{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:15:36Z","timestamp":1791400536611,"version":"4.3.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["EOI\/syst.review\/RMRU\/2023\/19\/BMS"],"award-info":[{"award-number":["EOI\/syst.review\/RMRU\/2023\/19\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00381-025-06931-0","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T18:19:12Z","timestamp":1755886752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stem cell therapy in neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"41","author":[{"given":"Prateek Kumar","family":"Panda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananthanarayanan","family":"Kasinathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragnya","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesa","family":"Dawman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Singh","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indar Kumar","family":"Sharawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"issue":"1","key":"6931_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/AOG.0000000000005392","volume":"143","author":"T Arnautovic","year":"2024","unstructured":"Arnautovic T, Sinha S, Laptook AR (2024) Neonatal hypoxic-ischemic encephalopathy and hypothermia treatment. Obstet Gynecol 143(1):67\u201381","journal-title":"Obstet Gynecol"},{"issue":"3","key":"6931_CR2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1053\/j.nainr.2011.07.004","volume":"11","author":"KA Allen","year":"2011","unstructured":"Allen KA, Brandon DH (2011) Hypoxic ischemic encephalopathy: pathophysiology and experimental treatments. Newborn Infant Nurs Rev 11(3):125\u2013133","journal-title":"Newborn Infant Nurs Rev"},{"issue":"4","key":"6931_CR3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/archdischild-2019-317311","volume":"105","author":"K Aker","year":"2020","unstructured":"Aker K, St\u00f8en R, Eikenes L, Martinez-Biarge M, Nakken I, H\u00e5berg AK et al (2020) Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 105(4):405\u2013411","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"6931_CR4","doi-asserted-by":"publisher","first-page":"1347529","DOI":"10.3389\/fphar.2024.1347529","volume":"15","author":"KL Marques","year":"2024","unstructured":"Marques KL, Rodrigues V, Balduci CTN, Montes GC, Barradas PC, Cunha-Rodrigues MC (2024) Emerging therapeutic strategies in hypoxic-ischemic encephalopathy: a focus on cognitive outcomes. Front Pharmacol 15:1347529","journal-title":"Front Pharmacol"},{"issue":"1","key":"6931_CR5","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1111\/ejn.16040","volume":"58","author":"B-Y Luo","year":"2023","unstructured":"Luo B-Y, Zhou H-S, Sun Y-F, Xiao Q-X, Chen L, She H-Q et al (2023) The fate and prospects of stem cell therapy in the treatment of hypoxic-ischemic encephalopathy. Eur J Neurosci 58(1):2384\u20132405","journal-title":"Eur J Neurosci"},{"issue":"5","key":"6931_CR6","doi-asserted-by":"publisher","first-page":"151929","DOI":"10.1016\/j.semperi.2024.151929","volume":"48","author":"A Mintoft","year":"2024","unstructured":"Mintoft A, Vallatos A, Robertson NJ (2024) Mesenchymal Stromal Cell therapy for Hypoxic Ischemic Encephalopathy: Future directions for combination therapy with hypothermia and\/or melatonin. Semin Perinatol 48(5):151929","journal-title":"Semin Perinatol"},{"issue":"2","key":"6931_CR7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s12519-019-00310-x","volume":"16","author":"F Li","year":"2020","unstructured":"Li F, Zhang K, Liu H, Yang T, Xiao D-J, Wang Y-S (2020) The neuroprotective effect of mesenchymal stem cells is mediated through inhibition of apoptosis in hypoxic ischemic injury. World J Pediatr 16(2):193\u2013200","journal-title":"World J Pediatr"},{"issue":"2","key":"6931_CR8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/stcltm\/szab024","volume":"11","author":"L Zhou","year":"2022","unstructured":"Zhou L, McDonald C, Yawno T, Jenkin G, Miller S, Malhotra A (2022) Umbilical cord blood and cord tissue-derived cell therapies for neonatal morbidities: current status and future challenges. Stem Cells Transl Med 11(2):135\u2013145","journal-title":"Stem Cells Transl Med"},{"key":"6931_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1749-6632.2010.05659.x","volume":"1205","author":"XY Zhong","year":"2010","unstructured":"Zhong XY, Zhang B, Asadollahi R, Low SH, Holzgreve W (2010) Umbilical cord blood stem cells: what to expect. Ann N Y Acad Sci 1205:17\u201322","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"6931_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/bio.2019.0063","volume":"18","author":"PH Nguyen","year":"2020","unstructured":"Nguyen PH, Nguyen V-T, Chu TT, Truong L-H, Do TTH, Nguyen TD et al (2020) Factors affecting human umbilical cord blood quality before cryopreservation: the importance of birth weight and gestational age. Biopreserv Biobank 18(1):18\u201324","journal-title":"Biopreserv Biobank"},{"issue":"6","key":"6931_CR11","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.3390\/ijms22063142","volume":"22","author":"I Serrenho","year":"2021","unstructured":"Serrenho I, Rosado M, Dinis AM, Cardoso C, Gr\u00e3os M, Manadas B, Baltazar G (2021) Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies. Int J Molecul Sci 22(6):3142","journal-title":"Int J Molecul Sci"},{"key":"6931_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3389\/fneur.2014.00147","volume":"5","author":"GS Gonzales-Portillo","year":"2014","unstructured":"Gonzales-Portillo GS, Reyes S, Aguirre D, Pabon MM, Borlongan CV (2014) Stem cell therapy for neonatal hypoxic-ischemic encephalopathy. Front Neurol 5:147","journal-title":"Front Neurol"},{"issue":"21","key":"6931_CR13","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1080\/14767058.2018.1468881","volume":"32","author":"Q Wang","year":"2019","unstructured":"Wang Q, Lv H, Lu L, Ren P, Li L (2019) Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury. J Matern Fetal Neonatal Med 32(21):3685\u20133692","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"7","key":"6931_CR14","doi-asserted-by":"publisher","first-page":"4538","DOI":"10.1007\/s12035-023-03848-0","volume":"61","author":"Q-X Xiao","year":"2024","unstructured":"Xiao Q-X, Geng M-J, Sun Y-F, Pi Y, Xiong L-L (2024) Stem cell therapy in neonatal hypoxic-ischemic encephalopathy and cerebral palsy: a bibliometric analysis and new strategy. Mol Neurobiol 61(7):4538\u20134564","journal-title":"Mol Neurobiol"},{"issue":"1","key":"6931_CR15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00381-013-2304-4","volume":"30","author":"L Chicha","year":"2014","unstructured":"Chicha L, Smith T, Guzman R (2014) Stem cells for brain repair in neonatal hypoxia-ischemia. Childs Nerv Syst 30(1):37\u201346","journal-title":"Childs Nerv Syst"},{"issue":"1\u20132","key":"6931_CR16","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/pr.2017.260","volume":"83","author":"M Nabetani","year":"2018","unstructured":"Nabetani M, Shintaku H, Hamazaki T (2018) Future perspectives of cell therapy for neonatal hypoxic-ischemic encephalopathy. Pediatr Res 83(1\u20132):356\u2013363","journal-title":"Pediatr Res"},{"key":"6931_CR17","first-page":"013202","volume":"8","author":"M Bruschettini","year":"2020","unstructured":"Bruschettini M, Romantsik O, Moreira A, Ley D, Th\u00e9baud B (2020) Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants. Cochrane Database Syst Rev 8:013202","journal-title":"Cochrane Database Syst Rev"},{"key":"6931_CR18","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JPA et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700","journal-title":"BMJ"},{"issue":"3","key":"6931_CR19","first-page":"158","volume":"13","author":"HB Sarnat","year":"1977","unstructured":"Sarnat HB (1977) Changing concepts of the absence seizure: a review of the pathogenesis of petit mal epilepsy. Aust Paediatr J 13(3):158\u2013162","journal-title":"Aust Paediatr J"},{"key":"6931_CR20","doi-asserted-by":"publisher","first-page":"108602","DOI":"10.1016\/j.envint.2024.108602","volume":"186","author":"JPT Higgins","year":"2024","unstructured":"Higgins JPT, Morgan RL, Rooney AA, Taylor KW, Thayer KA, Silva RA et al (2024) A tool to assess risk of bias in non-randomized follow-up studies of exposure effects (ROBINS-E). Environ Int 186:108602","journal-title":"Environ Int"},{"key":"6931_CR21","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898","journal-title":"BMJ"},{"key":"6931_CR22","unstructured":"Cotten M. A Phase II Multi-site Study of Autologous Cord Blood Cells for Hypoxic (HIE). clinicaltrials.gov; 2024; [cited 2024 Dec 20].Available from: https:\/\/clinicaltrials.gov\/study\/NCT02612155"},{"issue":"5","key":"6931_CR23","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","volume":"164","author":"CM Cotten","year":"2014","unstructured":"Cotten CM, Murtha AP, Goldberg RN, Grotegut CA, Smith PB, Goldstein RF et al (2014) Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J Pediatr 164(5):973-979.e1","journal-title":"J Pediatr"},{"issue":"6","key":"6931_CR24","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/stcltm\/szad027","volume":"12","author":"CM Cotten","year":"2023","unstructured":"Cotten CM, Fisher K, Malcolm W, Gustafson KE, Cheatham L, Marion A et al (2023) A pilot phase i trial of allogeneic umbilical cord tissue-derived mesenchymal stromal cells in neonates with hypoxic-ischemic encephalopathy. Stem Cells Transl Med 12(6):355\u2013364","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"6931_CR25","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.1038\/s41598-020-61311-9","volume":"10","author":"M Tsuji","year":"2020","unstructured":"Tsuji M, Sawada M, Watabe S, Sano H, Kanai M, Tanaka E et al (2020) Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety. Sci Rep 10(1):4603","journal-title":"Sci Rep"},{"issue":"7109","key":"6931_CR26","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"key":"6931_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1313","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Akl EA, Sch\u00fcnemann HJ (2018) Using systematic reviews in guideline development: the GRADE approach. Res Synth Methods. https:\/\/doi.org\/10.1002\/jrsm.1313","journal-title":"Res Synth Methods"},{"issue":"7414","key":"6931_CR28","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557\u2013560","journal-title":"BMJ"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-06931-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-025-06931-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-06931-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:16:21Z","timestamp":1770815781000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-025-06931-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["6931"],"URL":"https:\/\/doi.org\/10.1007\/s00381-025-06931-0","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"3 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval of this study was exempted by the Institutional review board of All India Institute of Medical Sciences, Rishikesh, India.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"265"}}