{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:28:10Z","timestamp":1773966490161,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s00381-024-06293-z","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T17:34:32Z","timestamp":1706204072000},"page":"1617-1621","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurovascular considerations in patients with Down syndrome and moyamoya syndrome"],"prefix":"10.1007","volume":"40","author":[{"given":"Arevik","family":"Abramyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen Ye","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khushi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipta","family":"Roychowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"6293_CR1","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/NEJMra0804622","volume":"360","author":"RM Scott","year":"2009","unstructured":"Scott RM, Smith ER (2009) Moyamoya disease and moyamoya syndrome. N Engl J Med 360:1226\u20131237. https:\/\/doi.org\/10.1056\/NEJMra0804622","journal-title":"N Engl J Med"},{"key":"6293_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/jhg.2010.132","volume":"56","author":"F Kamada","year":"2011","unstructured":"Kamada F, Aoki Y, Narisawa A, Abe Y, Komatsuzaki S, Kikuchi A, Kanno J, Niihori T, Ono M, Ishii N, Owada Y, Fujimura M, Mashimo Y, Suzuki Y, Hata A, Tsuchiya S, Tominaga T, Matsubara Y, Kure S (2011) A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. J Hum Genet 56:34\u201340. https:\/\/doi.org\/10.1038\/jhg.2010.132","journal-title":"J Hum Genet"},{"key":"6293_CR3","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1093\/brain\/awad172","volume":"146","author":"Pinard A, Ye W, Fraser SM, Rosenfeld JA, Pichurin P, Hickey SE, Guo D, Cecchi AC, Boerio ML, Guey S, Aloui C, Lee K, Kraemer M, Alyemni SO, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Tournier-Lasserve E, Haider S, Jin SC, Smith ER, Kahle KT, Jan LY, He M, Milewicz DM","year":"2023","unstructured":"Pinard A, Ye W, Fraser SM, Rosenfeld JA, Pichurin P, Hickey SE, Guo D, Cecchi AC, Boerio ML, Guey S, Aloui C, Lee K, Kraemer M, Alyemni SO, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Tournier-Lasserve E, Haider S, Jin SC, Smith ER, Kahle KT, Jan LY, He M, Milewicz DM (2023) Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease. Brain 146:3616\u20133623. https:\/\/doi.org\/10.1093\/brain\/awad172","journal-title":"Brain"},{"key":"6293_CR4","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1001\/jamaneurol.2021.1681","volume":"78","author":"AJ Kundishora","year":"2021","unstructured":"Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D, Marlier A, Duy PQ, Diab NS, Reeves BC, Robert SM, Sujijantarat N, Stratman AN, Chen Y-H, Zhao S, Roszko I, Lu Q, Zhang B, Mane S, Castaldi C, L\u00f3pez-Gir\u00e1ldez F, Knight JR, Bamshad MJ, Nickerson DA, Geschwind DH, Chen S-SL, Storm PB, Diluna ML, Matouk CC, Orbach DB, Alper SL, Smith ER, Lifton RP, Gunel M, Milewicz DM, Jin SC, Kahle KT (2021) DIAPH1 Variants in non-East Asian patients with sporadic moyamoya disease. JAMA Neurol 78:993\u20131003. https:\/\/doi.org\/10.1001\/jamaneurol.2021.1681","journal-title":"JAMA Neurol"},{"key":"6293_CR5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23502","volume":"14","author":"A Abdelgadir","year":"2022","unstructured":"Abdelgadir A, Akram H, Dick MH, Ahmed NR, Chatterjee A, Pokhrel S, Vaijaya Kulkarni V, Khan S (2022) A better understanding of moyamoya in trisomy 21: a systematic review. Cureus 14:e23502. https:\/\/doi.org\/10.7759\/cureus.23502","journal-title":"Cureus"},{"key":"6293_CR6","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1161\/01.str.27.11.2131","volume":"27","author":"SC Cramer","year":"1996","unstructured":"Cramer SC, Robertson RL, Dooling EC, Scott RM (1996) Moyamoya and Down syndrome. Clinical and radiological features Stroke 27:2131\u20132135. https:\/\/doi.org\/10.1161\/01.str.27.11.2131","journal-title":"Clinical and radiological features Stroke"},{"key":"6293_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/jpn.JPN_116_17","volume":"13","author":"P Kumar","year":"2018","unstructured":"Kumar P, Panigrahi I, Sankhyan N, Ahuja C, Goyadi PK (2018) Down syndrome with moyamoya disease: a case series. J Pediatr Neurosci 13:201\u2013204. https:\/\/doi.org\/10.4103\/jpn.JPN_116_17","journal-title":"J Pediatr Neurosci"},{"key":"6293_CR8","first-page":"248","volume":"25","author":"J Takanashi","year":"1993","unstructured":"Takanashi J, Sugita K, Ishii M, Iai M, Goto M, Tanabe Y, Niimi H (1993) A girl with Down syndrome complicated by moyamoya disease and symptomatic atlanto-axial instability. No To Hattatsu 25:248\u2013252","journal-title":"No To Hattatsu"},{"key":"6293_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1227\/NEU.0b013e31827b9beb","volume":"72","author":"DS Kainth","year":"2013","unstructured":"Kainth DS, Chaudhry SA, Kainth HS, Suri FK, Qureshi AI (2013) Prevalence and characteristics of concurrent Down syndrome in patients with moyamoya disease. Neurosurgery 72:210\u2013215. https:\/\/doi.org\/10.1227\/NEU.0b013e31827b9beb","journal-title":"Neurosurgery"},{"key":"6293_CR10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jocn.2017.03.043","volume":"42","author":"X Deng","year":"2017","unstructured":"Deng X, Zhang D, Zhang Y, Wang R, Wang B, Zhao J (2017) Moyamoya disease with occlusion of bilateral vertebral arteries and the basilar artery fed by the collateral vessels of vertebral arteries: a rare case report. J Clin Neurosci 42:116\u2013118. https:\/\/doi.org\/10.1016\/j.jocn.2017.03.043","journal-title":"J Clin Neurosci"},{"key":"6293_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0090-3019(84)90222-2","volume":"22","author":"S Miyamoto","year":"1984","unstructured":"Miyamoto S, Kikuchi H, Karasawa J, Nagata I, Ikota T (1984) Moyamoya disease associated with bilateral occlusion of the vertebral artery. Surg Neurol 22:21\u201328. https:\/\/doi.org\/10.1016\/0090-3019(84)90222-2","journal-title":"Surg Neurol"},{"key":"6293_CR12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/BF01808612","volume":"131","author":"T Matsushima","year":"1994","unstructured":"Matsushima T, Inoue T, Natori Y, Fujii K, Fukui M, Hasuo K, Kuwabara Y (1994) Children with unilateral occlusion or stenosis of the ICA associated with surrounding moyamoya vessels \u2014 \u201cunilateral\u201d moyamoya disease. Acta Neurochir (Wien) 131:196\u2013202. https:\/\/doi.org\/10.1007\/BF01808612","journal-title":"Acta Neurochir (Wien)"},{"key":"6293_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00381-018-3948-x","volume":"35","author":"Y Hu","year":"2019","unstructured":"Hu Y, Du J, Liu Z, Wu H, Ding J, Jian F (2019) Vertebral artery dissection caused by atlantoaxial dislocation: a case report and review of literature. Child\u2019s Nervous System 35:187\u2013190. https:\/\/doi.org\/10.1007\/s00381-018-3948-x","journal-title":"Child\u2019s Nervous System"},{"key":"6293_CR14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0270-3092(86)90019-6","volume":"7","author":"N Alvarez","year":"1986","unstructured":"Alvarez N, Rubin L (1986) Atlantoaxial instability in adults with Down syndrome: a clinical and radiological survey. Appl Res Ment Retard 7:67\u201378. https:\/\/doi.org\/10.1016\/0270-3092(86)90019-6","journal-title":"Appl Res Ment Retard"},{"key":"6293_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.wneu.2014.02.006","volume":"82","author":"M El-Khouri","year":"2014","unstructured":"El-Khouri M, Mour\u00e3o MA, Tobo A, Battistella LR, Herrero CFP, Riberto M (2014) Prevalence of atlanto-occipital and atlantoaxial instability in adults with Down syndrome. World Neurosurg 82:215\u2013218. https:\/\/doi.org\/10.1016\/j.wneu.2014.02.006","journal-title":"World Neurosurg"},{"key":"6293_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00975185","volume":"10","author":"SM Pueschel","year":"1981","unstructured":"Pueschel SM, Scola FH, Perry CD, Pezzullo JC (1981) Atlanto-axial instability in children with Down syndrome. Pediatr Radiol 10:129\u2013132. https:\/\/doi.org\/10.1007\/BF00975185","journal-title":"Pediatr Radiol"},{"key":"6293_CR17","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43955","author":"S Alfhmi","year":"2023","unstructured":"Alfhmi S, Sejeeni N, Alharbi K, Alharbi R, Malayoo B (2023) Atlantoaxial subluxation in a 10-year-old girl with down syndrome: a case report. Cureus. https:\/\/doi.org\/10.7759\/cureus.43955","journal-title":"Cureus"},{"key":"6293_CR18","doi-asserted-by":"publisher","first-page":"778","DOI":"10.14245\/ns.2142720.360","volume":"18","author":"Y Takeoka","year":"2021","unstructured":"Takeoka Y, Kakutani K, Miyamoto H, Suzuki T, Yurube T, Komoto I, Ryu M, Satsuma S, Uno K (2021) Complications of posterior fusion for atlantoaxial instability in children with Down syndrome. Neurospine 18:778\u2013785. https:\/\/doi.org\/10.14245\/ns.2142720.360","journal-title":"Neurospine"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-024-06293-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-024-06293-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-024-06293-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T10:33:57Z","timestamp":1713436437000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-024-06293-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["6293"],"URL":"https:\/\/doi.org\/10.1007\/s00381-024-06293-z","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"5 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}