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Most prior reports describe this association with high-grade gliomas; however, reports of a co-occurrence with low grade gliomas are very rare. It is unclear whether such cases represent a true co-occurrence of separate pathologies or simply an unusually vascular phenotype of the neoplasm. Most such reports pre-date the era of molecularly defined gliomas. We present the first report of the spatial and temporal co-occurrence of an intracranial arteriovenous malformation traversing and within a papillary glioneuronal tumour, molecularly defined by the presence of <jats:italic>SLC44A1::PRKCA<\/jats:italic> fusion. This case was successfully managed by resection of both lesions adhering to the principles of AVM surgery. It is possible these exceptionally rare co-occurrences may have common underlying molecular drivers relating to the mitogen activated protein kinase (MAPK) pathway.<\/jats:p>","DOI":"10.1007\/s00381-024-06621-3","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T20:16:14Z","timestamp":1726690574000},"page":"4329-4333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synchronous intracranial arteriovenous malformation and papillary glioneuronal tumour: hypothesis or reality?"],"prefix":"10.1007","volume":"40","author":[{"given":"Michael","family":"Stuart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle","family":"Harbison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Coulthard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"issue":"1","key":"6621_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4103\/aian.AIAN_219_18","volume":"23","author":"T Tunthanathip","year":"2020","unstructured":"Tunthanathip T, Kanjanapradit K (2020) Glioblastoma multiforme associated with arteriovenous malformation: a case report and literature review. 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