{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:12:18Z","timestamp":1770819138867,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00381-025-06976-1","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T04:04:25Z","timestamp":1763784265000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical challenges of cancer predisposition syndromes with pediatric central nervous system tumors: a single-center study"],"prefix":"10.1007","volume":"41","author":[{"given":"Hirohito","family":"Kubota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"6976_CR1","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1093\/neuonc\/noz108","volume":"21","author":"IS Muskens","year":"2019","unstructured":"Muskens IS, Zhang C, De Smith AJ et al (2019) Germline genetic landscape of pediatric central nervous system tumors. Neuro Oncol 21:1376\u20131388. https:\/\/doi.org\/10.1093\/neuonc\/noz108","journal-title":"Neuro Oncol"},{"key":"6976_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01277-w","author":"P Patil","year":"2022","unstructured":"Patil P, Pencheva BB, Patil VM, Fangusaro J (2022) Nervous system (NS) tumors in cancer predisposition syndromes. Neurotherapeutics. https:\/\/doi.org\/10.1007\/s13311-022-01277-w","journal-title":"Neurotherapeutics"},{"key":"6976_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1093\/nop\/npab012","volume":"8","author":"S Farouk Sait","year":"2021","unstructured":"Farouk Sait S, Walsh MF, Karajannis MA (2021) Genetic syndromes predisposing to pediatric brain tumors. Neurooncol Pract 8:375\u2013390. https:\/\/doi.org\/10.1093\/nop\/npab012","journal-title":"Neurooncol Pract"},{"issue":"11","key":"6976_CR4","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1158\/1078-0432.CCR-17-0702","volume":"23","author":"GM Brodeur","year":"2017","unstructured":"Brodeur GM, Nichols KE, Plon SE et al (2017) Pediatric cancer predisposition and surveillance: an overview, and a tribute to Alfred G. Knudson Jr. Clin Cancer Res 23(11):e1\u2013e5. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-0702","journal-title":"Clin Cancer Res"},{"key":"6976_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/gim.2014.175","volume":"17","author":"WLA Fung","year":"2015","unstructured":"Fung WLA, Butcher NJ, Costain G et al (2015) Practical guidelines for managing adults with 22q11.2 deletion syndrome. Genet Med 17:599\u2013609","journal-title":"Genet Med"},{"key":"6976_CR6","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1056\/nejmoa1508054","volume":"373","author":"J Zhang","year":"2015","unstructured":"Zhang J, Walsh MF, Wu G et al (2015) Germline mutations in predisposition genes in pediatric cancer. N Engl J Med 373:2336\u20132346. https:\/\/doi.org\/10.1056\/nejmoa1508054","journal-title":"N Engl J Med"},{"key":"6976_CR7","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1158\/1078-0432.ccr-23-4033","volume":"30","author":"JR Hansford","year":"2024","unstructured":"Hansford JR, Das A, McGee RB et al (2024) Update on cancer predisposition syndromes and surveillance guidelines for childhood brain tumors. Clin Cancer Res 30:2342\u20132350. https:\/\/doi.org\/10.1158\/1078-0432.ccr-23-4033","journal-title":"Clin Cancer Res"},{"key":"6976_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30725","author":"B Roy","year":"2024","unstructured":"Roy B, Knapke S, Pillay-Smiley N et al (2024) Current practice of cancer predisposition testing in pediatric patients with CNS tumors in the United States. Pediatr Blood Cancer. https:\/\/doi.org\/10.1002\/pbc.30725","journal-title":"Pediatr Blood Cancer"},{"key":"6976_CR9","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17:405\u2013424. https:\/\/doi.org\/10.1038\/gim.2015.30","journal-title":"Genet Med"},{"key":"6976_CR10","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1002\/ajmg.a.31443","volume":"140","author":"NH Robin","year":"2006","unstructured":"Robin NH, Taylor CJ, McDonald-McGinn DM et al (2006) Polymicrogyria and deletion 22q11.2 syndrome: window to the etiology of a common cortical malformation. Am J Med Genet A 140:2416\u20132425. https:\/\/doi.org\/10.1002\/ajmg.a.31443","journal-title":"Am J Med Genet A"},{"key":"6976_CR11","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1038\/s41467-021-23097-w","volume":"12","author":"Y Ochi","year":"2021","unstructured":"Ochi Y, Yoshida K, Huang YJ et al (2021) Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia. Nat Commun 12:2833. https:\/\/doi.org\/10.1038\/s41467-021-23097-w","journal-title":"Nat Commun"},{"key":"6976_CR12","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.54157","volume":"6","author":"JJ Bakhuizen","year":"2023","unstructured":"Bakhuizen JJ, Hopman SMJ, Bosscha MI et al (2023) Assessment of cancer predisposition syndromes in a national cohort of children with a neoplasm. JAMA Netw Open 6:E2254157. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.54157","journal-title":"JAMA Netw Open"},{"key":"6976_CR13","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.3390\/cancers14153741","volume":"14","author":"L Rossini","year":"2022","unstructured":"Rossini L, Durante C, Bresolin S et al (2022) Diagnostic strategies and algorithms for investigating cancer predisposition syndromes in children presenting with malignancy. Cancers (Basel) 14:3741. https:\/\/doi.org\/10.3390\/cancers14153741","journal-title":"Cancers (Basel)"},{"key":"6976_CR14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1093\/neuonc\/now254","volume":"19","author":"CN Kline","year":"2017","unstructured":"Kline CN, Joseph NM, Grenert JP et al (2017) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol 19:699\u2013709. https:\/\/doi.org\/10.1093\/neuonc\/now254","journal-title":"Neuro Oncol"},{"key":"6976_CR15","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/s10147-022-02133-9","volume":"27","author":"A Escudero","year":"2022","unstructured":"Escudero A, Ferreras C, Rodriguez-Salas N et al (2022) Cancer predisposing syndrome: a retrospective cohort analysis in a pediatric and multidisciplinary genetic cancer counseling unit. Int J Clin Oncol 27:992\u20131000. https:\/\/doi.org\/10.1007\/s10147-022-02133-9","journal-title":"Int J Clin Oncol"},{"key":"6976_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-226434","volume":"2018","author":"L Nguyen","year":"2018","unstructured":"Nguyen L, Crawford JR (2018) Pineoblastoma in a child with 22q11.2 deletion syndrome. BMJ Case Rep 2018:bcr2018226434. https:\/\/doi.org\/10.1136\/bcr-2018-226434","journal-title":"BMJ Case Rep"},{"key":"6976_CR17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00401-019-02111-y","volume":"139","author":"BK Li","year":"2020","unstructured":"Li BK, Vasiljevic A, Dufour C et al (2020) Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a rare brain tumor consortium registry study. Acta Neuropathol 139:223\u2013241. https:\/\/doi.org\/10.1007\/s00401-019-02111-y","journal-title":"Acta Neuropathol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-06976-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-025-06976-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-06976-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:57Z","timestamp":1770815877000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-025-06976-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["6976"],"URL":"https:\/\/doi.org\/10.1007\/s00381-025-06976-1","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"26 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"370"}}