{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:06:29Z","timestamp":1740107189517,"version":"3.37.3"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004702","name":"Universit\u00e0 degli Studi di Genova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004702","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Diffuse neonatal hemangiomatosis (DNH) is a rare disorder typically recognized at birth or during the neonatal period. DNH involves three or more organ systems, including the central nervous system (CNS). In these cases, serious complications such as hemorrhages and obstructive hydrocephalus can develop.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case report<\/jats:title>\n                <jats:p>We present a case of DNH with intracranial hypertension and CNS hemorrhagic lesions on the mesencephalic aqueduct, resulting in triventricular hydrocephalus, treated with endoscopic ventriculocisternostomy (ETV) and medical therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>DNH is a rare condition that can involve the CNS with serious complications. From a review of the literature, we highlighted only two cases of DNH with brain involvement treated surgically. We report the successful outcome of ETV, along with surgical considerations, imaging findings, and the complete resolution of cerebral and skin lesions following medical therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Medical therapy is not standardized and must be individualized. In patients who develop severe neurological symptoms such as obstructive hydrocephalus, surgery may be considered to avoid neurological sequelae.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00381-023-06226-2","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T05:10:50Z","timestamp":1700284250000},"page":"953-956","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of hemorrhagic presentation of diffuse neonatal hemangiomatosis (DNH) associated to obstructive hydrocephalus: Medical and neurosurgical considerations"],"prefix":"10.1007","volume":"40","author":[{"given":"Marco","family":"Pavanello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Piro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Roggero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Piatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Vercellino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"issue":"1","key":"6226_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1542\/peds.2012-1128","volume":"131","author":"TS Chen","year":"2013","unstructured":"Chen TS, Eichenfield LF, Friedlander SF (2013) Infantile hemangiomas: an update on pathogenesis and therapy. Pediatrics 131(1):99\u2013108. https:\/\/doi.org\/10.1542\/peds.2012-1128. Epub 2012 Dec 24 PMID: 23266916","journal-title":"Pediatrics"},{"issue":"10","key":"6226_CR2","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1007\/s00381-012-1858-x","volume":"28","author":"T Patiroglu","year":"2012","unstructured":"Patiroglu T, Sarici D, Unal E, Yikilmaz A, Tucer B, Karakukcu M, Ozdemir MA, Canoz O, Akcakus M (2012) Cerebellar hemangioblastoma associated with diffuse neonatal hemangiomatosis in an infant. Childs Nerv Syst 28(10):1801\u20131805. https:\/\/doi.org\/10.1007\/s00381-012-1858-x. 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Pediatrics 46(3):411\u2013421.\u00a0PMID: 5465931","journal-title":"Pediatrics"},{"key":"6226_CR5","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s002470050612","volume":"29","author":"E Balaci","year":"1999","unstructured":"Balaci E, Sumner TE, Auringer ST, Cox TD (1999) Diffuse neonatal hemangiomatosis with extensive involvement of the brain and cervical spinal cord. Pediatr Radiol 29:441\u2013443","journal-title":"Pediatr Radiol"},{"issue":"1","key":"6226_CR6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pediatrneurol.2008.09.022","volume":"40","author":"A Al-Kaabi","year":"2009","unstructured":"Al-Kaabi A, Yanofsky R, Bunge M, Hyman J, Rafay MF (2009) Diffuse hemangiomatosis with predominant central nervous system involvement. Pediatr Neurol 40(1):54\u201357. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2008.09.022. PMID: 19068256","journal-title":"Pediatr Neurol"},{"key":"6226_CR7","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1111\/ped.12517","volume":"57","author":"T Okuno","year":"2015","unstructured":"Okuno T, Tokuriki S, Yoshino T, Tanaka N, Ohshima Y (2015) Diffuse neonatal hemangiomatosis in a very low-birthweight infant treated with erythropoietin. Pediatr Int 57:e34\u2013e36. https:\/\/doi.org\/10.1111\/ped.12517","journal-title":"Pediatr Int"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-023-06226-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-023-06226-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-023-06226-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T11:13:33Z","timestamp":1708686813000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-023-06226-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,18]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["6226"],"URL":"https:\/\/doi.org\/10.1007\/s00381-023-06226-2","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"type":"print","value":"0256-7040"},{"type":"electronic","value":"1433-0350"}],"subject":[],"published":{"date-parts":[[2023,11,18]]},"assertion":[{"value":"9 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}