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Google Scholar, PubMed, Trip Medical Database, and Cochrane Library searched utilizing a keyphrase, articles filtered per inclusion\/exclusion criteria, duplicates excluded. Based on criteria, 25 articles identified, 7 further excluded from the systematic data but included in discussion (5\u2009\u00d7\u2009insufficient data, 2\u2009\u00d7\u2009other systematic reviews).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Many studies did not contain all explored data. 2487 patients reviewed, 325 later found to have RICM (143 male, 92 female). Mean age at irradiation 7.6\u00a0years (range 1.5\u201319). Mean total radiation dose 56\u00a0Gy (12\u2013112). Most common indications for radiation\u2014medulloblastoma 133x, astrocytoma 23x, ependymoma 21x, germinoma 19x. Mean age at RICM diagnosis 18\u00a0years (3.6\u201357). Mean latency to RICM 9.9\u00a0years (0.25\u201341). Most common anatomic locations\u2014temporal 36, frontal 36, parietal 13, basal ganglia 16, infratentorial 20. Clinical presentation\u2014incidental 270, seizures 19, headache 11, focal neurological deficit 7, other 13. 264 patients observed, 34 undergone surgery. RICM bled in 28 patients. Mean follow-up 11.7\u00a0years (0.5\u201350.3). Prognostic reporting highly variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>From our data, pediatric RICMs appear to display slight male predominance, present about 10\u00a0years after initial irradiation in late teen years, and present incidentally in majority of cases. They are mostly operated on when they bleed, with incidental lesions mostly being observed over time. Further prospective detailed studies needed to draw stronger conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00381-024-06543-0","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:01:26Z","timestamp":1721347286000},"page":"3527-3536","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-7404","authenticated-orcid":false,"given":"Adam","family":"Vacek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-5949","authenticated-orcid":false,"given":"Chandrasekaran","family":"Kaliaperumal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"issue":"1","key":"6543_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.spen.2012.02.012","volume":"19","author":"S Partap","year":"2012","unstructured":"Partap S (2012) Stroke and cerebrovascular complications in childhood cancer survivors. 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