{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:34:13Z","timestamp":1792247653503,"version":"4.4.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00381-024-06703-2","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T03:50:06Z","timestamp":1733716206000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of stem cells in the management of neonatal posthemorrhagic hydrocephalus"],"prefix":"10.1007","volume":"41","author":[{"given":"Christodoulos","family":"Komiotis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Mavridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"issue":"4","key":"6703_CR1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.jpeds.2012.09.038","volume":"162","author":"T Alderliesten","year":"2013","unstructured":"Alderliesten T, Lemmers PM, Smarius JJ, van de Vosse RE, Baerts W, van Bel F (2013) Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage. J Pediatr 162(4):698-704.e2","journal-title":"J Pediatr"},{"key":"6703_CR2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/B978-0-444-64029-1.00008-4","volume":"162","author":"LM Leijser","year":"2019","unstructured":"Leijser LM, de Vries LS (2019) Preterm brain injury: germinal matrix-intraventricular hemorrhage and post-hemorrhagic ventricular dilatation. Handb Clin Neurol 162:173\u2013199","journal-title":"Handb Clin Neurol"},{"issue":"4","key":"6703_CR3","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1542\/peds.71.4.541","volume":"71","author":"T Dolfin","year":"1983","unstructured":"Dolfin T, Skidmore MB, Fong KW, Hoskins EM, Shennan AT (1983) Incidence, severity, and timing of subependymal and intraventricular hemorrhages in preterm infants born in a perinatal unit as detected by serial real-time ultrasound. Pediatrics 71(4):541\u2013546","journal-title":"Pediatrics"},{"issue":"4","key":"6703_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2214\/ajr.132.4.631","volume":"132","author":"J Burstein","year":"1979","unstructured":"Burstein J, Papile LA, Burstein R (1979) Intraventricular hemorrhage and hydrocephalus in premature newborns: a prospective study with CT. AJR Am J Roentgenol 132(4):631\u2013635","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"6703_CR5","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0022-3476(94)70023-0","volume":"125","author":"DG Batton","year":"1994","unstructured":"Batton DG, Holtrop P, DeWitte D, Pryce C, Roberts C (1994) Current gestational age-related incidence of major intraventricular hemorrhage. J Pediatr 125(4):623\u2013625","journal-title":"J Pediatr"},{"issue":"2","key":"6703_CR6","doi-asserted-by":"publisher","first-page":"F86","DOI":"10.1136\/fn.86.2.F86","volume":"86","author":"AM Heuchan","year":"2002","unstructured":"Heuchan AM, Evans N, Henderson Smart DJ, Simpson JM (2002) Perinatal risk factors for major intraventricular haemorrhage in the Australian and New Zealand Neonatal Network, 1995\u201397. Arch Dis Child Fetal Neonatal Ed 86(2):F86-90","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"6703_CR7","doi-asserted-by":"crossref","unstructured":"Pinto Cardoso G, Abily-Donval L, Chadie A, Guerrot AM, Pinquier D, Marret S; Le r\u00e9seau de p\u00e9rinatalit\u00e9 de Haute-Normandie (2013) \u00c9volution de la mortalit\u00e9, de la morbidit\u00e9 et de la prise en charge des grands pr\u00e9matur\u00e9s dans un centre de niveau III\u00a0: comparaison des ann\u00e9es 2000, 2005\u00a0et 2010 [Epidemiological study of very preterm infants at Rouen University Hospital: changes in mortality, morbidity, and care over 11 years]. Arch Pediatr 20(2):156\u2013163. French","DOI":"10.1016\/j.arcped.2012.11.011"},{"key":"6703_CR8","doi-asserted-by":"crossref","unstructured":"Poryo M, Boeckh JC, Gortner L, Zemlin M, Duppr\u00e9 P, Ebrahimi-Fakhari D, Wagenpfeil S, Heckmann M, Mildenberger E, Hilgendorff A, Flemmer AW, Frey G, Meyer S; PROGRESS study consortium and NGFN - Nationales Genomforschungsnetz Deutschland (2018) Ante-, peri- and postnatal factors associated with intraventricular hemorrhage in very premature infants. Early Hum Dev 116:1-8","DOI":"10.1016\/j.earlhumdev.2017.08.010"},{"issue":"Suppl","key":"6703_CR9","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1177\/0883073889004001S06","volume":"4","author":"PJ Holt","year":"1989","unstructured":"Holt PJ (1989) Posthemorrhagic hydrocephalus. J Child Neurol 4(Suppl):S23-31","journal-title":"J Child Neurol"},{"key":"6703_CR10","doi-asserted-by":"crossref","unstructured":"Payne AH, Hintz SR, Hibbs AM, Walsh MC, Vohr BR, Bann CM, Wilson-Costello DE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2013) Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA Pediatr 167(5):451-459","DOI":"10.1001\/jamapediatrics.2013.866"},{"issue":"2","key":"6703_CR11","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.pcl.2018.12.015","volume":"66","author":"EC McGowan","year":"2019","unstructured":"McGowan EC, Vohr BR (2019) Neurodevelopmental follow-up of preterm infants: what is new? Pediatr Clin North Am 66(2):509\u2013523","journal-title":"Pediatr Clin North Am"},{"key":"6703_CR12","unstructured":"Starr R, De Jesus O, Shah SD, Borger J (2024) Periventricular and intraventricular hemorrhage. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing"},{"issue":"3","key":"6703_CR13","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3340\/jkns.2023.0052","volume":"66","author":"S Ichi","year":"2023","unstructured":"Ichi S (2023) Clinical feature and general management of post-hemorrhagic hydrocephalus in premature infants. J Korean Neurosurg Soc 66(3):247\u2013257","journal-title":"J Korean Neurosurg Soc"},{"issue":"1","key":"6703_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.clp.2021.11.002","volume":"49","author":"S Cohen","year":"2022","unstructured":"Cohen S, Flibotte J (2022) Treatment of posthemorrhagic hydrocephalus. Clin Perinatol 49(1):15\u201325","journal-title":"Clin Perinatol"},{"key":"6703_CR15","doi-asserted-by":"crossref","unstructured":"Zakrzewski W, Dobrzy\u0144ski M, Szymonowicz M, Rybak Z (2019) Stem cells: past, present, and future. Stem Cell Res Ther 26;10(1):68","DOI":"10.1186\/s13287-019-1165-5"},{"issue":"4","key":"6703_CR16","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1097\/PRS.0b013e3181ea42bb","volume":"126","author":"B Behr","year":"2010","unstructured":"Behr B, Ko SH, Wong VW, Gurtner GC, Longaker MT (2010) Stem cells. Plast Reconstr Surg 126(4):1163\u20131171","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"6703_CR17","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1161\/STROKEAHA.112.679092","volume":"44","author":"SY Ahn","year":"2013","unstructured":"Ahn SY, Chang YS, Sung DK, Sung SI, Yoo HS, Lee JH, Oh WI, Park WS (2013) Mesenchymal stem cells prevent hydrocephalus after severe intraventricular hemorrhage. Stroke 44(2):497\u2013504","journal-title":"Stroke"},{"issue":"6","key":"6703_CR18","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3727\/096368915X689640","volume":"25","author":"WS Park","year":"2016","unstructured":"Park WS, Sung SI, Ahn SY, Sung DK, Im GH, Yoo HS, Choi SJ, Chang YS (2016) Optimal timing of mesenchymal stem cell therapy for neonatal intraventricular hemorrhage. Cell Transplant 25(6):1131\u20131144","journal-title":"Cell Transplant"},{"issue":"1","key":"6703_CR19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3727\/096368916X692861","volume":"26","author":"SY Ahn","year":"2017","unstructured":"Ahn SY, Chang YS, Sung DK, Sung SI, Ahn JY, Park WS (2017) Pivotal role of brain-derived neurotrophic factor secreted by mesenchymal stem cells in severe intraventricular hemorrhage in newborn rats. Cell Transplant 26(1):145\u2013156","journal-title":"Cell Transplant"},{"issue":"11","key":"6703_CR20","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1002\/sctm.19-0082","volume":"8","author":"G Vinukonda","year":"2019","unstructured":"Vinukonda G, Liao Y, Hu F, Ivanova L, Purohit D, Finkel DA, Giri P, Bapatla L, Shah S, Zia MT, Hussein K, Cairo MS, La Gamma EF (2019) Human cord blood-derived unrestricted somatic stem cell infusion improves neurobehavioral outcome in a rabbit model of intraventricular hemorrhage. Stem Cells Transl Med 8(11):1157\u20131169","journal-title":"Stem Cells Transl Med"},{"key":"6703_CR21","doi-asserted-by":"publisher","first-page":"633185","DOI":"10.3389\/fncel.2021.633185","volume":"15","author":"D Purohit","year":"2021","unstructured":"Purohit D, Finkel DA, Malfa A, Liao Y, Ivanova L, Kleinman GM, Hu F, Shah S, Thompson C, Joseph E, Wolin MS, Cairo MS, La Gamma EF, Vinukonda G (2021) Human cord blood derived unrestricted somatic stem cells restore aquaporin channel expression, reduce inflammation and inhibit the development of hydrocephalus after experimentally induced perinatal intraventricular hemorrhage. Front Cell Neurosci 15:633185","journal-title":"Front Cell Neurosci"},{"issue":"12","key":"6703_CR22","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/sctm.17-0219","volume":"7","author":"SY Ahn","year":"2018","unstructured":"Ahn SY, Chang YS, Sung SI, Park WS (2018) Mesenchymal stem cells for severe intraventricular hemorrhage in preterm infants: phase I dose-escalation clinical trial. Stem Cells Transl Med 7(12):847\u2013856","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"6703_CR23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00431-018-3279-7","volume":"178","author":"T Keller","year":"2019","unstructured":"Keller T, K\u00f6rber F, Oberthuer A, Schafmeyer L, Mehler K, Kuhr K, Kribs A (2019) Intranasal breast milk for premature infants with severe intraventricular hemorrhage-an observation. Eur J Pediatr 178(2):199\u2013206","journal-title":"Eur J Pediatr"},{"issue":"10","key":"6703_CR24","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1002\/stem.1188","volume":"30","author":"F Hassiotou","year":"2012","unstructured":"Hassiotou F, Beltran A, Chetwynd E, Stuebe AM, Twigger AJ, Metzger P, Trengove N, Lai CT, Filgueira L, Blancafort P, Hartmann PE (2012) Breastmilk is a novel source of stem cells with multilineage differentiation potential. Stem Cells 30(10):2164\u20132174","journal-title":"Stem Cells"},{"issue":"1","key":"6703_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pcl.2012.10.002","volume":"60","author":"O Ballard","year":"2013","unstructured":"Ballard O, Morrow AL (2013) Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am 60(1):49\u201374","journal-title":"Pediatr Clin North Am"},{"issue":"2","key":"6703_CR26","first-page":"344","volume":"32","author":"D Bozkaya","year":"2022","unstructured":"Bozkaya D, Ceran B, Ozmen E, Okman E, Dizdar EA, Oguz SS, Bozkaya IO (2022) A new hope in the treatment of intraventricular haemorrhage in preterm infants: mesenchymal stem cells. Turk Neurosurg 32(2):344\u2013346","journal-title":"Turk Neurosurg"},{"issue":"3","key":"6703_CR27","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00381-021-05427-x","volume":"38","author":"GW Koutsouras","year":"2022","unstructured":"Koutsouras GW, Koustov T, Zyck S, Krishnamurthy S (2022) Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity. Childs Nerv Syst 38(3):511\u2013520","journal-title":"Childs Nerv Syst"},{"issue":"8","key":"6703_CR28","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1097\/01.TP.0000082540.43730.80","volume":"76","author":"I Rasmusson","year":"2003","unstructured":"Rasmusson I, Ringd\u00e9n O, Sundberg B, Le Blanc K (2003) Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 76(8):1208\u20131213","journal-title":"Transplantation"},{"issue":"5","key":"6703_CR29","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/ana.22518","volume":"70","author":"L Titomanlio","year":"2011","unstructured":"Titomanlio L, Kavelaars A, Dalous J, Mani S, El Ghouzzi V, Heijnen C, Baud O, Gressens P (2011) Stem cell therapy for neonatal brain injury: perspectives and challenges. Ann Neurol 70(5):698\u2013712","journal-title":"Ann Neurol"},{"issue":"1","key":"6703_CR30","doi-asserted-by":"publisher","first-page":"4754","DOI":"10.1038\/s41598-022-08398-4","volume":"12","author":"QH Jin","year":"2022","unstructured":"Jin QH, Kim HK, Na JY, Jin C, Seon JK (2022) Anti-inflammatory effects of mesenchymal stem cell-conditioned media inhibited macrophages activation in vitro. Sci Rep 12(1):4754","journal-title":"Sci Rep"},{"issue":"10","key":"6703_CR31","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.1182\/blood-2004-02-0586","volume":"105","author":"XX Jiang","year":"2005","unstructured":"Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, Mao N (2005) Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105(10):4120\u20134126","journal-title":"Blood"},{"issue":"8","key":"6703_CR32","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3727\/096368909X471189","volume":"18","author":"YS Chang","year":"2009","unstructured":"Chang YS, Oh W, Choi SJ, Sung DK, Kim SY, Choi EY, Kang S, Jin HJ, Yang YS, Park WS (2009) Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell Transplant 18(8):869\u2013886","journal-title":"Cell Transplant"},{"issue":"7","key":"6703_CR33","doi-asserted-by":"publisher","first-page":"e0132919","DOI":"10.1371\/journal.pone.0132919","volume":"10","author":"SY Ahn","year":"2015","unstructured":"Ahn SY, Chang YS, Sung DK, Sung SI, Yoo HS, Im GH, Choi SJ, Park WS (2015) Optimal route for mesenchymal stem cells transplantation after severe intraventricular hemorrhage in newborn rats. PLoS ONE 10(7):e0132919","journal-title":"PLoS ONE"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-024-06703-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-024-06703-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-024-06703-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:15:28Z","timestamp":1770815728000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-024-06703-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["6703"],"URL":"https:\/\/doi.org\/10.1007\/s00381-024-06703-2","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"12 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"40"}}