{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:24:06Z","timestamp":1773458646247,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369\u20131374, 2006). In this report, we provide an update on this patient\u2019s journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group.<\/jats:p>","DOI":"10.1007\/s00381-022-05749-4","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:11:46Z","timestamp":1669162306000},"page":"1077-1081","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 13-year patient journey of infant giant clival chordoma: case report and literature review"],"prefix":"10.1007","volume":"39","author":[{"given":"J.","family":"Apps","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Solanki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6087-3490","authenticated-orcid":false,"given":"M.","family":"English","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"issue":"10","key":"5749_CR1","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1007\/s00381-006-0069-8","volume":"22","author":"D Kombogiorgas","year":"2006","unstructured":"Kombogiorgas D et al (2006) Infantile clivus chordoma without clivus involvement: case report and review of the literature. Childs Nerv Syst 22(10):1369\u20131374","journal-title":"Childs Nerv Syst"},{"issue":"11","key":"5749_CR2","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1093\/annonc\/mdp210","volume":"20","author":"S Stacchiotti","year":"2009","unstructured":"Stacchiotti S et al (2009) Response to imatinib plus sirolimus in advanced chordoma. Ann Oncol 20(11):1886\u20131894","journal-title":"Ann Oncol"},{"issue":"9","key":"5749_CR3","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1002\/cncr.20618","volume":"101","author":"PG Casali","year":"2004","unstructured":"Casali PG et al (2004) Imatinib mesylate in chordoma. Cancer 101(9):2086\u20132097","journal-title":"Cancer"},{"issue":"6","key":"5749_CR4","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1093\/jnen\/nlx032","volume":"76","author":"NA Dahl","year":"2017","unstructured":"Dahl NA et al (2017) Chordoma occurs in young children with tuberous sclerosis. 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J Clin Neurosci 34:169\u2013176","journal-title":"J Clin Neurosci"},{"key":"5749_CR7","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3389\/fneur.2020.00657","volume":"11","author":"SE Hoffman","year":"2020","unstructured":"Hoffman SE et al (2020) Translational windows in chordoma: a target appraisal. Front Neurol 11:657","journal-title":"Front Neurol"},{"key":"5749_CR8","doi-asserted-by":"crossref","unstructured":"Stacchiotti S, Sommer J, Chordoma\u00a0G (2015) Global Consensus, Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol 16(2):e71\u201383","DOI":"10.1016\/S1470-2045(14)71190-8"},{"issue":"15","key":"5749_CR9","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1200\/JCO.2005.02.170","volume":"23","author":"R Chugh","year":"2005","unstructured":"Chugh R et al (2005) Phase II study of 9-nitro-camptothecin in patients with advanced chordoma or soft tissue sarcoma. 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