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Doses for reRT were as follows: 50\u201354\u00a0Gy (1.8\u20132.0\u00a0Gy daily\/fractions) or 39\u00a0Gy (3\u00a0Gy daily\/fractions). Overall survival (OS) was defined as the time from diagnosis to the date of death and reRT OS, reirradiation starting to death. The Kaplan\u2013Meier method and log-rank test were used for survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 7.1\u00a0years (range 2.9\u201316.2\u00a0years). Twenty-six patients underwent a biopsy. The\n                      <jats:italic>H3K27M<\/jats:italic>\n                      mutation was the most prevalent in our study, followed by\n                      <jats:italic>TP53<\/jats:italic>\n                      altered gene. Twenty-two patients underwent reRT at progression. The median time from initial treatment to reRT was 9.9\u00a0months (range 6.7 to 20.5\u00a0months). Seven of the 22 patients received reRT at a dose of 39\u00a0Gy while 14 at doses of 50\u201354\u00a0Gy. The median OS from reRT to death was 5.8\u00a0months (range, 0.9\u201318.3\u00a0months). Patients who received reRT had a longer OS compared to those who did not (median OS of 17.9 versus 9.8\u00a0months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Longer time for progression (&gt;\u20099\u00a0months) and dose of reRT\u2009&gt;\u200950\u00a0Gy were statistically significantly correlated with better OS. Reirradiation was generally well-tolerated by all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study offers molecular insights into this tumor type and presents a therapeutic option with higher nominal doses reRT within a palliative context to prolong survival of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00381-026-07390-x","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:01:19Z","timestamp":1787216479000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reirradiation for diffuse intrinsic pontine glioma in an upper middle-income country: does full dose improve outcomes?"],"prefix":"10.1007","volume":"42","author":[{"given":"Nat\u00e1lia","family":"Dassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa Sucharski","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine Tesser","family":"Gamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Devanir Silva","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"dos Santos Torquato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Benigno","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Modesto","family":"de Souza Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Cavalheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Alessandra","family":"Dastoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Adolfo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlota Vitoria Blassioli","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Regina Caminada","family":"de Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasjla Saba","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Jenwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Maria","family":"Cappellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"8","key":"7390_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-019-0577-y","volume":"21","author":"NA Vitanza","year":"2019","unstructured":"Vitanza NA, Monje M (2019) Diffuse intrinsic pontine glioma: from diagnosis to next-generation clinical trials. 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