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Our aim is to study a retrospective cohort to improve the understanding of the disease course and guide patient management.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a multicenter retrospective analysis across the European Society for Pediatric Oncology SIOP-E HGG\/DIPG Working Group linked centers, including patients with a brainstem tumor diagnosed between 2009 and 2020 and aged\u2009&lt;\u20093\u00a0months at diagnosis. Clinical data were collected, and imaging characteristics were analyzed blindly and independently by two neuroradiologists.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Five cases were identified. No patient received any therapy. The epicenter of two tumors was in the medulla oblongata alone and in the medulla oblongata and the pons in three. For patients with tumor in equal parts in the medulla oblongata and the pons (<jats:italic>n<\/jats:italic>\u2009=\u20093), the extension at diagnosis involved the spinal cord; for the two patients with the tumor epicenter in the medulla oblongata alone (<jats:italic>n<\/jats:italic>\u2009=\u20092), the extension at diagnosis included the pons (<jats:italic>n<\/jats:italic>\u2009=\u20092) and the spinal cord (<jats:italic>n<\/jats:italic>\u2009=\u20091). Biopsy was performed in one patient identifying a pilocytic astrocytoma. Two patients died. In one patient, autopsy revealed a high-grade glioma (case 3). Three survivors showed either spontaneous tumor regression (<jats:italic>n<\/jats:italic>\u2009=\u20092) or stable disease (<jats:italic>n<\/jats:italic>\u2009=\u20091). Survivors were followed up for 10, 7, and 0.6\u00a0years, respectively. One case had the typical imaging characteristics of a dorsal exophytic low-grade glioma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>No patient fulfilled the radiologic criteria defining a high-grade glioma. Central neuroradiological review and biopsy may provide useful information regarding the patient management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00381-023-06272-w","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T06:02:05Z","timestamp":1708408925000},"page":"1053-1064","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain stem tumors in children less than 3\u00a0months: Clinical and radiologic findings of a rare disease"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-4720","authenticated-orcid":false,"given":"Danai","family":"Papangelopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-8671","authenticated-orcid":false,"given":"Brigitte","family":"Bison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-6498","authenticated-orcid":false,"given":"Marc","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-5376","authenticated-orcid":false,"given":"Karoline","family":"Ehlert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-3283","authenticated-orcid":false,"given":"Ofelia Cruz","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-926X","authenticated-orcid":false,"given":"Christof M.","family":"Kramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7083-4316","authenticated-orcid":false,"given":"Andres","family":"Morales La Madrid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-6264","authenticated-orcid":false,"given":"Andre O.","family":"von Bueren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"6272_CR1","first-page":"471","volume-title":"Brainstem tumors","author":"M Choux","year":"2000","unstructured":"Choux M, Lena G, Do L (2000) Pediatric Neurosurgery. 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