosynostosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00381-022-05598-1","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T03:02:51Z","timestamp":1660618971000},"page":"1937-1947","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The use of OCT to detect signs of intracranial hypertension in patients with sagittal suture synostosis: Reference values and correlations"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-6412","authenticated-orcid":false,"given":"Stephanie D. 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