{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:33:23Z","timestamp":1792172003229,"version":"4.4.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00381-025-06982-3","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:29:44Z","timestamp":1761125384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Desmoplastic infantile ganglioglioma and astrocytoma: A narrative review of the literature"],"prefix":"10.1007","volume":"41","author":[{"given":"Marios","family":"Lampros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Baxevanidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsegkelidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Voulgaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"3","key":"6982_CR1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1750-3639.1993.tb00754.x","volume":"3","author":"SR VandenBerg","year":"1993","unstructured":"VandenBerg SR (1993) Desmoplastic infantile ganglioglioma and desmoplastic cerebral astrocytoma of infancy. Brain Pathol 3(3):275\u2013281","journal-title":"Brain Pathol"},{"issue":"8","key":"6982_CR2","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al (2021) The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncol 23(8):1231\u20131251","journal-title":"Neuro-Oncol"},{"issue":"6","key":"6982_CR3","first-page":"1028","volume":"25","author":"G Trehan","year":"2004","unstructured":"Trehan G, Bruge H, Vinchon M, Khalil C, Ruchoux MM, Dhellemmes P et al (2004) MR imaging in the diagnosis of desmoplastic infantile tumor: retrospective study of six cases. AJNR Am J Neuroradiol 25(6):1028\u20131033","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"6982_CR4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11060-021-03860-1","volume":"155","author":"S Wang","year":"2021","unstructured":"Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A et al (2021) Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA). J Neurooncol 155(2):155\u2013163","journal-title":"J Neurooncol"},{"issue":"11","key":"6982_CR5","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1097\/00000478-200211000-00015","volume":"26","author":"K De Munnynck","year":"2002","unstructured":"De Munnynck K, Van Gool S, Van Calenbergh F, Demaerel Ph, Uyttebroeck A, Buyse G et al (2002) Desmoplastic infantile ganglioglioma: a potentially malignant tumor? Am J Surg Pathol 26(11):1515\u20131522","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"6982_CR6","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1007\/s00381-016-3149-4","volume":"32","author":"F Bianchi","year":"2016","unstructured":"Bianchi F, Tamburrini G, Massimi L, Caldarelli M (2016) Supratentorial tumors typical of the infantile age: desmoplastic infantile ganglioglioma (DIG) and astrocytoma (DIA). A review. Childs Nerv Syst 32(10):1833\u20131838","journal-title":"Childs Nerv Syst"},{"issue":"372","key":"6982_CR7","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"29","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 29(372):n71","journal-title":"BMJ"},{"issue":"11","key":"6982_CR8","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1002\/1097-0142(19841201)54:11<2505::AID-CNCR2820541132>3.0.CO;2-G","volume":"54","author":"AL Taratuto","year":"1984","unstructured":"Taratuto AL, Monges J, Lylyk P, Leiguarda R (1984) Superficial cerebral astrocytoma attached to dura Report of six cases in infants. Cancer 54(11):2505\u20132512","journal-title":"Cancer"},{"issue":"3","key":"6982_CR9","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/00005072-197805000-00007","volume":"37","author":"RL Friede","year":"1978","unstructured":"Friede RL (1978) Gliofibroma. A peculiar neoplasia of collagen forming glia-like cells. J Neuropathol Exp Neurol 37(3):300\u2013313","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"6982_CR10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3171\/jns.1987.66.1.0058","volume":"66","author":"SR VandenBerg","year":"1987","unstructured":"VandenBerg SR, May EE, Rubinstein LJ, Herman MM, Perentes E, Vinores SA et al (1987) Desmoplastic supratentorial neuroepithelial tumors of infancy with divergent differentiation potential (\u201cdesmoplastic infantile gangliogliomas\u201d). Report on 11 cases of a distinctive embryonal tumor with favorable prognosis. J Neurosurg 66(1):58\u201371","journal-title":"J Neurosurg"},{"issue":"1","key":"6982_CR11","doi-asserted-by":"publisher","first-page":"vdae050","DOI":"10.1093\/noajnl\/vdae050","volume":"6","author":"MI Barros Guinle","year":"2024","unstructured":"Barros Guinle MI, Nirschl JJ, Xing YL, Nettnin EA, Arana S, Feng ZP et al (2024) CDC42BPA::BRAF represents a novel fusion in desmoplastic infantile ganglioglioma\/desmoplastic infantile astrocytoma. Neuro-Oncol Adv 6(1):vdae050","journal-title":"Neuro-Oncol Adv"},{"issue":"10","key":"6982_CR12","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1158\/1541-7786.MCR-17-0507","volume":"16","author":"AC Wang","year":"2018","unstructured":"Wang AC, Jones DTW, Abecassis IJ, Cole BL, Leary SES, Lockwood CM et al (2018) Desmoplastic infantile ganglioglioma\/astrocytoma (DIG\/DIA) are distinct entities with frequent BRAFV600 mutations. Mol Cancer Res 16(10):1491\u20131498","journal-title":"Mol Cancer Res"},{"issue":"6","key":"6982_CR13","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131(6):803\u2013820","journal-title":"Acta Neuropathol"},{"issue":"12","key":"6982_CR14","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/s00381-011-1587-6","volume":"27","author":"JH Phi","year":"2011","unstructured":"Phi JH, Koh EJ, Kim SK, Park SH, Cho BK, Wang KC (2011) Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report. Childs Nerv Syst 27(12):2177\u20132181","journal-title":"Childs Nerv Syst"},{"issue":"1","key":"6982_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01392-x","volume":"10","author":"J Meg\u00edas","year":"2022","unstructured":"Meg\u00edas J, San-Miguel T, S\u00e1nchez M, Navarro L, Monle\u00f3n D, Calabuig-Fari\u00f1as S et al (2022) Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation. Acta Neuropathol Commun 10(1):88","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"6982_CR16","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/bcp.12651","volume":"80","author":"R Rissmann","year":"2015","unstructured":"Rissmann R, Hessel MHM, Cohen AF (2015) Vemurafenib\/dabrafenib and trametinib. Br J Clin Pharmacol 80(4):765\u2013767","journal-title":"Br J Clin Pharmacol"},{"key":"6982_CR17","doi-asserted-by":"crossref","unstructured":"Dias DJL, Dias ASDS, Camargo MV, Lederman HM (2023) MRI Findings of Desmoplastic Infantile Ganglioglioma: A Case Report and Analysis. Cureus [Internet]. 2023 Aug 19 [cited 2025 Feb 11]; Available from: https:\/\/www.cureus.com\/articles\/174057-mri-findings-of-desmoplastic-infantile-ganglioglioma-a-case-report-and-analysis","DOI":"10.7759\/cureus.43770"},{"issue":"1","key":"6982_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s11060-009-0075-2","volume":"98","author":"E Uro-Coste","year":"2010","unstructured":"Uro-Coste E, Ssi-Yan-Kai G, Guilbeau-Frugier C, Boetto S, Bertozzi AI, Sevely A et al (2010) Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation. J Neurooncol 98(1):143\u2013149","journal-title":"J Neurooncol"},{"issue":"11","key":"6982_CR19","doi-asserted-by":"publisher","first-page":"608129","DOI":"10.3389\/fonc.2021.608129","volume":"9","author":"Q Wang","year":"2022","unstructured":"Wang Q, Meng J, Cheng J, Zhang S, Hui X, Li Q et al (2022) Multifocal Desmoplastic Infantile Ganglioglioma\/Astrocytoma (DIA\/DIG): An Institutional Series Report and a Clinical Summary of This Rare Tumor. Front Oncol 9(11):608129","journal-title":"Front Oncol"},{"issue":"4","key":"6982_CR20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3171\/2018.4.PEDS17638","volume":"22","author":"RM Naylor","year":"2018","unstructured":"Naylor RM, Wohl A, Raghunathan A, Eckel LJ, Keating GF, Daniels DJ (2018) Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution\u2019s experience. J Neurosurg Pediatr 22(4):397\u2013403","journal-title":"J Neurosurg Pediatr"},{"issue":"5","key":"6982_CR21","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.jocn.2006.01.024","volume":"14","author":"B Darwish","year":"2007","unstructured":"Darwish B, Arbuckle S, Kellie S, Besser M, Chaseling R (2007) Desmoplastic infantile ganglioglioma\/astrocytoma with cerebrospinal metastasis. J Clin Neurosci 14(5):498\u2013501","journal-title":"J Clin Neurosci"},{"issue":"1","key":"6982_CR22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s13256-022-03615-0","volume":"16","author":"MH Habib","year":"2022","unstructured":"Habib MH, Alavi MZ, Goraya A, Zaman S, Ahmed A (2022) High-grade desmoplastic infantile astrocytoma in a 1-year-old child with Down\u2019s syndrome: a case report. J Med Case Reports 16(1):427","journal-title":"J Med Case Reports"},{"issue":"1","key":"6982_CR23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3171\/PED-08\/01\/095","volume":"1","author":"EW Hoving","year":"2008","unstructured":"Hoving EW, Kros JM, Groninger E, den Dunnen WFA (2008) Desmoplastic infantile ganglioglioma with a malignant course. J Neurosurg Pediatr 1(1):95\u201398","journal-title":"J Neurosurg Pediatr"},{"issue":"4","key":"6982_CR24","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1227\/01.NEU.0000084165.60662.6D","volume":"53","author":"H Takeshima","year":"2003","unstructured":"Takeshima H, Kawahara Y, Hirano H, Obara S, Niiro M, Kuratsu J (2003) Postoperative regression of desmoplastic infantile gangliogliomas: report of two cases. Neurosurgery 53(4):979\u2013984","journal-title":"Neurosurgery"},{"issue":"3","key":"6982_CR25","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1750-3639.2012.00590.x","volume":"22","author":"S Costa","year":"2012","unstructured":"Costa S, Marques J, Pereira P, Firmo C, Pimentel J (2012) 23-year-old man with a superficial cortical brain tumor. Brain Pathol 22(3):429\u2013432","journal-title":"Brain Pathol"},{"issue":"11","key":"6982_CR26","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1093\/jnen\/nlz086","volume":"1","author":"MM Blessing","year":"2019","unstructured":"Blessing MM, Blackburn PR, Krishnan C, Harrod VL, Barr Fritcher EG, Zysk CD, Jackson RA, Milosevic D, Nair AA, Davila JI, Balcom JR, Jenkins RB, Halling KC, Kipp BR, Nageswara Rao AA, Laack NN, Daniels DJ, Macon WR, Ida CM (2019) Desmoplastic infantile ganglioglioma: a MAPK pathway-driven and microglia\/macrophage-rich neuroepithelial tumor. J Neuropathol Exp Neurol 1(11):1011\u20131021. https:\/\/doi.org\/10.1093\/jnen\/nlz086","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"6982_CR27","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3171\/2019.5.PEDS19151","volume":"24","author":"AR Cohen","year":"2019","unstructured":"Cohen AR (2019) The great neurosurgical masquerader: 3 cases of desmoplastic infantile ganglioglioma. J Neurosurg Pediatr 24(3):258\u2013266. https:\/\/doi.org\/10.3171\/2019.5.PEDS19151","journal-title":"J Neurosurg Pediatr"},{"key":"6982_CR28","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.humpath.2018.06.005","volume":"80","author":"D Chatterjee","year":"2018","unstructured":"Chatterjee D, Garg C, Singla N, Radotra BD (2018) Desmoplastic non-infantile astrocytoma\/ganglioglioma: rare low-grade tumor with frequent BRAF V600E mutation. Hum Pathol 80:186\u2013191. https:\/\/doi.org\/10.1016\/j.humpath.2018.06.005","journal-title":"Hum Pathol"},{"issue":"6","key":"6982_CR29","doi-asserted-by":"publisher","first-page":"e12801","DOI":"10.1111\/nan.12801","volume":"48","author":"JC Chiang","year":"2022","unstructured":"Chiang JC, Ellison DW, Biegel JA, Judkins AR (2022) Molecular classification of glioneuronal tumors: relevance to tumor biology and clinical practice. Neuropathol Appl Neurobiol 48(6):e12801. https:\/\/doi.org\/10.1111\/nan.12801","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-06982-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-025-06982-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-06982-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:42Z","timestamp":1770815862000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-025-06982-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["6982"],"URL":"https:\/\/doi.org\/10.1007\/s00381-025-06982-3","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"28 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Non applicated.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"324"}}