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This report reviews the literature on neurodevelopmental outcome in SS and presents our experience with 488 children who underwent open, wide, strip craniectomy and were evaluated for long-term functional outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative literature review was conducted using PubMed and Google Scholar to identify studies reporting neurodevelopmental, cognitive, or functional outcomes in children with SS. In parallel, a retrospective cohort included children who underwent early, wide, open strip craniectomy for isolated SS between 1999 and 2022, with a minimum follow-up of two years. Functional outcomes were assessed using structured parental telephone questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-two original research articles and six review studies met inclusion criteria, showing heterogeneous methodologies but generally normal long-term neurodevelopmental outcome with occasional mild, domain-specific vulnerabilities. In our cohort, 488 children (397 males) had a mean follow-up of 9.4\u2009\u00b1\u20096.3\u00a0years (range 2\u201325). The majority demonstrated normal\n                      <jats:italic>functional<\/jats:italic>\n                      development. Educational support was rarely required, and no neurodevelopmental or functional limitations related to surgery were identified in adulthood. Among 386 children of school age, mild reading difficulties were reported in 8 children (2.3%). 3\/488 patients (0.6%) required secondary surgical intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both the literature review and our cohort suggest that children with isolated sagittal synostosis who undergo early surgical correction generally have favorable long-term functional and neurodevelopmental outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00381-026-07292-y","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:14:50Z","timestamp":1777850090000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuro-developmental outcome in sagittal synostosis; Analysis of 488 children in the context of the existing literature"],"prefix":"10.1007","volume":"42","author":[{"given":"May","family":"Brami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapir","family":"Sadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehuda","family":"Soleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Leshem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Constantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"7292_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1055\/s-2003-44667","volume":"34","author":"E Boltshauser","year":"2003","unstructured":"Boltshauser E, Ludwig S, Dietrich F, Landolt M (2003) Sagittal craniosynostosis: cognitive development, behaviour, and quality of life in unoperated children. 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