{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:46:27Z","timestamp":1793295987024,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00381-025-07049-z","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T15:15:00Z","timestamp":1763997300000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Paroxysmal sympathetic hyperactivity in tubercular meningitis: An underacknowledged association"],"prefix":"10.1007","volume":"41","author":[{"given":"Aanchal","family":"Datta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Vishnu","family":"Vardhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhitij","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"7049_CR1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/ana.22066","volume":"68","author":"I Perkes","year":"2010","unstructured":"Perkes I, Baguley IJ, Nott MT, Menon DK (2010) A review of paroxysmal sympathetic hyperactivity after acquired brain injury. Ann Neurol 68:126\u2013135. https:\/\/doi.org\/10.1002\/ana.22066","journal-title":"Ann Neurol"},{"issue":"7","key":"7049_CR2","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1089\/neu.2011.2033","volume":"29","author":"JF Fernandez-Ortega","year":"2012","unstructured":"Fernandez-Ortega JF, Prieto-Palomino MA, Garcia-Caballero M, Galeas-Lopez JL, Quesada-Garcia G, Baguley IJ (2012) Paroxysmal sympathetic hyperactivity after traumatic brain injury: clinical and prognostic implications. J Neurotrauma 29(7):1364\u20131370. https:\/\/doi.org\/10.1089\/neu.2011.2033","journal-title":"J Neurotrauma"},{"key":"7049_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/S40064-016-1898-X","author":"S Lee","year":"2016","unstructured":"Lee S, Jun GW, Jeon SB, Kim CJ, Kim JH (2016) Paroxysmal sympathetic hyperactivity in brainstem-compressing huge benign tumors: clinical experiences and literature review. Springerplus. https:\/\/doi.org\/10.1186\/S40064-016-1898-X","journal-title":"Springerplus"},{"key":"7049_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/FNEUR.2020.00081","volume":"11","author":"RZ Zheng","year":"2020","unstructured":"Zheng RZ, Lei ZQ, Yang RZ, Huang GH, Zhang GM (2020) Identification and management of paroxysmal sympathetic hyperactivity after traumatic brain injury. Front Neurol 11:81. https:\/\/doi.org\/10.3389\/FNEUR.2020.00081","journal-title":"Front Neurol"},{"key":"7049_CR5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.24953\/TURKJPED.2020.3609","volume":"64","author":"PY \u00d6zkaya","year":"2022","unstructured":"\u00d6zkaya PY, Turanl\u0131 EE, Ar\u0131 HF, Kurt S, Karap\u0131nar B (2022) Cardiac failure in a child with tuberculous meningitis as a complication of paroxysmal sympathetic hyperactivity. Turk J Pediatr 64:381\u2013384. https:\/\/doi.org\/10.24953\/TURKJPED.2020.3609","journal-title":"Turk J Pediatr"},{"issue":"3","key":"7049_CR6","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/S12028-015-0124-Y","volume":"23","author":"R Farias-Moeller","year":"2015","unstructured":"Farias-Moeller R, Carpenter JL, Dean N, Wells EM (2015) Paroxysmal Sympathetic Hyperactivity in Critically Ill Children with Encephalitis and Meningoencephalitis. Neurocrit Care 23(3):380\u2013385. https:\/\/doi.org\/10.1007\/S12028-015-0124-Y","journal-title":"Neurocrit Care"},{"key":"7049_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/S11910-013-0370-3","author":"HA Choi","year":"2013","unstructured":"Choi HA, Jeon SB, Samuel S, Allison T, Lee K (2013) Paroxysmal sympathetic hyperactivity after acute brain injury. Curr Neurol Neurosci Rep. https:\/\/doi.org\/10.1007\/S11910-013-0370-3","journal-title":"Curr Neurol Neurosci Rep"},{"key":"7049_CR8","doi-asserted-by":"publisher","unstructured":"Dichoso LP, Pagaling G, Roland RD, Veeda VM. Case Report: Paroxysmal autonomic instability with dystonia syndrome: a rare complication of tuberculous meningitis. F1000Res 2023;12. https:\/\/doi.org\/10.12688\/F1000RESEARCH.141196.1.","DOI":"10.12688\/F1000RESEARCH.141196.1"},{"key":"7049_CR9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1177\/08830738241276234","volume":"39","author":"P Jauhari","year":"2024","unstructured":"Jauhari P, Singh S, Jain A, Sundaram MS, Kamila G, Sinha R et al (2024) Paroxysmal sympathetic hyperactivity in childhood tuberculous meningitis: a new association. J Child Neurol 39:403\u2013408. https:\/\/doi.org\/10.1177\/08830738241276234","journal-title":"J Child Neurol"},{"key":"7049_CR10","unstructured":"Slane VH, Unakal CG. Tuberculous Meningitis. StatPearls 2024."},{"key":"7049_CR11","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1136\/JNNP.69.6.832","volume":"69","author":"D Do","year":"2000","unstructured":"Do D, Sheen VL, Bromfield E (2000) Treatment of paroxysmal sympathetic storm with labetalol. J Neurol Neurosurg Psychiatry 69:832\u2013833. https:\/\/doi.org\/10.1136\/JNNP.69.6.832","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"7049_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4103\/0972-5229.148638","volume":"19","author":"R Verma","year":"2015","unstructured":"Verma R, Giri P, Rizvi I (2015) Paroxysmal sympathetic hyperactivity in neurological critical care. Indian J Crit Care Med 19:34. https:\/\/doi.org\/10.4103\/0972-5229.148638","journal-title":"Indian J Crit Care Med"},{"key":"7049_CR13","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0025-6196(11)63647-1","volume":"73","author":"BF Boeve","year":"1998","unstructured":"Boeve BF, Wijdicks EFM, Benarroch EE, Schmidt KD (1998) Paroxysmal sympathetic storms (\u201cdiencephalic seizures\u201d) after severe diffuse axonal head injury. Mayo Clin Proc 73:148\u2013152. https:\/\/doi.org\/10.1016\/S0025-6196(11)63647-1","journal-title":"Mayo Clin Proc"},{"key":"7049_CR14","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/088307389100600204","volume":"6","author":"MR Pranzatelli","year":"1991","unstructured":"Pranzatelli MR, Pavlakis SG, Gould RJ (1991) Hypothalamic-midbrain dysregulation syndrome: hypertension, hyperthermia, hyperventilation, and decerebration. J Child Neurol 6:115\u2013122. https:\/\/doi.org\/10.1177\/088307389100600204","journal-title":"J Child Neurol"},{"key":"7049_CR15","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.144632","volume":"5","author":"KS Meyer","year":"2014","unstructured":"Meyer KS (2014) Understanding paroxysmal sympathetic hyperactivity after traumatic brain injury. Surg Neurol Int 5:S490. https:\/\/doi.org\/10.4103\/2152-7806.144632","journal-title":"Surg Neurol Int"},{"key":"7049_CR16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3109\/02688698809029601","volume":"2","author":"E Rossitch","year":"1988","unstructured":"Rossitch E, Bullard DE (1988) The autonomic dysfunction syndrome: aetiology and treatment. Br J Neurosurg 2:471\u2013478. https:\/\/doi.org\/10.3109\/02688698809029601","journal-title":"Br J Neurosurg"},{"key":"7049_CR17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1474-4422(17)30259-4","volume":"16","author":"G Meyfroidt","year":"2017","unstructured":"Meyfroidt G, Baguley IJ, Menon DK (2017) Paroxysmal sympathetic hyperactivity: the storm after acute brain injury. Lancet Neurol 16:721\u2013729. https:\/\/doi.org\/10.1016\/S1474-4422(17)30259-4","journal-title":"Lancet Neurol"},{"key":"7049_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/S12028-007-9021-3","volume":"8","author":"IJ Baguley","year":"2008","unstructured":"Baguley IJ, Heriseanu RE, Cameron ID, Nott MT, Slewa-Younan S (2008) A critical review of the pathophysiology of dysautonomia following traumatic brain injury. Neurocrit Care 8:293\u2013300. https:\/\/doi.org\/10.1007\/S12028-007-9021-3","journal-title":"Neurocrit Care"},{"key":"7049_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/J.MEHY.2007.04.037","volume":"70","author":"IJ Baguley","year":"2008","unstructured":"Baguley IJ (2008) The excitatory:inhibitory ratio model (EIR model): an integrative explanation of acute autonomic overactivity syndromes. Med Hypotheses 70:26\u201335. https:\/\/doi.org\/10.1016\/J.MEHY.2007.04.037","journal-title":"Med Hypotheses"},{"key":"7049_CR20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0022-510X(85)90038-3","volume":"71","author":"AI Bhigjee","year":"1985","unstructured":"Bhigjee AI, Ames FR (1985) Adult aqueduct stenosis and diencephalic epilepsy. A case report. J Neurol Sci 71:77\u201389. https:\/\/doi.org\/10.1016\/0022-510X(85)90038-3","journal-title":"J Neurol Sci"},{"key":"7049_CR21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/PHM.0000000000000990","volume":"98","author":"A Thomas","year":"2019","unstructured":"Thomas A, Greenwald BD (2019) Paroxysmal sympathetic hyperactivity and clinical considerations for patients with acquired brain injuries: a narrative review. Am J Phys Med Rehabil 98:65\u201372. https:\/\/doi.org\/10.1097\/PHM.0000000000000990","journal-title":"Am J Phys Med Rehabil"},{"key":"7049_CR22","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cnur.2018.05.003","volume":"53","author":"E Compton","year":"2018","unstructured":"Compton E (2018) Paroxysmal sympathetic hyperactivity syndrome following traumatic brain injury. Nurs Clin North Am 53:459\u2013467. https:\/\/doi.org\/10.1016\/j.cnur.2018.05.003","journal-title":"Nurs Clin North Am"},{"key":"7049_CR23","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1080\/02699050701687375","volume":"21","author":"IJ Baguley","year":"2007","unstructured":"Baguley IJ, Slewa-Younan S, Heriseanu RE, Nott MT, Mudaliar Y, Nayyar V (2007) The incidence of dysautonomia and its relationship with autonomic arousal following traumatic brain injury. Brain Inj 21:1175\u20131181. https:\/\/doi.org\/10.1080\/02699050701687375","journal-title":"Brain Inj"},{"key":"7049_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1136\/JNNP.67.1.39","volume":"67","author":"IJ Baguley","year":"1999","unstructured":"Baguley IJ, Nicholls JL, Felmingham KL, Crooks J, Gurka JA, Wade LD (1999) Dysautonomia after traumatic brain injury: a forgotten syndrome? J Neurol Neurosurg Psychiatry 67:39. https:\/\/doi.org\/10.1136\/JNNP.67.1.39","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"7049_CR25","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1089\/NEU.2013.3301","volume":"31","author":"IJ Baguley","year":"2014","unstructured":"Baguley IJ, Perkes IE, Fernandez-Ortega JF, Rabinstein AA, Dolce G, Hendricks HT (2014) Paroxysmal sympathetic hyperactivity after acquired brain injury: consensus on conceptual definition, nomenclature, and diagnostic criteria. J Neurotrauma 31:1515\u20131520. https:\/\/doi.org\/10.1089\/NEU.2013.3301","journal-title":"J Neurotrauma"},{"key":"7049_CR26","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1089\/NEU.2014.3540","volume":"31","author":"M Pozzi","year":"2014","unstructured":"Pozzi M, Locatelli F, Galbiati S, Radice S, Clementi E, Strazzer S (2014) Clinical scales for paroxysmal sympathetic hyperactivity in pediatric patients. J Neurotrauma 31:1897\u20131898. https:\/\/doi.org\/10.1089\/NEU.2014.3540","journal-title":"J Neurotrauma"},{"key":"7049_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/S11940-008-0016-Y","volume":"10","author":"AA Rabinstein","year":"2008","unstructured":"Rabinstein AA, Benarroch EE (2008) Treatment of paroxysmal sympathetic hyperactivity. Curr Treat Options Neurol 10:151\u2013157. https:\/\/doi.org\/10.1007\/S11940-008-0016-Y","journal-title":"Curr Treat Options Neurol"},{"key":"7049_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/421563","volume":"2015","author":"JW Siefferman","year":"2015","unstructured":"Siefferman JW, Lai G (2015) Propranolol for paroxysmal sympathetic hyperactivity with lateralizing hyperhidrosis after stroke. Case Rep Neurol Med 2015:1\u20133. https:\/\/doi.org\/10.1155\/2015\/421563","journal-title":"Case Rep Neurol Med"},{"key":"7049_CR29","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/MDS.870060424","volume":"6","author":"C-S Lu","year":"1991","unstructured":"Lu C-S, Ryu S-J (1991) Neuroleptic malignant\u2010like syndrome associated with acute hydrocephalus. Mov Disord 6:381\u2013383. https:\/\/doi.org\/10.1002\/MDS.870060424","journal-title":"Mov Disord"},{"key":"7049_CR30","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1001\/ARCHNEUR.1988.00520330129022","volume":"45","author":"WT Talman","year":"1988","unstructured":"Talman WT, Florek G, Bullard DE (1988) A hyperthermic syndrome in two subjects with acute hydrocephalus. Arch Neurol 45:1037\u20131040. https:\/\/doi.org\/10.1001\/ARCHNEUR.1988.00520330129022","journal-title":"Arch Neurol"},{"key":"7049_CR31","unstructured":"Global TB Programme World Health Organization 2014."},{"key":"7049_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCTUBE.2021.100255","volume":"24","author":"A Rai","year":"2021","unstructured":"Rai A, Prasad R, Das BK, Anupurba S, Singh UK (2021) Cerebrospinal fluid gene XPERT (CBNAAT) in children with tuberculous meningitis. J Clin Tuberc Other Mycobact Dis 24:100255. https:\/\/doi.org\/10.1016\/J.JCTUBE.2021.100255","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"7049_CR33","doi-asserted-by":"publisher","unstructured":"Raghupathy N, Belinda N, T JK. 456 International Journal of Academic Medicine and Pharmacy (www.academicmed.org) TUBERCULOUS VASCULITIS-A RARE CASE PRESENTATION n.d. https:\/\/doi.org\/10.47009\/jamp.2023.5.4.290.","DOI":"10.47009\/jamp.2023.5.4.290"},{"key":"7049_CR34","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4103\/JGID.JGID_24_23","volume":"15","author":"R Verma","year":"2023","unstructured":"Verma R, Chakraborty R (2023) Extensive vasculitis in tuberculous meningitis. J Glob Infect Dis 15:169. https:\/\/doi.org\/10.4103\/JGID.JGID_24_23","journal-title":"J Glob Infect Dis"},{"key":"7049_CR35","doi-asserted-by":"publisher","DOI":"10.1136\/BCR-2024-262681","volume":"17","author":"S Valliappan","year":"2024","unstructured":"Valliappan S, Indiran M, Mallikarjuna SK, Arumugam GS (2024) Atypical presentation of tuberculous vasculitis: dual large vessel occlusions leading to malignant ischaemic stroke. BMJ Case Rep CP 17:e262681. https:\/\/doi.org\/10.1136\/BCR-2024-262681","journal-title":"BMJ Case Rep CP"},{"issue":"1","key":"7049_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/1971400919881188","volume":"33","author":"N Soni","year":"2019","unstructured":"Soni N, Kumar S, Shimle A, Ora M, Bathla G, Mishra P (2019) Cerebrovascular complications in tuberculous meningitis\u2014a magnetic resonance imaging study in 90 patients from a tertiary care hospital. Neuroradiol J 33(1):3\u201316. https:\/\/doi.org\/10.1177\/1971400919881188","journal-title":"Neuroradiol J"},{"key":"7049_CR37","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S1695-4033(04)78427-1","volume":"61","author":"J Gil Ant\u00f3n","year":"2004","unstructured":"Gil Ant\u00f3n J, L\u00f3pez Bay\u00f3n J, L\u00f3pez Fern\u00e1ndez Y, Pilar OJ (2004) Autonomic dysfunction syndrome secondary to tuberculous meningitis. An Pediatr (Barc) 61:449\u2013450. https:\/\/doi.org\/10.1016\/S1695-4033(04)78427-1","journal-title":"An Pediatr (Barc)"},{"key":"7049_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-304","volume":"4","author":"NA Ramdhani","year":"2010","unstructured":"Ramdhani NA, Sikma MA, Witkamp TD, Slooter AJ, Lange D Wde (2010) Paroxysmal autonomic instability with dystonia in a patient with tuberculous meningitis: a case report. J Med Case Rep 4:304. https:\/\/doi.org\/10.1186\/1752-1947-4-304","journal-title":"J Med Case Rep"},{"key":"7049_CR39","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1159\/000334276","volume":"47","author":"DK Singh","year":"2012","unstructured":"Singh DK, Singh N (2012) Paroxysmal autonomic instability with dystonia in a child: rare manifestation of an interpeduncular tuberculoma. Pediatr Neurosurg 47:275\u2013278. https:\/\/doi.org\/10.1159\/000334276","journal-title":"Pediatr Neurosurg"},{"key":"7049_CR40","doi-asserted-by":"publisher","first-page":"543","DOI":"10.7727\/wimj.2016.055","volume":"64","author":"Y Xu","year":"2015","unstructured":"Xu Y, Wan L, Ning J, Guo W, Ren L (2015) Paroxysmal Sympathetic Hyperactivity in a Child with Tuberculous Meningitis A Case Study and Review of Related Literature Hiperactividad Simp\u00e1tica Parox\u00edstica en un Ni\u00f1o con Meningitis Tuberculosa: Un Estudio de Caso y Revisi\u00f3n de Literatura Relacionada. West Indian Med J 64:543. https:\/\/doi.org\/10.7727\/wimj.2016.055","journal-title":"West Indian Med J"},{"key":"7049_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJSCR.2022.107619","author":"AMP Siahaan","year":"2022","unstructured":"Siahaan AMP, Tandean S, Indharty RS, Nainggolan BWM, Susanto M (2022) Paroxysmal sympathetic hyperactivity syndrome in tuberculous meningitis with paradoxical reaction. Int J Surg Case Rep. https:\/\/doi.org\/10.1016\/J.IJSCR.2022.107619","journal-title":"Int J Surg Case Rep"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-07049-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-025-07049-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-025-07049-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:54Z","timestamp":1770815874000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-025-07049-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["7049"],"URL":"https:\/\/doi.org\/10.1007\/s00381-025-07049-z","relation":{},"ISSN":["0256-7040","1433-0350"],"issn-type":[{"value":"0256-7040","type":"print"},{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"5 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Yes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Yes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"377"}}