{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:18:41Z","timestamp":1783361921596,"version":"3.54.6"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Childs Nerv Syst"],"DOI":"10.1007\/s00381-026-07364-z","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:50:37Z","timestamp":1783360237000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare child primary intracranial sarcoma associated with DICER1 mutation: a case report and review of the literature"],"prefix":"10.1007","volume":"42","author":[{"given":"YaXuan","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AXue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnGen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"issue":"8","key":"7364_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231\u20131251. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"issue":"1","key":"7364_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40478-023-01522-z","volume":"11","author":"A Tauzi\u00e8de-Espariat","year":"2023","unstructured":"Tauzi\u00e8de-Espariat A, Hasty L, M\u00e9tais A, Varlet P (2023) Mesenchymal non-meningothelial tumors of the central nervous system: a literature review and diagnostic update of novelties and emerging entities. Acta Neuropathol Commun 11(1):22. https:\/\/doi.org\/10.1186\/s40478-023-01522-z","journal-title":"Acta Neuropathol Commun"},{"issue":"12","key":"7364_CR3","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3760\/cma.j.cn112151-20240530-00353","volume":"53","author":"L Qiu","year":"2024","unstructured":"Qiu L, Xi S, Fu L et al (2024) Primary intracranial DICER1-mutant sarcoma: a clinicopathological analysis of seven cases. Chin J Pathol 53(12):1231\u20131237. https:\/\/doi.org\/10.3760\/cma.j.cn112151-20240530-00353","journal-title":"Chin J Pathol"},{"issue":"12","key":"7364_CR4","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3760\/cma.j.cn112151-20210825-00602","volume":"50","author":"L Junlei","year":"2021","unstructured":"Junlei L, Meng Z, Lei C et al (2021) DICER1 and relevant tumor. Chinese Journal of Pathology 50(12):1419\u20131422. https:\/\/doi.org\/10.3760\/cma.j.cn112151-20210825-00602","journal-title":"Chinese Journal of Pathology"},{"issue":"07","key":"7364_CR5","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3760\/cma.j.cn112141-20191107-00605","volume":"55","author":"L Zhang","year":"2020","unstructured":"Zhang L, Hong Y, Hua D (2020) Research progress on tumors associated with DICER1 syndrome. Chin J Obstet Gynecol 55(07):498\u2013502. https:\/\/doi.org\/10.3760\/cma.j.cn112141-20191107-00605","journal-title":"Chin J Obstet Gynecol"},{"issue":"1","key":"7364_CR6","doi-asserted-by":"publisher","first-page":"3682","DOI":"10.1038\/s41467-019-11610-1","volume":"10","author":"J Vedanayagam","year":"2019","unstructured":"Vedanayagam J et al (2019) Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis. Nat Commun 10(1):3682. https:\/\/doi.org\/10.1038\/s41467-019-11610-1","journal-title":"Nat Commun"},{"issue":"10","key":"7364_CR7","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/nrc3802","volume":"14","author":"WD Foulkes","year":"2014","unstructured":"Foulkes WD, Priest JR, Duchaine TF (2014) DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer 14(10):662\u2013672. https:\/\/doi.org\/10.1038\/nrc3802","journal-title":"Nat Rev Cancer"},{"issue":"8","key":"7364_CR8","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.1007\/s00018-020-03753-y","volume":"78","author":"E Gu\u00e9rit","year":"2021","unstructured":"Gu\u00e9rit E, Arts F, Dachy G, Boulouadnine B, Demoulin J-B (2021) PDGF receptor mutations in human diseases. Cell Mol Life Sci 78(8):3867\u20133881. https:\/\/doi.org\/10.1007\/s00018-020-03753-y","journal-title":"Cell Mol Life Sci"},{"key":"7364_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12830","author":"S L","year":"2022","unstructured":"L S et al (2022) Evidence of neural crest cell origin of a DICER1 mutant CNS sarcoma in a child with DICER1 syndrome and NRAS-mutant neurocutaneous melanosis. Neuropathol Appl Neurobiol. https:\/\/doi.org\/10.1111\/nan.12830","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"10","key":"7364_CR10","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1002\/ijc.30907","volume":"141","author":"J Kim","year":"2017","unstructured":"Kim J, Field A, Schultz KAP, Hill DA, Stewart DR (2017) The prevalence of DICER1 pathogenic variation in population databases. Int J Cancer 141(10):2030\u20132036. https:\/\/doi.org\/10.1002\/ijc.30907","journal-title":"Int J Cancer"},{"key":"7364_CR11","doi-asserted-by":"publisher","first-page":"614541","DOI":"10.3389\/fonc.2020.614541","volume":"10","author":"AM Caroleo","year":"2020","unstructured":"Caroleo AM et al (2020) DICER1 syndrome and cancer predisposition: from a rare pediatric tumor to lifetime risk. Front Oncol 10:614541. https:\/\/doi.org\/10.3389\/fonc.2020.614541","journal-title":"Front Oncol"},{"issue":"1","key":"7364_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13000-022-01252-1","volume":"17","author":"K Yao","year":"2022","unstructured":"Yao K, Duan Z, Feng J, Yan C, Qi X (2022) DICER1-associated central nervous system sarcoma with neural lineage differentiation: a case report. Diagn Pathol 17(1):72. https:\/\/doi.org\/10.1186\/s13000-022-01252-1","journal-title":"Diagn Pathol"},{"issue":"3","key":"7364_CR13","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3171\/2015.6.PEDS14709","volume":"17","author":"L Lafay-Cousin","year":"2016","unstructured":"Lafay-Cousin L et al (2016) Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children. J Neurosurg Pediatr 17(3):298\u2013302. https:\/\/doi.org\/10.3171\/2015.6.PEDS14709","journal-title":"J Neurosurg Pediatr"},{"issue":"4","key":"7364_CR14","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/cncr.33977","volume":"128","author":"RY Diaz Coronado","year":"2022","unstructured":"Diaz Coronado RY et al (2022) Primary central nervous system sarcoma with DICER1 mutation-treatment results of a novel molecular entity in pediatric peruvian patients. Cancer 128(4):697\u2013707. https:\/\/doi.org\/10.1002\/cncr.33977","journal-title":"Cancer"},{"issue":"1","key":"7364_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s10014-024-00495-8","volume":"42","author":"H Honma","year":"2025","unstructured":"Honma H et al (2025) Primary intracranial sarcoma associated with DICER1 mutant: a case report and preclinical investigation. Brain Tumor Pathol 42(1):12\u201320. https:\/\/doi.org\/10.1007\/s10014-024-00495-8","journal-title":"Brain Tumor Pathol"},{"issue":"5","key":"7364_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3390\/cancers10050143","volume":"10","author":"JC Robertson","year":"2018","unstructured":"Robertson JC, Jorcyk CL, Oxford JT (2018) DICER1 syndrome: DICER1 mutations in rare cancers. Cancers (Basel) 10(5):143. https:\/\/doi.org\/10.3390\/cancers10050143","journal-title":"Cancers (Basel)"},{"issue":"3","key":"7364_CR17","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3171\/2022.6.PEDS22119","volume":"30","author":"HG Vuong","year":"2022","unstructured":"Vuong HG, Le M-K, Dunn IF (2022) A systematic review of the clinicopathological features and prognostic outcomes of DICER1-mutant malignant brain neoplasms. J Neurosurg Pediatr 30(3):308\u2013315. https:\/\/doi.org\/10.3171\/2022.6.PEDS22119","journal-title":"J Neurosurg Pediatr"},{"issue":"7","key":"7364_CR18","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/brainsci13071040","volume":"13","author":"SE Kosteniuk","year":"2023","unstructured":"Kosteniuk SE, Michaiel G, Dunham C (2023) A case of primary intracranial sarcoma, DICER1-mutant, in a child with a germline DICER1 mutation. Brain Sci 13(7):1040. https:\/\/doi.org\/10.3390\/brainsci13071040","journal-title":"Brain Sci"},{"issue":"4","key":"7364_CR19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s10014-019-00352-z","volume":"36","author":"M Sakaguchi","year":"2019","unstructured":"Sakaguchi M et al (2019) Two cases of primary supratentorial intracranial rhabdomyosarcoma with DICER1 mutation which may belong to a \u2018spindle cell sarcoma with rhabdomyosarcoma-like feature, DICER1 mutant.\u2019 Brain Tumor Pathol 36(4):174\u2013182. https:\/\/doi.org\/10.1007\/s10014-019-00352-z","journal-title":"Brain Tumor Pathol"},{"key":"7364_CR20","doi-asserted-by":"publisher","first-page":"253","DOI":"10.25259\/SNI_259_2024","volume":"15","author":"BM Edelbach","year":"2024","unstructured":"Edelbach BM, Gospodarev V, Raghavan R, Dye J (2024) Primary intracranial sarcoma, DICER-1 mutant, with hemorrhagic presentation: a case report. Surg Neurol Int 15:253. https:\/\/doi.org\/10.25259\/SNI_259_2024","journal-title":"Surg Neurol Int"},{"issue":"5","key":"7364_CR21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnen\/nlae024","volume":"83","author":"LJ Robinson","year":"2024","unstructured":"Robinson LJ et al (2024) A rare case of an adult primary intracranial sarcoma associated with a DICER1 mutation. J Neuropathol Exp Neurol 83(5):365\u2013369. https:\/\/doi.org\/10.1093\/jnen\/nlae024","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"7364_CR22","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10014-022-00437-2","volume":"39","author":"K Yang","year":"2022","unstructured":"Yang K et al (2022) A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL. Brain Tumor Pathol 39(4):225\u2013231. https:\/\/doi.org\/10.1007\/s10014-022-00437-2","journal-title":"Brain Tumor Pathol"},{"issue":"6","key":"7364_CR23","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00381-024-06356-1","volume":"40","author":"A Lachance","year":"1965","unstructured":"Lachance A et al (1965) Recurrent primary intracranial sarcoma, DICER1-mutant in a pediatric patient with DICER1 syndrome: the importance of molecular testing. Childs Nerv Syst 40(6):1965\u20131969. https:\/\/doi.org\/10.1007\/s00381-024-06356-1","journal-title":"Childs Nerv Syst"},{"issue":"1","key":"7364_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s10014-024-00495-8","volume":"42","author":"H Honma","year":"2025","unstructured":"Honma H et al (2025) Primary intracranial sarcoma associated with DICER1 mutant: a case report and preclinical investigation. Brain Tumor Pathol 42(1):12\u201320. https:\/\/doi.org\/10.1007\/s10014-024-00495-8","journal-title":"Brain Tumor Pathol"},{"issue":"2","key":"7364_CR25","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3390\/brainsci13020235","volume":"13","author":"A Marinelli","year":"2023","unstructured":"Marinelli A et al (2023) A rare adult primary intracranial sarcoma, DICER1-mutant identified by epigenomic profiling: a case report. Brain Sci 13(2):235. https:\/\/doi.org\/10.3390\/brainsci13020235","journal-title":"Brain Sci"},{"issue":"5","key":"7364_CR26","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.asjsur.2023.11.096","volume":"47","author":"M Huang","year":"2024","unstructured":"Huang M, Huang M, Gao X (2024) Primary intracranial DICER1-mutant sarcoma: a case report. Asian J Surg 47(5):2212\u20132213. https:\/\/doi.org\/10.1016\/j.asjsur.2023.11.096","journal-title":"Asian J Surg"},{"issue":"9","key":"7364_CR27","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/jnen\/nlac053","volume":"81","author":"N Leelatian","year":"2022","unstructured":"Leelatian N, Goss J, Pastakia D, Dewan MC, Snuderl M, Mobley BC (2022) Primary intracranial sarcoma, DICER1-mutant presenting as a pineal region tumor mimicking pineoblastoma: case report and review of the literature. J Neuropathol Exp Neurol 81(9):762\u2013764. https:\/\/doi.org\/10.1093\/jnen\/nlac053","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"7364_CR28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12957-018-1469-4","volume":"16","author":"O Abbo","year":"2018","unstructured":"Abbo O et al (2018) Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review. World J Surg Oncol 16(1):164. https:\/\/doi.org\/10.1186\/s12957-018-1469-4","journal-title":"World J Surg Oncol"},{"key":"7364_CR29","doi-asserted-by":"publisher","first-page":"153553","DOI":"10.1016\/j.prp.2021.153553","volume":"225","author":"S Rossi","year":"2021","unstructured":"Rossi S et al (2021) DICER1-associated malignancies mimicking germ cell neoplasms: report of two cases and review of the literature. Pathol Res Pract 225:153553. https:\/\/doi.org\/10.1016\/j.prp.2021.153553","journal-title":"Pathol Res Pract"}],"container-title":["Child's Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-026-07364-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00381-026-07364-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00381-026-07364-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:50:39Z","timestamp":1783360239000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00381-026-07364-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7364"],"URL":"https:\/\/doi.org\/10.1007\/s00381-026-07364-z","relation":{},"ISSN":["1433-0350"],"issn-type":[{"value":"1433-0350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"19 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and the guidelines of the Jiangsu Cancer Hospital ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent has been obtained from the patient\u2019s family member (father) for the publication of any potentially identifiable images or data contained in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"286"}}