{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:50:58Z","timestamp":1777621858342,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Cape Town"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosette-forming glioneuronal tumor (RGNT) is a rare, low-grade glioneuronal neoplasm of the posterior fossa, most commonly affecting children and young adults. Although typically indolent, its variable clinical and radiologic presentation may pose diagnostic and management challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>The present case is that of a 19-year-old woman who presented with headache and vomiting and was found to have a hemorrhagic, multicystic lesion centered on the right cerebellar peduncle. Serial radiological imaging demonstrated lesion persistence and stability over a period of more than 12\u00a0months, prompting surgical debulking. Histopathologic examination revealed a biphasic glioneuronal tumor composed of true neuropil-centered neurocytic rosettes within a fibrillary glial background. Immunohistochemistry revealed synaptophysin positivity within the rosette cores, glial fibrillary acidic protein\u00a0(GFAP) expression confined to the glial component, and a low proliferative index (&lt;\u20091%), meeting the World Health Organization (WHO) essential diagnostic criteria for RGNT, CNS WHO grade 1. Molecular testing was not performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates the diagnostic value of integrated clinical, radiologic, and pathologic assessment in establishing a confident diagnosis of RGNT, even in the setting of atypical hemorrhagic presentation. Recognition of classic morphologic and immunophenotypic features remains central to accurate diagnosis and appropriate management, particularly in resource-limited settings where access to molecular testing is limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00381-026-07284-y","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:53:16Z","timestamp":1777413196000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosette-forming glioneuronal tumor of the cerebellum with intratumoral hemorrhage: case report with radiologic\u2013pathologic correlation in a resource-limited setting"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-7655","authenticated-orcid":false,"given":"Raymond","family":"Chimatira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"7284_CR1","unstructured":"Hainfeller JA, Jacques TS, Rosenblum MK et al (2022) Rosette-forming glioneuronal tumour. 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