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Preoperative glucocorticoids (pGC) are considered standard treatment to reduce tumour oedema; in addition, glucocorticoids are often administered intraoperatively (iGC) to reduce both postoperative nausea and vomiting. The study aims to investigate whether the occurrence of POSI may be associated with pGC and iGC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective observational multicentre study, we included children with a PF tumour requiring either resection or open biopsy. The use of pGC and iGC, including drug type and dose, was registered. Postoperative speech status was classified as mutism, reduced speech, or habitual speech, where mutism and reduced speech were considered POSI of higher and lower severity, respectively. Proportional odds logistic regression with adjustment for tumour type, tumour location, and age was used to analyse the occurrence of POSI associated with glucocorticoids (GC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From August 2014 to November 2024, we recruited 810 children, of whom 605 were included in the primary analysis. We found no association between the use of GC (pGC nor iGC) and the occurrence of POSI. The result did not change when adjusting for tumour type, tumour location, and age. The analysis included both a comparison between using and not using pGC (OR 1.06 [95% CI 0.46 \u20132.49], reference level: use of pGC) and\/or iGC (1.28 [0.58\u20132.82], reference level: use of iGC), and a dose\u2013response analysis of the occurrence of POSI in relation to doubling the dose of GC (pGC OR 1.28 [0.84\u20131.98]; iGC OR 1.07 [0.62\u20131.82]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study did not find evidence of a significant change in the occurrence of POSI with the use of pGC or iGC, but our results alone cannot rule out that the administration of pGC or iGC may have some effect. Therefore, our data do not call for a change in recommendations for the use of GC as protection against the development of POSI.<\/jats:p>\n                    <jats:p>Trial registration number:\u00a0Clinicaltrials.gov (NCT02300766).\u00a0<\/jats:p>\n                    <jats:p>Date of registration:\u00a0November 25, 2014<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00381-025-06850-0","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T08:29:33Z","timestamp":1752222573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glucocorticoid use in paediatric posterior fossa tumour surgery and the occurrence of postoperative speech 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